• Tuberculosis and Respiratory Diseases
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• v.47 no.5
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• pp.704-708
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• 1999

Hemangioma is benign tumor that represent an fail in development of the vascular system, network or retiform stage. As with hemangioma elsewhere, spontaneous regression may occur. Histologically capillary hemangioma has a diagnostic lobular arrangement of capillaries and almost all of them are located in nasal or oral mucous membranes. But, as we know, there is no report of hemangioma located in the trachea in Korea, so we report a case of tracheal hemangioma which was manifested massive hemoptysis.

• Tuberculosis and Respiratory Diseases
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• v.57 no.6
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• pp.579-583
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• 2004

Actinomycosis is an indolent infectious disease characterized by pyogenic response and necrosis, followed by intense fibrosis. The main forms of human actinomycosis are cervicofacial, pulmonary, and abdominopelvic type. Pulmonary actinomycosis accounts for 15% to 20% of total cases and unfortunately, clinical manifestations and radiologic findings are nonspecific. Small pleural effusion or empyema may develop in advanced disease but massive empyema is infrequent and rarely reported. We report a case of huge empyema caused by pulmonary actinomycosis in a 55 year-old man, presented with one-month history of productive cough and fever. The CT scan revealed a huge cavity with air-fluid level occupying the left hemithorax. Empyema caused by actinomycosis was confirmed microscopically by demonstration of sulfur granules in empyema sac through thracotomy. Decortication and surgical resection of empyema sac and destructed lung was accomplished and followed by intravenous infusion of penicillin G.

• Childhood Kidney Diseases
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• v.24 no.2
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• pp.91-97
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• 2020

Purpose: Alport syndrome (AS) is one of the most common inherited renal diseases caused due to mutations of genes encoding specific proteins of the type IV collagen family, and its major clinical manifestations include progressive renal failure, sensorineural deafness, and ocular abnormalities. We investigated the clinical characteristics and long-term prognosis of AS in Korean pediatric and adult populations. Methods: We conducted a retrospective review of medical records of 33 children and adults who had been diagnosed or treated with AS from 1985 to 2019. Results: The mean age of the 33 patients diagnosed with AS was 16.2±13.6 years, and the male-to-female ratio was 2:1. At the first visit, recurrent gross hematuria was the most common initial symptom. In 10 of 33 patients (30.3%), sensorineural hearing loss (SNHL) was diagnosed, but none had ophthalmic problems. Moreover, 11 of 33 patients (33.3%) had advanced to end-stage renal disease (ESRD), and a significant difference was observed in the age of the patients who progressed to ESRD based on the presence or absence of SNHL (P=0.035). Conclusion: SNHL in AS can be an important prognostic factor for long-term deterioration of renal function. Further investigation is required to confirm the clinical course and the genetic characteristics of AS in Korea through prospective national cohort studies.

• Journal of Fisheries and Marine Sciences Education
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• v.25 no.6
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• pp.1315-1323
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• 2013

The purpose of this research is to evaluate the effects of a commercial mixed extruded pellet(EP) and raw fish moist pellet(MP) diet on diseases prevalence and serological constituents and HSI of korean rockfish, Sebastes schlegeli grown in two commercial-scale aquaculture farms from June to December in 2009. The growth of MP-fed rockfish was slightly faster than EP-fed rockfish during experimental period, but did not show significant differences. The levels of TCHO, TG, Glucose and TP in the MP-fed rockfish group were higher than those of EP-fed group, whereas there was no significant difference in other biochemical factors of blood between two groups. In addition, bacteria and virus were not detected in both MP- and EP-fed rockfish groups, and the infection rates of gill fluke between two groups did not show clear difference. In conclusion, there was no comparable difference in growth and the health extents of one year rockfish by administration of the commercial mixed extruded pellet(EP) and raw fish moist pellet(MP) diets.

• Korean Journal of Clinical Pharmacy
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• v.30 no.2
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• pp.87-91
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• 2020

Background: Levothyroxine is an essential drug for the treatment of hypothyroidism or related diseases. Several studies have reported an association between the effects of levothyroxine treatment and time of administration, which can be inconsistent. Objective: This study was conducted to compare the levels of thyroid-stimulating hormone or free thyroxine between morning and nighttime dosing of levothyroxine. Methods: We reviewed previously reported relevant articles and conducted a meta-analysis. Results: In total, five studies were included in this meta-analysis. Results showed that thyroid-stimulating hormone (standard difference in means [SE]=0.321; 95% confidence interval [CI], -0.016 to 0.657) and free thyroxine (SE= -1.367; 95% CI, -2.943 to 0.210) levels did not differ significantly between morning (before breakfast) and nighttime (before bedtime) administration. Conclusion: This is the first meta-analysis to evaluate the effects of time of administration on levothyroxine levels in patients with hypothyroidism. Based on our results, we suggest considering patients' lifestyles or daily routines when counselling them on the optimal time of administration for levothyroxine.

• Biomedical Science Letters
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• v.26 no.3
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• pp.192-200
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• 2020

Natural products have received revived interest via traditional remedies or alternative medicine used for the treatment of various diseases. Zanthoxylum piperitum (ZP) has been utilized in traditional medicine for various medicinal purposes. The present study was conducted to evaluate whether ZP modulates allergic inflammation both in vivo and in vitro. We examined the pharmacological effects of ZP on 2, 4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) symptoms in mice. Additionally, in order to clarify the anti-inflammatory mechanisms of ZP, we elucidate the effect of ZP on the expression levels of inflammatory cytokines and nuclear factor-κB (NF-κB) in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells (HMC-1). The results demonstrated that ZP attenuated AD clinical symptoms such as erythema, edema and dryness as well as histamine and IgE serum levels in DNCB-induced AD model mice. Additionally, ZP suppressed the expression of inflammatory cytokines and activation of NF-κB in AD-like skin lesions and stimulated HMC-1. These results provide experimental evidence that ZP may be useful candidate for treating allergic inflammation including AD.

• The Plant Pathology Journal
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• v.34 no.5
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• pp.445-450
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• 2018

Bacteriophages, bacteria-infecting viruses, have been recently reconsidered as a biological control tool for preventing bacterial pathogens. Erwinia amylovora and E. pyrifoliae cause fire blight and black shoot blight disease in apple and pear, respectively. In this study, the bacteriophage phiEaP-8 was isolated from apple orchard soil and could efficiently and specifically kill both E. amylovora and E. pyrifoliae. This bacteriophage belongs to the Podoviridae family. Whole genome analysis revealed that phiEaP-8 carries a 75,929 bp genomic DNA with 78 coding sequences and 5 tRNA genes. Genome comparison showed that phiEaP-8 has only 85% identity to known bacteriophages at the DNA level. PhiEaP-8 retained lytic activity up to $50^{\circ}C$, within a pH range from 5 to 10, and under 365 nm UV light. Based on these characteristics, the bacteriophage phiEaP-8 is novel and carries potential to control both E. amylovora and E. pyrifoliae in apple and pear.

• Korean Journal of Plant Resources
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• v.28 no.6
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• pp.710-717
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• 2015

Humankind has been searching for medicinal materials from various plant sources in an attempt to treat disease. Mistletoe is one indubitable plant source for these materials due to its effectiveness in treating various diseases, but it has almost disappeared from the mountainous areas of Korea due to excessive harvesting. In this study, in order to select host tree species for Korean mistletoe [Viscum album var. coloratum (Kom.) Ohwi] by seed inoculation and to clarify the effect of host specificity among various tree species were conducted for the purpose of gaining basic information for the artificial cultivation of Korean mistletoe. Almost all the seeds of Korean mistletoe germinated in vitro at the temperature of 15℃. Among host trees used in this study, Prunus mume showed the highest parasitic affinity with inoculated Korean mistletoe, compared with any other host plants. However, treatment of hormones could not increase the low survival rate of Korean mistletoe on the host trees.

• Journal of Biomedical Engineering Research
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• v.27 no.1
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• pp.14-21
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• 2006

As information technologies are developing, the improvement of the quality of life becomes worldwide issues. Especially, to improve the quality of life of a patient suffering intermittent diseases, in addition to the some portable equipments for measuring, analyzing, and notifying the status of the patients, methods of communication for seamless transmission of the measured data over to the remote site, such as an emergency center or a hospital, are required. In this paper, we address a seamless transmission of patient monitoring data such as ECG from a moving patient to a remote site, wherever the patient may be. We divide the whole environments into two wireless communication environments: an indoor one based on WLAN and an outdoor one based on CDMA cellular network in which the patient is assumed to move anywhere. We develop algorithms, implement them on a PDA-based hardware platform, and show some of the results for handover between the two environments in addition to the data transmission for each of the two environments.

• Proceedings of the PSK Conference
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• 2003.10a
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• pp.72-72
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• 2003

Welders working in a the confined space, like in the shipbuilding industry, are have at risk of being exposed toing a high concentrations of welding fumes and of developing pneumoconiosis or other welding- fume exposure related diseases. Among such diseasesthem, manganism resulting fromcaused by welding- fume exposure remains ais still controversial issue, as the movement ofnd no clear demonstration of manganese movement into the specific brain regions has not been clearly established. (omitted)