• The Korean Journal of Pesticide Science
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• v.2 no.3
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• pp.64-69
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• 1998

New thirty derivatives of 5,6-dihydro-2-trifluoromethyl-1,4-oxathiin carboxanilide as substrate(S) were synthesized and their fungicidal activities in vivo against rice sheath blight(Rhizoctonia solani) and wheat leaf rust(Puccinia recondita) were examined. The structure activity relationships(SAR) between the activities($pI_{50}$) and a physicochemical parameters of substituents(X) at the phenylcarbamoyl group were analyzed using the adaptive regression analysis method. The 3-methoxy, 11, 3-isopropyloxy, 13 and 3-isopropyl substituent, 25 as X on the phenylcarbamoyl group exhibited the most highest fungicidal activity against the two fungi. The fungicidal potency of the (S) against Puccinia recondita was higher than Rhizoctonia solani. In case of Rhizoctonia solani, the molecular hydrophobicity(${\pi}>0$) and resonance effect(R<0) by meta-alkyl substitutents with electron donating were important factors in determining fungicidal activity. And the HOMO energy(HOMO>0), ABSQ, sum of absolute values of the atomic charges on each atom and specific polarizability(Sp.Pol<0) of (S) were significantly influential towards fungicidal activity against Puccinia recondita.. The interaction between (S) and receptor agonist from the based on SAR studies proceeds through charge-control reaction, and conditions to show higher activity has been also discussed.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.28 no.1
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• pp.29-38
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• 2010

The airborne LiDAR which was introduced in the early 2000's provides the point data. The new methods for the verification of LiDAR materials with high accuracy which is different from the existing airborne survey are needed. In accordance with the rules of airborne laser survey which were enacted in 2009, the verifications by three methods of Unmeasured Rate and point accuracy, point density have been executed, and Unmeasured Rate is to evaluate the rate for the presence of points within uniform grids except non-reflective areas such as watershed areas. For the calculation of Unmeasured Rate, non-reflective areas should be removed by all means, and in case of normal LiDAR materials, as there are scant points for watershed areas, watershed areas should be divided by additional spatial information. So, in this study, the watershed areas were extracted using domain extension technique from the high resolution CIR images of 0.3m grade. In addition, in order to compare the accuracy of Unmeasured Rate calculated, the comparative analysis of the Unmeasured Rate calculated by digital maps has been done. In conclusion, we found that 1I1e accuracy of Unmeasured Rate extracted by domain extension technique is similar to the value extracted by digitizing technique.

• Asian-Australasian Journal of Animal Sciences
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• v.29 no.5
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• pp.666-673
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• 2016

Two experiments were conducted to evaluate the effects of the level of corn dry distillers grains with solubles (CDDGS) supplementation on growing performance, blood metabolites, digestion characteristics and ruminal fermentation patterns in steers grazing dormant forage. In Exp. 1, of growth performance, 120 steers ($204{\pm}5kg$ initial body weight [BW]) were distributed randomly into 3 groups (each of 40 steers), which were provided with the following levels of CDDGS supplement: 0%, 0.25%, or 0.50% BW. All groups of steers were grazed for 30 days in each of 3 grazing periods (March, April, and May). Approximately 1,000 ha of the land was divided with electric fencing into 3 equally sized pastures (333 ha in size). Blood samples were collected monthly from 20 steers in each grazing group for analysis of glucose (G), urea-nitrogen (UN) and non-esterified fatty acids. Final BW, average daily gain (ADG) and supplement conversion (CDDGS-C) increased with increasing levels of CDDGS supplementation (p<0.05).The CDDGS supplementation also increased the plasma G and UN concentrations (p<0.05). In Exp. 2, of digestive metabolism, 9 ruminally cannulated steers ($BW=350{\pm}3kg$) were distributed, following a completely randomized design, into groups of three in each pasture. The ruminally cannulated steers were provided the same levels of CDDGS supplementation as in the growing performance study (0%, 0.25%, and 0.50% BW), and they grazed along with the other 40 steers throughout the grazing periods. The dry matter intake, crude protein intake, neutral detergent fiber intake (NDFI), apparent digestibility of dry matter (ADDM), crude protein (ADCP) and neutral detergent fiber (ADNDF) increased with increasing levels of CDDGS supplementation (p<0.05). The ruminal degradation rates of CP (kdCP), NDF (kdNDF) and passage rate (kp) also increased with increasing levels of CDDGS supplementation (p<0.05). Ruminal ammonia nitrogen ($NH_3$-N) and propionate concentrations also increased with increasing levels of CDDGS supplementation (p<0.05). However, acetate concentrations decreased with increasing levels of CDDGS supplementation (p<0.05). Liquid dilution rate increased with increasing levels of CDDGS supplementation but ruminal liquid volume decreased (p<0.05). On the basis of these findings, we can conclude that CDDGS supplementation enhanced the productive performance of cattle grazing native rangeland without negatively affecting forage intake, glucose and urea-nitrogen blood concentrations, ruminal degradation and ruminal fermentation patterns.

• Journal of Internet Computing and Services
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• v.13 no.2
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• pp.41-49
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• 2012

Wireless network support and extended mobile network environment with exponential growth of smart phone users allow us to utilize the network anytime or anywhere. Malicious attacks such as distributed DOS, internet worm, e-mail virus and so on through high-speed networks increase and the number of patterns is dramatically increasing accordingly by increasing network traffic due to this internet technology development. To detect the patterns in intrusion detection systems, an existing research proposed an efficient algorithm called the jumping window algorithm and analyzed approximately 2,000 patterns in Snort 2.1.0, the most famous intrusion detection system. using the algorithm. However, it is inappropriate from the number of TCAM lookups and TCAM memory efficiency to use the result proposed in the research in current environment (Snort 2.9.0) that has longer patterns and a lot of patterns because the jumping window algorithm is affected by the number of patterns and pattern length. In this paper, we simulate the number of TCAM lookups and the required TCAM size in the jumping window with approximately 8,100 patterns from Snort-2.9.0 rules, and then analyse the simulation result. While Snort 2.1.0 requires 16-byte window and 9Mb TCAM size to show the most effective performance as proposed in the previous research, in this paper we suggest 16-byte window and 4 18Mb-TCAMs which are cascaded in Snort 2.9.0 environment.

• Journal of Korean Society for Atmospheric Environment
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• v.28 no.5
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• pp.595-605
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• 2012

Fine particles ($PM_{2.5}$) were collected and analyzed from April 2010 through January 2011 in Chungju to investigate the characteristics of $PM_{2.5}$ and its ionic species. The annual mean concentrations of $PM_{2.5}$, ${SO_4}^{2-}$, $NO_3{^-}$, and $NH_4{^+}$ in the particulate phase were 40.84, 7.61, 7.14 and $3.74{\mu}g/m^3$, respectively. $PM_{2.5}$ concentrations were higher in fall and spring than in winter and summer. The elevated concentrations episodes are the main factor that enhanced the $PM_{2.5}$ concentrations in the fall. Among the major ionic species ${SO_4}^{2-}$ showed the highest concentration, followed by $NO_3{^-}$ and $NH_4{^+}$, $NO_3^-$ exhibited higher concentrations during the winter, but ${SO_4}^{2-}$ and $NH_4{^+}$ were not showed seasonal variation. The high correlations were found among $PM_{2.5}$, ${SO_4}^{2-}$, $NO_3{^-}$ and $NH_4{^+}$ during all seasons except for spring. The evaluation of backward trajectories and meteorological records show that the highest $PM_{2.5}$ concentration levels occurred during W-NW weather conditions, which influenced by the emission sources of China area. The low pollution levels generally occurred during E-S weather conditions, which influenced by the East Sea and south of the Yellow Sea. The elevated $PM_{2.5}$ mass concentrations arouse the concentration of $NO_3{^-}$, but no effects on ${SO_4}^{2-}$ and $NH_4{^+}$.

• Asian-Australasian Journal of Animal Sciences
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• v.11 no.5
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• pp.559-565
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• 1998

This study was conducted to investigate the effects of different feeding regimen on the growth and nutrients excretion in finishing pigs. A total of 80 pigs (59.91 kg BW) and 6 pigs (85 kg BW) were employed in a growth trial and metabolic trial, respectively. Treatments were grower-grower (GG), grower-early finisher(GE), early finisher-early finisher (EE), and early finisher-late finisher (EL) diet feeding regimens for feeding trial and G, E, L diets for metabolic trial. Through whole experimental period, no significant difference was found in any of the criteria measured. Pigs fed on a GG regimen gained slightly faster than pigs fed on other feeding regimens, with no significant difference. Although there was a trend that pigs fed on a GG or GE regimen showed improved feed/gain over pigs fed on a EE or EL regimen, the difference also was not significant. In the metabolic trial, dry matter and phosphorus digestibility was not affected by diets, however, phosphorus digestibility tended to be decreased as nutrients contents was decreasing in the diets. Crude protein digestibility was significantly influenced by the nutrients contents in th diets. The data suggested that 11.7% crude protein seemed to be low for the 85 kg pigs. Though nutrients excretion was not significantly influenced by dietary treatment except phosphorus, there was a trend that pigs fed diets with low nutrient content excreted less amount of nitrogen and phosphorus than pigs fed diets with high nutrients content. There was a trend that GG or GE feeding regimen gad a favorable effect on carcass grade when only 10 lighter pigs of each treatment were subjected to statistical analysis. However, with 10 heavier pigs, EE and EL feeding regimen showed better carcass grade, though the difference was not significant. In summary, it seemed that producers generally oversupply the expensive nutrients for the finishing pigs. High nutrient diets do not always guarantee high growth rate of pigs. It rather seems that to meet nutrient requirements for the each growth phase is more important in economical pork production.

• Journal of Gastric Cancer
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• v.20 no.2
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• pp.139-151
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• 2020

Purpose: Globally, there is a high incidence of gastric cancer (GC). Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) is reported to play a vital role in several human malignancies. However, there is limited understanding of the role of LETM1 in GC. This study aims to investigate the effects of LETM1 on proliferation, migration, and invasion of GC cells. Materials and Methods: The expression levels of LETM1 in the normal gastric mucosal epithelial cells (GES-1) and GC cells were analyzed by quantitative real-time polymerase chain reaction and western blotting. CCK-8, wound healing, and Transwell invasion assays were performed to evaluate the effect of LETM1 knockdown or overexpression on the proliferation, migration, and invasion of the GC cells, respectively. Additionally, the effect of LETM1 knockdown or overexpression on GC cell apoptosis was determined by flow cytometry. Furthermore, the effect of LETM1 knockdown or overexpression on the expression levels of PI3K/Akt signaling pathway-related proteins was evaluated by western blotting. Results: The GC cells exhibited markedly higher mRNA and protein expression levels of LETM1 than the GES-1 cells. Additionally, the knockdown of LETM1 remarkably suppressed the GC cell proliferation, migration, and invasion, and promoted the apoptosis of GC cells, which were reversed upon LETM1 overexpression. Furthermore, the western blotting analysis indicated that LETM1 facilitates GC progression via the PI3K/Akt signaling pathway. Conclusions: LETM1 acts as an oncogenic gene to promote GC cell proliferation, migration, and invasion via the PI3K/Akt signaling pathway. Therefore, LETM1 may be a potential target for GC diagnosis and treatment.

• IMMUNE NETWORK
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• v.1 no.1
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• pp.36-44
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• 2001

Background : Peritoneal metastasis is one of the maj or types of the stomach cancer recurrence and the role of the adhesion molecules is thought to be very much important in this event. Retinoic acid (RA) has been known to induce the growth inhibition and differentiation of various malignancies, and apoptpsis and the change of expression of adhesion molecules have been reported to be involved in the action of RA. Methods : We studied the adhesion abilities of SNU-1, SNU-5, and SNU-6 cells to the peritoneal endothelial cells as well as the expression of the adhesion molecules (CD44, ICAM-1) in Western blot analysis. And also we studied the expression of apoptosis and the change of expression patterns of the various isoforms of CD44 and the change of the adhsion abilities of the cell line cells after RA treatment. Results: CD44 was expressed in SNU-5 and -16, together with an isoform in SNU-16. ICAM-1 was not expressed in any of the cell line cells tested. After the treatment of RA in the concentration range of $1-5{\times}10^{-5}M$ to three stomach cancer cell lines, growth inhibition, apoptosis and the change of expression of the CD44 were noted. After RA treatment, the expression of CD44H was weakly increased in SNU-1, and was markedly increased in SNU-5. In SNU-16, the expression of CD44H was decreased while that of CD44E were markedly increased. The adhesibility of cells to peritoneal cells was increased in relation with the increase of the CD44H expression, which shows the fact that the adhesibility of tumor cells to peritoneal mesothelial cells is mediated by CD44H recognizing hyaluronic acid. Conclusion : RA induces growth inhibition of stomach cancer cell line cells and increase the adhesiblity of stomach cancer cell line cells to peritoneal mesothelium. It is believed that RA decreases the metastatic ability of stomach cancer cells by upregulating the CD44H expression.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 2017.04a
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• pp.58-58
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• 2017

점적 호스의 원통형 미로 구조물내의 유동특성을 분석하기 위해 금속판에 동일한 구조의 미로가 가공된 시험부를 활용하여 압력과 유량의 변화에 대한 실험을 CFD 해석하였다. 해석은 미로의 길이에 따른 유량 특성을 정밀하게 분석하기 위해 전체 미로에 구간별 총 8개의 배출구를 배치하고 밸브 조절을 통해 구간별 압력에 따른 유량을 측정함으로서 실험에 의한 압력과 유량의 관계를 검증하고 새로운 경질 미로를 설계하는데 응용하고자 한다. 경질 미로의 이론적인 해석에서 정밀도가 실험을 대신할 가능성이 있는지에 관심을 두었다. 점적관수의 경질 미로는 디자인을 달리함으로써 성능이 높고 미세한 스케일이 침착되지 않는 고성능의 점적관수 장치의 개발이 가능할 것으로 판단하였다. 미로 입구의 공급 유체 압력(Gauge pressure)을 0.5, 1.5, 2.5, 3.0 bar로 나누어 공급하였으며, 8개의 구간별 유출되는 유량은 전자저울에서 측정하였다. 향후 최적 미로의 새로운 설계를 위해 미로구조 전체를 CFD 해석하였고 그 결과를 실험치와 비교 분석하였다. 또한 경질 미로내 각 구간별 세부적인 유동구조를 분석하였고 해석결과와 실험결과를 통해 향후 새로운 경질 구조의 개발이 가능 할 것으로 판단되었다. 경질 미로의 입구압력에 따른 미로의 길이 #1과 #2에 대한 CFD 분석에서는 전체적으로 경질 미로에 압력이 증가할수록 미로의 유체 속도가 증가됨을 알 수 있었으며 이것은 #2에서도 거의 같은 양상을 나타내었다. 미로 통로에서는 와류로 인한 이물질의 멈춤 현상이 발생하지 않을 만큼 흐름이 원활함을 알 수 있었다. 미로의 길이 #3과 #4에 대한 CFD 분석과 미로의 길이 #5와 #6에 대한 CFD 분석에서는 압력이 증가하고 미로의 길이가 길어질수록 속도에도 영향을 미치고 있는 것으로 나타났으며 미로와 미로 사이의 넒은 통로에서는 유속이 크게 떨어지고 있음을 알 수 있었다. 따라서 이 부분에는 유체속의 이물질이 침착할 수 있는 가능성이 있으며 통로가 좁은 곳에서는 유속이 증가되는 것으로 나타났다. #7과 #8은 미로의 상하단으로 유출되는 부분의 차이이므로 실질적으로 해석의 결과는 차이가 없었다. 경질 미로에 대한 압력에 따른 미로의 길이별 유출량은 지수적인 반비례 현상을 나타내어 앞서 실험한 연구의 결과와 1~2% 오차 범위에서 잘 일치하였다. 따라서 점적 호스의 경질 미로에 대한 설계는 이론적인 해석을 통하여 새로운 디자인이 가능할 것으로 판단되었다. 경질 미로의 미로의 길이에 따른 CFD 분석의 결과는 실험적인 유출량의 값과 거의 일치하였다. 미로와 미로 사이의 넒은 통로에서는 유속이 크게 떨어져 이물질들이 침착될 가능성이 있었으며 실질적으로 넓게 설계하는 것이 유리하지 않을 것으로 판단되었다. 경질 미로에 대한 압력에 따른 미로의 길이별 유출량은 지수적으로 반비례 하였으며 점적 호스의 경질 미로에 대한 새로운 설계는 이론적인 해석을 통하여 가능할 것으로 판단되었다.

• Journal of Preventive Medicine and Public Health
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• v.32 no.1
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• pp.60-64
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• 1999

Objectives. Changes in lung function are frequently used as biological markers to assess the health effects of criteria air pollutants. We tried to formulate the prediction models of pulmonary functions based on height, weight, age and gender, especially for children aged 12 years who are commonly selected for the study of health effects of the air pollution. Methods. The target pulmonary function parameters were forced vital capacity(FVC) and forced expiratory volume in one second(FEV1). Two hundreds and fifity-eight male and 301 female 12-year old children were included in the analysis after excluding unsatisfactory tests to the criteria recommended by American Thoracic Sosiety and excluding more or less than 20% predicted value by previous prediction equations. The weight prediction equation using height as a independent variable was calculated, and then the difference of observed weight and predicted weight (i.e. residual) was used as the independent variable of pulmonary function prediction equations with height. Results. The prediction equations of FVC and FEV1 for male are FVC(ml) = $50.84{\times}height(cm)+7.06{\times}weight$ residual 4838.86, FEV1(ml) = $43.57{\times}height(cm)+3.16{\times}weight$ residual - 4156.66, respectively. The prediction equations of FVC and FEV1 for female are FVC(ml) = $42.57{\times}height(cm)+12.50{\times}weight$ residual - 3862.39, FEV1(ml) = $36.29{\times}height(cm)+7.74{\times}weight$ residual - 3200.94, respectively.