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Brachial Artery Thrombosis in an 8-year-old Boy with Antiphospholipid Antibodies Induced by Mycoplasma pneumoniae Infection: a Case Report

  • Woo, Jung Hee;Kwon, Jung Hyun;Je, Bo-Kyung;Shin, Jae Seoung;Seo, Won Hee;Jang, Gi Young
    • Pediatric Infection and Vaccine
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    • v.26 no.1
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    • pp.60-65
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    • 2019
  • Antiphospholipid antibodies may be produced in cases involving autoimmune diseases and can sometimes be caused by infections, such as Mycoplasma pneumoniae infection. However, antiphospholipid antibodies causing thrombosis associated with M. pneumoniae pneumonia in children have rarely been reported. We report a case of an 8-year-old boy with M. pneumoniae pneumonia with antiphospholipid antibodies, complicated by brachial artery thrombosis. He was found to have antiphospholipid antibodies and low protein S levels. The brachial artery thrombus was removed via thrombectomy. The titers of antiphospholipid antibodies turned normal within 5 months. This is a rare case of M. pneumoniae infection with brachial artery thrombosis associated with transient antiphospholipid antibodies.

Analysis of Wave and Current in Anmok Coastal Waters (안목해안의 파랑과 흐름 분석)

  • Lim, Hak-Soo;Kim, Mujong
    • Journal of Coastal Disaster Prevention
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    • v.4 no.1
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    • pp.7-19
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    • 2017
  • In this study, waves and currents observed by acoustic AWAC, VECTOR and Aquadopp Profiler in Anmok coastal waters were analysed to account for the variability of wave and current and to understand the mechanism of sediment transport generated by wave-induced current in the surf-zone. The monthly variation of wave and residual currents were analysed and processed with long-term observed AWAC data at station W1, located at the water depth of about 18m measured during from February 2015 to September 2016. Wave-induced currents were also analysed with intensive field measurements such as wave, current, suspended sediment, and bathymetry data observed at the surf-zone during in winter and summer. The statistical result of wave data shows that high waves coming from NNE and NE in winter (DEC-FEB) are dominant due to strong winds from NE. But in the other season waves coming from NE and ENE are prevalent due to the seasonal winds from E and SE. The residual currents with southeastern direction parallel to the shoreline are dominant throughout a year except in winter showing in opposite direction. The speed of ebb-dominant southeastern residual currents decreasing from surface to the bottom is strong in summer and fall but weak in winter and spring. By analysing wave-induced current, we found that cross-shore current were generated by swell waves mainly in winter with incoming wave direction about $45^{\circ}$ normal to the shoreline. Depending on the direction of incoming waves, longshore currents in the surf-zone were separated to southeastern and northwestern flows in winter and summer respectively. The variation of observed currents near crescentic bars in the surf-zone shows different direction of longshore and cross-shore currents depending on incoming waves implying to the reason of beach erosion generating the beach cusp and sandbar migration during high waves at Anmok.

Relation of Various Parameters Used to Estimate Cardiac Vagal Activity and Validity of pNN50 in Anesthetized Humans

  • Lee, Jae Ho;Huh, In Young;Lee, Jae Min;Lee, Hyung Kwan;Han, Il Sang;Kang, Ho Jun
    • Kosin Medical Journal
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    • v.33 no.3
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    • pp.369-379
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    • 2018
  • Objectives: Analysis of heart rate variability (HRV) has been used as a measure of cardiac autonomic function. According to the pNN50 statistic, the percentage of differences between successive normal RR intervals (RRI) that exceed 50 ms, has been known to reflect cardiac vagal modulation. Relatively little is known about the validity of pNN50 during general anesthesia (GA). Therefore, we evaluated the correlation of pNN50 with other variables such as HF, RMSSD, SD1 of HRV reflecting the vagal tone, and examined the validity of pNN50 in anesthetized patients. Methods: We assessed changes in RRI, pNN50, root mean square of successive differences of RRI (RMSSD), high frequency (HF) and standard deviation 1 (SD1) of $Poincar{\acute{e}}$ plots after GA using sevoflurane anesthesia. We also calculated the probability distributions for the family of pNNx statistics (x: 2-50 ms). Results: All HRV variables were significantly decreased during GA. HF power was not correlated with pNN50 during GA (r = 0.096, P = 0.392). Less than pNN47 was shown to have a correlation with other variables. Conclusions: These data suggest that pNN50 can not reflect the level of vagal tone during GA.

The prevalence of causative agents of calf diarrhea in Korean native calves

  • Chae, Jeong-Byoung;Kim, Hyeon-Cheol;Kang, Jun-Gu;Choi, Kyoung-Seong;Chae, Joon-Seok;Yu, Do-Hyeon;Park, Bae-Keun;Oh, Yeon-su;Choi, Hak-Jong;Park, Jinho
    • Journal of Animal Science and Technology
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    • v.63 no.4
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    • pp.864-871
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    • 2021
  • Infectious calf diarrhea is one of the most significant diseases of neonatal calves. This study is conducted to identify the prevalence of pathogens in calf diarrhea for 2 years. A total of 544 feces samples from Korean native beef calves were obtained to investigate selected seven pathogens causing calf diarrhea: bovine rotavirus, bovine coronavirus, Cryptosporidium parvum, bovine viral diarrhea virus, Eimeria species, Escherichia coli K99, and Salmonella species. The presence of diarrhea, the number and species of detected pathogens, and the calves' ages were analyzed using various statistical methods depending on the case. Of the 544 calves, 340 calves (62.5%) had normal feces and 204 calves (37.5%) had diarrhea. The presence of pathogens was significantly associated with diarrhea (p < 0.01) and fecal scores and the number of detected pathogens showed a significant linear trend (p < 0.001). Of the 7 target pathogens, 6 were detected in samples, but only C. parvum (p = 0.001) and bovine rotavirus (p < 0.001) were found at significantly higher rates in diarrheic calves than in non-diarrheic calves. Only Eimeria spp. showed a significant linear trend between the detection rate of the pathogen and the age groups (p < 0.05).

The Relationship Between Green Stem Disorder and the Accumulation of Vegetative Storage Protein in Soybean

  • Zhang, Jiuning;Katsube-Tanaka, Tomoyuki;Shiraiwa, Tatsuhiko
    • Proceedings of the Korean Society of Crop Science Conference
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    • 2019.09a
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    • pp.22-22
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    • 2019
  • Green stem disorder (GSD) of soybean (Glycine max (L.) Merr.) is characterized by delayed senescence of stems with normal pod ripening and seed maturation (Hobbs, 2006). GSD complicates harvesting of soybeans by significantly increasing the difficulty in cutting the affected plants. There is also the potential for moisture in the stems to be scattered on the seed, reducing the grade and storability of the seed. Not only the cause of GSD is yet unknown, but also GSD cannot be evaluated until maturity, therefore the method to evaluate GSD in early growth stage with high sensitivity is necessary. In previous studies, it has been reported that vegetative storage protein (VSP) accumulates and the syndrome of GSD appears in soybean after depod treatment (Fischer, 1999). Soybean VSP is a storage protein which is abundant in young sink leaves and degraded during seed fill (Wittenbach, 1982). Hence, we have established a system to quantify VSP of high sensitivity by using standard protein made by genetically transformed E. coli and specific antibody against VSP, and studied the relationship between VSP and GSD, by depod experiment and drought/excess wet experiments. The result of depod experiment with the cultivar 'Yukihomare' was the same with the previous studies, VSP accumulated much more than control and the syndrome of GSD appeared in soybean in depod treatment. Drought and excess wet had different impact on GSD. Excess wet caused GSD of the cultivar 'Tachinagaha (GSD susceptible)', while drought caused a little syndrome of GSD in the cultivar 'Touhoku 129 (GSD resistant)'. The accumulation of VSP differed between the two cultivars over time. In conclusion, the accumulation of VSP came along with the emergence of GSD. Different cultivars showed different response to drought and excess wet. In the future, it is expected that the dynamics of VSP will be elucidated in detail, leading to the development of early diagnosis technology for green stem disorder and the elucidation of mechanism of soybean GSD.

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The Design and Implementation of Module supporting Trusted Channel in Secure Operating System Environment (보안운영체제 환경에서의 신뢰채널 지원을 위한 모듈의 설계 및 구현)

  • 유준석;임재덕;나재훈;손승원
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.14 no.3
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    • pp.3-12
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    • 2004
  • Secure operating system is a special operating system that integrates some security functions(i.e. access control, user authentication, audit-trail and etc.) with normal operating system in order to protect system from various attacks. But it doesn't consider my security of network traffic. To guarantee the security of the whole system, network traffic must be protected by a certain way and IPsec is a representative technology for network security. However, it requires administrator's carefulness in managing security policies and the key management mechanism is very heavy as well as complicated. Moreover, it doesn't have a suitable framework for delivery of security information for access control mechanism. So we propose a simple trusted channel mechanism for secure communication between secure operating systems. It provides confidentiality md authentication for network traffic and ability to deliver security information. It is implemented at the kernellevel of IP layer and the simplicity of the mechanism can minimize the overhead of trusted channel processing.

Cryptanalysis of LILI-128 with Overdefined Systems of Equations (과포화(Overdefined) 연립방정식을 이용한 LILI-128 스트림 암호에 대한 분석)

  • 문덕재;홍석희;이상진;임종인;은희천
    • Journal of the Korea Institute of Information Security & Cryptology
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    • v.13 no.1
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    • pp.139-146
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    • 2003
  • In this paper we demonstrate a cryptanalysis of the stream cipher LILI-128. Our approach to analysis on LILI-128 is to solve an overdefined system of multivariate equations. The LILI-128 keystream generato $r^{[8]}$ is a LFSR-based synchronous stream cipher with 128 bit key. This cipher consists of two parts, “CLOCK CONTROL”, pan and “DATA GENERATION”, part. We focus on the “DATA GENERATION”part. This part uses the function $f_d$. that satisfies the third order of correlation immunity, high nonlinearity and balancedness. But, this function does not have highly nonlinear order(i.e. high degree in its algebraic normal form). We use this property of the function $f_d$. We reduced the problem of recovering the secret key of LILI-128 to the problem of solving a largely overdefined system of multivariate equations of degree K=6. In our best version of the XL-based cryptanalysis we have the parameter D=7. Our fastest cryptanalysis of LILI-128 requires $2^{110.7}$ CPU clocks. This complexity can be achieved using only $2^{26.3}$ keystream bits.

Stochastic Optimization of Multipath TCP for Energy Minimization and Network Stability over Heterogeneous Wireless Network

  • Arain, Zulfiqar Arain;Qiu, Xuesong;Zhong, Lujie;Wang, Mu;Chen, Xingyan;Xiong, Yongping;Nahida, Kiran;Xu, Changqiao
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.15 no.1
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    • pp.195-215
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    • 2021
  • Multipath Transport Control Protocol (MPTCP) is a transport layer protocol that enables multiple TCP connections across various paths. Due to path heterogeneity, it incurs more energy in a multipath wireless network. Recent work presents a set of approaches described in the literature to support systems for energy consumption in terms of their performance, objectives and address issues based on their design goals. The existing solutions mainly focused on the primary system model but did not discourse the overall system performance. Therefore, this paper capitalized a novel stochastically multipath scheduling scheme for data and path capacity variations. The scheduling problem formulated over MPTCP as a stochastic optimization, whose objective is to maximize the average throughput, avoid network congestion, and makes the system more stable with greater energy efficiency. To design an online algorithm that solves the formulated problem over the time slots by considering its mindrift-plus penalty form. The proposed solution was examined under extensive simulations to evaluate the anticipated stochastic optimized MPTCP (so-MPTCP) outcome and compared it with the base MPTCP and the energy-efficient MPTCP (eMPTCP) protocols. Simulation results justify the proposed algorithm's credibility by achieving remarkable improvements, higher throughput, reduced energy costs, and lower-end to end delay.

Novel nomogram-based integrated gonadotropin therapy individualization in in vitro fertilization/intracytoplasmic sperm injection: A modeling approach

  • Ebid, Abdel Hameed IM;Motaleb, Sara M Abdel;Mostafa, Mahmoud I;Soliman, Mahmoud MA
    • Clinical and Experimental Reproductive Medicine
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    • v.48 no.2
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    • pp.163-173
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    • 2021
  • Objective: This study aimed to characterize a validated model for predicting oocyte retrieval in controlled ovarian stimulation (COS) and to construct model-based nomograms for assistance in clinical decision-making regarding the gonadotropin protocol and dose. Methods: This observational, retrospective, cohort study included 636 women with primary unexplained infertility and a normal menstrual cycle who were attempting assisted reproductive therapy for the first time. The enrolled women were split into an index group (n=497) for model building and a validation group (n=139). The primary outcome was absolute oocyte count. The dose-response relationship was tested using modified Poisson, negative binomial, hybrid Poisson-Emax, and linear models. The validation group was similarly analyzed, and its results were compared to that of the index group. Results: The Poisson model with the log-link function demonstrated superior predictive performance and precision (Akaike information criterion, 2,704; λ=8.27; relative standard error (λ)=2.02%). The covariate analysis included women's age (p<0.001), antral follicle count (p<0.001), basal follicle-stimulating hormone level (p<0.001), gonadotropin dose (p=0.042), and protocol type (p=0.002 and p<0.001 for short and antagonist protocols, respectively). The estimates from 500 bootstrap samples were close to those of the original model. The validation group showed model assessment metrics comparable to the index model. Based on the fitted model, a static nomogram was built to improve visualization. In addition, a dynamic electronic tool was created for convenience of use. Conclusion: Based on our validated model, nomograms were constructed to help clinicians individualize the stimulation protocol and gonadotropin doses in COS cycles.

A Case of Lyme Disease Complicated with Atrioventricular Block in a 13-year-old Boy

  • Ahn, Bin;Kim, Gi Beom;Lee, Hoan Jong;Choi, Eun Hwa
    • Pediatric Infection and Vaccine
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    • v.27 no.3
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    • pp.184-189
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    • 2020
  • Lyme disease is a common vector-borne disease caused by Borrelia burgdorferi. Erythema migrans represents the most common manifestation during the early phase of this disease; however, systemic manifestations involving the nervous system, joints, or heart are known to occur. We report a case of Lyme disease accompanied by cardiac complications in a 13-year-old Korean male adolescent. The patient developed annular erythematous lesions on his lower extremities after a field trip during his visit to Connecticut, USA, for a boarding school camp, and his skin lesions were consistent with erythema migrans. Indirect immunofluorescence assay and Western blot analysis for Lyme immunoglobulin M showed positive results. Electrocardiography revealed a first-degree atrioventricular block, and he was diagnosed with Lyme carditis and received a 4-week course of oral doxycycline. Follow-up electrocardiography performed a week later revealed normal findings, and the patient showed an uneventful recovery. Lyme carditis often presents as an asymptomatic heart block that can progress to an advanced heart block; however, this condition is reversible with appropriate antibiotic treatment.