• The Korean Journal of Applied Statistics
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• v.21 no.2
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• pp.327-340
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• 2008

This paper derives joint and conditional Lagrange multiplier tests based on information matrix for testing functional form and/or the presence of autocorrelation in a regression model. Small sample properties of these tests are assessed by Monte Carlo study and comparisons are made with LM tests based on Hessian matrix. The results show that the proposed $LM_E$ tests have the most appropriate finite sample performance.

• Animal cells and systems
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• v.16 no.4
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• pp.280-288
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• 2012

Targeted degradation of proteins through ubiquitin-mediated proteolysis is an important control mechanism in various cellular processes. The process of ubiquitin conjugation is achieved by three enzyme complexes, among which the ubiquitin ligase complex (E3) is in charge of substrate specificity. The SCF (SKP1-CUL1-F-box) family portrays the largest and the most characterized member of the E3 ligases. For each SCF complex, the ubiquitination target is recognized by the F-box protein subunit, which interacts with the substrate through a unique C-terminal domain. We have characterized a novel F-box protein CFL-1 that represents a single LRR-type F-box (FBXL) in the Caenorhabditis elegans genome. CFL-1 is highly homologous to FBXL20 and FBXL2 of mammals, which are known to regulate synaptic vesicle release and cell cycle, respectively. A green fluorescence protein (GFP)-reporter gene fused to the cfl-1 promoter showed restricted expression around the amphid and the anus. Modulation of CFL-1 activity by RNAi affected the time interval between defecations. RNAi-treated worms also exhibited reduced tendency to form dauer when exposed to daumone. The potential involvement of CFL-1 in the control of defecation and pheromone response adds to the ever expanding list of cellular processes controlled by ubiquitin-mediated proteolysis in C. elegans. We suggest that CFL-1, as a single LRR-type F-box protein in C. elegans, may portray a prototype gene exerting diverse functions that are allocated among multiple FBXLs in higher organisms.

• Journal of the Korean Society of Safety
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• v.31 no.3
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• pp.68-74
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• 2016

This paper presents a new strengthening method of underground box structures against seismic loads for anti-seismic capacity improvement. A threaded steel member with pressure devices(so called 'Pre-flexed member system') is used to improve seismic capacity of the RC box structure. The pre-flexed member system is fixed the corner of opening after chemical anchor was installed by drilling hole on the box structure. The structural performance was evaluated analytically. Two bracing types of strengthening methods were used; conventional bracing method and I-bracing pressure system. For the performance evaluation, seismic analyses were performed on moment and shear resisting structures with and without strength member system. Numerical results confirmed that the proposed pre-flexed member system can enhance the seismic capacity of the underground RC box structures.

• Journal of the Korea Furniture Society
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• v.15 no.1
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• pp.9-16
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• 2004

Five type boxes manufactured from cement(A), wood panel(B), charcoal-packed wood panel(C), plywood panel(D) and charcoal-packed plywood panel(E) were prepared. Relationship of preservation characteristic of strawberry and relative humidity, and properties of thermal and sound insulations in the boxes were examined. During the experimental duration, relative humidity in the cement box was highest and lowest in the charcoal-packed wood panel box. Weight loss of strawberry was greatest in charcoal-packed wood panel box and very little in cement box. In the boxes with charcoal-packed wood panel box and very little in cement box. In the boxes with charcoal, strawberry was preserved for 10 days without getting mold, but in cement box it was covered with mold in 3 days. The charcoal-packed boxes showed higher thermal insulation property than the cement box. There were no significant differences in the property of sound insulation among the 5 type boxes. Consequently, it is suggested that charcoal-packed wood panels can be used for a better ecomaterial.

• Bulletin of the Korean Mathematical Society
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• v.50 no.3
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• pp.935-949
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• 2013

In this paper, we study surfaces in $\mathb{E}^3$ whose Gauss map G satisfies the equation ${\Box}G=f(G+C)$ for a smooth function $f$ and a constant vector C, where ${\Box}$ stands for the Cheng-Yau operator. We focus on surfaces with constant Gaussian curvature, constant mean curvature and constant principal curvature with such a property. We obtain some classification and characterization theorems for these kinds of surfaces. Finally, we give a characterization of surfaces whose Gauss map G satisfies the equation ${\Box}G={\lambda}(G+C)$ for a constant ${\lambda}$ and a constant vector C.

• Journal of Environmental Science International
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• v.19 no.7
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• pp.889-900
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• 2010

The experimental design and response surface methodology (RSM) have been applied to the investigation of the electro-UV complex process for the disinfection of E. coli in the water. The disinfection reactions of electro-UV process were mathematically described as a function of parameters power ($X_1$), NaCl dosage ($X_2$), initial pH ($X_3$) and disinfection time ($X_4$) being modeled by use of the Box-Behnken technique. The application of RSM using the Box-Behnken technique yielded the following regression equation, which is an empirical relationship between the residual E. coli number and test variables in actual variables: Ln (CFU) = 23.57 - 0.87 power - 1.87 NaCl dosage - 2.13 pH - 2.84 time - 0.09 power time - 0.07 NaCl dosage pH + 0.14 pH time + 0.03 $power^2$ + 0.47 NaCl $dosage^2$ + 0.20 $pH^2$+ 0.33 $time^2$. The model predictions agreed well with the experimentally observed result ($R^2$ = 0.9987). Graphical response surface and contour plots were used to locate the optimum point. The estimated ridge of maximum response and optimal conditions for the E. coli disinfection using canonical analysis was Ln 1.06 CFU (power, 15.40 W; NaCl dosage, 1.95 g/L, pH, 5.94 and time, 4.67 min). To confirm this optimum condition, the obtained number of the residual E. coli after three additional experiments were Ln 1.05, 1.10 and Ln 1.12. These values were within range of 0.62 (95% PI low)~1.50 (95% PI high), which indicated that conforming the reproducibility of the model.

• Journal of Korean Society on Water Environment
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• v.20 no.3
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• pp.223-230
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• 2004

The QUAL2E and Box-Jenkins time series model were applied to the Miho river, a main tributary of the Geum river, to predict water quality. The models are widely used to predict water quality in rivers and watersheds because of its accuracy. As results of the study, we concluded as follows: Pollutant loadings in upper stream of Miho river were determined to 57,811 kgBOD/d, 19,350 kgTN/d, and 5,013 kgTP/d. The loading of TN in Mushim river was 19,450 kgTN/d, respectively. As the mass loadings were compared with pollutant sources, it concluded that the farming livestock contributed highly to mass emissions of BOD and TP and the population contributed to TN mass loading. The observed water quality values were applied to the models to verify and the models were used to predict the water quality. The QUAL2E Model predicted the concentrations of DO, BOD, TN and TP with high accuracy, but not for E-Coli. The Box-Jenkins time series model also showed high prediction for DO, BOD and TN. However, the concentrations of TP and E-Coli were poorly predicted. The result shows that the QUAL2E model is more applicable in Miho basin for prediction of water quality compared to Box-Jenkins time series model.

• Journal of Life Science
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• v.19 no.6
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• pp.705-710
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• 2009

Sodium butyrate (NaBt), a naturally occurring short chain fatty acid derived from carbohydrate metabolism in the gut, is known to exhibit strong anti-cancer potentials in various human cancer cells; however, its action mechanism is poorly understood. In the present study, we demonstrated that NaBt up-regulates levels of E-cadherin, a key cell adhesion molecule implicated as a tumor suppressor, in a cell type-specific manner. Although levels of p21, a potential activator for E-cadherin expression, were also up-regulated by treatment with NaBt in several types of cells, it does not seem to be associated with the activation of E-cadherin in the NaBt-treated cells. Instead, the data from promoter analysis suggest that NaBt up-regulates expression of E-cadherin at the transcription level by enhancing its promoter strength via a CCAAT-box. The elevated E-cadherin in the presence of NaBt was primarily localized at the cell-cell contacts, converting Hep3B cells into a more differentiated form.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.2
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• pp.429-434
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• 2017

In a graph G=(V, E) with n vertices, there is an unique box which is finally laid on each vertex. Thus each vertex and box is both numbered from 1 to n and the box i should be laid on the vertex i. But, the box ${\pi}$(i) is initially located on the vertex i according to a permutation ${\pi}$. In each step, the robot can walk along an edge of G and can carry at most one box at a time. Also when arriving at a vertex, the robot can swap the box placed there with the box it is carrying. The problem is to minimize the total step so that every vertex has its own box, that is, the shuffled boxes are sorted. In this paper, we shall find an upper bound of the minimum number of steps and show that the movement of the robot is found in $O(n^2)$ time when G is a cycle.

• Magazine of the Korean Society of Agricultural Engineers
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• v.32 no.E
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• pp.20-32
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• 1990

Abstract This study was conducted to pursue the normalization of frequency distribution by making an approach to the coefficient of skewness to nearly zero through the Box-Cox transformation, to get probable flood flows can be calculated by means of the transformation equation which has been derivated by Box-Cox transformation in the annual maximum series of the applied watersheds. It has been concluded that Box-Cox transfromation is proved to be more efficient than logarithmic, square root and SMEMAX transformation which is based on the trigonometric solution of a right triangle whose three verteces repesent the smallest, median and largest observed values of a population in making the coefficient of skewness nearer to zero. Consequently it is shown that probable flood flows according to the return period based on Box-Cox transformation are closer to the observed data as compared to other methods including SMEMAX transformation and fitted probability distributions such as the three parameter lognormal and the type I extremal distribution for the applied watersheds.