• 대한수의학회지
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• 제15권1호
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• pp.27-38
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• 1975

개에 자연발생(自然發生)한 다음과 같은 종양(腫瘍)을 수집(蒐集)하여, 그 육안적(肉眼的) 및 조직학적(組織學的) 소견(所見)을 검토(檢討)하고, 이에 관(關)한 간단한 고찰(考察)을 가(加)했다. 피부(皮膚) 및 피하직(皮下織)의 종양(腫瘍) : 섬유종(纖維腫), 지방종(脂肪腫), 표피성(表皮性) 낭종(囊腫), 흑색육종(黑色肉腫), 한선종(汗腺腫), 비만세포종(肥滿細胞腫)(2예(例)), 비만세포육종(肥滿細胞肉腫), 피지선암종(皮脂腺癌腫). 비장(脾臟) 및 임파절(淋巴節)의 종양(腫瘍) : 비피막(脾被膜)의 섬유육종(纖維肉腫), 비(脾)의 평활근육종(平滑筋肉腫), 임파절(淋巴節)의 임파육종(淋巴肉腫)(2예(例)). 폐장(肺臟)의 종양(腫瘍) : 기관지성암종(氣管枝性癌腫)(3예(例)), 각각(各各) 선암종형(腺癌腫型), 편평세포암종형(扁平細胞癌腫型) 및 미분화세포(未分化細胞)(원형(圓形))암종형(癌腫型). 소화관(消化管) 및 간장(肝臟)의 종양(腫瘍) : 위(胃)의 섬유종(纖維腫), 간(肝)의 혈관종(血管腫), 담관암종(膽管癌腫), 간세포암종(肝細胞癌腫), 간(肝)에 출현(出現)한 골수성백혈세포세포(骨髓性白血細胞細胞). 복막(腹膜)의 종양(腫瘍) : 섬유육종(纖維肉腫). 비뇨생식계(泌尿生殖系)의 종양(腫瘍) : 자궁(子宮)의 섬유종(纖維腫), 난소(卵巢)의 난포낭종(卵胞囊腫), 질(膣)의 전염성(傳染性) 성기종(性器腫)(6예(例)), 신암종(腎癌腫), 섭호선종(攝護腺腫)(2예(例)), 포피(包皮)의 섬유종(纖維腫), 고환(睾丸)의 정충종(精蟲腫). 유선(乳腺)의 종양(腫瘍) : 혼합종(混合腫)(2예(例)), 근상피종(筋上皮腫). 신경계(神經系)의 종양(腫瘍) : 대퇴부(大腿部)의 신경섬유육종(神經纖維肉腫).

• 항공우주시스템공학회지
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• 제14권1호
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• pp.68-73
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• 2020

본 논문은 산악 지형, 도심, 함정, 교량 등에서 수직 이·착륙 비행, 제자리 비행, 고정익기처럼 저속 및 고속비행을 할 수 있는 덕티드 추진체를 사용한 수직 이·착륙 초소형 무인 항공기 개발 동향을 기술한다. 이 항공기는 여러 측면에서 헬리콥터와 고정익기와는 비행 특성이 다르다. 미육군 미래 전투 체계와 DARPA의 OAV 프로그램의 목적은 운용자에 안전하고 낮은 음향 특성을 갖는 수직 이·착륙 덕티드 팬 초소형 무인 항공기 개발이다. 현재의 초소형 무인 항공기에 영상/적외선 카메라를 탑재하고 숲이나 언덕 뒤에 숨어 있는 적을 정지비행과 응시로 약 1 시간 동안 감시 및 정찰을 한다. OAV의 Class-I은 개인 병사가 배낭에 담아 운반할 수 있는 크기와 무게의 수직 이·착륙 덕티드 MAV 개발이다. Class-II는 Class-I보다 두 배의 운용 시간과 더 넓은 범위의 비행이 가능한 유기체의 수직 이·착륙 덕티드 팬 초소형 무인 항공기 개발이다. 초소형 무인기는 장시간 운용을 위해 현재의 '호버 및 응시'에서 '퍼치-앤-응시'으로 기술을 발전시켜야 한다. 근 미래의 OAV 개념은 유·무인 지상 차량이 주행하는 동안에 차량의 상부에 자동 이착륙하고, 탑재된 상태로 이동하고, 재급유, 재충전, 재이륙하는 합동 운용으로 임무 능력과 효율성을 확장하는 것이다. 덕티드 MAV는 지상 차량의 착륙 패드에서 자동으로 이착륙하기 위해 저렴한 초소형 GPS를 활용한 고정밀 상대 위치 기술 개발이 필요하다. 또한, VTOL 덕티드 MAV와 유·무인 지상 차량 간에 유기체의 협업 동작이 가능케하는 공통 명령과 제어 아키텍처를 개발할 필요가 있다.

• 한국자동차공학회논문집
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• 제22권2호
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• pp.91-99
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• 2014

The common-rail injectors are the most critical component of the CRDI diesel engines that dominantly affect engine performances through high pressure injection with exact control. Thus, from now on the advanced combustion technologies for common-rail diesel injection engine require high performance fuel injectors. Accordingly, the previous studies on the numerical and experimental analysis of the diesel injector have focused on a optimum geometry to induce proper injection rate. In this study, computational predictions of performance of the diesel injector have been performed to evaluate internal flow characteristics for various needle lift and the spray pattern at the nozzle exit. To our knowledge, three-dimensional computational fluid dynamics (CFD) model of the internal flow passage of an entire injector duct including injection and return routes has never been studied. In this study, major design parameters concerning internal routes in the injector are optimized by using a CFD analysis and Response Surface Method (RSM). The computational prediction of the internal flow characteristics of the common-rail diesel injector was carried out by using STAR-CCM+7.06 code. In this work, computations were carried out under the assumption that the internal flow passage is a steady-state condition at the maximum needle lift. The design parameters are optimized by using the L16 orthogonal array and polynomial regression, local-approximation characteristics of RSM. Meanwhile, the optimum values are confirmed to be valid in 95% confidence and 5% significance level through analysis of variance (ANOVA). In addition, optimal design and prototype design were confirmed by calculating the injection quantities, resulting in the improvement of the injection performance by more than 54%.

• 한국임상약학회지
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• 제8권2호
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• pp.122-132
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• 1998

SB-31 which contains Pursatilla, Licoris and Ginseng extracts was recently proved as an anticancer agent. In a preclinical effort to be applied this drug to human, pharmacokinetics of SB-31 was carried out in rats and rabbits. Glycyrrhizin(GZ), a saponin of Licoris was used as a standard ingradient for the pharmacokinetics of SB-31. The rat's blood, bile and urine samples were serially collected in femoral vein, common bile duct and bladder, respectively, after bolus i.v. injection at a dose of 1 or 1/5 ampul/rat and rabbit's blood samples from the marginal ear vein at a dose of 1 or 3 amp./rabbit. GZ and glycyrrhetic acid(GA), a major metabolite of GZ in the physiological samples were analysed by HPLC with UV detection. The decline of GZ in plasma concentration was generally biexponential at each dose. GZ was almost completely recovered in bile within 18 hour. GA wasn't detected in the samples with UV detector. In the rat, Vss and Kel at a dose of 1 and 1/5 ampul of SB-31 were $98.06\pm6.07\;ml,\;0.33\pm0.05\;hr^{-1}\;and\;65.46\pm11.19\;ml,\;0.68\pm0.25\;hr^{-1}$, respectively. Those in rabbits at a dose of 3 and 1 ampul of SB-31 were $235.24\pm30.72\;ml,\;0.13\pm0.36\;hr^{-1}\;and\;341.32\pm28.58\;ml,\;0.27\pm0.04\;hr^{-1}$, respectively. 'WinNonlin' was utilized for the compartmental analysis. A two-compartment model was chosen as the most appropriate pbarmaco-kinetic model. The data were best described by using a weighting factor of $1/y^2$. To evaluate the effect of SB-31 on cardiovascular system, serially diluted SB-31 was directly injected into coronary artery in the isolated perfused rat heart and the effect of PSF, PSH, saponins of Pursatilla, and SB-31 on PT, APTT of healthy human plasma was examined. Except the positive inotropic effect of ten times diluted solution of SB-31, there was no significant effect on LVDP, (- dp/dt)/(+dp/dt), heart rate and coronary flow in comparision with that of vehicle. SB-31 had no effect on PT but slightly delayed APTT about $6.9{\sim}11.5\%$. There was no significant effect of PSF and PSH on PT & APTT. Conclusively, SB-31 did not show any notable toxic effects on cardiovascular system.

• 한국터널지하공간학회 논문집
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• 제19권6호
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• pp.845-856
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• 2017

초장대 철도터널에서는 화재 시 안전성 확보를 위해서 구난역을 설치하도록 하고 있으나, 구난역에서 제연방식 및 제연풍량에 대한 기준이나 연구결과는 없는 실정으로 제연방식과 적정풍량에 대한 연구가 필요한 실정이다. 이에 본 연구에서는 서비스터널이나 상대터널과 연결하는 피난연결통로가 일정간격(40 m 간격)으로 설치된 구난역을 모델링하고 화재강도(15, 30 MW), 제연방식(급기만하는 경우, 강제급배기를 하는 경우, 강제배기만을 하는 경우), 제연풍량(7, 14, $40m^3/s$)을 변화시켜 화재해석을 수행하였다. 화재해석결과로 부터 구난역 승강장의 온도 및 CO농도를 분석하고 한계온도 기준 ASET을 비교 분석하였다. 그 결과, 화재강도가 15 MW일 때에는 제연풍량이 $7m^3/s$ 이상인 경우에 강제급배기하는 방식과 강제배연을 하는 방식을 적용하면 충분히 안전한 대피환경을 확보할 수가 있는 것으로 나타났다. 또한 화재강도가 30 MW인 경우에는 배연풍량이 $14m^3/s$ 이하에서는 900초 이상 대피환경을 유지하는 것이 불가능하며, 풍량이 $40m^3/s$일 때에는 상부덕트의 측면부에서 배기하는 경우(SA + EA2, SA + EA4)가 온도측면에서 안전성 확보에 가장 유리한 것으로 나타나고 있다.

• 대한기계학회논문집B
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• 제38권11호
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• pp.915-924
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• 2014

항공기용 가스터빈 엔진에 있어서, 기어 어셈블리 및 전자장비에 사용되는 오일의 냉각을 위하여 열교환기가 사용되며 이를 Surface air-oil heat exchanger (SAOHE) 라고 한다. 이 열교환기는 엔진 팬 케이싱 내부에 설치되며 기어박스 시스템 및 전자장비로부터 바이패스 덕트 후류 쪽으로 열을 소산시킨다. 본 연구의 목적은 SAOHE 의 설계를 위한 효율적인 수치해석방법을 개발하는 것이다. SAOHE 설치에 따른 핀에서의 열공력학적 성능을 평가하기 위하여 다공성 모델을 활용한 2 차원 수치해석을 수행하였고, 열교환기 성능평가에 대해 시간 및 비용적으로 효과적인 1 차원 열유동 네트워크 프로그램을 개발하였다. 이 프로그램을 이용하여 열교환기의 압력강하 및 열전달 성능을 예측하였고, 1 차원 열유동 네트워크 프로그램을 검증하기 위해 2 차원 전산해석 결과 및 실험 결과와 비교하였다.

• Journal of Veterinary Science
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• 제23권6호
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• pp.88.01-88.14
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• 2022

Background: The olfactory mucosa (OM) is crucial for odorant perception in the main olfactory system. The terminal carbohydrates of glycoconjugates influence chemoreception in the olfactory epithelium (OE). Objectives: The histological characteristics and glycoconjugate composition of the OM of Korean native cattle (Hanwoo, Bos taurus coreae) were examined to characterize their morphology and possible functions during postnatal development. Methods: The OM of neonate and adult Korean native cattle was evaluated using histological, immunohistochemical, and lectin histochemical methods. Results: Histologically, the OM in both neonates and adults consists of the olfactory epithelium and the lamina propria. Additionally, using periodic acid Schiff and Alcian blue (pH 2.5), the mucus specificity of the Bowman's gland duct and acini in the lamina propria was determined. Immunohistochemistry demonstrated that mature and immature olfactory sensory neurons of OEs express the olfactory marker protein and growth associated protein-43, respectively. Lectin histochemistry indicated that numerous glycoconjugates, including as N-acetylglucosamine, mannose, galactose, N-acetylgalactosamine, complex type N-glycan, and fucose groups, were expressed at varied levels in the different cell types in the OMs of neonates and adults at varying levels. According to our observations, the cattle possessed a well-developed olfactory system, and the expression patterns of glycoconjugates in neonatal and adult OMs varied considerably. Conclusions: This is the first study to describe the morphological assessment of the OM of Korean native cattle with a focus on lectin histochemistry. The findings suggest that glycoconjugates may play a role in olfactory chemoreception, and that their labeling properties may be closely related to OM development and maturity.

• 항공우주시스템공학회지
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• 제16권3호
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• pp.23-34
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• 2022

UAM (Urban Air Mobility) 항공기에 대한 수요가 세계 각 도시들은 인구집중으로 인한 교통체증 문제로 늘어나고 있다. 세계 각국에서 고정익 날개의 유무와 추진 시스템에 따라 다양한 형태를 가진 항공기가 연구개발을 통해 상용화 준비 중이며, 도심을 비행하고 사람이 탑승하는 유인운송수단이므로 감항증명이 요구된다. UAM 항공기는 복합재 사용 비중 증가, 전기모터 사용, 다양한 전자 장비 탑재 등 낙뢰 및 HIRF 환경에 취약하다. 현재 UAM 항공기에 대한 낙뢰 및 HIRF 환경에서의 인증기술과 지침 및 요건 개발은 미비한 상태이다. 본 연구에서는 미연방항공청(FAA)에서 발행한 AC 20-136B와 AC 20-158A에 나타난 회전익 항공기의 낙뢰 및 HIRF 간접 영향에 대한 적합성 인증 절차를 확인하고 UAM 항공기 전자기 전산 시뮬레이션에 적용하였다. 덕티드 팬 형 UAM 항공기에 대한 낙뢰 및 HIRF 영향성을 전산 시뮬레이션을 통해 분석하였고, 향후 운용될 UAM 항공기의 인증을 위한 실무지침 수립의 근거를 제시하였다.

• 통합자연과학논문집
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• 제16권1호
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• pp.13-31
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• 2023

The sesarmid crab Muradium tetragonum, inhabiting the mangrove, are considered as a key consumer of litter and thereby play an important role in the detritus food chain and energy flow in the mangrove ecosystem. The present investigation was carried out with objectives to enlighten the reproductive system of Muradium tetragonum through histological and histochemical studies. Histological organization of the testis of M. tetragonum revealed that each testis has a lobular structure consisting of several testicular lobules arranged around the collecting duct. Histology of the deferens of M. tetragonum revealed it to be composed of three-layer of tissues along the entire length:the outer connective tissue, the middle muscular and the inner epithelial layer. Based on the histological architecture these three regions are recognized as proximal vas deferens (PVD), middle vas deferens (MVD) and distal vas deferens (DVD). Histological characteristics of the ovary of M. tetragonum during different phases of ovarian development were studied. Based on the colour changes of the ovary and diameter of the oocytes five stages of ovarian development can be pronounced. Histochemical analysis of the male reproductive tissues of M. tetragonum signifies the secretion of a different biomolecule by specifying their origin in the reproductive tissue and their possible transformation into spermatophores. In the female reproductive tissues, histochemical evaluation envisaged the secretory products during different stages of ovarian development The secretory substances of the spermatheca expound on the significance of its secretion in dehiscing the spermatophore wall and in nourishing as well as protecting the spermatozoa.

• 설비공학논문집
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• 제14권12호
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• pp.1102-1139
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• 2002

A review on the papers published in the Korean Journal of Air-Conditioning and Refrigerating Engineering in 2000 and 2001 has been done. Focus has been put on current status of research in the aspect of heating, cooling, ventilation, sanitation and building environment. The conclusions are as follows. (1) Most of fundamental studies on fluid flow were related with heat transportation of facilities. Drop formation and rivulet flow on solid surfaces were interesting topics related with condensation augmentation. Research on micro environment considering flow, heat, humidity was also interesting for comfortable living environment. It can be extended considering biological aspects. Development of fans and blowers of high performance and low noise were continuing topics. Well developed CFD technologies were widely applied for developing facilities and their systems. (2) Most of papers related with heat transfer analysis and heat exchanger shows dealt with convection, evaporation, and channel flow for the design application of heat exchanger. The numerical heat transfer simulation studies have been peformed and reported to show heat transfer characteristics. Experimental as well as numerical studies on heat exchanger were reported, while not many papers are available for the system analysis including heat exchanger. (3) A review of the recent studies on heat pump system shows that performance analysis and control of heat pump have been peformed by various simulations and experiments. The research papers on multi-type heat pump system increased significantly. The studies on heat pipe have been examined experimently for change of working characteristics and strut lure. Research on the phase change has been carried out steadily and operation strategies of encapsulated ice storage tank are reported experimentally in several papers. (4) A review of recent studies on refrigeration/air conditioning system have focused on the system performance and efficiency for new alternative refrigerants. Evaporation and condensation heat transfer characteristics are investigated for tube shapes and new alternative refrigerants. Studies on components of refrigeration/air conditioning system are carried to examine efficiency for various compressors and performance of new expansion devices. In addition to thermophysical properties of refrigerant mixtures, studies on new refrigerants are also carried out, however research works on two-phase flow seemed to be insufficient. (5) A review of the recent studies on absorption cooling system indicates that heat and mass transfer phenomena have been investigated to improve absorber performance. Various experimental data have been presented and several simulation models have been proposed. A review of the recent studies on duct and ventilation shows that ventilation indices have been proposed to quantify the ventilation performance in buildings and tunnels. Main efforts have been focused on the applications of ventilation effectiveness in practice, either numerically using computational fluid dynamics or experimentally using tracer gas techniques. (6) Based on a review of recent studies on indoor thermal environment and building service systems, research issues have mainly focused on many innovative ideas such as underfloor air-conditioning system, personal environmental modules, radiant floor cooling and etc. Also, the new approaches for minimizing energy consumption as well as improving indoor environmental conditions through predictive control of HVAC systems, various activities of building energy management and cost-benefit analysis for economic evaluation were highlighted.