• Steel and Composite Structures
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• v.19 no.1
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• pp.173-190
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• 2015

This study presents an analytical investigation on the seismic response of a medium-rise buckling-restrained braced frame (BRBF) under the near-fault ground motions. A seven-story BRBF is designed as per the current code provisions for five different combinations of brace configurations and beam-column connections. Two types of brace configurations (i.e., Chevron and Double-X) are considered along with a combination of the moment-resisting and the non-moment-resisting beam-to-column connections for the study frame. Nonlinear dynamic analyses are carried out for all study frames for an ensemble of forty SAC near-fault ground motions. The main parameters evaluated are the interstory and residual drift response, brace displacement ductility, and plastic hinge mechanisms. Fragility curves are developed using log-normal probability density functions for all study frames considering the interstory drift ratio and residual drift ratio as the damage parameters. The average interstory drift response of BRBFs with Double-X brace configurations significantly exceeded the allowable drift limit of 2%. The maximum displacement ductility characteristics of BRBs is efficiently utilized under the seismic loading if these braces are arranged in the Double-X configurations instead of Chevron configurations in BRBFs located in the near-fault regions. However, BRBFs with the Double-X brace configurations exhibit the higher interstory drift and residual drift response under near-fault ground motions due to the formation of plastic hinges in the columns and beams at the intermediate story levels.

• Food Science of Animal Resources
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• v.35 no.4
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• pp.541-550
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• 2015

The purpose of this study was to investigate the effect of lactic acid bacteria (LAB) cell wall extract on the proliferation and cytokine production of immune cells to select suitable probiotics for space food. Ten strains of LAB (Lactobacillus bulgaricus, L. paracasei, L. casei, L. acidophilus, L. plantarum, L. delbruekii, Lactococcus lactis, Streptococcus thermophilus, Bifidobacterium breve, and Pedicoccus pentosaceus) were sub-cultured and further cultured for 3 d to reach 7-10 Log colony-forming units (CFU)/mL prior to cell wall extractions. All LAB cell wall extracts failed to inhibit the proliferation of BALB/c mouse splenocytes or mesenteric lymphocytes. Most LAB cell wall extracts except those of L. plantarum and L. delbrueckii induced the proliferation of both immune cells at tested concentrations. In addition, the production of T_H1 cytokine (IFN-γ) rather than that of T_H2 cytokine (IL-4) was enhanced by LAB cell wall extracts. Of ten LAB extracts, four (from L. acidophilus, L. bulgaricus, L. casei, and S. thermophiles) promoted both cell proliferating and T_H1 cytokine production. These results suggested that these LAB could be used as probiotics to maintain immunity and homeostasis for astronauts in extreme space environment and for general people in normal life.

• Fashion & Textile Research Journal
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• v.17 no.5
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• pp.815-827
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• 2015

This study analyzes the characteristics by age and type for middle aged and elderly women foot shapes aged 40-69 years. ANOVA, factor, and cluster analyzed middle aged and elderly women's foot shapes. The results of the study are as follows. First, higher age groups tended to have smaller foot lengths, ball/instep circumferences, circumferences, and ball heights with larger heel height values and higher degrees of gathering of toe 1 and toe 5 toward the feet reference axis. Second, foot lengths were 220 mm-240 mm and the ball circumference's size symbol in high frequency sections were distributed from E to EEEE in the 40s and 60s groups and from D to EEEE in the 50s group. Third, eight factors were extracted through the factor analyses of middle aged and elderly women's foot measurement items. Fourth, a cluster analyses classified the subjects into four types. Type 1 is a normal foot type with medium foot length and small ball circumference and type 2 is a long and flat foot type with a type with large foot length and ball circumference values as well as small ball height values. Type 3 is a thick foot type with a medium foot length, large ball circumference, large ball height and type 4 is a toe deformation foot type with medium foot length, small ball circumference, and a high degree of toe gathering toward the center.

• Steel and Composite Structures
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• v.21 no.5
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• pp.1085-1103
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• 2016

The present paper is aimed to evaluate and compare the effective elastic properties of CNT- and graphene-based nanocomposites using 3-D nanoscale representative volume element (RVE) based on continuum mechanics using finite element method (FEM). Different periodic displacement boundary conditions are applied to the FEM model of the RVE to evaluate various elastic constants. The effects of the matrix material, the volume fraction and the length of reinforcements on the elastic properties are also studied. Results predicted are validated with the analytical and/or semiempirical results and the available results in the literature. Although all elastic stiffness properties of CNT- and graphene-based nanocomposites are found to be improved compared to the matrix material, but out-of-plane and in-plane stiffness properties are better improved in CNT- and graphene-based nanocomposites, respectively. It is also concluded that long nanofillers (graphene as well as CNT) are more effective in increasing the normal elastic moduli of the resulting nanocomposites as compared to the short length, but the values of shear moduli, except $G_{23}$ of CNT nanocomposite, of nanocomposites are slightly improved in the case of short length nanofillers (i.e., CNT and graphene).

• Genomics & Informatics
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• v.18 no.1
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• pp.3.1-3.8
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• 2020

Patient-derived xenograft (PDX) mouse models are frequently used to test the drug efficacy in diverse types of cancer. They are known to recapitulate the patient characteristics faithfully, but a systematic survey with a large number of cases is yet missing in lung cancer. Here we report the comparison of genomic characters between mouse and patient tumor tissues in lung cancer based on exome sequencing data. We established PDX mouse models for 132 lung cancer patients and performed whole exome sequencing for trio samples of tumor-normal-xenograft tissues. Then we computed the somatic mutations and copy number variations, which were used to compare the PDX and patient tumor tissues. Genomic and histological conclusions for validity of PDX models agreed in most cases, but we observed eight (~7%) discordant cases. We further examined the changes in mutations and copy number alterations in PDX model production and passage processes, which highlighted the clonal evolution in PDX mouse models. Our study shows that the genomic characterization plays complementary roles to the histological examination in cancer studies utilizing PDX mouse models.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.19 no.6
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• pp.9-16
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• 2020

This study aims to assess the effects of specimen thickness (ST) on fatigue crack growth in the early stages of crack propagation and near failure in magnesium alloys. The analysis of variance (ANOVA) method was adopted because fatigue crack propagation in magnesium alloys exhibits statistical behavior. The equality of variance test and residual diagnostics were performed on the grown cracks to confirm the validity of ANOVA by verifying the normal distribution and mutual independence of the residuals and their homoscedasticity. ANOVA confirmed that ST heavily impacts crack growth; i.e., when ST is smaller, cracks grow faster in the early crack propagation stage and break more quickly before the formation of larger cracks. We found that ST significantly affects fatigue crack growth in the early crack propagation stage and near the failure stage in magnesium alloys. The regression model was also used to predict crack formation near the failure stage.

• Korean Institute of Interior Design Journal
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• v.25 no.1
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• pp.35-46
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• 2016

The purpose of this study was to identify the characteristics of expressionism in the space of deconstructive architecture by comparing the spaces of "The Cabinet of Dr. Caligari" video with the expressionist characteristics of film narrative structure and expressionist architecture and making an expansion based on the results. The findings were as follows: first, the "The Cabinet of Dr. Caligari" is divided into two set spaces: one has the perspective representation distorted in the viewpoint of a mad person applied to it, and the other reflects the viewpoint of a normal person from medieval paintings with no perspective. Second, the expressionist buildings did not reflect the expressionist characteristics in the interior spaces as fully as in the exterior ones. Third, the incomplete combination of Signifiant and $Signifi{\acute{e}}$, which were the theoretical basis of deconstructive architecture, showed a tendency of binary opposition like the double narrative structure of "The Cabinet of Dr. Caligari." Fourth, deconstructive architecture seems to embody the exterior form and interior space of "The Cabinet of Dr. Caligari" and its set spaces in the phenomenal aspect but exhibits its limitations with the realization of dynamics, one of the characteristics of expressionism. Finally, the Seattle Public Library presents the best embodiment of expressionist characteristics found in the set spaces of "The Cabinet of Dr. Caligari" while seeking after the combination of horizontal and vertical paths of action through the spiral ramps and inclined slabs.

• Journal of Periodontal and Implant Science
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• v.25 no.1
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• pp.35-44
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• 1995

The purpose of present study was to evaluate the relationship between the early change of gingival condition and methyl mercaptan concentration during experimental gingivitis. Ten men(23-25 years old) whose gingiva were clinically healthy were selected. The participants have ceased to perform all forms of oral hygiene during 14 days and then did thorough plaque control for 7 days. For each subject, the methyl mercaptan concentration was measured by $B.B.Checker^{(R)}$ (Bad Breath Checker with printer, Tokuyama Soda Co.,LTD., Japan)before experiment and 1,4,7,14,21 days during experiment. Plaque index(Silness & $L\ddot{o}e$), gingival sulcus depth and sulcus bleeding index($M\ddot{u}hlemann$ & Son)score were recorded. The results were as follows. 1. Methyl mercaptan concentration increased continuously from the first day to the 14th day, decreased on the 21th day but it was still higher(P<0.001). 2. Plaque index score and sulcus bleeding index score tended to increase on the 4th day, markedly increased on the 14th day and returned to baseline level on the 21th day. 3. There was parallel relationhsip among methyl mercaptan concentration, plaque index score and sulcus bleeding index score. This result suggests that methyl mercaptan concentration increased with deterioration in gingival health, but decreased during recovery of normal health condition.

• Bulletin of the Korean Chemical Society
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• v.24 no.8
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• pp.1155-1162
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• 2003

Nanocrystalline semiconductor film electrodes have been prepared by sintering three different sizes of TiO₂ nanoparticle sols on conducting indium-tin-oxide (ITO) glass substrate. The electrochemical and photoelectrochemical properties of the prepared electrodes were comparatively investigated. The particle sizes, surface morphologies and crystallinities of the films were studied by scanning electron microscopy, transmission electron microscopy, and X-ray diffraction. Cyclic voltammetry and capacitance measurements in the dark implies the formation of depletion layer in the semiconductor films which was usually neglected in the previous studies and shows that flat band potential ($E_{fb}$

• Molecular & Cellular Toxicology
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• v.3 no.4
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• pp.231-237
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• 2007

Exposure to DNA-damaging agents can elicit a variety of stress-related responses that may alter the expression of genes associated with numerous biological pathways. We used 19 k whole human genome chip to detect gene expression profiles and potential signature genes in human normal hepatocytes (THLE-3) by treatment of five direct acting mutagens, furylfuramide (AF-2), N-nitroso-N-methylurea (MNU), methylmethanesulfonate (MMS), 4-nitroquinoline-N-oxide (4-NQO) and 2-nitrofluorene (2NF) of the $IC_{20}$ concentration for 3 h. Fifty one up-regulated common genes and 45 down-regulated common genes above 1.5-fold by five direct-acting mutagens were identified by clustering analysis. Many of these changed genes have some association with apoptosis, control of cell cycle, regulation of transcription and signal transduction. Genes related to these functions, as TP73L, E2F5, MST016, SOX5, MAFB, LIF, SII3, TFIIS, EMR1, CYTL1, CX3CR1 and RHOH are up-regulated. Down-regulated genes are ALOX15B, xs155, IFITM1, BATF, VAV2, CD79A, DCDC2, TNFSF8 and KOX8. We suggest that gene expression profiling on mutagens by toxicogenomic analysis affords promising opportunities to reveal potential new mechanistic markers of genotoxicity.