• 사상체질의학회지
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• 제13권1호
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• pp.104-108
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• 2001

The tremor which has been showed most frequently in the clinic has various reasons, which is common in the dyskinesias and has rhythmic vibration involuntarily. The purpose of this study is to give an account of the effects of the Korean herbal medicine therapy which is based on the constitutional medicine for the patient who has suffered from tremor which is accompanied with diarrhea in the lacunar infarction. The subject is a 70-year-old woman who has had the symptoms caused by lacunar infarction, which are tremor, right side weakness, right facial palsy, dizziness, chest discomfort, and chronic diarrhea, dipsia, abdominal discomfort, andominal pain and so forth. We have diagnosed her as Shaoyangin(少陽人) Mangyin(亡陰證) and have prescribed Huashi Kushen Tang(滑石苦蔘湯) in accordance with the principle of Pyoeumganggi(表陰降氣). The consequence is that the accompanied tremor and diarrhea and general depressed condition have improved.

• Journal of Genetic Medicine
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• 제16권1호
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• pp.19-22
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• 2019

The infantile convulsions and choreoathetosis (ICCA) syndrome is defined when two overlapping clinical features of benign familial infantile epilepsy (BFIE) and paroxysmal kinesigenic dyskinesia (PKD) are present in an individual or a family. Since the gene encoding proline-rich transmembrane protein 2 (PRRT2) was first identified in Han Chinese families with PKD, mutations of PRRT2 have additionally been reported in patients with BFIE and ICCA. We attempted to identify the genetic etiology in an ICCA family where the proband, her elder sister, and a maternal male cousin had BFIE, and her mother had PKD. Whole-exome sequencing performed in the proband and her sister and mother identified a novel pathogenic mutation of PRRT2 (c.640delinsCC; p.Ala214ProfsTer11), which was verified by Sanger sequencing. This frameshift PRRT2 mutation located near the genetic hot spot of base 649_650 results in the premature termination of the protein, as do most previously reported mutations in BFIE, ICCA, and PKD.

• Clinics in Shoulder and Elbow
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• 제25권4호
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• pp.321-327
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• 2022

Background: Scapular dyskinesis is considered a risk factor for the shoulder pain that may warrant screening for prevention. Clinicians of all experience screen scapular dyskinesis using the scapular dyskinesis test yes-no classification (Y-N), yet its reliability in asymptomatic individuals is unknown. We aimed to establish Y-N's intra- and inter-reliability between students and expert physical therapists. Methods: We utilized a cross-sectional design using consecutive asymptomatic subjects. Six students and two experts rated 100 subjects using the Y-N. Cohen's kappa (κ) and Krippendorff's alpha (K-α) were calculated to determine intra- and inter-rater reliability. Results: Intra- and inter-rater values for experts were κ=0.92 (95% confidence interval [CI], 0.91-0.93) and 0.85 (95% CI, 0.84-0.87) respectively; students were κ=0.77 (95% CI, 0.75-0.78) and K-α=0.63 (95% CI, 0.58-0.67). Conclusions: The Y-N is reliable in detecting scapular dyskinesis in asymptomatic individuals regardless of experience.

• Journal of Oral Medicine and Pain
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• 제38권4호
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• pp.325-331
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• 2013

보툴리눔 톡신은 신경독소로, 운동신경 말단부위에서 분비되는 아세틸콜린의 분비를 차단하여 근육의 위축을 유발하게 된다. 의학계 및 치의학계에서는 이를 이용하여 다양한 질환을 치료하는 것을 시도하고 있다. 치과영역에서는 저작근 수축, 심한 이갈이, 안면 틱, 구강안면 운동장애, 교근비대의 치료 등 과활성 근육성 질환을 치료하는 데 사용하고 있다. 악안면 영역에 보툴리눔 톡신을 주입하고 난 뒤 발생되고 있는 합병증으로는, 자연스럽지 못한 안면표정, 통증의 증가, 두통 등이 유발될 수 있다고 보고되고 있다. 본 증례에서는 교근부에 보툴리눔 톡신 주입 후 발생된 전방 개교합 증상에 대하여 보고하고자 한다.

• Journal of Acupuncture Research
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• 제22권5호
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• pp.183-193
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• 2005

Objectives : The purpose of this case is to report the improvement after the acupuncture therapy and herbal medicine about two patients with senile oro-facial dyskinesia. Methods : We treated the patient with acupuncture therapy and herbal medicine by evaluating facial, lips, jaw and tongue expression of AIMS(Abnormal Involuntary Movement Scale) and clinical symptom progress. Results : We have recently experienced two cases of senile oro-facial dyskinesia. Two patients were improved significantly through the acupuncture therapy and herbal medicine, so we report it for the better treatment. Conclusion : Oro-facial dyskinesia is stereotyped movements, consisting of smacking and pursing of the lips, lateral deviation and protrusion of the tongue, and occasionally lateral deviation and protrusion of the jaw. Spontaneous oro-facial dyskinesias occur in the elderly and had been said to result from edentulousness. Oriental medical treatment for oro-facial dyskinesia resulted in satisfactory results by diminishing the symptoms progressively during the admission periods. More research of oro-facial dyskinesia is needed.

• Clinical and Experimental Pediatrics
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• 제59권sup1호
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• pp.133-138
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• 2016

Anti-N-methyl D-aspartate receptor (anti-NMDAR) encephalitis, recently recognized as a form of paraneoplastic encephalitis, is characterized by a prodromal phase of unspecific illness with fever that resembles a viral disease. The prodromal phase is followed by seizures, disturbed consciousness, psychiatric features, prominent abnormal movements, and autonomic imbalance. Here, we report a case of anti-NMDAR encephalitis with initial symptoms of epilepsia partialis continua in the absence of tumor. Briefly, a 3-year-old girl was admitted to the hospital due to right-sided, complex partial seizures without preceding febrile illness. The seizures evolved into epilepsia partialis continua and were accompanied by epileptiform discharges from the left frontal area. Three weeks after admission, the patient's seizures were reduced with antiepileptic drugs; however, she developed sleep disturbances, cognitive decline, noticeable oro-lingual-facial dyskinesia, and choreoathetoid movements. Anti-NMDAR encephalitis was confirmed by positive detection of NMDAR antibodies in the patient's serum and cerebrospinal fluid, and her condition slowly improved with immunoglobulin, methylprednisolone, and rituximab. At present, the patient is no longer taking multiple antiepileptic or antihypertensive drugs. Moreover, the patient showed gradual improvement of motor and cognitive function. This case serves as an example that a diagnosis of anti-NMDAR encephalitis should be considered when children with uncontrolled seizures develop dyskinesias without evidence of malignant tumor. In these cases, aggressive immunotherapies are needed to improve the outcome of anti-NMDAR encephalitis.