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Lung Function Trajectory Types in Never-Smoking Adults With Asthma: Clinical Features and Inflammatory Patterns

  • Kim, Joo-Hee;Chang, Hun Soo;Shin, Seung Woo;Baek, Dong Gyu;Son, Ji-Hye;Park, Choon-Sik;Park, Jong-Sook
    • Allergy, Asthma & Immunology Research
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    • v.10 no.6
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    • pp.614-627
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    • 2018
  • Purpose: Asthma is a heterogeneous disease that responds to medications to varying degrees. Cluster analyses have identified several phenotypes and variables related to fixed airway obstruction; however, few longitudinal studies of lung function have been performed on adult asthmatics. We investigated clinical, demographic, and inflammatory factors related to persistent airflow limitation based on lung function trajectories over 1 year. Methods: Serial post-bronchodilator forced expiratory volume (FEV) 1% values were obtained from 1,679 asthmatics who were followed up every 3 months for 1 year. First, a hierarchical cluster analysis was performed using Ward's method to generate a dendrogram for the optimum number of clusters using the complete post-FEV1 sets from 448 subjects. Then, a trajectory cluster analysis of serial post-FEV1 sets was performed using the k-means clustering for the longitudinal data trajectory method. Next, trajectory clustering for the serial post-FEV1 sets of a total of 1,679 asthmatics was performed after imputation of missing post-FEV1 values using regression methods. Results: Trajectories 1 and 2 were associated with normal lung function during the study period, and trajectory 3 was associated with a reversal to normal of the moderately decreased baseline FEV1 within 3 months. Trajectories 4 and 5 were associated with severe asthma with a marked reduction in baseline FEV1. However, the FEV1 associated with trajectory 4 was increased at 3 months, whereas the FEV1 associated with trajectory 5 was persistently disturbed over 1 year. Compared with trajectory 4, trajectory 5 was associated with older asthmatics with less atopy, a lower immunoglobulin E (IgE) level, sputum neutrophilia and higher dosages of oral steroids. In contrast, trajectory 4 was associated with higher sputum and blood eosinophil counts and more frequent exacerbations. Conclusions: Trajectory clustering analysis of FEV1 identified 5 distinct types, representing well-preserved to severely decreased FEV1. Persistent airflow obstruction may be related to non-atopy, a low IgE level, and older age accompanied by neutrophilic inflammation and low baseline FEV1 levels.

Effects of Body Composition, Nutrient Intakes and Biochemical Indices on Skin Health Status of Female University Students with Sensitive Skin (체성분, 영양소 섭취상태 및 생화학적 지표가 민감성 피부 여대생의 피부건강상태에 미치는 영향)

  • Kim, Mi-Young;Cho, Kyung-Dong;Baek, Ok-Hee;Lee, Bog-Hieu
    • Journal of the Korean Society of Food Culture
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    • v.23 no.2
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    • pp.258-267
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    • 2008
  • The purpose of this study was to investigate the effects that body composition, nutrient intake, and biochemical indices have on skin status, as well as their associations with skin health status, by assessing 44 female university students. The subjects were classified into 3 groups according to skin sensitivity: sensitive skin (n=11), slightly sensitive skin (n=24), and normal skin (n=9). The study included anthropometric measurements and body composition analyses, dietary intake evaluations, blood chemical analyses, and skin health status assessments. Based on % body fat, the results indicated the subjects were moderately obese (29.6%). Obesity indices were not different among the groups, but the sensitive skin group tended to have higher skinfold thickness. Dry skin was determined as the skin type of all subjects. In the sensitive skin groups, U-zone and T-zone sebum were significantly lower (p<0.05), and spots were significantly higher (p<0.05) than in the normal skin group. In terms of nutrient intakes, the sensitive skin groups consumed significantly lower amounts of P and vitamins A and E (p<0.05). There were no significant differences in serum lipid fractions or total antioxidant status among the groups. In correlation coefficients analysis, skin elasticity had significant negative correlations with subscapular and midaxillary skinfold thickness, body protein, and body minerals (p<0.05). Wrinkling had positive correlations with triceps and thigh skinfold thickness (p<0.05). Skin evenness had negative correlations with energy intake, vitamins A, $B_1,\;B_2$, C, E, niacin, and zinc (p<0.05), as well as folate and P (p<0.01) and vitamin $B_6$ (p<0.001). A similar correlation tendency was observed for spots and nutrient intake, showing negative correlations with vitamins A, $B_6$, and E, as well as folate, Fe, and P. U-zone sebum showed significant positive correlations with serum levels of total cholesterol and triglycerides. From these findings, skin health status appears to be affected by both nutrient intake and body composition. Therefore, having a proper balance between dietary intake and body composition may influence skin health status in females with sensitive skin.

The Effect of Juglandis Semen Aquacupuncture on Diuresis of Rat in Glycerol-Induced Acute Renal Failure (호도약침(胡桃藥鍼)이 Glycerol로 유발(誘發)된 급성신부전(急性腎不全) 백서(白鼠)의 이뇨(利尿)에 미치는 영향(影響))

  • Jung, Hyun-Chol;Song, Choon-Ho
    • Journal of Acupuncture Research
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    • v.17 no.1
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    • pp.107-117
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    • 2000
  • This study was undertaken to determine if Juglandis Semen Aquacupuncture(Ja) has a protective effect against glycerol-induced acute renal failure in rats. Rats were dehydrated for 24hr and then injected with $5m{\ell}/kg$ of 50% glycerol, one-half of dose in each hindlimb muscle. In experiments for Ja effect, rats received $0.1m{\ell}$ of Ja extraction in both sides of corresponding $Sh{\grave{e}}ns{\bar{u}}$($BL_{23}$) of human body and non-acupuncture points(the root of tail) for 3 days after injection of glycerol. The experimental group were divided into the Normal group, the Control group, the Ja to $Sh{\grave{e}}ns{\bar{u}}$($BL_{23}$) group(Ja-AS), the Ja to non-acupuncture points group(Ja-AN). There were significant decrease of Urine vollume, total protein and phosphate level in Ja-AS as compared with the control group. There were not any significant change of Urine creatinine in Ja-AS as compared with the control group. There were significant decrease of Unine glucose in Ja-AS, Ja-AN as compared with the control group. This suggests that Ja-AS could be used in prevention and treatment of acute renal failure. However, the precise mechanisms of Ja protection remain to be determined.

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Corrosion Evaluation of Epoxy-Coated Bars in Chloride Contaminated Concrete Using Linear Polarization Tests

  • Choi, Oan-Chul;Jung, Si-Young;Park, Young-Soo
    • International Journal of Concrete Structures and Materials
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    • v.18 no.1E
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    • pp.3-9
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    • 2006
  • Five slab specimens with predefined cracks are examined to evaluate the corrosion behavior of epoxy-coated bars in chloride contaminated concrete, using linear polarization method. The test specimens were subjected to alternating weekly cycles of ponding in a salt solution and drying for 48 weeks. Test results show that the current density of the specimen of normal steel bars becomes 0.715 ${\mu}A/cm^2$ indicating that the steel bars are in moderate or high corrosion condition. However, the corrosion rates of the specimens with damaged epoxy-coated bars are significantly below 0.1 ${\mu}A/cm^2$ and the bars appears to be in passive condition. The damaged epoxy-coated bars with a corrosion inhibitor of calcium nitrite showed a corrosion rate of 0.110 ${\mu}m/year$ or 56 percents of the corrosion rate of damaged epoxy-coated specimen without such an inhibitor, 0.195 ${\mu}m/year$. However, the corrosion rates of specimens containing the other two corrosion inhibitors, a combination of amines and esters or mixtures of organic alkenyl dicarboxyl acid salts are quite equivalent to the control specimen. The research technique of linear polarization resistance method has proven itself to be useful in measuring corrosion rates of reinforcement in concrete.

Effectiveness of Clinical Examination for Detection of Dermatophagoides farinae Allergen Asthma Disease (북아메리카 집먼지진드기에 의한 알레르기 천식 환자에서 임상검사의 유용성)

  • Choi, Woo-Soon;Kim, Sung-Chul;Choo, Sang-Kyu
    • Korean Journal of Clinical Laboratory Science
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    • v.37 no.1
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    • pp.16-21
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    • 2005
  • To find out the effectiveness of clinical examination for detection of dermatophagoides farinae allergen asthma disease, 50 patients (control group) and 50 healthy persons matched by sex and age to the control group, were tested for allergen asthma. The results of the study follow. The ESR there was significantly different from the comparisons of the patients' normal reference values, 95.3 % in ESR, patient groups allergen asthma and heamatology values with control group. The ESR level of allergen asthma patients, $62.23{\pm}35.09$ mm/hr, was higher than that of the controls, $9.47{\pm}5.36$ mm/hr (p<0.001). The eosinophil count level of the patients, $370.65{\pm}365.45mm^3$, was higher than that of the controls with $171.99{\pm}131.80mm^3$ (p<0.001). The IgE level of the patients, $1137.79{\pm}784.69IU/ml$, was higher than that of the controls with $71.29{\pm}14.28 IU/ml$ (p<0.001).

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The evolution of Magnetic fields in IntraClusterMedium

  • Park, Kiwan;Ryu, Dongsu;Cho, Jungyeon
    • The Bulletin of The Korean Astronomical Society
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    • v.40 no.1
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    • pp.49.2-49.2
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    • 2015
  • IntraCluster Medium (ICM) located at the galaxy cluster is in the state of very hot, tenuous, magnetized, and highly ionized X-ray emitting plasmas. High temperature and low density make ICM very viscous and conductive. In addition to the high conductivity, fluctuating random plasma motions in ICM, occurring at all evolution stages, generate and amplify the magnetic fields in such viscous ionized gas. The amplified magnetic fields in reverse drive and constrain the plasma motions beyond the viscous scale through the magnetic tension. Moreover, without the influence of resistivity viscous damping effect gets balanced only with the magnetic tension in the extended viscous scale leading to peculiar ICM energy spectra. This overall collisionless magnetohydrodynamic (MHD) turbulence in ICM was simulated using a hyper diffusivity method. The results show the plasma motions and frozen magnetic fields have power law of $E_V^k{\sim}k^{-3}$, $E_M^k{\sim}k^{-1}$. To explain these abnormal power spectra we set up two simultaneous differential equations for the kinetic and magnetic energy using an Eddy Damped Quasi Normal Markovianized (EDQNM) approximation. The solutions and dimensions of leading terms in the coupled equations derive the power spectra and tell us how the spectra are formed. We also derived the same results with a more intuitive balance relation and stationary energy transport rate.

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A Study on Nutrient Intake and Food Consumption by Food Frequency Questionnaire According to the Obesity Index of Women College Students in Kunsan. (군산시 일부 여대생의 비만도에 따른 영양소 섭취와 식품섭취빈도)

  • 장혜순;김미라
    • Korean Journal of Human Ecology
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    • v.6 no.1
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    • pp.45-56
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    • 2003
  • The purpose of this study was to compare nutrient intake and food consumption by food frequency according to the obesity index of women college student in Kunsan. The subjects were 251 women college students who were randomly selected from Kunsan national university. Subjects were assigned to one of the following group based on BMI : underweight, normal weight and overweight. Nutrient intake and food consumption by food frequency were evaluated based on questionnaires and 24 hour recall method. The results were as follows. %RDA of calcium, iron and zinc of obese group were more than the underweight group(p<0.05). %Fat was significantly correlated with the daily intakes of protein and vitamin E(p<0.05). %Fat was significantly correlated with %RDA of energy, protein, vitamin E, vitamin B$_{6}$. RBW was significantly correlated with %RDA of iron. BMI was significantly correlated with %RDA of energy, calcium, phosphorus. The foods frequently consumed among students were cooked rice and gimchi. The frequencies of fish and mushroom were correlated with food behavior scores(p<0.01). The frequencies of carbonated beverage(p<0.01), hamburger & piazza, deep fried foods(p<0.01), soybean curd fried fish cake(p(0.05) were correlated with nutritional knowledge scores.

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A Study on Personality Traits of the Patients with TMJ Dysfunction through the MMPI (MMPI를 중심으로 한 악관절 기능장애 환자의 인성에 관한 연구)

  • 고명연;김영구
    • Journal of Oral Medicine and Pain
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    • v.10 no.1
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    • pp.17-31
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    • 1985
  • Personality characteristics of TMJ dysfunction patients was studied by means of MMPI test. 100 TMJ dysfunction patients and 100 healthy controls were subjected at the Department of Oral Diagnosis and Oral Medicine, Pusan National University Hospital, during the period from March 1983 to February 1985. All the patients were divided into 2 groups namely, acute group and chronic group by duration of path and discomfort problems for 6 months or longer. The obtained results were as follows : 1. Mean value of T-scores on each clinical scale was within normal range in both patient and control group. 2. There was significant difference in scales of Hs, D. Hy, Pt, Sc and IR between patient and control group. 3. As compared with control group by sexual subclass, scales of Hs, Hy and Pt of both sex, scales of Sc and M-DI of male and scales of D of female in patient group were significantly higher than those in control group 4. The longer was duration of TMJ problems, i.e., in increasing order of control, acute and chronic group, the higher was mean value of T-scores on scales of Hs, D, Hy, Pt, Sc, IR and M-DI. 5. Mean values of T-scores on scales of Hs, D and Hy were the highest in all the clinical scales of total class and subclasses(i. e. male group, female group, acute group and chronic group) with TMJ dysfunction and showed 1-:i-2 (Hs, -Hy, -D. ) profile pattern, conversion "V.ot;V.

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Ground Software Validation Test for Wheel Off-loading of COMS (통신해양기상위성의 휠오프로딩 지상국 소프트웨어 검증시험)

  • Park, Young-Woong;Yang, Koon-Ho
    • Aerospace Engineering and Technology
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    • v.9 no.2
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    • pp.51-56
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    • 2010
  • There are two main software in COMS ground station at the normal mode operation - stationkeeping and wheel off-loading. In this paper, ground software validation test for wheel off-loading is summarized and described. The wheel off-loading was performed the design change from E3000 heritage and analyzed. The wheel off-loading of ground software has two part; one is wheel off-loading management for parameters change at the thruster set switching time and the other is wheel off-loading set-point being sent to satellite for the reference momentum.

A Study on the Fault Diagnosis of Roller-Shape Using Frequency Analysis of Tension Signals and Artificial Neural Networks Based Approach in a Web Transport System

  • Tahk, Kyung-Mo;Shin, Kee-Hyun
    • Journal of Mechanical Science and Technology
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    • v.16 no.12
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    • pp.1604-1612
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    • 2002
  • Rollers in the continuous process systems are ones of key components that determine the quality of web products. The condition of rollers (e.g. eccentricity, runout) should be consistently monitored in order to maintain the process conditions (e.g. tension, edge position) within a required specification. In this paper, a new diagnosis algorithm is suggested to detect the defective rollers based on the frequency analysis of web tension signals. The kernel of this technique is to use the characteristic features (RMS, Peak value, Power spectral density) of tension signals which allow the identification of the faulty rollers and the diagnosis of the degree of fault in the rollers. The characteristic features could be used to train an artificial neural network which could classify roller conditions into three groups (normal, warning, and faulty conditions) The simulation and experimental results showed that the suggested diagnosis algorithm can be successfully used to identify the defective rollers as well as to diagnose the degree of the defect of those rollers.