• 한국보건간호학회지
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• 제16권2호
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• pp.400-411
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• 2002

This study was performed to identify the drug use and reuse relating characteristics and reuse relating factors in illegal drug users. Subjects consisted of 88 illegal drug users. Some of them were confined in a mental hospital or National Forensic Psychiatric Hospital located in Chung-nam province, others on attending a drug abuse prevention program in Seoul Probational Institute. Data were collected during the period from February 1, 2002 to February 25, 2002, and analyzed by SAS program. version 6.12. for Wilcoxon rank sum test, Pearson Correlation, Multiple regression. Results were as follows; 1. Drug use characteristics were as follows. $19.3\%$ was has drug family history and $20.7\%$ was has alcohol family history. Main drug was Phillopon$44.3\%$, inhalants $35.2\%$, LSD et al $22.7\%$. Drug use rate of months was everyday $31.2\%$, every other day $24.4\%$. 2. $100\%$ has experienced abstinence and reuse. Abstinence period was less than 12 months in $49.4\%$ and reuse period was less than 6 months in $58.6\%$. 3. Drug use and reuse characteristics related to general characteristics was identified as below. Abstinence period of male was longer than that of female. Person who have drug family history experienced more drugs and person who have family alcohol history started earlier. 4. Reuse periods was correlated with abstinence periods, age. And abstinence period was correlated with age and outcome that following reuse. 5. The multiple regression was used to identify the relating factors that influence reuse period and abstinence period. At the state of controlling abstinence period. inhalants users have 10.07 days shorter reuse period than others. And abstinence period had lengthened age, bad health status, early initiate age, and long reuse period.

• Asian Pacific Journal of Cancer Prevention
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• 제16권14호
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• pp.6055-6059
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• 2015

Background: Medication policy development in Thailand is continually promoting rational drug use. Letrozole, an endocrine therapy drug, is usually prescribed for post-menopausal status early and advanced stage breast cancer. After Ministry of Public Health announced Letrozole as compulsory licensed drug in 2009, more breast cancer patients can access to this drug at low cost especially those within universal coverage schemes. To ensure that Letrozole is rationally prescribed, the drug utilization study was conducted. Objectives: The aim of this study was to describe the appropriate use of Letrozole in breast cancer and the relationship between appropriate use and health benefit schemes. Materials and Methods: A retrospective study to evaluate use of Letrozole in breast cancer patients was performed for six months between January - June 2010 in seven regional cancer hospitals, Thailand. All prescriptions of Letrozole were identified from pharmacy dispensing databases and prescription papers. A medical record review was also performed to evaluate appropriate use referring to the drug use evaluation criteria. The approved criterion of this study was referred from the guideline of Thai National Formulary version 2010. Results: There were 681 prescriptions of Letrozole for 254 breast cancer patients with an average age of $58.6{\pm}10.0years$. The patients in universal coverage scheme (UCS), civil servant medication benefit scheme (CSMBS) and social security scheme (SSS) were 77.7%, 18.5% and 8.7% respectively. 10.6% were prescribed Letrozole for the first time. Letrozole were prescribed by oncologists (82.8%). The average number of tablets per prescription was $58{\pm}10$. Calcium supplements were prescribed concomitant with Letrozole for 19.4%. To assess drug use evaluation criteria, 45 prescriptions were excluded because of uncompleted clinical data, 636 prescriptions were evaluated. The study showed 86 prescriptions (13.5%) with inappropriate use including 6 (0.9%) not prescribed for estrogen receptor (ER) and/or progesterone receptor (PR) positive, 31 (4.9%) not prescribed for post-menopausal and 49 (7.7%) not prescribed for an appropriate duration. Appropriate use percentages in different health benefit schemes were similar, 85.7% of CSMBS, 86.4% of SSS and 86.7% of UCS. The relationship between health benefit scheme and appropriate use of Letrozole was not significantly different, ${\chi}^2$ (2, N = 636) = 0.081, p > 0.05. Conclusions: The study showed inappropriate use in breast cancer patients because of non-compliance with duration, menopausal status and hormone receptor requirements. To prescribe appropriate indication did not referred to the appropriate practice along the treatment. Drug use evaluation proved very useful for detecting the sign of inappropriate use and allows immediate feedback to the stakeholder for developing medication policy in the future. Importantly, there was no significantly difference in appropriate use of Letrozole across health benefit schemes.

• 대한간호학회지
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• 제29권1호
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• pp.150-160
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• 1999

Background and purpose : Drug abuse is one of the most serious problems among the Korean adolescents today and has been associated with delinquent behavior in adolescents. The number of adolescents who abuse drugs is increasing yearly. Solutions to the problem, however, have not been well developed. The purpose of this study was to determine the effectiveness of a drug use prevention program which was developed by researchers. The program was a modified DARE(Drug Abuse Resistance Education) program for Korean adolescents. Methods: This study used an experimental, one-group pretest-posttest design with a convenience sample of 122 middle school students who were at one middle school located in Seoul. Data were collected using a self-administered questionnaire where ‘knowledge and attitude about drug use’, ‘social skill’, and ‘self-esteem’ were measured. The program had 12 sessions to improve knowledge and attitudes towards drugs, decision making skills, social resistance skills, management of stress and self-esteem of students. Teaching strategies for each session were varied lectures, group discussion. role-playing, question-and-answer sessions and audiovisual materials. Paired t-test was used to analyze the differences between the pre- and post-test scores on knowledge of and attitudes towards drug use, social skills, and self-esteem. Results : There were significant differences in knowledge and attitudes about drug use between pretest and post-test (p＜.05), but no significant differences in social skill and self-esteem(p＞.05). Conclusion: Our results showed that the drug use prevention program was not effective in promoting social-skill and self-esteem of Korean adolescents. These findings might be due to the respondents being in the period of early adolescence (puberty) and not being good at group discussion. So, further study is needed to develop a drug use prevention program appropriate to students 9 and 10 years old, and to encourge small group discussion.

• 보건교육건강증진학회지
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• 제22권2호
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• pp.125-139
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• 2005

Objectives: More than half of youth smokers start to use cigarettes in their middle-school ages. Thus, middle school students should be the primary target population for smoking prevention education although the technical smoking rate is higher in high school students than in middle school students. Based on this significance, this study examined personal and social factors reinforcing non-smoking middle school students to acquire positive attitudes on smoking cigarettes. Methods: A total of 1,081 students of the 3 middle schools in Seoul participated in the self-administered survey. The designated schools were conveniently selected and all the 2nd-grade students of the schools participated in the survey. The questionnaire asked reinforcing social factors of smoking such as, family and parental history of drug use, close-people's smoking and drug use, personal experience of drug use, perceived smoking and drug use knowledge and attitudes, perceived smoking intention in future, and other delinquent behaviors. Results: Personal experience of drug and delinquent behaviors, perceived smoking intention in future, perceived knowledge of smoking, educational experience, and close-people's smoking and drug use were significantly related to students' attitudes on smoking. The significant factors affecting the positive attitudes of smoking were living with broken family and few education experience of smoking in school as social factors and strong smoking intention in future, high score of delinquent behavior, and low score of drug use knowledge as personal factors. Conclusions: Adolescents' strong smoking intention and little smoking education experience would primary personal and social factors reinforcing positive attitudes on smoking. Thus, school-based educational programs preventing smoking intention need to be developed and to be delivered to middle school students to minimize the future smoking population in a long-term perspective.

• 기본간호학회지
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• 제15권2호
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• pp.195-205
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• 2008

Purpose: This study was conducted to identify drug use by elders. Method: There were 304 participants age 65 or older included in this study. Data were collected using a questionnaire about drug use in the past 4 weeks. The questionnaire, a modification of Uhm's (2005), Lee's (2001), and Ellor and Kurz's (1982) tools, consisted of 17 questions on general and health characteristics, 17 on drug usage and 9 on behaviors related to drug misuse. Results: 85.5% of participants reported laking at least one type of prescription or non-prescription drug. 26.0% of participants reported taking only prescription drugs, 3.9% reported taking only non-prescription drugs, and 55.6% reported taking both prescription and non-prescription drugs. 17.1% of participants reported side effects from the drugs. The mean score for behaviors related to drug misuse was 7.53. Elders taking only non-prescription drugs showed more drug misuse than elders taking only prescription drugs or both. Women used more prescription, non-prescription drugs or both than man. Elders in rural areas used more non-prescription drugs than those in urban areas. Conclusion: Even though pharmacies were separated from medical practices in 2000, most older adults continue to use and misuse prescription and non-prescription drugs.

• 한국학교보건학회지
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• 제34권3호
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• pp.161-169
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• 2021

Purpose: The purpose of the study was to investigate the effect of loneliness on habitual drug use in Korean adolescents. Methods: The study was designed as a cross-sectional study. Using statistics from the 16th (2020) Korea Youth Risk Behavior Web-based Survey, multiple logistic regression analysis was conducted. A total 54,948 adolescents were included in the analysis. Results: Adolescents were more likely to engage in habitual drug use when they were lonely than when they were not (OR: 1.55, 95% CI: 1.20~2.02). As for sociodemographic characteristics, gender, academic achievement, and living with family were factors influencing habitual drug use. As for health behavior characteristics, perceived stress, depression, current drinking, violence, sexual intercourse, and perceived health were identified as factors affecting habitual drug use. Conclusion: Provision of education that includes loneliness as a factor, which was not previously considered important in school education for preventing habitual drug use of adolescents, should be considered.

• Biomolecules & Therapeutics
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• 제30권1호
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• pp.1-18
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• 2022

Drug-drug interactions are a major cause of hospitalization and deaths related to drug use. A large fraction of these is due to inhibition of enzymes involved in drug metabolism and transport, particularly cytochrome P450 (P450) enzymes. Understanding basic mechanisms of enzyme inhibition is important, particularly in terms of reversibility and the use of the appropriate parameters. In addition to drug-drug interactions, issues have involved interactions of drugs with foods and natural products related to P450 enzymes. Predicting drug-drug interactions is a major effort in drug development in the pharmaceutical industry and regulatory agencies. With appropriate in vitro experiments, it is possible to stratify clinical drug-drug interaction studies. A better understanding of drug interactions and training of physicians and pharmacists has developed. Finally, some P450s have been the targets of drugs in some cancers and other disease states.

• 기본간호학회지
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• 제14권4호
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• pp.524-535
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• 2007

Purpose: The purpose was to identify the risk of drug use by adolescents. Method: The participants were 933 male students in the first grade of a high school in D city. The data were collected from Aug. 5th to Oct. 30th, 2004. The instrument was the High Risk Group Adolescent Drug User Screening Test(HIRIGADUST) developed by the Korea Adolescent Society(1996). The data were analyzed using SPSS. Results: For substance use, 64.5% of the students answered that they had drunk, 40.3% that they had smoked, and 2.0% that they had tried drug use. For scores on HIRIGADUST regarding socio-demographic characteristics, there were significant differences depending on school type, personality, academic performance, economic status, and ability to talk with parents. For scores on HIRIGADUST regarding drug using-related characteristics, there were significant differences depending on drinking experience, frequency of drinking, amount of alcohol intake, smoking experience and number of cigarettes smoked. Of the students 27.2% students were in the high risk group. Conclusion: In schools, systematic and intensive assessment of drug use should be done, and if needed, a service system connected to clinics specializing in drug addiction should be established. Prevention education should be carried out continuously.

• 대한간호학회지
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• 제37권3호
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• pp.295-304
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• 2007

Purpose: This study was conducted to develop an education program for safe drug use in the rural elderly and to measure the effect of the program. Method: This study utilized a nonequivalent control group pretest-posttest design. The subjects of this study consisted of 40 older persons who were more than 65 years old and lived in G and C moon, Y gun, Gyeongsang-bukdo and visited the public health subcenter. Twenty were assigned to the experimental group and 20 to the control group. The education was provided for one and a half hours, once a week for 3 weeks. Data was collected before, right after, and one month after the program. Result: The first hypothesis was supported(F=79.24, p=0.000) showing that the knowledge scores of the drug use of the experimental group were significantly higher than those of the control group at post education and one month after education. The second hypothesis was supported(F=23.84, p=0.000) showing that the drug misuse and abuse prevention behavior scores in the experimental group were significantly higher than those of the control group at post education and one month after the education. Conclusion: This study suggests that the education for safe drug use is effective in promoting knowledge and behavior for safe drug use of the rural elderly.

• 지역사회간호학회지
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• 제6권2호
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• pp.286-298
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• 1995

The purposes of this study were to suggest the need for drug prevention program in primary school and to provide basic data for preventing the youth from their drug abuse. A total of 680 students of primary school in Pusan were selected to answer this questionnair. The data was collected from July 1 to July 15, 1994. The major findings of this study were as follows : 1) The attitude about drugs of primary school students was desirable. By groups, girl students showed more desirable attitude than boy students. 2) 5.9% of subjects had smoking experience, and for the motives of smoking 77.5% of them, the largest numbers, was with curiosity. 3) 39.8% of subjects had experienced alcohol use, and for the motives alcohol use 50.5% of them, the largest numbers, was with curiosity. 4) 1.8% of subjects had experienced inhalants (gas, butane gas), and for the motives of inhalants use 58.4% of them, the largest numbers, was also with curiosity. 5) The rates of smoking, alcohol use and inhalants use were higher in boy students than girl students. 6) The attitude points about drugs in case of smoking, alcohol use and inhalants use were lower than the points in case of not using them. 7) Knowledge level about .drugs of subjects was appeared poor. 8) For the need of drug education 65.9% of subjects responded 'necessary', and they responded most suitable educator as school nurse. 9) The students had received drug education from school in 38.2%, from their parents in 8% and from mass media in 63.5%.