• Journal of muscle and joint health
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• v.5 no.1
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• pp.83-109
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• 1998

This study was carried out to identify the Important modifiable risk factors for reduced bone mass and to construct prediction model which can classify women with either low or high bone mass. Through the literature review, individual characteristics such as age, body weight, height, education level, family history, age of menarche, postmenopausal period, gravity, parity, menopausal status, and breast feeding period were identified and factors of life style such as past milk consumption, past physical activity, present daily activity, present calcium intake, alcohol intake, cigarette smoking, coffee consumption were identified as influencing factors of reduced bone mass in women. Four hundred and eighty women aged between 28 and 76 who had given measurement bone mineral density by dual energy x-ray absortiometry in lumbar vertebrae and femur from July to October, 1997 at 4 general hospitals in Seoul and Pusan were selected for this study. Women were excluded if they had a history of any chronic illness such as rheumatoid arthritis, diabetes mellitus, hyperthroidism, & gastrointestinal disorder and any medication such as calcium supplements, calcitonin, estrogen, thyroxine, antacids, & corticosteroids known affect bone. As a result of these exclusion criteria, four hundred and seventeen women were used for analysis. Multiple logistic regression model was developed for estimating the likelihood of the presence or absence of reduced bone mass. A SAS procedure was used to estimate risk factor coefficient. The results are as follows For lumbar spine, the variables significant were age, body weight, menopause status, daily activity, past milk consumption, and past physical activity(p<0.01), while for femoral Ward's triangle, age, body weight, level of education, past milk consumption, past physical activity(p<0.001). Past physical activity, present daily activity and past milk consumption are the most powerful modifiable predictors in vertebrae and femur among the predictors. When the model performance was evaluated by comparing the observed outcome with predicted outcome, the model correctly identified 74.1% of persons with reduced bone mass and 84.5% of persons with normal bone mass in the lumbar vertebrae and 82.9% of persons with reduced bone mass and 75.0% of persons with normal bone mass in the femoral Ward's triangle. On the basis of these results, a number of recommendations for the management of reduced bone mass may be made : First, those woman who are classified as high risk group of the reduced bone mass in the prediction model should examine the bone mineral density to further examine the usefulness of this model. Second, the optimal amount of milk consumption and a regular weight bearing exercise in childhood, adolescence, and early adult should be ensured.

• Atmosphere
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• v.17 no.1
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• pp.69-86
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• 2007

The characteristics of the dual-Doppler wind retrieval method based on a three dimensional variational (3DVAR) conception were investigated from the following four points of view; the sensitivity of the number of iteration, the effect of the weak constraint term, the effect of the smoothness term, and the sensitivity of the error mixing ratio of the radial velocities. In the experiment, the radial velocities relative to the Gosan and Jindo radar sites of the Korea Meteorological Administration (KMA) were calculated from the forecasting of the WRF (Weather Research and Forecast; Skamarock, 2004) model at 1330 UTC 30 June 2006, which is the one and half hour forecast from the initial time, 1200 UTC on that day. The results showed that the retrieval performance of the horizontal wind field was robust, but that of the vertical wind was sensitive to the external conditions, such as iteration number and the on/off of the weak constraint term. The sensitivity of error mixing ratio was so large that even the horizontal wind retrieval efficiency was reduced a lot. But the sensitivity of the smooth term was not so large. When we applied this method to the real mesoscale convective system (MCS) between the Gosan and Jindo radar pair at 1430 UTC 30 June 2006, the wind structure of the convective cells in the MCS was consistently retrieved relative to the reflectivity factor structure. By comparing the vertical wind structure of this case with that of 10 minutes after, 1440 UTC 30 June 2006, we got the physical consistency of our method.

• Smart Structures and Systems
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• v.24 no.1
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• pp.53-65
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• 2019

Misaligned wind-wave and seismic loading render offshore wind turbines suffering from excessive bi-directional vibration. However, most of existing research in this field focused on unidirectional vibration mitigation, which is insufficient for research and real application. Based on the authors' previous work (Sun and Jahangiri 2018), the present study uses a three dimensional pendulum tuned mass damper (3d-PTMD) to mitigate the nacelle structural response in the fore-aft and side-side directions under wind, wave and near-fault ground motions. An analytical model of the offshore wind turbine coupled with the 3d-PTMD is established wherein the interaction between the blades and the tower is modelled. Aerodynamic loading is computed using the Blade Element Momentum (BEM) method where the Prandtl's tip loss factor and the Glauert correction are considered. Wave loading is computed using Morison equation in collaboration with the strip theory. Performance of the 3d-PTMD is examined on a National Renewable Energy Lab (NREL) monopile 5 MW baseline wind turbine under misaligned wind-wave and near-fault ground motions. The robustness of the mitigation performance of the 3d-PTMD under system variations is studied. Dual linear TMDs are used for comparison. Research results show that the 3d-PTMD responds more rapidly and provides better mitigation of the bi-directional response caused by misaligned wind, wave and near-fault ground motions. Under system variations, the 3d-PTMD is found to be more robust than the dual linear TMDs to overcome the detuning effect. Moreover, the 3d-PTMD with a mass ratio of 2% can mitigate the short-term fatigue damage of the offshore wind turbine tower by up to 90%.

• Korean Circulation Journal
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• v.54 no.5
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• pp.233-252
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• 2024

Background and Objectives: Myocardial ischemia-reperfusion injury (MIRI) refers to the damage of cardiac function caused by restoration of blood flow perfusion in ischemic myocardium. However, long non-coding RNA prostate androgen regulated transcript 1 (PART1)'s role in MIRI remain unclear. Methods: Immunofluorescence detected LC3 expression. Intermolecular relationships were verified by dual luciferase reporter assay. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide, flow cytometry and transferase-mediated dUTP nick-end labeling (TUNEL) assays analyzed cell viability and apoptosis. The release of lactate dehydrogenase was tested via enzyme-linked immunosorbent assay (ELISA). Left anterior descending coronary artery surgery induced a MIRI mouse model. Infarct area was detected by 2,3,5-triphenyltetrazolium chloride staining. Hematoxylin and eosin staining examined myocardial injury. ELISA evaluated myocardial marker (creatine kinase MB) level. Results: PART1 was decreased in hypoxia/reoxygenation (H/R) induced AC16 cells and MIRI mice. PART1 upregulation attenuated the increased levels of Bax, beclin-1 and the ratio of LC3II/I, and enhanced the decrease of Bcl-2 and p62 expression in H/R-treated cells. PART1 upregulation alleviated H/R-triggered autophagy and apoptosis via miR-302a-3p. Mechanically, PART1 targeted miR-302a-3p to upregulate transcription factor activating enhancer-binding protein 2C (TFAP2C). TFAP2C silencing reversed the protected effects of miR-302a-3p inhibitor on H/R treated AC16 cells. We further established TFAP2C combined to dual-specificity phosphatase 5 (DUSP5) promoter and activated DUSP5. TFAP2C upregulation suppressed H/R-stimulated autophagy and apoptosis through upregulating DUSP5. Overexpressed PART1 reduced myocardial infarction area and attenuated MIRI in mice. Conclusion: PART1 improved the autophagy and apoptosis in H/R-exposed AC16 cells through miR-302a-3p/TFAP2C/DUSP5 axis, which might provide novel targets for MIRI treatment.

• 한국사회복지학회:학술대회논문집
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• 2004.04a
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• pp.261-297
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• 2004

Social welfare facilities where provide the socially disadvantaged with proper social services, face financial difficulties. This is because not only of the lack of governmental support, but also of social welfare facilities' lack of skills in developing abundant resources from the private sector. In this context, this study tried to find factors affecting resource mobilization of the social welfare facilities to devise policies in resource development. Mail survey was conducted with the structured questionnaire. Employees in charge of community resource development were asked to answer the questionnaire. The study population were two types of welfare facilities: community welfare centers and residential care facilities. A total of 293 community welfare centers and 632 residential care facilities responded to the survey. The response rate was about 62%. The dependent variable of the study was the amount of resource mobilization in the year 2001 which was measured as the number of donors, the total amount of donation, and estimated amount of gift-in-kind. Three types models were constructed per each welfare facility. Independent variables were selected based on the previous research findings: community environment factor, structural factor, and resource development factor. Multiple regression was utilized to analyze the data. The resource development factor turned out to be significant variable in various models. In the models of donors, the amount of donation, and the amount of gift-in-kind, at least one out of four variables in the resource development factor was significant. Welfare centers which establish the resource development department or hire employees to take care of resource development, and adopt computer software in managing donors, receive more donations than their counterparts. Interestingly, the centers where employees take the responsibility of resource development as well as other responsibilities (dual duty), did not have more resources mobilized than those with no employees for resource development. Using computer software in managing donors turned out to be a significant variable in many models, except for the donor model. In addition, residential care facilities located in urban area have more donors and donations, and among residential facilities those for the elderly, children, and the mentally retarded and those hiring more employees, receive more donations than those for the disabled and those hiring less employees. As for the gift-in-kind model, the centers located in high income area and residential facilities for the elderly, women and mentally retarded receive less gift-in-kind than those for the disabled. Based on the above findings, this study suggested that to mobilize resources the welfare centers as well residential care facilities need to have community resource development department or resource development staffs, and adopt computer software to systematically organize donors.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.5
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• pp.2233-2252
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• 2018

For the problem of cross-layer joint resource allocation (JRA) in the Long-Term Evolution (LTE)-Advanced standard using carrier aggregation (CA) technology, it is difficult to obtain the optimal resource allocation scheme. This paper proposes a joint resource allocation algorithm based on the weights of user's average quality of experience (JRA-WQOE). In contrast to prevalent algorithms, the proposed method can satisfy the carrier aggregation abilities of different users and consider user fairness. An optimization model is established by considering the user quality of experience (QoE) with the aim of maximizing the total user rate. In this model, user QoE is quantified by the mean opinion score (MOS) model, where the average MOS value of users is defined as the weight factor of the optimization model. The JRA-WQOE algorithm consists of the iteration of two algorithms, a component carrier (CC) and resource block (RB) allocation algorithm called DABC-CCRBA and a subgradient power allocation algorithm called SPA. The former is used to dynamically allocate CC and RB for users with different carrier aggregation capacities, and the latter, which is based on the Lagrangian dual method, is used to optimize the power allocation process. Simulation results showed that the proposed JRA-WQOE algorithm has low computational complexity and fast convergence. Compared with existing algorithms, it affords obvious advantages such as improving the average throughput and fairness to users. With varying numbers of users and signal-to-noise ratios (SNRs), the proposed algorithm achieved higher average QoE values than prevalent algorithms.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.62 no.1
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• pp.109-119
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• 2013

This paper presents the design of the Safety Programmable Logic Controller (SPLC) used in the Nuclear Power Plants, an analysis of a reliability for the SPLC using a markov model. The architecture of the SPLC is designed to have the multiple modular redundancy composed of the Dual Modular Redundancy(DMR) and the Triple Modular Redundancy(TMR). The operating system of the SPLC is designed to have the non-preemptive state based scheduler and the supervisory task managing the sequential scheduling, timing of tasks, diagnostic and security. The data communication of the SPLC is designed to have the deterministic state based protocol, and is designed to satisfy the effective transmission capacity of 20Mbps. Using Markov model, the reliability of SPLC is analyzed, and assessed. To have the reasonable reliability such as the mean time to failure (MTTF) more than 10,000 hours, the failure rate of each SPLC module should be less than $2{\times}10^{-5}$/hour. When the fault coverage factor (FCF) is increased by 0.1, the MTTF is improved by about 4 months, thus to enhance the MTTF effectively, it is needed that the diagnostic ability of each SPLC module should be strengthened. Also as the result of comparison the SPLC and the existing safety grade PLCs, the reliability and MTTF of SPLC is up to 1.6-times and up to 22,000 hours better than the existing PLCs.

• Molecules and Cells
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• v.23 no.2
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• pp.246-251
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• 2007

Osteoporosis is a common metabolic bone disease characterized by low bone mineral density (BMD) with an increased risk of fracture. Low bone mass results from an imbalance between bone formation by osteoblasts and bone resorption by osteoclasts. Microphthalmia-associated transcription factor (MITF) plays a critical role in osteoclast development and thus is an important candidate gene affecting bone turnover and BMD. In order to investigate the genetic effects of MITF variations on osteoporosis, we directly sequenced the MITF gene in 24 Koreans, and identified fifteen sequence variants. Two polymorphisms (+227719C > T and +228953A > G) were selected based on their allele frequencies, and then genotyped in a larger number of postmenopausal women (n = 560). Areal BMD ($g/cm^2$) of the anterior-posterior lumbar spine and the non-dominant proximal femur was measured by dual-energy X-ray absorptiometry. We found that the MITF + 227719C > T polymorphism was significantly associated with low BMD of the trochanter (p = 0.005-0.006) and total femur (p = 0.02-0.03) (codominant and dominant models), while there was no association with BMD of the lumbar spine. The MITF+228953A > G polymorphism was also associated with low BMD of the femoral shaft (p = 0.05) in the recessive model. Haplotype analysis showed that haplotype 3 of the MITF gene (MITF-ht3) was associated with low BMD of the trochanter (p = 0.03-0.05) and total femur (p = 0.05) (dominant and codominant models). Our results suggest that MITF variants may play a role in the decreased BMD of the proximal femur in postmenopausal women.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.34 no.1
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• pp.59-70
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• 2008

Purpose: We evaluated the therapeutic effect of AEE788, a dual inhibitor of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) receptor tyrosine kinases on human salivary adenoid cystic carcinoma (ACC) cells growing in nude mice. Experimental Design: We examined the effects of AEE788 on salivary ACC cell growth and apoptosis. To determine the in vivo effects of AEE788, nude mice with orthotopic parotid tumors were randomized to receive oral AEE788 (50 mg/kg) three times per week, injected paclitaxel ($200{\mu}g$) once per week, AEE788 plus paclitaxel, or placebo. Mechanisms of in vivo AEE788 activity were determined by immunohistochemical analysis. Results: Treatment of salivary ACC cells with AEE788 led to growth inhibition and induction of apoptosis. AEE788 inhibited tumor growth and prevented lung metastasis in nude mice. Furthermore, AEE788 potentiated growth inhibition and apoptosis of ACC tumor cells mediated by paclitaxel. Tumors of mice treated with AEE788 and AEE788 plus paclitaxel exhibited down-regulation of activated EGFR and its downstream mediators (Akt and MAPK), increased tumor and endothelial cell apoptosis, and decreased microvessel den-sity, which correlated with a decrease in the level of MMP-9, MMP-2 and bFGF expression and a decrease in the incidence of vascular metastasis. Conclusions: These data show that tumor-associated endothelial cells are important in the process of tumor-metastasis. And VEGFR can be a molecular target for therapy of metastatic lung lesion of salivary ACC.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.15
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• pp.6227-6232
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• 2014

Background: Oral squamous cell carcinoma (OSCC) remains as one of the most difficult malignancies to control because of its high propensity for local invasion and cervical lymph node dissemination. The aim of present study was to evaluate the efficacy of novel pH and temperature sensitive doxorubicin-methotrexate-loaded nanoparticles (DOX-MTX NP) in terms of their potential to change the VEGF-C expression profile in a rat OSCC model. Materials and Methods: 120 male rats were divided into 8 groups of 15 animals administrated with 4-nitroquinoline-1-oxide to induce OSCCs. Newly formulated doxorubicin-methotrexate-loaded nanoparticles (DOX-MTX NP) and free doxorubicin were IV and orally administered. Results: Results indicated that both oral and IV forms of DOX-MTX-nanoparticle complexes caused significant decrease in the mRNA level of VEGF-C compared to untreated cancerous rats (p<0.05). Surprisingly, the VEGF-C mRNA was not affected by free DOX in both IV and oral modalities (p>0.05). Furthermore, in DOX-MTX NP treated group, less tumors characterized with advanced stage and VEGF-C mRNA level paralleled with improved clinical outcome (p<0.05). In addition, compared to untreated healthy rats, the VEGF-C expression was not affected in healthy groups that were treated with IV and oral dosages of nanodrug (p>0.05). Conclusions: VEGF-C is one of the main prognosticators for lymph node metastasis in OSCC. Down-regulation of this lymph-angiogenesis promoting factor is a new feature acquired in group treated with dual action DOX-MTX-NPs. Beside the synergic apoptotic properties of concomitant use of DOX and MTX on OSCC, DOX-MTX NPs possessed anti-angiogenesis properties which was related to the improved clinical outcome in treated rats. Taking together, we conclude that our multifunctional doxorubicin-methotrexate complex exerts specific potent apoptotic and anti-angiogenesis properties that could ameliorate the clinical outcome presumably via down-regulating dissemination factor-VEGF-C expression in a rat OSCC model.