• Clinical Endoscopy
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• 제56권1호
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• pp.65-74
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• 2023

Background/Aims: Gastric varices (GV) are present in 25% of cirrhotic patients with high rates of rebleeding and mortality. Data on endoscopic ultrasound (EUS)-guided treatment in severe liver disease (model for end stage liver disease sodium [MELD-Na] >18 and Child-Turcotte-Pugh [CTP] C with GV) are scarce. Thus, we performed a retrospective comparison of endoscopic glue injection with EUS-guided therapy in cirrhotic patients with large GV. Methods: A retrospective study was performed in the tertiary hospitals of India. A total of 80 patients were recruited. The inclusion criteria were gastroesophageal varices type 2, isolated gastric varices type 1, bleeding within 6 weeks, size of GV >10 mm, and a MELD-Na >18. Treatment outcomes and complications of endoscopic glue injection and EUS-guided GV therapy were compared. Results: In this study, the patients' age, sex, liver disease severity (CTP, MELD-Na) and clinical parameters were comparable. The median number of procedures, injected glue volume, complications, and GV obturation were better in the EUS group, respectively. On subgroup analysis of the EUS method (e.g., direct gastric fundus vs. paragastric collateral [PGC] coil placement), PGC coil placement showed decreased coil requirement, less injected glue volume, decreased luminal coil extrusion, and increased successful GV obturation. Conclusions: EUS-guided treatment is more efficient and safer, and requires a smaller number of treatment sessions, as compared to endoscopic treatment in severe liver disease patients with large GV. Furthermore, PGC coil placement increases the complete obliteration of GV.

• 전력전자학회:학술대회논문집
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• 전력전자학회 1998년도 Proceedings ICPE 98 1998 International Conference on Power Electronics
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• pp.961-965
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• 1998

The rapid development of small-scale (1-10 MJ) Superconducting Magnetic Energy Storage Systems (SMES) can be explained by real perspective of practical implementation of these devices in electro power nets. However the serious problem of all high mechanically stressed superconducting coils-problem of training and degradation (decreasing) of operating current still exists. Moreover for SMES systems this problems is more dangerous because of pulsed origin of mechanical stresses-one of the major sources of local heat disturbances in superconducting coils. We investigated acoustic emission (AE) phenomenon on model and 0.5 MJ SMES coils taking into account close correlation of AE and local heat disturbances. Two-coils 0.5 MJ SMES system was developed, manufactured and tested at Russian Research Center in the frames of cooperation with Korean Electrical Engineering Company (KEPCO) [1]. The two-coil SMES operates with the stored energy transmitted between coils in the course of a single cycle with 2 seconds energy transfer time. Maximum operating current 1.55 kA corresponds to 0.5 MF in each coil. The Nb-Ti-based conductor was designed and used for SMES manufacturing. It represents transposed cable made of Nb-Ti strands in copper matrix, several cooper strands and several stainless steel strands. The coils are wound onto fiberglass cylindrical bobbins. To make AE event information more useful a real time instrumentation system was used. Two main measured and computer processed AE parameters were considered: the energy of AE events (E) and the accumulated energy of AE events (E ). Influence of current value in 0.5 MJ coils on E and E was studied. The sensors were installed onto the bobbin and the external surface of magnets. Three levels of initial current were examined: 600A, 1000A, 2450 A. An extraordinary strong dependence of the current level on E and E was observed. The specific features of AE from model coils, operated in sinusoidal vibration current changing mode were investigated. Three current frequency modes were examined: 0.012 Hz, 0.03 Hz and 0.12 Hz. In all modes maximum amplitude 1200 A was realized.

• 한국식품과학회지
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• 제32권1호
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• pp.218-224
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• 2000

분자량이 상이한 세 종류의 키토산의 항균활성을 E. coli O157 : H7, S. aureus 및 C. albicans 균주를 이용하여 측정, 분석하였다. E. coli O157 : H7와 S. aureus에 대해서는 분자량 10,000인 키토산이 가장 강한 항균활성을 보였으며 C. albicans에 대해서는 6량체의 키토산 올리고당이 가장 강한 활성을 나타내었다. 키토산 첨가농도는 E. coil O157 : H7와 S. aureus의 경우 0.1 mg/mL의 농도에서, C. albicans의 경우는 chitohexaose 1 mg/mL의 농도에서 항균활성이 가장 높았다. 모든 키토산 처리구에서 미생물 사멸 속도는 키토산 처리 1시간 이내에서 가장 높게 나타났으며 그 이후로는 점차 낮은 속도를 보였다. 사멸되었거나 파손된 미생물 세포로부터 유래되는 단백질, 핵산물질 및 $Ca^{2+}$ 량은 키토산 처리 시간 이내에 가장 많았으며 ${\beta}-galactosidase$ 활성도 같은 시간대에서 가장 빠른 속도로 중대되는 것으로 나타났다. S. aureus에 대한 세포막 손상 정도를 측정하여 본 결과 전체 미생물균체중 약 10%에 상당하는 균수가 막손상을 가져 왔다. 따라서, 키토산은 고유의 양이온성 성질을 이용하여 미생물의 세포벽과 세포막에 결합하여 그 결과로 세포 내 물질의 세포 외로의 유출내지는 세포막 대사의 저해 등의 효과를 나타냄으로써 항균활성을 나타내는 것으로 추측되었다.

• 한국방사선학회논문지
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• 제12권4호
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• pp.475-480
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• 2018

하복부 MRI 검사에서 환자는 body array coil과 물리적으로 접촉하여 검사를 받는다. 이 연구에서는 아크릴 보조장치(ACR)를 설계하여 코일과 환자의 비접촉식 스캔을 가능하게하고, ACR을 이용해서 획득 한 영상을 ACR 없이 얻은 영상와 비교하여 실현 가능성을 평가하였다. Ingenia 3.0TTM MR 시스템과 dStreamTM torso coil (Philips Healthcare, Netherlands)을 사용하여 10건(F : 5, m : 5)을 테스트하였다. 대표적인 두가지 pulse sequence(T1 AXE TSE, eTHRIVE (GRE))를 사용하여, 스캔 한 영상을 정량적, 정성적으로 비교 분석 하였다. 정성적으로 보면, TSE는 ACR의 유무에 관계없이 4.44와 4.56의 평균값을, GRE에서는 각각 4.34와 4.28을 보여준다. 정량적으로, TSE는 ACR 유무에 관계없이 12.15 CNR, 17.95 SNR 및 12.71 CNR, 18.96 SNR을 보였으며, GRE는 ACR이 있는 경우와 없는 경우 각각 17.72 CNR, 22.59 SNR 및 18.26 CNR, 24.47 SNR을 보여주었다. 즉, ACR의 사용이 환자를 편안하게 하지만, 화질에는 큰 영향이 없음을 확인하였다. 우리는 하복부 환자의 MRI 검사용 아크릴 보조 장치를 설계하고 적용해보았다. 우리의 결과는 환자와의 물리적 접촉없이 현재의 복부 MRI 스캔과 유사한 이미지 품질을 얻을 수 있음을 보여주었다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1993년도 제2회 신약개발 연구발표회 초록집
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• pp.59-59
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• 1993

비방사능물질인 Biotin을 DNA probe에 표지하여 nonisotopic hybridization 방법을 사용하여 감도를 높임으로써, 손쉽게 생물공학 의약품의 품질관리에 사용되도록 하였다. Bethesda Research Laboratories(BRL) 회사 제품인 biotinylated probes-avidin alkaline phosphatase를 이용한 chemiluminescene detection방법으로 행하여 λ phage DNA, yeast DNA, E.coil DNA의 한계 검출 농도를 알아내고, 생물 공학 제품에 적용하였다. Dot blot hybridization 방법으로 행하여 λ phage DNA는 0.1pg, Yeast DHA는 4.5pg, E. coli DNA는 8.9pg까지 검출되었고, 기존 생물공학 제품에서는 숙주 유래 DNA가 전혀 검출되지 않았다.

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 1993년도 제2회 신약개발 연구발표회 초록집
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• pp.81-81
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• 1993

Reverse transcriptase가 유도되는 것을 SDS-PAGE 및 효소활성 분석으로 확인할 수 있었으며 효소의 정제를 위한 예비실험으로 ammonium sulfate 및 DEAE cellulose ion exchange chromatorgraphy를 시행하였을 때 specific activity의 증가를 보여주므로서 reverse transcriptase의 분자클로닝 후 발현된 효소가 활성을 갖고 있음을 알 수 있었다. pMAL; cRI 재조합 유전자에 있는 protease의 유전자 발현을 유도했을 때 E. coli세포의 성장에 toxic하게 작용함을 관찰할 수 있었다. 이는 발현된 protease가 E. coil의 번식에 영향을 주는 것으로 믿어지며 Protease의 유전자 발현을 위한 host의 선택, inducer의 첨가시간 등 실험조건의 확립이 필요할 것으로 사료된다.

• Journal of Power Electronics
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• 제13권2호
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• pp.275-286
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• 2013

An explicit frequency-domain circuit model for the conventional coupled magnetic resonance system (CMRS) is newly proposed in this paper. Detail circuit parameters such as the leakage inductances, magnetizing inductances, turn-ratios, internal coil resistances, and source/load resistances are explicitly included in the model. Accurate overall system efficiency, DC gain, and key design parameters are deduced from the model in closed form equations, which were not available in previous works. It has been found that the CMRS can be simply described by an equivalent voltage source, resistances, and ideal transformers when it is resonated to a specified frequency in the steady state. It has been identified that the voltage gain of the CMRS was saturated to a specific value although the source side or the load side coils were strongly coupled. The phase differences between adjacent coils were ${\pi}/2$, which should be considered for the EMF cancellations. The analysis results were verified by simulations and experiments. A detailed circuit-parameter-based model was verified by experiments for 500 kHz by using a new experimental kit with a class-E inverter. The experiments showed a transfer of 1.38 W and a 40 % coil to coil efficiency.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1992년도 추계학술대회
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• pp.117-122
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• 1992

In systems in which inductive coupling between a pancake-shaped coil on the surface of the body and a similar coil within the body is utilized for the transfort of electromagnetic energy, the minimization of temperature rise in the tissue is intimately related to the achievement of minimum losses in the region of the implanted coil. The new class of amplifiers, named "class E", for inverter is defined and is illustrated by a detailed description and a set of desist equations for one simple member of the class. For TET circuit the authors measured 65 to 76 percent efficiency at 1985kHz at 30 to 50 W output from IRF250 MOSFET transistor.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2001년도 춘계학술대회 논문집 전기기기 및 에너지변환시스템부문
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• pp.22-25
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• 2001

The research results on the superconducting magnet for whole body MRI are presented. The magnet consists of main coil with 6 solenoid coils, shielding coil with 2 solenoid coils and 6 sets of cryogenic shim coil. The ferromagnetic shim assembly is installed on the inside wall of the room temperature bore for shimming inhomogeneous field components generated due to manufacturing tolerances, installation misalignments and external ferromagnetic materials near the magnet. Also, the magnet is enclosed with the horizontal type cryostat with 80cm room temperature bore to keep the magnet under the operating temperature. The magnetic field distributions within the imaging volume were measured by the NMR field mapping system. Through the test, the central field of magnet was 1.5 Tesla and the field homogeneity of 9.3 ppm has been obtained on 40cm DSV(the diameter of spherical volume) and using this magnet, comparatively good images for human body, fruits and water phantoms have been achieved.

• 대한전기학회:학술대회논문집
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• 대한전기학회 1998년도 하계학술대회 논문집 A
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• pp.186-188
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• 1998

Acoustic emission monitoring on two racetrack superconducting field winding coil was performed during excitation and quenches to diagnose the integrity of the field winding coils. Two field windings were not impregnated with epoxy The results confirm that the acoustic emission signals are mainly due to conductor motions which cause premature quenching of the winding. The quench current of modified racetrack type field winding coil (Type B) are more higher than that of conventional field winding coil (Type A).