• Membrane Journal
• /
• v.30 no.1
• /
• pp.66-77
• /
• 2020

The current study focused on the effect of twisting hollow fibers (HFs) in a module during forward osmosis operation mode. Computational fluid dynamics simulation was employed for a straight HF module and twisted modules with five different angles to predict the mass transfer and observe the draw solution profile in terms of concentration and pressure. The simulation results showed that when the membranes were twisted, the concentration was distributed more evenly and the pressure at the module outlet increased gradually as the twisting angle increased. As pressure at the outlet increased, the fluid velocity inside the membrane decreased and the residence time of fluid increased, thereby facilitating mass exchange across the membrane. This is evidenced by a doubling of the ratio of water flux through the membrane in module flux when the HFs were twisted.

• Journal of the Korean Society for Railway
• /
• v.20 no.4
• /
• pp.448-457
• /
• 2017

In this paper, for high speed railway propulsion systems, a single phase PWM Converter using discontinuous PWM (DPWM) was investigated. The conventional PWM Converter uses a low frequency modulation index of less than 10 to reduce switching losses due to high power characteristics, which results in low control frequency bandwidth and requires an additional compensation method. To solve these problems, the DPWM method, which is commonly used in three phase PWM Inverters, was adopted to a single phase PWM Converter. The proposed method was easily implemented using offset voltage techniques. Method can improve the control performance by doubling the frequency modulation index for the same switching loss, and can also bring the same dynamic characteristics among switches. Proposed DPWM method was verified by simulation of 100 kW PWM converter.

• Journal of Radiation Protection and Research
• /
• v.34 no.2
• /
• pp.49-54
• /
• 2009

Mitochondrial DNA (mtDNA) deletion is a well-known marker for oxidative stress and aging and also contributes to their unfavorable effects in cultured cells and animal tissues. This study was conducted to investigate the effect of ionizing radiation (IR) on mtDNA deletion and the involvement of reactive oxygen species (ROS) in this process in human lung fibroblast (IMR-90) cells. Young IMR-90 cells at population doubling (PD) 39 were irradiated with $^{137}Cs$ $\gamma$-rays and the intracellular ROS level was determined by 2',7'-dichlorofluorescein diacetate (DCFH-DA) and mtDNA common deletion (4977bp) was detected by nested PCR. Old cells at PD 55 and $H_2O_2$-treated young cells were compared as the positive control. IR increased the intracellular ROS level and mtDNA 4977 bp deletion in IMR-90 cells dose-dependently. The increases of ROS level and mtDNA deletion were also observed in old cells and $H_2O_2$-treated young cells. To confirm the increased ROS level is essential for mtDNA deletion in irradiated cells, the effects of N-acetylcysteine (NAC) on IRinduced ROS and mtDNA deletion were examined. 5 mM NAC significantly attenuated the IR-induced ROS increase and mtDNA deletion. These results suggest that IR induces the mtDNA deletion and this process is mediated by ROS in IMR-90 cells.

• Proceedings of the Ginseng society Conference
• /
• 1978.09a
• /
• pp.43-49
• /
• 1978

This study was devised to observe the cytotoxic activity of extracts of Panax ginseng root against some cancer cells and to purify the crude extract. Three kinds of cancer cells(leukemic cells L5178Y, HeLa cells and Sarcoma 180 cells) and mouse embryo cells (as normal cells) were used for this study. The ginseng roots were extracted with petroleum ether in soxhlet apparatus, and the crude extracts were purified by the silicic acid column chromatography and thin-layer chromatography methods. The results obtained are summarized as follows; 1. Eight to ten mg of the petroleum ether extract (crude extract) were obtained from 1 g of Panax ginseng root, and its activities per mg were about 1,000 units. 2. Doubling time of the L5178Y cells was increased to two fold by 24 hours incubation in culture medium containing about one ${\mu}g$ of extract per ml, and eight and ten folds higher concentration of ginseng extract were required for the Sarcoma 180 cells and HeLa cells, respectively, than for the leukemic cells(L5178Y) to inhibit the cellular growth to the same degree. 3. When the L5178Y cells were exposed to medium containing various concentration of the extract for 24 hours before initiation of the soft agar cloning procedure, about $99\%$ of the L5178Y cells were killed at concentration of 8 units per ml. 4. The growth rate of mouse embryo cell (as normal cell) was not affected by the culture with media containing various amounts (1.45 to 30.0 ${\mu}g/ml$) of the extract. 5. The crude extract could be purified about four times by silicic acid column chromatography using several solvent systems, and one spot of active compound could be obtained on the thin-layer chromatogram. 6. In the Swiss mice inoculated with Sarcoma 180 cells, a survival time of the experimental group (injection group of active compound) was extended more. 1.5 to 2.0 times than the control group's(no injection group).

• Journal of Plant Biology
• /
• v.36 no.2
• /
• pp.133-140
• /
• 1993

The photosynthetic activities in relation to oxygen evolution rates, quantum yield, CO2 uptake rates and room temperature chlorophyll fluorescence were investigated in cotyledons of cucumber seedlings exposed to low temperature (at 4$^{\circ}C$) for 24 h. Light-chilling caused more inhibition on light-saturated maximum oxygen evolution rates, quantum yield, and CO2 uptake rates than dark-chilling did in the cucumber plant. Light-chilling induced more marked increase in Fo and decrease in (Fv)m/Fm than dark-chilling did in the room temperature chlorophyll induction kinetics. The above results affected by chilling in the light are considered to be associated with the partial damage of the reaction center of PS II and the decreased photosynthetic activities. There occurred a large decrease in qQ with little change in qNP in the light-chilling plant. When light- and dark-chilled plants were recovered at room temperature for 24 h and their chlorophyll fluorescences were induced with light doubling technique, light-chilled plants showed more smaller magnitude and rate of fluorescence relaxation than dark-chilled plants. These suggest that light-chilling might cause some alterations in transthylakoid pH formation, and that photosynthetic apparatus of cucumber cotyledons is more susceptible to light-chilling. In the fast fluorescence induction kinetics, FR was decreased by 60% in the light-chilled plants with reference to $25^{\circ}C$ light-grown plants, while the dark-chilled plants showed a decreased rate of only 20% with reference to $25^{\circ}C$ dark-treated plants for 24 h, indicating that cucumber seedling is very sensitive to chilling stress. So, it is certain that chilling injury to the photosynthetic apparatus is strongly dependent on the presence of light in cucumber seedlings.

• International Commerce and Information Review
• /
• v.18 no.1
• /
• pp.81-105
• /
• 2016

Recently, master plan on the Far East three provinces in China as well as the Russian Far East coupling with 'Eurasia Initiatives' of our government is doubling its importance. It should take advantage of Zarubino port for the hub of Eurasia Logistics Network. This study forecasts the volume demand and whether the expected items of cargo traffic of Zarubino port with O/Ds for the region including the Far East three provinces in China. Input data and the existing basic unit of Korea were utilized in order to overcome the absence of the relevant information to the region. It was derived by them confined to the industrial complex facility in Jilin Sheng on behalf of the Far East three provinces in China as a pilot study. Suitable for the transport sector as a basis for traditional traffic demand, four-step method for estimating the proposed modifications, complementing methodologies. This study is determined that the contribution to the implications on the region's logistics policies of our government has a commitment with raising awareness of the region's Logistics system.

• JSTS:Journal of Semiconductor Technology and Science
• /
• v.11 no.2
• /
• pp.121-129
• /
• 2011

It is progressing as new advents and remarkable developments of mobile device every year. On the upper line reason, NAND FLASH large density memory demands which can be stored into portable devices have been dramatically increasing. Therefore, the cell size of the NAND Flash memory has been scaled down by merely 50% and has been doubling density each per year. [1] However, side effects have arisen the cell distribution and reliability characteristics related to coupling interference, channel disturbance, floating gate electron retention, write-erase cycling owing to shrinking around 20nm technology. Also, FLASH controller to manage shrink effect leads to speed and current issues. In this paper, It will be introduced to solve cycling, retention and fail bit problems of sub-deep micron shrink such as Virtual negative read used in moving read, randomization. The characteristics of retention, cycling and program performance have 3 K per 1 year and 12.7 MB/s respectively. And device size is 179.32 $mm^2$ (16.79 mm ${\times}$ 10.68 mm) in 3 metal 26 nm CMOS.

• Journal of Radiation Protection and Research
• /
• v.36 no.3
• /
• pp.119-126
• /
• 2011

Mitochondrial DNA (mtDNA) deletion is a well-known marker for oxidative stress and aging, and contributes to harmful effects in cultured cells and animal tissues. mtDNA biogenesis genes (NRF-1, TFAM) are essential for the maintenance of mtDNA, as well as the transcription and replication of mitochondrial genomes. Considering that oxidative stress is known to affect mitochondrial biogenesis, we hypothesized that ionizing radiation (IR)-induced reactive oxygen species (ROS) causes mtDNA deletion by modulating the mitochondrial biogenesis, thereby leading to cellular senescence. Therefore, we examined the effects of IR on ROS levels, cellular senescence, mitochondrial biogenesis, and mtDNA deletion in IMR-90 human lung fibroblast cells. Young IMR-90 cells at population doubling (PD) 39 were irradiated at 4 or 8 Gy. Old cells at PD55, and H2O2-treated young cells at PD 39, were compared as a positive control. The IR increased the intracellular ROS level, senescence-associated ${\beta}$-galactosidase (SA-${\beta}$-gal) activity, and mtDNA common deletion (4977 bp), and it decreased the mRNA expression of NRF-1 and TFAM in IMR-90 cells. Similar results were also observed in old cells (PD 55) and $H_2O_2$-treated young cells. To confirm that a increase in ROS level is essential for mtDNA deletion and changes of mitochondrial biogenesis in irradiated cells, the effects of N-acetylcysteine (NAC) were examined. In irradiated and $H_2O_2$-treated cells, 5 mM NAC significantly attenuated the increases of ROS, mtDNA deletion, and SA-${\beta}$-gal activity, and recovered from decreased expressions of NRF-1 and TFAM mRNA. These results suggest that ROS is a key cause of IR-induced mtDNA deletion, and the suppression of the mitochondrial biogenesis gene may mediate this process.

• KSBB Journal
• /
• v.15 no.5
• /
• pp.428-433
• /
• 2000

Cell cultures of Camptotheca acuminata, which is known to produce the anticancer indole alkaloid camptothecin and its dervatives, were made to enhance the productivity of camptothecin. In suspension cultures, the maximum cell growth rate in exponential growth phase was $0.269day^{-1}$ which was correlated to 2.58days of cell doubling time. The production of camptothecin was non-growth associated. The camptothecin production was the highest at 11th day form inoculation and then it decreased. Various elicitors were applied to enhance the production of camptothecin. Both of jasmonic acid and cellulase increased the production of camptothecin. The optimal dosing time of elicitor was the beginning of the cultures. The combination of two elicitors was more effective to produce camptothecin than single applications. $20.42{\times}10^{-3}mg/\ell$ of camptothecin was obtained with combined application of two elicitors in two days.

• The KIPS Transactions:PartC
• /
• v.15C no.2
• /
• pp.133-140
• /
• 2008

In this paper, we propose a high performance elliptic curve cryptographic processor over $GF(2^{163})$. The proposed architecture is based on a modified Lopez-Dahab elliptic curve point multiplication algorithm and uses Gaussian normal basis for $GF(2^{163})$ field arithmetic. To achieve a high throughput rates, we design two new word-level arithmetic units over $GF(2^{163})$ and derive a parallelized elliptic curve point doubling and point addition algorithm with uniform addressing based on the Lopez-Dahab method. We implement our design using Xilinx XC4VLX80 FPGA device which uses 24,263 slices and has a maximum frequency of 143MHz. Our design is roughly 4.8 times faster with 2 times increased hardware complexity compared with the previous hardware implementation proposed by Shu. et. al. Therefore, the proposed elliptic curve cryptographic processor is well suited to elliptic curve cryptosystems requiring high throughput rates such as network processors and web servers.