• International Journal of Industrial Entomology and Biomaterials
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• v.3 no.2
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• pp.113-116
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• 2001

Fifth instar larvae of the new bivoltine hybrid (CSR2 ${\times}$ CSR5) were reared under different temperature and humidity viz., $20^{\circ}C$ and 85 ${pm}$ 5% R.H (T1), $25^{\circ}C$ and 70 ${pm}$ 5% R.H (T2-Optimum), $30^{\circ}C$ and 80% ${pm}$ 5 R.H (T3) and $35^{\circ}C$and 50 ${pm}$ 5% R.H (T4). The cocoon yield, cocoon characters and disease incidence were studied in normal (non infectious source, i.e control) rearing as well as in 1% infectious source of rearing. The results indicated that V instar larval duration was prolonged and cocoon weight was improved in T1. ERR and shell ratio were significantly improved and disease incidence was minimised in T2. Further significant difference was observed among the treatments with regard to spread of diseases.

• Korean Journal of Microbiology
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• v.25 no.4
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• pp.309-317
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• 1987

It was known that normal-haemolymph from the 3rd instar larvae of Lucillia illustris contain a lysozyme (or lysozyme-like substance) with bactericidal activity to fram positive bacteria, and the bactericidal activity of injured-haemolymph was increased significantly after injuring the body wall. To elucidate the defence mechanism of insect against the nonpathogenic bacteria, the immune-haemolymph against Escherichia coli K-12 was prepared after immunization. The bactericidal activity between injured and immune-haemolymph was compared, and it was revealed that the immune-haemolymph showed higher titer of bactericidal activity to fram positive bacteria as well as to Escherichia coli. The bactericidal substance from the immune-haemolymph was purified through a successive chromatographies on Sephacryl S-300 and CM-Sepharose CL-6B, and it was characterized as a basic protein in nature with heat stable property at acidic conditions.

• Journal of Oriental Neuropsychiatry
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• v.19 no.1
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• pp.29-42
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• 2008

Objectives : This study was performed to examine the effect of Sinchim on enhancing of memory in rat with water maze. Methods : Experimental animals(white rat) were classfied into normal, control, and aroma sample group. Then, they were injected .{\beta}-amyloid into control and aroma sample group rat's brain about $5{\mu}l$ to injure its brain. After rat smelt Sinchim about 12days, I did water maze test and anatomized its hippocampus. Sections were cut coronally at 30 ${\mu}m$.(XI00) Results: 1. In acquisition test of water maze learning, .{\beta}-amyloid injured group took more time than normal group to reach the escape platform noticeably and through the session of trial, Sinchim aroma sample group shortened time than .l3-amyloid injured group after 6 days. 2. In the acetyltransferase(AchE) immunostained method, it was shown that Sinchim aroma sample recovered tbe syntbesis of ChAT(Choloneacetyltransferase). Conclusion: Smelling Sinchim would be useful for enhancing of memory.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.10a
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• pp.248-251
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• 2005

To investigate the degeneration process in the intervertebral disc, a three dimensional (3D) poroelastic finite-element (FE) model was developed. Disc was modeled as two different regions, such as annulus modeled with fiber reinforced 20 node poroelastic ground matrix and nucleus having large porosity. Excess Von Mises stress in the disc element assumed to be a possible source of degeneration under compressive loading condition. Recursive calculation was continued until the desired convergence was attained by changing the permeability and porosity of those elements, which could be predicted from the previous iteration. The degenerated disc model showed that relatively small compressive stresses were generated in the nucleus elements compared to normal disc. Its distribution along the sagittal plane was matched well with a previously reported experimental result. Contrasts to this result, pore pressures in the nucleus were higher than those in the normal disc. Total stress indicated similar values for two different models. This new approach using poroelastic modeling could provide the explanation of the interaction between fluid and solid matrix in the disc during the degeneration process.

• Molecules and Cells
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• v.21 no.1
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• pp.1-6
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• 2006

Bcl-2/adenovirus E1B 19 kDa-interacting protein 3 (BNIP3) is a mitochondrial pro-apoptotic protein that has a single Bcl-2 homology 3 (BH3) domain and a COOH-terminal transmembrane (TM) domain. Although it belongs to the Bcl-2 family and can heterodimerize with Bcl-2, its pro-apoptotic activity is distinct from those of other members of the Bcl-2 family. For example, cell death mediated by BNIP3 is independent of caspases and shows several characteristics of necrosis. Furthermore, the TM domain, but not the BH3 domain, is required for dimerization, mitochondrial targeting and pro-apoptotic activity. BNIP3 plays an important role in hypoxia-induced death of normal and malignant cells. Its expression is markedly increased in the hypoxic regions of some solid tumors and appears to be regulated by hypoxia-inducible factor (HIF), which binds to a site on the BNIP3 promoter. Silencing, followed by methylation, of the BNIP3 gene occurs in a significant proportion of cancer cases, especially in pancreatic cancers. BNIP3 also has a role in the death of cardiac myocytes in ischemia. Further studies of BNIP3 should provide insight into hypoxic cell death and may contribute to improved treatment of cancers and cardiovascular diseases.

• Geomechanics and Engineering
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• v.21 no.3
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• pp.227-236
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• 2020

Non-destructive exploration using elastic waves has been widely used to characterize rock mass properties. Wave propagation in jointed rock masses is significantly governed by the characteristics and orientation of discontinuities. The relationship between spatial heterogeneity (i.e., joint spacing) and wavelength for elastic waves propagating through jointed rock masses have been investigated previously. Discontinuous rock masses can be considered as an equivalent continuum material when the wavelength of the propagating elastic wave exceeds the spatial heterogeneity. However, it is unclear how stress-dependent long-wavelength elastic waves propagate through a repetitive rock-joint system with multiple joints. A preliminary numerical simulation was performed in in this study to investigate long-wavelength elastic wave propagation in regularly jointed rock masses using the three-dimensional distinct element code program. First, experimental studies using the quasi-static resonant column (QSRC) testing device are performed on regularly jointed disc column specimens for three different materials (acetal, aluminum, and gneiss). The P- and S-wave velocities of the specimens are obtained under various normal stress levels. The normal and shear joint stiffness are calculated from the experimental results using an equivalent continuum model and used as input parameters for numerical analysis. The spatial and temporal sizes are carefully selected to guarantee a stable numerical simulation. Based on the calibrated jointed rock model, the numerical and experimental results are compared.

• Applied Science and Convergence Technology
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• v.27 no.4
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• pp.65-69
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• 2018

We studied the critical pressure characteristics of an anode type ion beam source driven by both charge repulsion and diffusion mechanism. The critical pressure $P_{crit}$ of the diffusion type ion beam source was linearly decreased from 2.5 mTorr to 0.5 mTorr when the gas injection was varied in 3~10 sccm, while the $P_{crit}$ of the charge repulsion ion beam source was remained at 3.5 mTorr. At the gas injection of 10 sccm, the range of having normal beam shape in the charge repulsion ion beam source was about 6.4 times wider than that in the diffusion type ion beam source. An impurity of Fe 2p (KE = 776.68 eV) of 12.88 at. % was observed from the glass surface treated with the abnormal beam of the charge repulsion type ion beam source. The body temperature of the diffusion type ion beam source was observed to increase rapidly at the rate of $1.9^{\circ}C/min$ for 30 minutes and to vary slowly at the rate of $0.1^{\circ}C/min$ for 200 minutes for an abnormal beam and normal beam, respectively.

• 한국지구물리탐사학회:학술대회논문집
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• 2010.10a
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• pp.27-27
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• 2010

There have been several studies about empirical relation between seismic source parameters(e.g., focal mechanisms, depths, magnitudes, etc.) and T-wave observation. In order to delineate the relation, numerical and theoretical approaches to figure out T-wave excitation mechanism are required. In an attempt to investigate source radiation and wave scattering effects in the oceanic crust on T-wave envelopes, we perform three-dimensional numerical modeling to synthesize T-wave envelopes. We first calculate seismic P- and SV-wave energy on the seafloor using the Direct Simulation Monte Carlo based on the Radiative Transfer Theory, which enables us to take into account both realistic seismic source parameters and wave scattering in heterogeneous media, and then estimate excited T-wave energy by normal mode computation. The numerical simulation has been carried out considering the following different conditions: source types (strike and normal faults), source depths (shallow and deep), and wave propagation through homogeneous and heterogeneous Earth media. From the results of numerical modeling, we confirmed that T-wave envelopes vary according to spatial seismic energy distributions on the seafloor for the various input parameters. Furthermore, the synthesized T-wave envelopes show directional patterns due to anisotropic source radiation, and the slope change of T-wave envelopes caused by focal depth. Seismic wave scattering in the oceanic crust is likely to control the shape of envelopes.

• International journal of steel structures
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• v.18 no.4
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• pp.1397-1409
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• 2018

Stiffened plates with high slenderness parameters show large out-of-plane deflections, due to elastic buckling, which may occur before the plates reach their ultimate strength. From a serviceability point of view, restriction of out-of-plane deflections exceeding the fabrication tolerance is of primary importance. Compressive strength at the serviceability limit state (SLS) for slender stiffened plates under uniaxial stress was investigated through nonlinear elasto-plastic finite element analysis, considering both geometric and material nonlinearity. Both normal and high-performance steel were considered in the study. The SLS was defined based on a deflection limit and an elastic buckling strength. Probabilistic distributions of the SLS strengths were obtained through Monte Carlo simulations, in association with the response surface method. On the basis of the obtained statistical distributions, partial safety factors were proposed for SLS. Comparisons with the ultimate strength of different design codes e.g. Japanese Code, AASHTO, and Canadian Code indicate that AASHTO and Canadian Code provide significantly conservative design, while Japanese Code matches well with a 5% non-exceedance probability for compressive strength at SLS.

• Korean Journal of Head & Neck Oncology
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• v.37 no.1
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• pp.1-10
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• 2021

Intensity-modulated radiation therapy (IMRT) using X-rays is a standard technique implemented for treating head and neck cancer (HN C). Compared to 3D conformal RT, IMRT can significantly reduce the radiation dose to surrounding normal tissues by using a highly conformal dose to the tumor. Proton therapy is a type of RT that uses positively charged particles named protons. Proton therapy has a unique energy deposit (i.e., Bragg peak) and greater biological effectiveness than that of therapy using X-rays. These inherent properties of proton therapy make the technique advantageous for HNC treatment. Recently, advanced techniques such as intensity-modulated proton therapy have further decreased the dose to normal organs with a higher conformal dose to the tumor. The usage of proton therapy for HNC is becoming widespread as the number of operational proton therapy centers has increased worldwide. This paper aims to present the current clinical evidence of proton therapy utility to HNC clinicians through a literature review. It also discusses the challenges associated with proton therapy and prospective development of the technique.