• Communications for Statistical Applications and Methods
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• v.16 no.4
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• pp.579-586
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• 2009

We have used multifactor dimensionality reduction(MDR) method to study interaction effect of statistical model in general. But MDR method cannot be applied in all cases. It can be applied to the only case-control data. So, two methods are suggested E-MDR and D-MDR method using regression tree algorithm and dummy variables. We applied the methods on the identify interaction effects of single nucleotide polymorphisms(SNPs) responsible for longissimus mulcle dorsi area(LMA), carcass cold weight(CWT) and average daily gain(ADG) in a Hanwoo beef cattle population. Finally, we compare the results using permutation test.

• The Korean Journal of Applied Statistics
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• v.23 no.4
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• pp.693-703
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• 2010

Diseases of human or economical traits of cattles are occured by interaction of genes. We introduce expanded multifactor dimensionality reduction(E-MDR), dummy multifactor dimensionality reduction(D-MDR) and SNPHarvester which are developed to find interaction of genes. We will select interaction of outstanding gene combinations and select final best genotype groups.

• KIPS Transactions on Software and Data Engineering
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• v.2 no.3
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• pp.161-172
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• 2013

Metadata registry (MDR) is the international standard, developed by ISO/IEC for exchange and sharing data between databases. Many MDR systems are used in diverse domains such as medical service, bibliography, environment for sharing and integrating data. However, those systems have different physical structures individually because the MDR standard defines only the metamodel for registering and storing metadata. It causes heterogeneity between the system structures and requires additional cost to maintain interoperability. ISO/IEC 13249-8 Metadata Registry Access (MRA) is developing as an international standard to provide a consistent access facility to data stored in different metadata registries. However, MRA does not consider the relationships between the concepts (classes) defined in the MDR specification. It causes that incorrect query results returned from MDR systems. It also requires additional cost of modeling and rewriting queries to reflect each physical model. Therefore, this paper suggests eMRA which considers the relationships between the concepts in MDR. The comparative evaluations are described to show the advantages of eMRA. eMRA has superior performance in query modeling and referential integrity than MRA defined by the relationship between the concept of MDR.

• Biomedical Science Letters
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• v.13 no.1
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• pp.47-53
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• 2007

Due to wide abuse of antibiotics both in human and livestock use, the advent and spread of multidrug resistant (MDR) pathogens becomes a serious health problem all over the world. Since the development of new antibiotics is at a standstill in pharmaceutical industry, the choice of therapeutic antibiotics is getting narrower. In this study, in an effort to search new antibiotics, the antimicrobial activity of Paenibacillus DY1 isolated from Korean soil was characterized on its growth inhibition spectrum against various health threatening MDR strains, with its stability and chemical structure. Extracellular culture filtrate of Paenibacillus DY1 effectively inhibits the growth of all the tested MDR enteropathogenic Eshcherichia coli, enterohemolytic E. coli, and enterotoxigenic E. coli strains, at a similar level to that on the nonresistant control E. coli strains. It showed significant growth inhibition effect against the causative agents of class one legal communicable disease, MDR Salmonella typhi, MDR Salmonella paratyphi A, food poisoning bacteria, MDR Salmonella typhimurium, and other MDR Salmonella spp. The growth of all of 10 different MDR Shigella spp. strains and 6 different Vibrio spp. strains tested was also inhibited. The antimicrobial activity of Paenibacillus DY1 was well preserved after heat treatment, and was also stable in both alkaline and acidic environment. The antimicrobial activity was partially purified with Diaion HP20 column and TLC. By NMR study, the putative structure of the activity was postulated as an alkane having hydroxyl groups.

• The Korean Journal of Applied Statistics
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• v.22 no.6
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• pp.1239-1247
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• 2009

Study the gene about economical characteristic of human disease or domestic animal is a matter of grave interest, preserve and elevation of gene of Korea cattle is key subject. Studies have been done on the gene of Korea cattle using EST based SNP map, but it is based on statistical model, therefore there are difference between real position and statistical position. These problems are solved using both EST_based SNP map and Gene on sequence by Lee et al. (2009b). We have used multifactor dimensionality reduction(MDR) method to study interaction effect of statistical model in general. But MDR method cannot be applied in all cases. It can be applied to the only case-control data. So, method is suggested E-MDR method using CART algorithm. Also we identified interaction effects of single nucleotide polymorphisms(SNPs) responsible for average daily gain(ADG) and marbling score(MS) using E-MDR method.

• Communications for Statistical Applications and Methods
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• v.15 no.2
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• pp.265-271
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• 2008

It is commonly believed that diseases of human or economic traits of livestock are caused not by single genes acting alone, but multiple genes interacting with one another. This issue is difficult due to the limitations of parametric-statistic methods of gene effects. So we introduce multifactor-dimensionality reduction(MDR) as a methods for reducing the dimensionality of multilocus information. The MDR method is nonparametric (i. e., no hypothesis about the value of a statistical parameter is made), model free (i. e., it assumes no particular inheritance model) and is directly applicable to case-control studies. Application of the MDR method revealed the best model with an interaction effect between the SNPs, SNP1 and SNP3, while only one main effect of SNP1 was statistically significant for LMA (p < 0.01) under a general linear mixed model.

• Proceedings of the Korean Information Science Society Conference
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• 2002.10e
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• pp.67-69
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• 2002

인터넷과 정보통신기술을 배경으로 한 전자상거래 확산은 유례가 없을 정도의 빠른속도로 이루어지고 있다. 특히 XML이 W3C의 공식 표준으로 공식화 된 이후, XML의 확장성, 호환성, 정보의 구조화와 같은 장점으로 XML은 전자상거래 프레임워크의 새로운 페러다임이 되었다. 이러한 XML 전자상거래 프레임워크로는 xCBL을 필두로, eCo 프레임워크, cXML, BizTalk, ebXML등 많은 국제 표준이 있다. 그러나 이러한 다양한 프래임워크들은 메시지규칙에 대한 정의와 전송 프로토콜 정의, 비즈니스 프로세스의 수평적 통합만을 고려하고 있다. 즉 비즈니스 객체간의 상호작용을 위한 일반된 표준을 제공해주지 못하고 새로운 비즈니스 상대자가 등장할 경우 새로운 규칙을 설정해야 하는 부담을 해결하지 못한다.본 논문에서는 ISO/IEC 11179에 기반을 둔 MDR(Metadata Registry)를 이용한 MDR 기반하이브리드(Hybrid) 프레임워크 (Framework)를 제안한다 본 하이브리드 구조의 프레임워크를 통하여 기존의 수평적 관계의 프레임워크가 갖고 있는 비즈니스 프로세스 및 메시지 규칙의 문제점들을 해결할 수 있다.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.32A no.7
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• pp.36-42
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• 1995

In this paper, the CAD program for designing the microwave waveguide narrow-band bandpass filters has been developed by the passband correction method with filter synthesis for the MDR(Microwave Digital Relay) system. Here, the modified double E-plane structures are employed in the filter structure which is analyzed by the variational method. Using the developed CAD program, 0.01dB equi-ripple chebyshev type 6-section bandpass filters used in the MDR system operating nationally is designed at the center frequency of 11.0GHz, fabricated with tunable type and then measured by tuning process. The experimantal results show good agreements with the theoretical results.

• Communications for Statistical Applications and Methods
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• v.17 no.5
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• pp.667-678
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• 2010

It is important to detect the gene-gene interaction in GWAS(Genome-Wide Association Study). There are many studies about detecting gene-gene interaction. The one is Multifactor dimensionality reduction method. But MDR method is not applied continuous data and expanded multifactor dimensionality reduction(E-MDR) method is suggested. The goal of this study is to evaluate the power of E-MDR for identifying gene-gene interaction by simulation. Also we applied the method on the identify interaction e ects of single nucleotid polymorphisms(SNPs) responsible for economic traits in a Korean cattle population (real data).

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.9
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• pp.4807-4814
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• 2012

Purpose: The chemoresistance of human hepatocellular carcinoma (HCC) to cytotoxic drugs, especially intrinsic or acquired multidrug resistance (MDR), still remains a major challenge in the management of HCC. In the present study, possible mechanisms involved in MDR of HCC were identified using a 5-fluorouracil (5-FU)-resistant human HCC cell line. Methods: BEL-7402/5-FU cells were established through continuous culturing parental BEL-7402 cells, imitating the pattern of chemotherapy clinically. Growth curves and chemosensitivity to cytotoxic drugs were determined by MTT assay. Doubling times, colony formation and adherence rates were calculated after cell counting. Morphological alteration, karyotype morphology, and untrastructure were assessed under optical and electron microscopes. The distribution in the cell cycle and drug efflux pump activity were measured by flow cytometry. Furthermore, expression of potential genes involved in MDR of BEL-7402/5-FU cells were detected by immunocytochemistry. Results: Compared to its parental cells, BEL-7402/5-FU cells had a prolonged doubling time, a lower mitotic index, colony efficiency and adhesive ability, and a decreased drug efflux pump activity. The resistant cells tended to grow in clusters and apparent changes of ultrastructures occurred. BEL-7402/5-FU cells presented with an increased proportion in S and G2/M phases with a concomitant decrease in G0/G1 phase. The MDR phenotype of BEL-7402/5-FU might be partly attributed to increased drug efflux pump activity via multidrug resistance protein 1 (MRP1), overexpression of thymidylate synthase (TS), resistance to apoptosis by augmentation of the Bcl-xl/Bax ratio, and intracellular adhesion medicated by E-cadherin (E-cad). P-glycoprotein (P-gp) might play a limited role in the MDR of BEL-7402/5-FU. Conclusion: Increased activity or expression of MRP1, Bcl-xl, TS, and E-cad appear to be involved in the MDR mechanism of BEL-7402/5-FU.