• Journal of the Korean Society of Groundwater Environment
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• v.4 no.2
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• pp.95-102
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• 1997

So far, several fractal models of fluid flow in a fractured aquifer have been developed. In this study, a new fractal model is derived that considers transient flow in the dual-porosity aquifer with the fracture skin between the fissure and the block, and the storage capacity and the wellbore skin on the pumping well. Constant-head upper boundary is specified in the block. This model is a generalized one which comprises both modified Hantush equation (1960) and Boulton-Streltsova equation (1978). Type curves are plotted for different flow dimensions (0.5, 1, 1.5, 2, 2.5 and 3) with various values of the leakage factor and the fracture skin. They show dimensionless drawdown in the pumping well and observation wells located either in the fissure system or in the matrix block.

• The Korean Journal of Physiology and Pharmacology
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• v.22 no.6
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• pp.679-688
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• 2018

Autism spectrum disorders (ASDs) are neurodevelopmental disorders that share behavioral features, the results of numerous studies have suggested that the underlying causes of ASDs are multifactorial. Behavioral and/or neurobiological analyses of ASDs have been performed extensively using a valid model of prenatal exposure to valproic acid (VPA). Abnormal synapse formation resulting from altered neurite outgrowth in neural progenitor cells (NPCs) during embryonic brain development has been observed in both the VPA model and ASD subjects. Although several mechanisms have been suggested, the actual mechanism underlying enhanced neurite outgrowth remains unclear. In this study, we found that VPA enhanced the expression of brain-derived neurotrophic factor (BDNF), particularly mature BDNF (mBDNF), through dual mechanisms. VPA increased the mRNA and protein expression of BDNF by suppressing the nuclear expression of methyl-CpG-binding protein 2 (MeCP2), which is a transcriptional repressor of BDNF. In addition, VPA promoted the expression and activity of the tissue plasminogen activator (tPA), which induces BDNF maturation through proteolytic cleavage. Trichostatin A and sodium butyrate also enhanced tPA activity, but tPA activity was not induced by valpromide, which is a VPA analog that does not induce histone acetylation, indicating that histone acetylation activity was required for tPA regulation. VPA-mediated regulation of BDNF, MeCP2, and tPA was not observed in astrocytes or neurons. Therefore, these results suggested that VPA-induced mBDNF upregulation was associated with the dysregulation of MeCP2 and tPA in developing cortical NPCs.

• Journal of Korean Society for Quality Management
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• v.52 no.3
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• pp.509-527
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• 2024

Purpose: This study aims to investigate the factors influencing the adoption of Generative AI in the workplace, focusing on both enablers and inhibitors. By employing the dual factor theory, this research examines how knowledge support, customization, entertainment, perceived risk, realistic threat, and identity threat impact the intention to adopt Generative AI technologies such as ChatGPT. Methods: Data were collected from 192 participants via MTurk, all of whom had experience using Generative AI. The survey was conducted in June 2024, and the data were analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM) to ensure the validity and reliability of the measurement model. Attention-check questions were used to ensure data quality, and participants provided demographic information at the end of the survey. Results: : The findings reveal that knowledge support and entertainment significantly enhance the intention to adopt Generative AI, whereas realistic threat poses a substantial barrier. Customization, perceived risk, and identity threat did not significantly affect adoption intentions. Conclusion: This study contributes to the literature by addressing the gap in understanding the adoption mechanisms of Generative AI in professional settings. It highlights the importance of promoting AI's knowledge support and entertainment capabilities while addressing employees' concerns about job security. Organizations should emphasize these benefits and proactively mitigate perceived threats to foster a positive reception of Generative AI technologies. The findings offer practical implications for enhancing user acceptance and provide a foundation for future research in this area.

• Journal of Information Processing Systems
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• v.16 no.4
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• pp.784-794
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• 2020

In order to effectively evaluate the urban water security, the study investigates a novel system to assess factors that impact urban water security and builds an urban water poverty evaluation index system. Based on the contribution rates of Resource, Access, Capacity, Use, and Environment, the study adopts the Water Poverty Index (WPI) model to evaluate the water poverty levels of 14 cities in Gansu during 2011-2018 and uses the least variance method to evaluate water poverty space drive types. The case study results show that the water poverty space drive types of 14 cites fall into four categories. The first category is the dual factor dominant type driven by environment and resources, which includes Lanzhou, Qingyang, Jiuquan, and Jiayuguan. The second category is the three-factor dominant type driven by Access, Use, and Capability, which includes Longnan, Linxia, and Gannan. The third category is the four-factor dominant type driven by Resource, Access, Capability, and Environment, which includes Jinchang, Pingliang, Wuwei, Baiyin, and Zhangye. The fourth category is the five-factor dominant type, which includes Tianshui and Dingxi. The driven types impacting the urban water security factors reflected by the WPI and its model are clear and accurate. The divisions of the urban water security level supply a reliable theoretical and numerical basis for an urban water security early warning mechanism.

• The Korean Journal of Mycology
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• v.39 no.1
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• pp.85-87
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• 2011

The opportunistic human pathogen Candida albicans has the ability to convert from yeast-form to pseudohyphal or true hyphal form. The morphological transition is considered as an important virulence factor, because the decrease or lack in dimorphism causes the reduction of virulence. Our previous study revealed that the disruption of dual specificity kinase gene caused the reduction of dimorphism in C. albicans. Therefore we tested the effect of dual specificity kinase in virulence using mouse model. The mean survival time for kinase-defective strains was about 15 days in comparison with those of wild-type, 3.9 days. Moreover the fungal burden on kidneys for kinase-defective strains was decreased by ten-fold than that for wild-type. These results suggest possible involvement of dual specificity kinase in a novel signal transduction pathway for morphological transition and virulence of C. albicans.

• Journal of Welding and Joining
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• v.26 no.2
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• pp.85-91
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• 2008

In general, the quality of a welding process tends to vary with depending on the work environment or external disturbances. Hence, in order to achieve the desirable quality of welding, we should have the optimal welding condition that is not significantly affected by these changes in the environment or external disturbances. In this study, we used a dual response surface method in consideration of both the mean output variables and the standard deviation in order to optimize the V-groove arc welding process. The input variables for GMA welding process with the dual response surface are welding voltage, welding current and welding speed. The output variables are the welding quality function using the shape factor of bead geometry. First, we performed welding experiment on the interested area according to the central composite design. From the results obtained, we derived the regression model on the mean and standard deviation between the input and output variables of the welding process and then obtained the dual response surface. Finally, using the grid search method, we obtained the input variables that minimize the object function which led to the optimal V-groove arc welding process.

• Journal of Hydrogen and New Energy
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• v.13 no.3
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• pp.214-223
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• 2002

Kinetic and effectiveness factors for methanol steam reforming using commercial copper-containing catalysts in a plug flow reactor were investigated over the temperature ranges of $180-250^{\circ}C$ at atmospheric pressure. The selectivity of $CO_2$/$H_2$ was almost 100%, and CO products were not observed under reaction conditions employed in this work. It was indicated that $CO_2$ was directly produced and CO was formed via the reverse water gas shift reaction after methanol steam reforming. The intrinsic kinetics for such reactions were well described by the Langmuir-Hinshelwood model based on the dual-site mechanism. The six parameters in this model, including the activation energy of 103kJ/mol, were estimated from diffusion-free data. The significant effect of internal diffusion was observed for temperature higher than $230^{\circ}C$ or particle sizes larger than 0.36mm. In the diflusion-limited case, this model combined with internal effectiveness factors was also found to be good agreement with experimental data.

• Fashion & Textile Research Journal
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• v.23 no.5
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• pp.586-597
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• 2021

Personalized product recommendation service is receiving attention as a new marketing strategy while supporting consumer information search and purchasing decisions. This study attempted to verify the effect of self-reference on service use behavior through the dual path of cognitive attitude and emotional attachment. Using convenience sampling, an online survey was conducted with 324 women who were in their 20s and 30s. After collecting and compiling the survey data, the reliability and validity of variables constituting the conceptual research model were verified through confirmatory factor analysis using AMOS 22.0. Next, the significance of sequentially mediated pathways was verified using Process 3.5 Model 80. The results showed that self-referencing not only significantly affects service use intention by simply mediating cognitive attitudes but also sequentially mediates cognitive attitudes and additional information search. Furthermore, self-referencing was significant as an indirect path to service use intention by mediating additional information search. However, in the path mediated by emotional attachment, self-referencing was considered as a simple mediated path leading to service usage intention. These results indicate a dual path in the psychological mechanism, through cognitive and emotional evaluation, that prompts consumer behavioral responses to the personalized product information provided in the shopping process.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.44 no.5
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• pp.695-705
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• 2024

As a result of Typhoon Hinnamnoh, several slope failures occurred in the Pohang region, it is necessary to perform infiltration and slope stability analyses due to the actual rainfall. In the failed sites, samples were collected, and the hydro-mechanical properties of unsaturated soil were examined. Modeling the actual behavior using a single-mode function characteristic curve was found to be inadequate, leading to the adoption of a dual-mode function characteristic curve. The dual-mode function showed better agreement with the water retention test data. We calculated the unsaturated hydraulic conductivity for single and dual modes and performed rainfall-induced infiltration analysis. The variations in saturation and pore water pressure were calculated due to rainfall for three landslide-prone areas, Stability analysis based on effective stress of unsaturated soil was conducted, and safety factors were computed over time steps. The dual-mode model successfully reproduced landslides triggered by Typhoon Hinnamnoh, while the single-mode model exhibited a minimum safety factor of 1.2-1.3, making slope failure unpredictable. The dual-mode model accurately predicted instability in the slope by appropriately accounting for pore water pressure variations during Typhoon.

• Plant Biotechnology Reports
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• v.2 no.3
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• pp.199-206
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• 2008

We have developed an efficient system of assessing the ability of a gene silencing cassette to silence transcripts from recalcitrant or poorly studied plant species by using a model plant as a host for the gene of interest. Tobacco plants transgenic for Lachrymatory Factor Synthase (LFS) enzyme activity from onion were first produced by introducing a CaMV 35S-onion-lfs gene construct. These plants were then subjected to a second transformation with an RNAi construct directed against the lfs gene sequence. LFS enzyme activity assay showed that the transgenic plants, containing both the lfs gene and the RNAi construct, had significantly reduced LFS activity. This observation was supported by Western analysis for the LFS protein and further validated by quantitative RT-PCR analysis that demonstrated a significant reduction in the lfs transcript level in the dual transformants. In this work, we have demonstrated that the RNAi construct is a suitable candidate for the development of a non-lachrymatory onion. Our model plant RNAi system has wide-reaching applications for assessment and targeting of plant secondary pathway genes, from poorly studied or recalcitrant plant species, that are important in the pharmacological, food and process industries.