• BMB Reports
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• v.47 no.3
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• pp.149-157
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• 2014

The recent dramatic improvements in high-resolution mass spectrometry (MS) have revolutionized the speed and scope of proteomic studies. Conventional MS-based proteomics methodologies allow global protein profiling based on expression levels. Although these techniques are promising, there are numerous biological activities yet to be unveiled, such as the dynamic regulation of enzyme activity. Chemical proteomics is an emerging field that extends these types proteomic profiling. In particular, activity-based protein profiling (ABPP) utilizes small-molecule probes to monitor enzyme activity directly in living intact subjects. In this mini-review, we summarize the unique roles of smallmolecule probes in proteomics studies and highlight some recent examples in which this principle has been applied.

• IEIE Transactions on Smart Processing and Computing
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• v.4 no.4
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• pp.251-257
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• 2015

This work presents modelling and simulation of a readout integrated circuit (ROIC) design considering pair-wise serial configuration along with thermal modeling of an uncooled microbolometer array. A fully differential approach is used at the input stage in order to reduce fixed pattern noise due to the process variation and self-heating-related issues. Each pair of microbolometers is pulse-biased such that they both fall under the same self-heating point along the self-heating trend line. A ${\pm}10%$ process variation is considered. The proposed design is simulated with a reference input image consisting of an array of $127{\times}92$ pixels. This configuration uses only one unity gain differential amplifier along with a single 14-bit analog-to-digital converter in order to minimize the dynamic range requirement of the ROIC.

• 전기의세계
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• v.31 no.3
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• pp.204-208
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• 1982

The objective of this paper is to present a digital method for improving the lateral resolution of the B-scan images in the medical applications of ultrasound. The method is based upon a mathematical model of the lateral blurring caused by the finite beam width of the transducers. This model provides a simple method of applying a recursive scheme for image restoration with fast computation time. The point spread function (P.S.F.) can be measured by the reflective signals after scanning the small pins located along the depth of interest. From the measured P.S.F., one can compute the coefficient matrices of the inverse discrete-time dynamic state variable equation of the blurring process. Then, a recursive scheme for deblurring is applied to the recorded B-scan to improve the lateral resolution. One major advantage of the present recursive scheme over the transform method is in its applicability for the space-variant imaging, such as in the case of the rotational movement of transducer.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2004.11a
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• pp.125-128
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• 2004

AFM(Atomic Force Microscope) becomes a versatile tool in the nanoscale measurements and processes. Especially the tapping mode is a very useful mode in AFM operation to measure and process at the nanoscale. Although the tapping mode has a great potential for the novel techniques such as phase imaging, however, it is not clearly known the fundamental mechanics affected by complex tip-sample interactions. This paper shows the various nonlinear dynamic features in tapping mode AFM microcantilevers including hysteretic jumps and period doublings of the microcantilevers. Also it is discussed the complex dynamics of CNT(Carbon Nanotube) probes and the opportunities on the nanoscale nonlinear dynamics.

• Journal of the Optical Society of Korea
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• v.18 no.3
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• pp.230-235
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• 2014

Two-step quadrature phase-shifting digital holography based on the calculated intensity of a reference wave is proposed. In the Mach-Zehnder interferometer (MZI) architecture, the method only records two quadrature-phase holograms, without reference-wave intensity or object-wave intensity measurement, to perform object recoding and reconstruction. When the reference-wave intensity is calculated from the 2D correlation coefficient (CC) method that we presented, the clear reconstruction image can be obtained by some specific algorithm. Its feasibility and validity were verified by a series of experiments with 2D objects and 3D objects. The presented method will be widely used in real-time or dynamic digital holography applications.

• Journal of information and communication convergence engineering
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• v.20 no.3
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• pp.153-159
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• 2022

Plain radiographic analysis is the initial imaging modality for suspected small bowel obstruction. Among the many features that affect the diagnosis of small bowel obstruction (SBO), the presence of gas-filled or fluid-filled small bowel loops is the most salient feature that can be automatized by computer vision algorithms. In this study, we compare three frequently applied pixel-clustering algorithms for extracting gas-filled areas without human intervention. In a comparison involving 40 suspected SBO cases, the Possibilistic C-Means and Fuzzy C-Means algorithms exhibited initialization-sensitivity problems and difficulties coping with low intensity contrast, achieving low 72.5% and 85% success rates in extraction. The Adaptive Resonance Theory 2 algorithm is the most suitable algorithm for gas-filled region detection, achieving a 100% success rate on 40 tested images, largely owing to its dynamic control of the number of clusters.

• The Bulletin of The Korean Astronomical Society
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• v.44 no.2
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• pp.70.2-70.2
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• 2019

Recent observational works have reported spiral wave patterns (SWPs) in sunspots, but there is a lack of samples to derive the physical properties. In this presentation, we suggest the automatic method to detect the SWPs in observational data and present their statistical properties. From our method, we find more than 1000 SWPs observed by the Atmospheric Imaging Assembly onboard in the Solar Dynamic Observatory from 2013 to 2018. From our samples, more than half of the SWPs has the one spiral arm. The predominant oscillation period is 2 to 3 minutes. The rotating direction of the spiral arms does not depend on the latitude and the polarity of the sunspots. Our statistical results support the physical model suggested by Kang et al. (2019) that explain the generation of SWPs as the depth of the wave driving source and azimuthal modes in the straight vertical magnetic flux tube.

• The Bulletin of The Korean Astronomical Society
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• v.46 no.2
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• pp.79.2-79.2
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• 2021

We explore the range of possibilities of temperatures, heated temperature, and Kappa values of a current sheet observation on 2017 September 10. First, we construct a grid model with rapid heating (T_heat) and various Kappa (κ) values. We assume a simple density model and use adiabatic cooling to set the temperature during expansion. Next, we calculate the ion fractions using a time-dependent ionization model with adiabatic cooling and various Kappa values. The calculated ion fractions are used to simulate the DNs of the Atmospheric Imaging Assembly on board the Solar Dynamic Observatory. Then, we explore the possible range of the temperatures and Kappa values, comparing the simulated images with the observations. Finally, we discuss the range of the heated temperature and Kappa values and whether the result of this study suggests continuous heating of the current sheet plasma during the expansion.

• Journal of radiological science and technology
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• v.39 no.2
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• pp.227-236
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• 2016

Dynamic positron emission tomography(dPET) is widely used medical imaging modality that can provide both physiological and functional neuro-image for diagnosing various brain disease. However, dPET images have low spatial-resolution and high noise level during spatio-temporal analysis (three-dimensional spatial information + one-dimensional time information), there by limiting clinical utilization. In order to overcome these issues for the spatio-temporal analysis, a novel computational technique was introduced in this paper. The computational technique based on singular value decomposition classifies multiple independent components. Signal components can be distinguished from the classified independent components. The results show that signal to noise ratio was improved up to 30% compared with the original images. We believe that the proposed computational technique in dPET can be useful tool for various clinical / research applications.

• Korean Journal of Remote Sensing
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• v.31 no.2
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• pp.85-99
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• 2015

TDI CCD sensors are being used for most of the electro-optical camera mounted on the low earth orbit satellite to meet high performance requirements such as SNR and MTF. However, the CMOS sensors which have a lot of implementation advantages over the CCD, are being upgraded to have the TDI function. A few methods for improving the issue of motion blur which is apparent in the CMOS sensor than the CCD sensor, are being introduced. Each pixel can be divided into a few sub-pixels to be read more than once as is the same case with three or four phased CCDs. The fill factor can be reduced intentionally or even a kind of mask can also be implemented at the edge of pixels to reduce the blur. The motion blur can also be reduced in the TDI CMOS sensor by reducing the integration time from the full line scan time. Because the integration time can be controlled easily by the versatile control electronics, one of two performance parameters, MTF and SNR, can be concentrated dynamically depending on the aim of target imaging. MATLAB simulation has been performed and the results are presented in this paper. The goal of the simulation is to compare dynamic MTFs affected by the different methods for reducing the motion blur in the TDI CMOS sensor.