• Journal of the Korea Institute of Building Construction
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• v.15 no.2
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• pp.177-183
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• 2015

In this study, the thermal conductivity, physical and mechanical properties of lightweight aggregate concretes with hollow micro sphere(HMS) are experimentally examined as a basic research for the development of structural insulation concrete. As the results of this experiment, in the case of concrete mixed with HMS, the value of slump has been reduced, so it is found that the dosage of superplasticizer should be increased. As the replacement ratio of HMS increases, it has shown that the compressive strength is somewhat decreased due to the low interfacial adhesion strength of HMS. But the thermal conductivity is found to be greatly improved with the replacement ratio of HMS increases, the thermal conductivity of HMS shows the lower value of 68% at lightweight aggregate concrete and 32% of normal concrete. Also it is found that the compressive strength is decreased and thermal conductivity is increased as the water-cement ratio increases. The most outstanding for insulation performance is observed when using 20% of HMS and 50% of water-cement ratio.

• Genomics & Informatics
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• v.3 no.4
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• pp.149-153
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• 2005

Asthma is an inflammatory airways disease characterized by bronchial hyperresponsiveness and airways obstruction, which results from a complex interaction of genetic and environmental factors. Interleukin (IL)-13 and IL-4 are important in IgE synthesis and allergic inflammation, therefore genes encoding IL-13 and IL-4 are candidates for predisposition to asthma. In the present study, we screened single-nucleotide polymorphisms (SNPs) in IL-13 and IL-4 and examined whether they are risk factors for asthma. We resequenced all exons and the promoter region in 12 asthma patients and 12 normal controls, and identified 18 SNPs including 2 novel SNPs. The linkage disequilibrium(LD) pattern was evaluated with 16 common SNPs, and haplotypes were also estimated within the block. Although IL-13 and IL-4 are localized within 27 kb on chromosome 5q31 and share many biological profiles, this region was partitioned into 2 blocks. One SNP and three SNPs were determined as haplotype-taggingSNPs (htSNPs) within IL-13 and IL-4 haplotype-block, respectively. No significant associations were observed between any of the SNPs or haplotypes and development of asthma in small number of Korean subjects. However, the genetic variants of IL-13 and IL-4 would provide valuable strategies for the genotyping studies in large population.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.15 no.3
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• pp.545-555
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• 2002

This paper presents a matrix analysis to get the torsional behavior of core structures with torsional reinforcements. Based on simplified assumptions, formulae for the forces and displacements of cote structures subjected to three typical load cases, i.e. uniformly distributed torque, triangularly distributed torque and a concentrated torque at the top of the structure, are derived analytically. The behavior of the cote according to the variation of reinforcement locations is investigated to estimate the optimum locations of reinforcements to minimize the core rotations and bimoments. The results by the program MIDAS-GEN have shown that this analysis can give quite satisfactory results for structural models with torsional reinforcements. Although three dimensional analysis by computer has come within reach as a normal structural design procedure, its use as an optimization tool may not be desirable in view of the expense and time required. Formulae that we presented here can be used to estimate the torsional rotations and forces of practical cote structures at the preliminary design stages.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.15 no.3
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• pp.399-407
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• 2002

A three-dimensional method of analysis is presented for determining the free vibration frequencies and mode shapes of hollow bodies of revolution (i.e., thick shells), not limited to straight line generators or constant thickness. The middle surface of the shell may have arbitrary curvatures, and the wall thickness may vary arbitrarily. Displacement components$U_\Phi, U_z, U_\theta$ in the meridional, normal and circumferential directions, respectively, are taken to be sinusoidal in time, periodic in$\theta$, and algebraic polynomials in the$\Phi$and z directions. Potential(strain) and kinetic energies of the entire body are formulated, and upper bound values of the frequencies are obtained by minimizing the frequencies. As the degrees of the polynomials are increased, frequencies converge to the exact values. Novel numerical results are presented for two types of thick conical shells and thick spherical shell segments having linear thickness variations. Convergence to four digit exactitude is demonstrated for the first five frequencies of both types of shells. The method is applicable to thin shells, as well as thick and very thick ones.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.34 no.3
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• pp.273-281
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• 2010

In this paper, a method to predict the fatigue life of an axle drive shaft by the calibrated accelerated life test (CALT) method is proposed. The CALT method is very effective for predicting lifetimes, significantly reducing test time, and quantifying reliability. The fatigue test is performed by considering two high stress and one low stress levels, and the lifetime at the normal stress level is predicted by extrapolation. In addition, in this study, the major reliability parameters such as the lifetime, accelerated power index, shape parameter, and scale parameter are determined by conducting various experiments. The lifetime prediction of the axle drive shaft is verified by comparing the experimental results with load spectrum data. The results confirm that the CALT method is effective for lifetime prediction and requires a short test time.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.39 no.11
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• pp.1137-1143
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• 2015

The stage II fretting fatigue crack growth and branching, i.e., the process of fretting fatigue crack growth starting in an inclined direction and then changing to the normal direction, is analyzed using the finite element method. The fretting fatigue experiment data of A7075-T6 are used in the analysis. The applicability of maximum tangential stress intensity factor, maximum tangential stress intensity factor range, and maximum crack growth rate as the crack growth direction criteria is examined. It is revealed that the stage II crack growth before and after the branching cannot be simulated with a single criterion, but can be done when different criteria are applied to the two stages of crack growth. Moreover, a method to determine the crack length at which the branching occurs is proposed.

• Journal of Ginseng Research
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• v.19 no.3
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• pp.212-218
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• 1995

A human hepatoma cell line, hep G2, was used to investigate the mechanism of serum cholesterol reduction by ginseng total saponin, ginsenoside-$Rb_1$, - $Rb_2$, and non-saponin fraction (ether extraction). Hep G2 cells were incubated in 10 $\mu\textrm{g}$/ml of cholesterol containing serum free-RPMl1640 medium with various concentration of ginseng components. The amounts of cholesterol in Hep G2 cells were decreased to maximum 51% in total saponin or two ginsenoside-treated groups while there was 137% increase in cholesterol level of control group as compared with that of normal group. Nonsaponin groups did not show the same effect. In order to elucidate the observed changes in the amount of cholesterol, the activity of amyl CoA : cholesterol acyltransferase (ACAT) in groups showing remarkable reduction in cholesterol amount, i.e., total saponin 10-6%, ginsenoside-$Rb_1$ $10^{-4}$%, ginsenoside-$Rb_2$, $10^{-4}$%, and non-saponin fraction $10^{-4}$%, was assayed using [1-$^{-14}C$%]oleic acid as enzyme substrate. The activity of ACAT was increased in all groups tested as compared with that of control group except for non-saponin group cultured in water soluble cholesterol containing medium. The serum cholesterol lowering effects of ginseng components can partially be attributed to the increased hepatocellular ACAT activity.

• YAKHAK HOEJI
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• v.41 no.6
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• pp.789-796
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• 1997

The purpose of this study was to determine the effect of sulfinpyrazone on fumonisin $B_1$-induced elevation of free sphingoid bases in LLC-$PK_1$ cells. Fumonis ins are a family of mycotoxins produced by the fungi Fusarium moniliforme which is common contaminant in corn. Fumonisins are also potent inhibiors of sphingosine and sphinganine N-acyltransferases (ceramide synthases), key enzymes in sphingolipid metabolism resulting in the elevation of free sphinganine. The cytosolic concentration of fumonisin B1 was known to be closely proportional to the elevation of free sphinganine in LLC-PK1 cells [Yoo, H.-S., Norred, W.P., Wang, E., Merrill, A.H., Jr., and Riley, R.T. (1992) Toxicol. Appl.Pharmacol. 114. 9-15]. Sulfinpyrazone, an anion transport inhibitor, reduced the elevated level of free sphinganine resulting from fumonisin B1 inhibition of de novo sphingolipid biosynthesis. Fumonisin B1 at a concentration of 20${\mu}$M showed approximately 120pmol/$10^6$ cells relative to 3-10pmol/$10^6$ cells in control cultures, and sulfinpyrazone at a concentration of 200${\mu}$M partially reversed the increased level of free sphinganine induced by fumonisin $B_1$ down to normal level after exposure to fumonisin $B_1$ for 8 to 24hr. However, the reduced effect of sulfinpyrazone on the fumonisin $B_1$-induced elevation of intracellular sphinganine was not shown after 24hr. Fumonisin $B_1$ exposure to LLC-PK1 cells for 36 and 48hr showed approximately 74 and 80pmol per $10^6$ cells relative to 82 and 76pmol,respectively, in fumonisin $B_1$ plus sulfinpyrazone-treated cultures. Sulfinpyrazone-induced less elevation of free sphinganine in confluent cells after exposure to fumonisin $B_1$ suggested that either sulfinpyrazone may block the availability of fumonisin $B_1$ to cells or act on the fumonisin $B_1$ interaction with ceramide synthase.

• Journal of the Ergonomics Society of Korea
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• v.32 no.3
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• pp.237-243
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• 2013

Objective: The present study developed an estimation method of boundary zone representative humanoids(hereafter, EBZ method) using descriptive statistics on the design target population. Background: The boundary zone method(hereafter, BZ method) generates representative humanoids at a boundary zone that statistically accommodates a designated percent of the design target population; however, the BZ method has a practical limitation because it requires a large scale anthropometric database on the design target population. Method: The EBZ method developed in the present study consisted of 3 steps. In the first step, the boundary zone of accommodating a designated percent(e.g., 90%) is formed under the assumption of normal distributions for anthropometric sizes. In the second step, cases that fall within the boundary zone are estimated using descriptive statistics(mean, standard deviation, and covariance) on the design target population. In the last step, K-mean cluster analysis is conducted for the cases, and representative humanoids are selected from each of clusters. Results: Evaluation results showed that mean accommodation percent of the EBZ method was 90.9%(range: 90.8~91.1%) which is similar to the target percent(90%). In addition, standard deviation of accommodation percent for 100 repetitions was 0.1%. Lastly, the number of representative humanoids generated by the EBZ method(n = 20) was similar to the BZ method(n = 16). Conclusion: The EBZ method can generate representative humanoids which accommodate a designated percent of the design target population using descriptive statistics. Application: The EBZ method can be utilized in the generation of humanoids for ergonomic design and evaluation of products when the large scale anthropometric database on the design target population is not existed.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.11 no.1
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• pp.33-40
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• 1981

The author studied on the effects of x-irradiation to the development of digital malformation in gestation rats. The time-matings occured between 6 p.m. and 8 a.m. and females with copulation. plugs at 8 a.m. were isolated and properly marked for evidence of copulation. The lower abdomen of mothers were exposed to x-irradiation on the 11½th day of gestation, the critical period developing digital malformation, respectively 100, 150, 200, 250, 300 and 350 rads. At 18½th day of post-conception total 50 pregnant females were dissected and the incidence of digital malformations were obtained. Rat embryos on the 12, 13, 14, 15, 16th day of gestation irradiated by 250 rads were examined for morphogenesis of digital malformation. Digital radiating lines were examined in water and histologically by H-E stain. Supra vital stain samples by Nile-blue sulfate in 37℃ normal saline were prepared for the observation of cell necrosis regions and morphogenesis of digits. The results obtained were as follows; 1. By x-irradiation on 11th day of gestation, digital malformations of Ectrodactylia, Syndactylia Polydactylia and Hematodactylia were developed. Ectrodactylia showed the effective relationship to the amount of irradiation, however Syndactylia ans Polydactylia did not. 2. By x-irradiation, cell necrosis of digital germ was appeared markedly, but in 48 hours after irradiation was depressed to the periphery of digital germ and in 72hours after irradiation was disappeared. Digital radiating line showed marked stage of malformation in 48hours after irradiation and continued to show the same amount of physiological cell necrosis as the compared control group in 72hours. after irradiaion. But in the Syndactylia, physiological cell necrosis was not able to be recognized. 3. Ectrodactylia induced by x-irradiation was considered as the direct resoult of cell necrosis of digital origin, however, Polydactylia and Syndactylia were considered as the resoult of some effect in repair process of x-irradiation damages.