• Genomics & Informatics
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• v.17 no.4
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• pp.45.1-45.3
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• 2019

To identify pathways associated with survival phenotypes using gene expression data, we recently proposed the hierarchical structural component model for pathway analysis of gene expression data (HisCoM-PAGE) method. The HisCoM-PAGE software can consider hierarchical structural relationships between genes and pathways and analyze multiple pathways simultaneously. It can be applied to various types of gene expression data, such as microarray data or RNA sequencing data. We expect that the HisCoM-PAGE software will make our method more easily accessible to researchers who want to perform pathway analysis for survival times.

• Journal of Food Hygiene and Safety
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• v.18 no.1
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• pp.14-24
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• 2003

Two aims of the present study were the evaluation of hygienic, microbial safety on food services of elementary schools in Western Gyeongnam province, and then, the construction of database for the SSOP (Sanitation Standard Operation Procedures) practice. A total of 98 samples were collected from drinking water, waterworks, kitchen utensils, kitchen equipments, employees and cooked foods. Total bacteria was counted and pathogenic bacteria such E. coli, salmonella, yersinia, vibrio parahaemolyticus and staphylococcus were identified based on the biochemical analysis. Following are the results: the number of bacteria showed from 1.0x10$^2$CFU/ mL to 1.0x10$^{6}$ CFU/mL in most samples, which the level exceeds normal range. Over 1.0x10$^{5}$ CFU/ml bacteria were observed from the kimchi in 4 places (B, C, D, E), because cooked food such as kimchi had not been heated. As a rule, the bacterium level in place B was higher than that in any of the other places. E-coli were isolated from kitchen knives (C, E) and Kimchi (E): staphylococci were isolated from drinking water (A), hands (D), refrigerator (E) and apron (E). But, salmonella, vibrio and yersinia were not detected in anywhere. In conclusion, the presence of bacteria and pathogenic agents in school food service was closely related to hygienic practice. For that reason, it is necessary to have more systematic and efficient management in order to enhance the food safety.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2012.05a
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• pp.821-822
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• 2012

• Electrical & Electronic Materials
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• v.10 no.9
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• pp.952-959
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• 1997

• Proceedings of the PSK Conference
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• 2000.10a
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• pp.247.2-247.2
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• 2000

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.20
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• pp.8975-8979
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• 2014

Objective: To explore the possible significance of aromatase P450 in endometrial hyperplasia with a background of polycystic ovary syndrome (PCOS). Methods: Immunohistochemistry was used to determine the expression of aromatase P450 in endometrium of PCOS patients. Semiquantitative analysis of aromatase P450 expression of mRNA and protein level wasalso carried out by real-time quantitative RT-PCR method. After endometrial cells were stimulated by testosterone and letrozole in vitro, the estradiol ($E_2$) level was determined, and the expression of cell aromatase P450 mRNA was assessed. Results: The aromatase P450 mRNA level was increased in endometria of PCOS patients. When endometrial cells were cultured with $10^{-6}M$ testosterone, the $E_2$ level in the culture medium increased. An inhibitory effect on $E_2$ generation and expression of aromatase P450 mRNA was observed when the endometrial cells were treated with $10^{-5}M$ letrozole. Conclusions: There is an increased expression of aromatase P450 in PCOS patient endometrium. Androgen stimulation could enhance the synthesis of aromatase P450 mRNA and the production of $E_2$ in endometrial cells in vitro while letrozole could do the reverse.

• Analytical Science and Technology
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• v.37 no.1
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• pp.25-38
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• 2024

The study aimed to investigate a novel approach by utilizing liquid chromatography (LC) and liquid chromatography-mass spectrometry (LC-MS) to separate, identify and characterize very nominal quantities of degradation products (DPs) of balsalazide along with its process related impurities without isolation from their reaction mixtures. The impurities along with balsalazide were resolved on spherisorb ODS2 (250×4.6 mm, 5.0 ㎛) column at room temperature using 0.2 M sodium acetate solution at pH 4.5 and methanol in the ratio of 55:45 (v/v) as mobile phase pumped isocratically at 1.0 mL/min as mobile phase and UV detection at 255 nm. The method shows sensitive detection limit of 0.003 ㎍/mL, 0.015 ㎍/mL and 0.009 ㎍/mL respectively for impurity 1, 2 and 3 with calibration curve liner in the range of 50-300 ㎍/mL for balsalazide and 0.05-0.30 for its impurities. The balsalazide pure compound was subjected to stress studies and a total of four degradation products (DPs) were formed during the stress study and all the DPs were characterized with the help of their fragmentation pattern and the masses obtained upon LC-MS/MS. The DPs were identified as 3-({4-[(E)-(4-hydroxyphenyl) diazenyl]benzoyl}amino)propanoic acid (DP 1), 4-[(E)-(4-hydroxyphenyl)diazenyl] benzamide (DP 2), 5-[(E)-(4-carbamoylphenyl)diazenyl]-2-hydroxybenzoic acid (DP 3) and 3-({4-[(E)-phenyldiazenyl]benzoyl}amino)propanoic acid (DP 4). Based on findings, it was concluded that, the proposed method was successfully applicable for routine analysis of balsalazide and its process related impurities in pure drug and formulations and also applicable for identification of known and unknown impurities of balsalazide.

• Korean Journal of Environment and Ecology
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• v.27 no.4
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• pp.449-461
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• 2013

This study is contributed to examine the vegetation characteristics of the Quercus mongolica which are located in between two summits, hyangnobong and gitdaebaggybong, with dividing two regions(I, II). A total of 63 Quercus mongolica communities were enrolled in this survey. A~E, 5 communities were the result of analysed classification by TWINSPAN. Spatial distribution of the communities; 'A' community is concentrated at an altitude of about 1,300 meters in Mt. Taebaek(II region). 'B' and 'C' communities are concentrated at an altitude of between 700 and 1500 meters in Mt. Seorak and Odae(Iregion). 'D' and 'E' communities are concentrated at an altitude of below 1,100 meters in Mt. Cheongok and geumdaebong(II region), and also Mt. Seorak and Odae(Iregion). Arboral and shrub populations, maximum species diversity and height of arboral of each communities have a characteristic of decreasing according to increasing altitude gradually. And the result of studying on arboreal growth increment with up to 40-year-old trees, there is no special tendency with growth increment in the altitude of subnormal 1,100 meters, but there is a tendency that growth increment becomes lower in the altitude of more than 1,100 meters. In correlation analysis, it is -0.53 in the Quercus mongolica and Betula costata community at an altitude of over 1,000 meters, the correlation shows negative(-). It is +0.59 in the Quercus mongolica and Rubus crataegifolius community at an altitude of less than 1,000 meters, the correlation shows positive(+). And those are cognate trees with the correlation of Betula costata, Betula costata Trautv., Tripterygium regelii Sprague&Takeda., Acer barbinerve Maxim. With a summary of the results, the changes in the environment according to the elevation affect Quercus mongolica community.

• Journal of Korea Technical Association of The Pulp and Paper Industry
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• v.35 no.1
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• pp.7-12
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• 2003

The test results for water repellency of paper and paperboard according to KS M 7057 can readily be influenced by an operator's bias. In order to discard such bias, the automatic analysis program of water repellency was developed based on different shape features of a liquid trace formed on a specimen. That is, the shape of a liquid track flowing down on the specimen with an angle of $45^{\circ}$ was evaluated according to width variation between head and tail of the trace($S_{Hr}$), uniformity of a liquid flow($S_{d}$), length of long traces($L_{SHr}$), eccentricity of liquid traces($E_{i}$), and then was recognized as a specific degree of water repellency. Finally, the automatic analysis system of water repellency based upon KS M 7057 made it possible to readily measure water resistance of paper and paperboards classified into R0 to R10.

• Korean Journal of Applied Biomechanics
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• v.17 no.1
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• pp.29-39
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• 2007

This study were obtained elapsed time phase-by-phases, displacement, user angle, velocity and angular velocity to analyse kinematically contributing factors at impact of forehand drive motion, on targeting three male players. The results of the study were presented as follows; In the forehand drive swing, the elapsed time by phases was a total of .52 seconds: .30 seconds from backswing to impact and .22 seconds from impact to follow-through, Considering the mean change in locations of COM of each(part$\rightarrow$body segment) at impact, racket head, left shoulder, right wrist and left hip, the left-right directions(X-axis) were showm to be each $.61{\pm}.03$, $1.19{\pm}.08$, $.66{\pm}.03$, $.94{\pm}.06$, and $.45{\pm}.03m$. The displacement differences of COM of each body segment were shown to be -.57, -.05, -.33, and .16m. For the vertical direction(Z-axis), the center of mass was lowest at impact and highest at E3. For the displacement of the right wrist on the left hip, the right wrist moved to .82m to the lower direction without change in the locations of the hip from E1 from E2. When the left hip moved .02m from E2 to E3, the right wrist moved .7m in the upper direction. In respect to the velocity of each body segment, the hip and the shoulder joint accelerated and then the wrist followed. Then the right wrists of all the subjects and their racket heads showed maximum speed, and an effective swing was observed. At the angle of each part, the angle of the right wrist was the smallest at the backswing and the largest at the moment of the impact. Then it increased gradually in the follow-through section. In respect of angular velocity for subject A, the hip moved and the largest change occurred. Immediately before the impact, the subject made a swing using his right wrist, his hip, and the shoulder joint, showing the maximum value, which was judged to be effective.