• Speech Sciences
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• v.6
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• pp.197-217
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• 1999

In a noisy class, the acoustic-phonetic features of the teacher and the perceptual features of learners are changed comparison with a quiet environment. Acoustical analyses were carried out on a set of French monosyllables consisting of 17 consonants and three vowel /a, e, i/, produced by 1 male speaker talking in quiet and in 50, 60 and 70 dB SPL of masking noise on headphone. The results of the acoustic analyses showed consistent differences in energy and formant center frequency amplitude of consonants and vowels, $F_1$ frequency of vowel and duration of voiceless stops suggesting the increase of vocal effort. The perceptual experiments in which 18 undergraduate female students learning French served as the subjects, were conducted in quiet and in 50, 60 dB of masking noise. The identification scores on consonants were higher in Lombard speech than in normal speech, suggesting that the speaker's vocal effort is useful to overcome the masking effect of noise. And, with increased noise level, the perceptual response to the French consonants given had a tendency to be complex and the subjective reaction score on the noise using the vocabulary representative of 'unpleasant' sensation to be higher. And, in the point of view on the L2(second language) acquisition, the influence of L1 (first language) on L2 examined in the perceptual result supports the interference theory.

• Phonetics and Speech Sciences
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• v.5 no.4
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• pp.17-24
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• 2013

This study is aimed at finding out different types of speech characteristics categorized based on voice rehabilitation techniques used on twenty-six patients (all-male) with total or partial laryngectomees. The speech intelligibility of standard esophageal (SE), tracheoesophageal speech (TE), and electriclarynx (EL) was measured by using the CSL and eleven listeners were instructed to rate the speech on a 5-point scale. The vowel space parameters such as vowel space, VAI, FCR, and F2 ratio were measured by averaging 5 repeats of each vowel (/a/, /e/, /i/, /u/) and the results were put into the parameter formula. The results showed significant statistical differences in speech intelligibility and vowel space between SE and TE. The speech intelligibility and vowel space of TE were higher than those of SE or EL and there was a high correlation between speech intelligibility and some parameters (vowel space, VAI, F2 ratio). The results also showed that TE's speech characteristics were most similar to normal groups comparing with SE and EL, but still very deviant in laryngeal speech. This was due to insufficient airflow intake into the esophagus when producing sounds, and because articulation movement was carried out differently among groups. Therefore, these findings will contribute to establishing a baseline related to speech characteristics in voice rehabilitation for patients with alaryngeal speech.

• ETRI Journal
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• v.28 no.6
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• pp.770-776
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• 2006

This paper presents a hyperspectral imaging technique based on laser-induced fluorescence for non-invasive detection of tumorous tissue on mouse skin. Hyperspectral imaging sensors collect image data in a number of narrow, adjacent spectral bands. Such high-resolution measurement of spectral information reveals contiguous emission spectra at each image pixel useful for the characterization of constituent materials. The hyperspectral image data used in this study are fluorescence images of mouse skin consisting of 21 spectral bands in the visible spectrum of the wavelengths ranging from 440 nm to 640 nm. Fluorescence signal is measured with the use of laser excitation at 337 nm. An acousto-optic tunable filter (AOTF) is used to capture images at 10 nm intervals. All spectral band images are spatially registered with the reference band image at 490 nm to obtain exact pixel correspondences by compensating the spatial offsets caused by the refraction differences in AOTF at different wavelengths during the image capture procedure. The unique fluorescence spectral signatures demonstrate a good separation to differentiate malignant tumors from normal tissues for rapid detection of skin cancers without biopsy.

• Toxicological Research
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• v.21 no.4
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• pp.271-278
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• 2005

Reproductive and developmental toxicology is concerned with various physical or chemical agents interfering with fertility in both gender or normal growth of offsprings. Reproductive and developmental toxicology is rather a complex science, with many fields, i.e., various endpoints are involved and many different mechanisms of action. For that reason, diverse aspects must be considered when attempting to assess possible adverse health effects in the area of reproductive and developmental toxicology. The thalidomide tragedy made it clear to regulatory authorities around the world that systematic, comprehensive evaluation of the reproductive cycle was needed to adequately evaluate the potential of medicinal drugs to impair the process of reproduction or the development of embryos, fetuses, and children. International Conference on Harmonization of Technical Requirements for the Registration of Pharmaceuticals for Human Use (ICH) and U.S. Food and Drug Administration (FDA) developed a guideline to assess the reproductive and developmental toxicity. Also these guidelines have since been applied to the detection and regulation of environmental toxicants, food additives, and so on. Although it was hoped that testing procedures of guideline would be updated constantly to reflect the current state of the science in reproductive and developmental toxicology, it was not until this decade that regulatory guidelines and testing methods have been altered in a significant way. In this paper, we would like to present the recommended approaches and recent trends for improvement of testing guidelines or experimental methods in reproductive and developmental toxicology.

• Biomolecules & Therapeutics
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• v.26 no.3
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• pp.313-321
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• 2018

Anti-cancer drug resistance is a major problem in colorectal cancer (CRC) research. Although several studies have revealed the mechanism of cancer drug resistance, molecular targets for chemotherapeutic combinations remain elusive. To address this issue, we focused on the expression of cellular prion protein ($PrP^C$) in 5-FU-resistant CRC cells. In 5-FU-resistant CRC cells, $PrP^C$ expression is significantly increased, compared with that in normal CRC cells. In the presence of 5-FU, $PrP^C$ increased CRC cell survival and proliferation by maintaining the activation of the PI3K-Akt signaling pathway and the expression of cell cycle-associated proteins, including cyclin E, CDK2, cyclin D1, and CDK4. In addition, $PrP^C$ inhibited the activation of the stress-associated proteins p38, JNK, and p53. Moreover, after treatment of 5-FU-resistant CRC cells with 5-FU, silencing of $PrP^C$ triggered apoptosis via the activation of caspase-3. These results indicate that $PrP^C$ plays a key role in CRC drug resistance. The novel strategy of combining chemotherapy with $PrP^C$ targeting may yield efficacious treatments of colorectal cancer.

• Transactions of the Korean Society of Mechanical Engineers
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• v.19 no.3
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• pp.846-857
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• 1995

An experimental study is made of turbulent shear flows in a nearly two-dimensional 90.deg. curved duct by using the hot-wire anemometer. The Reynolds normal and shear stresses, triple velocity products, integral length scales, Taylor micro length scales and dissipation length scales are measured and analyzed. For a positive shear at the inlet, the afore-mentioned turbulence quantities are all suppressed. However, when the inlet shear flow is negative, they are augmented, i.e., the convex curvature suppresses the turbulence whereas the concave curvature augments it. It is found that the curvature effects are rather sensitive to the triple velocity products than the Reynolds stresses. The evolution of turbulence under the curvature with the different shear conditions is well described by the modified curvature parameter S' and the non-dimensional development time ${\tau}$.'

• Transactions of the Korean Society of Mechanical Engineers
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• v.18 no.4
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• pp.1050-1056
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• 1994

When a vibration data for a rotating machine such as a pump or a compressor is concerned, the frequency fluctuation of the energy contents at an instant time may provide useful information on understanding the vibration characteristics of the rotating machinery, rather than the averaged energy distribution along the frequency axis. Especially, when a periodic signal has different spectral contents, the approach to use the averaged frequency distribution, called the normal frequency analysis, may not be appropriate to extract vibration source characteristics of the structure. This paper introduces a way to analyze the signal based on an instant time. In order to evaluate the performance of the various approach, the investigatation compares three different algorithms which are frequently implemented in the instantaneous frequency analysis. Also for the noise effect embodied in the true signal, various cases for different SN ratio have been examined. The result shows that the noise level is crucial to evalute the instantaneous frequency analysis. In order to implement the instantaneous frequency analysis, the extraction of the relevant information from the measured signal should have the high S/N ratio, i, e., 40 dB or above.

• Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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• v.11 no.1
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• pp.104-112
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• 2000

An evaluation of voice disorder has two methods. One is a perceptual analysis and the other is an acoustic analysis. All of these methods are just focused on sustained vowel. The analysis of conversational speech levels in voice disorder has not been achieved enough. The purpose of the present study is to compare two syllable words and sustained vowel in the vocal polyp patients and normal male speakers and to be applied on the vocal assessment and the voice therapy as a basic data. fifteen male patients with vocal polyp were the subject group. Fifteen healthy male were the control group for this study. The voices of the subject and control group, saved in MDVP of CSL were analyzed by its own analysis program. As a results, in subject group, the voice qualities between the vowel following lenis stop and the sustained vowel had no differences, and the voice qualities were different significantly between the vowel following heavily aspirated stop and the sustained vowel. In the control group the vowel fllowing stops and sustained vowel had also many differences in their voice quality, especially significant between the vowel following glottal stop and e sustained vowel.

• Korean journal of food and cookery science
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• v.22 no.3 s.93
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• pp.402-417
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• 2006

Research interest on functional food and phytochemicals has mainly focused on their health effects, mechanism of action and structure-activity relationship for the development of nutraceuticals. Considering the intake of phytochemicals via the normal diet, further information is required on changes in food functionality or individual phytochemicals that occur during the cooking or processing of foods, in order to increase the intake of these bioactive compounds, because many of the unit-operating procedures involved in cooking or food processing may result in physicochemical changes of food constituents. This study reviews the changes of selected phytochemicals, i.e. flavonoids, organosulfur compounds and carotenoids, or food functionality by major cooking or processing procedures such as heating, fermentation, and pH changes. In general, heating has a negative effect on food functionality, although in some cases, mild heating increases bioactive phytochemical contents. Some phytochemicals, including anthocyanins and catechins, are stabilized in lower pH conditions. The structures of phytochemicals, including isoflavones and catechins, are changed by fermentation. The loss of bioactive compounds may be decreased by recently developed cooking or processing methods such as microwave cooking or use of high hydrostatic pressure. However, the effects of cooking and processing procedures on food functionality and phytochemicals are so diverse and dependent on test conditions that further research efforts are needed to form accurate conclusions on the effects of cooking and processing of foods.

• Asian-Australasian Journal of Animal Sciences
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• v.15 no.11
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• pp.1568-1572
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• 2002

A 152 day trial was conducted to see the effect of feeding naturally fermented wheat straw (FWS) with either energy, protein or energy protein supplements on the growth of buffalo calves. Twenty four male buffalo calves (10-12 months old) divided in 6 equal groups were individually offered FWS as sole roughage along with either conventional concentrate mixture (conc), maize grains (M), solvent extracted mustard cake (DMC), M-DMC mixture (50:50), deoiled rice bran (DRB) or uromol bran mixture (UBM) in 70:30 ratio. The digestibility of nutrients, nitrogen retention and nutritive value was maximum in FWS:UBM followed by FWS:DMC and FWS:Conc groups. Almost, all the blood parameters were observed well within the normal range except that of blood urea (FWS:UBM) and creatinine (FWS:DMC and FWS:DRB). The dietary combination in which FWS was supplemented with only conventional protein supplement like DMC proved to be highly efficient as far as live weight gain was concerned. FWS supplemented with energy-protein combination i.e. MDMC could also be used as complete feed for growing calves in comparison to conventional feeding system.