• Korean Journal of Veterinary Service
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• v.32 no.1
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• pp.49-59
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• 2009

At the present study, it was aimed to explore the states of antimicrobial resistant Salmonella spp. isolates from 3,850 pigs (2,732 ileocecocolic lymphnodes and 1,118 cecal contents) and 1,764 cattle (965 cecal lymphnodes and 799 cecal contents) slaughtered in Busan province from December 2000 to November 2001. Among 5,614 samples, 457 of Salmonella spp. were isolated from pig lymphnodes (13.5%), pig cecal contents (4.4%), cattle lymphnodes (3.5%) and cattle cecal contents (0.5%). Salmonella spp. were showed different isolation ratio, that was 10.8% in summer, 9.0% in autumn, 8.4% in spring and 5.0% in winter. As a result of serotyping, B group (65.4%) were identified as the most common in pigs and cattle, in order of $C_1$ (14.0%), $D_1$ (5.5%), $C_2$ (4.2%), $E_1$ (4.2%) and L (3.5%). 34 serotypes were found, among them, Salmonella Typhimurium (S. Typhimurium) (21.0%) was the most common serotype from pigs and cattle. The major serotypes were in order of S. Derby (15.3%), S. Schwarzengrund (14.7%), S. Typhimurium var Copenhagen (9.2%), S. Mbandaka (5.7%), S. Enteritidis (5.5%) and S. Ruiru (3.5%). The most common serotype was S. Typhimurium in pigs, and S. Ruiru in cattle. S. Ruiru was firstly isolated from pigs and cattle in Korea. In antimicrobial susceptibility test, all the isolates were demonstrated susceptibility to norfloxacin and ofloxacin. But the isolates were showed resistance other antibiotics in order of doxycycline (68.3%), tetracycline (67.8%), penicillin (54.5%) and streptomycin (52.5%). S. Typhimurium were exhibited resistance to ampicillin (34.8%), chloramphenicol (36.2%), streptomycin (94.9%), sulfamethoxazole/trimethoprim (34.8%) and tetracycline (97.8%). There were 53 strains (38.4%) which had multi drug resistant (MDR) isolates, resistant to more than 6 antimicrobial agents. The most common resistance patterns of MDR isolates were ampicillin, chloramphenicol, carbenicillin, doxycycline, nalidixic acid, penicillin, streptomycin, sulfamethoxazole/trimethoprim and tetracycline (ACCbDNaPSSuT).

• Journal of the Korean Society for information Management
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• v.20 no.3
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• pp.241-259
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• 2003

The Basic Semantic Register(BSR) is and official ISO register designed for interoperability among eBusiness and EDI systems. The entities registered in the current BSR are not defined in a machine-understandable way, which renders automatic extraction of structural and relationship information from the register impossible. The purpose of this study is to offer a framework for designing an ontology that can provide semantic interoperability among BSR-based systems by defining data structures and relationships with RDF and OWL, similar meaning by the 'equivalentClass' construct in OWL, the hierachical relationships among classes by the 'subClassOf' construct in RDF schema, definition of any entities in BSR by the 'label' construct in RDF schema, specification of usage guidelines by the 'comment' construct in RDF schema, assignment of classes to BSU's by the 'domain' construct in RDF schema, specification of data types of BSU's by the 'range' construct in RDF schema. Hierarchical relationships among properties in BSR can be expressed using the 'subPropertyOf' in RDF schema. Progress in semantic interoperability can be expected among BSR-based systems through applications of semantic web technology suggested in this study.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.7
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• pp.3219-3226
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• 2014

Chemotherapy continues to be a mainstay of cancer treatment, although drug resistance is a major obstacle. Lipid metabolism plays a critical role in cancer pathology, with elevated ether lipid levels. Recently, alkylglyceronephosphate synthase (AGPS), an enzyme that catalyzes the critical step in ether lipid synthesis, was shown to be up-regulated in multiple types of cancer cells and primary tumors. Here, we demonstrated that silencing of AGPS in chemotherapy resistance glioma U87MG/DDP and hepatic carcinoma HepG2/ADM cell lines resulted in reduced cell proliferation, increased drug sensitivity, cell cycle arrest and cell apoptosis through reducing the intracellular concentration of lysophosphatidic acid (LPA), lysophosphatidic acid-ether (LPAe) and prostaglandin E2 (PGE2), resulting in reduction of LPA receptor and EP receptors mediated PI3K/AKT signaling pathways and the expression of several multi-drug resistance genes, like MDR1, MRP1 and ABCG2. ${\beta}$-catenin, caspase-3/8, Bcl-2 and survivin were also found to be involved. In summary, our studies indicate that AGPS plays a role in cancer chemotherapy resistance by mediating signaling lipid metabolism in cancer cells.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.31 no.8B
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• pp.716-729
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• 2006

The information systems in the most enterprise environments are distributed locally and are comprised with various heterogeneous data sources, so that it is difficult to obtain necessary and integrated information for supporting user decision. For solving 'this problems efficiently, it provides uniform interface to users and constructed database systems between heterogeneous systems make a consistence each independence and need to provide transparency like one interface. This paper presents XMDR that consists of category, standard ontology, location ontology and knowledge base. Standard ontology solves heterogeneous problem about naming, attributes, relations in data expression. Location ontology is a mediator that connects each legacy systems. Knowledge base defines the relation for sharing glossary. Adaptive retrieve proposes integrated retrieve system through reflecting site weight by location ontology, information sharing of various forms of knowledge base and integration and propose conceptual domain model about how to share unstructured knowledge.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.11
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• pp.2047-2058
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• 2007

The business environment of enterprises could be difficult to obviate redundancy to filtrate data source occurred on data integrated to standard rules and meta-data and to produce integration of data and single viewer in geographical and spatial distributed environment. Specially, To can interchange various data from a heterogeneous system or various applications without types and forms and synchronize continually exactly integrated information#s is of paramount concern. Therefore data hub system based on SQL/XMDR message to overcome a problem of meaning interoperability occurred on exchanging or jointing between each legacy systems are proposed in this paper. This system use message mapping technique of query transform system to maintain data modified in real-time on cooperating data. It can consistently maintain data modified in realtime on exchanging or jointing data for cooperating legacy systems, it improve clarity and availability of data by providing a single interface on data retrieval.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.5
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• pp.921-929
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• 2008

Recently, many researches have been conducted to solve data heterogeneity as a way for data integration. The elements of the system that we suggest are an XMDR wrapper and XMDR Repository. XMDR wrapper solves the heterogeneity of the existing system by creating the interface based on the standard information of XMDR, and performing the inter-conversion between global XMDR query and local query using mapping data on standard information and local schema. XMDR Repository are composed of XMDR which manages the mapping data on standard information and local schema, and of Proxy DB which saves the accomplished results. With XMDR wrapper and XMDR Repository, users can use the same interface, and they need not conduct repeated queries since XMDR wrapper not only solves the heterogeneity of the schema using the meta-semantic ontology of XMDR, but also considers the heterogeneity accompanying the meaning of the value through instance semantic ontology. Therefore, in this paper we suggest the grid wrapper for the solution of data heterogeneity and efficient data integration.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.12 no.6
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• pp.1087-1094
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• 2008

Recently, XML has been widely used as a standard for a data exchange, and there has emerged the tendency that the size of XML document becomes larger. The data transfer can cause problems due to the increase in traffic, especially when a massive data such as Data Warehouse is being collected and analyzed. Therefore, an XMDR wrapper can solve this problem since it analyzes the tree structures of XML Schema, regenerates XML Schema using the analyzed tree structures, and sends it to each station with an XMDR Query. XML documents which are returned as an outcome encode XML tags according to XML Schema, and send standardized messages. As the formalized XML documents decrease network traffic and comprise XML class information, they are efficient for extraction, conversion, and alignment of data. In addition, they are efficient for the conversion process through XSLT, too, as they have standardized forms. In this paper we profuse a method in which XML Schema and XMDR_Query sent to each station are generated through XMDR(extended Meta-Data Registry) and the generation of products and XML conversion occur in each station wrapper.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.11 no.10
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• pp.1957-1967
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• 2007

User can be offered various information form internet and reserve. However this operation is hard to be satisfied with user's requirement. Because it offer the alternative by self-mediation and the place where offer the information is distributed and a form or stored f[nm of data would be different. These cases occurred in change of enterprise recently. In a process of M&A, outsourcing or cooperation. necessity of new strategy become a pressing issue for ensuring interoperability on application, database of each enterprise and integration information management. Thus, interoperability of distributed data is a base condition for cooperation of legacy system, it will solve a problem such as available or clarity of data, problem of cooperation system. This paper use a XMDR for integration of distributed system and ensuring interoperability. By using XMDR, integrate a traveling information system and it will be solve the problem of interoperability and variety data problem that be occurred in integration of data by suggesting a technique of transaction management.

• Journal of Microbiology and Biotechnology
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• v.31 no.9
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• pp.1200-1209
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• 2021

Sepsis is an acute inflammatory response that leads to life-threatening complications if not quickly and adequately treated. Cytolysin, hemolysin, and pneumolysin are toxins produced by gram-positive bacteria and are responsible for resistance to antimicrobial drugs, cause virulence and lead to sepsis. This work assessed the effects of aloe-emodin (AE) and photodynamic therapy (PDT) on sepsis-associated gram-positive bacterial toxins. Standard and antibiotic-resistant Enterococcus faecalis, Staphylococcus aureus, and Streptococcus pneumonia bacterial strains were cultured in the dark with varying AE concentrations and later irradiated with 72 J/cm^-2 light. Colony and biofilm formation was determined. CCK-8, Griess reagent reaction, and ELISA assays were done on bacteria-infected RAW264.7 cells to determine the cell viability, NO, and IL-1β and IL-6 pro-inflammatory cytokines responses, respectively. Hemolysis and western blot assays were done to determine the effect of treatment on hemolysis activity and sepsis-associated toxins expressions. AE-mediated PDT reduced bacterial survival in a dose-dependent manner with 32 ㎍/ml of AE almost eliminating their survival. Cell proliferation, NO, IL-1β, and IL-6 cytokines production were also significantly downregulated. Further, the hemolytic activities and expressions of cytolysin, hemolysin, and pneumolysin were significantly reduced following AE-mediated PDT. In conclusion, combined use of AE and light (435 ± 10 nm) inactivates MRSA, S. aureus (ATCC 29213), S. pneumoniae (ATCC 49619), MDR-S. pneumoniae, E. faecalis (ATCC 29212), and VRE (ATCC 51299) in an AE-dose dependent manner. AE and light are also effective in reducing biofilm formations, suppressing pro-inflammatory cytokines, hemolytic activities, and inhibiting the expressions of toxins that cause sepsis.

• Tuberculosis and Respiratory Diseases
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• v.60 no.2
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• pp.194-204
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• 2006

Background : Even though tuberculosis (TB) is still a major public concern in Korea, there is little data on the management of TB patients and its outcomes in the private sector. This study evaluated the status of TB treatment in the private sector. Methods : Sixteen-hundred-sixty-six TB patients who were notified in a private university hospital from 2001 to 2002 were enrolled in this study. The patients were divided into pulmonary ($TB_P$), extrapulmonary ($TB_E$), and combined ($TB_{P+E}$) groups, and were also divided into initial and retreatment groups. The clinical characteristics, diagnostic methods, treatment regimens, and outcomes were analyzed and compared. Results : The mean age of the 1,666 patients was 48.9 years and the male-to-female ratio was 1.3:1. The number of patients in the initial and retreatment groups of $TB_P$, and those of ($TB_E+TB_{P+E}$) were 809, 276, 480, 101, respectively. A bacteriological study was performed in 92.0% of cases, and a positive culture was confirmed in 58.1% and 31.7% of patients with TBP and ($TB_E+TB_{P+E}$), respectively (p<0.05). The AFB smear was positive in 45.4 % of the $TB_P$ patients. PCR was carried out in 60.4% of the ($TB_E+TB_{P+E}$) group. The MDR was detected in 14.0% of isolates. Overall, the treatment completion, default, and death rates were 70.2%, 13.5% and 1.9%, respectively. Conclusion : Even though the management of TB patients in a private hospital was satisfactory in terms of the national guidelines, the high default rate was is still a problem. Efforts to decrease the default rate either independently or in cooperation with the public sector will be needed.