• Title/Summary/Keyword: Dosimetric Parameters

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Determination of dosimetric dependence for effective atomic number of LDR brachytherapy seed capsule by Monte Carlo simulation

  • Berkay Camgoz;Dilara Tarim
    • Nuclear Engineering and Technology
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    • v.55 no.8
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    • pp.2734-2741
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    • 2023
  • Brachytherapy is a special case of radiotherapy. It should be arranged according to some principles in medical radiation applications and radiation physics. The primary principle is to use as low as reasonably achievable dose in all ionizing radiation applications for diagnostic and therapeutic treatments. Dosimetric distributions are dependent on radioactive source properties and radiation-matter interactions in an absorber medium such as phantom or tissue. In this consideration, the geometrical structure and material of the seed capsule, which surrounds a radioactive material, are directly responsible for isodose profiles and dosimetric functions. In this study, the radiometric properties of capsule material were investigated on dose distribution in a water phantom by changing its nuclear properties using the EGSnrc Monte Carlo (MC) simulation code. Effective atomic numbers of hypothetic mixtures were calculated by using different elements with several fractions for capsule material. Model 6711 brachytherapy seed was modeled by EGSnrc/Dosrcnrc Code and dosimetric functions were calculated. As a result, dosimetric parameters of hypothetic sources have been acquired in large-scale atomic number. Dosimetric deviations between the data of hypothetic seeds and the original one were analyzed. Unit dose (Gy/Particle) distributions belonging to different types of material in seed capsule have remarkably differed from the original capsule's data. Capsule type is major variable to manage the expected dose profile and isodose distribution around a seed. This study shows us systematically varied scale of material type (cross section or effective atomic number dependent) offers selective material usage in production of seed capsules for the expected isodose profile of a specific source.

Dosimetric Plan Comparison of Accelerated Partial Breast Irradiation (APBI) Using CyberKnife

  • Lee, Chang Yeol;Kim, Woo Chul;Kim, Hun Jeong;Lee, Jeongshim;Park, Seungwoo;Huh, Hyun Do
    • Progress in Medical Physics
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    • v.29 no.2
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    • pp.73-80
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    • 2018
  • Accelerated partial breast irradiation (APBI) is a new treatment delivery technique that decreases overall treatment time by using higher fractional doses than conventional fractionation. Here, a quantitative analysis study of CyberKnife-based APBI was performed on 10 patients with left-sided breast cancer who had already finished conventional treatment at the Inha University Hospital. Dosimetric parameters for four kinds of treatment plans (3D-CRT, IMRT, VMAT, and CyberKnife) were analyzed and compared with constraints in the NSABP B39/RTOG 0413 protocol and a published CyberKnife-based APBI study. For the 10 patients recruited in this study, all the dosimetric parameters, including target coverage and doses to normal structures, met the NSABP B39/RTOG 0413 protocol. Compared with other treatment plans, a more conformal dose to the target and better dose sparing of critical structures were observed in CyberKnife plans. Accelerated partial breast irradiation via CyberKnife is a suitable treatment delivery technique for partial breast irradiation and offers improvements over external beam APBI techniques.

Dosimetric comparison of volumetric modulated arc therapy with robotic stereotactic radiation therapy in hepatocellular carcinoma

  • Paik, Eun Kyung;Kim, Mi-Sook;Choi, Chul Won;Jang, Won Il;Lee, Sung Hyun;Choi, Sang Hyoun;Kim, Kum Bae;Lee, Dong Han
    • Radiation Oncology Journal
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    • v.33 no.3
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    • pp.233-241
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    • 2015
  • Purpose: To compare volumetric modulated arc therapy of RapidArc with robotic stereotactic body radiation therapy (SBRT) of CyberKnife in the planning and delivery of SBRT for hepatocellular carcinoma (HCC) treatment by analyzing dosimetric parameters. Materials and Methods: Two radiation treatment plans were generated for 29 HCC patients, one using Eclipse for the RapidArc plan and the other using Multiplan for the CyberKnife plan. The prescription dose was 60 Gy in 3 fractions. The dosimetric parameters of planning target volume (PTV) coverage and normal tissue sparing in the RapidArc and the CyberKnife plans were analyzed. Results: The conformity index was $1.05{\pm}0.02$ for the CyberKnife plan, and $1.13{\pm}0.10$ for the RapidArc plan. The homogeneity index was $1.23{\pm}0.01$ for the CyberKnife plan, and $1.10{\pm}0.03$ for the RapidArc plan. For the normal liver, there were significant differences between the two plans in the low-dose regions of $V_1$ and $V_3$. The normalized volumes of $V_{60}$ for the normal liver in the RapidArc plan were drastically increased when the mean dose of the PTVs in RapidArc plan is equivalent to the mean dose of the PTVs in the CyberKnife plan. Conclusion: CyberKnife plans show greater dose conformity, especially in small-sized tumors, while RapidArc plans show good dosimetric distribution of low dose sparing in the normal liver and body.

Dosimetric Comparison of Noncoplanar and Coplanar Volumetric Modulated Arc Therapy Plans for Esophageal Cancer

  • Park, So-Yeon
    • Progress in Medical Physics
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    • v.31 no.4
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    • pp.179-188
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    • 2020
  • Purpose: We compared noncoplanar volumetric modulated arc therapy (ncVMAT) plans to coplanar VMAT (cVMAT) plans by evaluating the dosimetric quality of each for esophageal cancer. Methods: Twenty patients treated for esophageal cancer with the cVMAT technique were retrospectively selected. The cVMAT plans consisted of three coplanar full arc beams. The ncVMAT plans consisted of two coplanar full arc beams and one noncoplanar partial arc beam ranging from 45° to 315° with a couch rotation angle of 315°±5°. For dosimetric evaluation, the dose-volumetric (DV) parameters of the planning target volume (PTV) and organs at risk (OARs) were calculated for all VMAT plans. Results: No clinically noticeable differences between the cVMAT and ncVMAT plans were observed in the DV parameters of the PTV. For the lungs, the V13 Gy and mean dose for ncVMAT plans were smaller than those for cVMAT plans, showing statistically significant differences. For the heart, the values of the maximum dose for cVMAT and ncVMAT plans were 53.8±2.9 and 50.9±3.3 Gy, respectively (P=0.004). For the spinal cord, the values of the maximum dose for cVMAT and ncVMAT plans were 37.1±5.1 and 34.7±5.7 Gy, respectively (P<0.001). Conclusions: The use of ncVMAT plans provides better PTV coverage and sparing of OARs compared to that of cVMAT plans for long, tube-like esophageal cancer. For esophageal cancer, the ncVMAT plans showed a more favorable plan quality than the cVMAT plans.

The Retrieval of Abnormal TL Glow Curves Using Modified Glow Curve Analysis Method

  • Lee, Sang-Yoon;Lee, Kun-Jai;Kim, Jang-Lyul;Chang, Si-Young
    • Nuclear Engineering and Technology
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    • v.29 no.5
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    • pp.385-392
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    • 1997
  • The shape of TL glow curve is a useful indicator for assurance of correct reading of the personal dosimeter. Since the reading procedure of TLD is irreversible, however, an analytic remedy should be considered to procure reliable dosimetric information for the readings with irregular glow con shape. In this study, kinetic trapping parameters of CaSO$_4$ : Dy Teflon personal dosimeter(Teledyne PB-6A) were analyzed by Halperin and Braner's model for general-order kinetics. From these kinetic tapping parameters, we also developed a simple procedure to retrieve the dosimetric information from abnormally distorted glow curves. The computerized glow curve deconvolution(CGCD) fitting of the reference glow curve with kinetic parameters from this study yields relative errors of about 5% from the expected integral. It was also found that the glow curve remedial procedure developed could retrieve the distorted TL glow curves within ewer ranges of 1575. With the glow curve retrieval techniques, doses incurred by gamma radiation can now be successfully re-constructed for the CaSO$_4$ : Dy Teflon dosimeter resulting abnormal glow curves.

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Evaluations of a Commercial CLEANBOLUS-WHITE for Clinical Application

  • Geum Bong Yu;Jung-in Kim;Jaeman Son
    • Progress in Medical Physics
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    • v.35 no.1
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    • pp.10-15
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    • 2024
  • Purpose: This study aimed to comprehensively investigate the diverse characteristics of a novel commercial bolus, CLEANBOLUS-WHITE (CBW), to ascertain its suitability for clinical application. Methods: The evaluation of CBW encompassed both physical and biological assessments. Physical parameters such as mass density and shore hardness were measured alongside analyses of element composition. Biological evaluations included assessments for skin irritation and cytotoxicity. Dosimetric properties were examined by calculating surface dose and beam quality using a treatment planning system (TPS). Additionally, doses were measured at maximum and reference depths, and the results were compared with those obtained using a solid water phantom. The effect of air gap on dose measurement was also investigated by comparing measured doses on the RANDO phantom, under the bolus, with doses calculated from the TPS. Results: Biological evaluation confirmed that CBW is non-cytotoxic, nonirritant, and non-sensitizing. The bolus exhibited a mass density of 1.02 g/cm3 and 14 shore 00. Dosimetric evaluations revealed that using the 0.5 cm CBW resulted in less than a 1% difference compared to using the solid water phantom. Furthermore, beam quality calculations in the TPS indicated increased surface dose with the bolus. The air gap effect on dose measurement was deemed negligible, with a difference of approximately 1% between calculated and measured doses, aligning with measurement uncertainty. Conclusions: CBW demonstrates outstanding properties for clinical utilization. The dosimetric evaluation underscores a strong agreement between calculated and measured doses, validating its reliability in both planning and clinical settings.

Benefit of volumetric-modulated arc therapy over three-dimensional conformal radiotherapy for stage I-II extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue in the stomach: a dosimetric comparison

  • Chung, Joo-Hyun;Na, Kyoungsu;Kim, Il Han
    • Radiation Oncology Journal
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    • v.36 no.4
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    • pp.332-340
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    • 2018
  • Purpose: To retrospectively analyze dosimetric parameters of volumetric-modulated arc therapy (VMAT) and three-dimensional conformal radiotherapy (3D-CRT) delivered to extranodal marginal zone B-cell lymphomas of mucosa-associated lymphoid tissue in the stomach (gastric MALT lymphoma) to find out advantages of VMAT and conditions for definite benefits of VMAT. Materials and Methods: Fifty patients with stage I-II gastric MALT lymphoma received VMAT (n = 14) or 3D-CRT (n = 36) between December 2005 and April 2018. Twenty-seven patients were categorized according to whether the planning target volume (PTV) overlaps kidney(s). Dosimetric parameters were analyzed by dose-volume histogram. Results: Radiation dose to the liver was definitely lower with VMAT in terms of mean dose (p = 0.026) and V15 (p = 0.008). The V15 of the left kidney was lower with VMAT (p = 0.065). For those with PTV overlapping kidney(s), the left kidney V15 was significantly lower with VMAT. Furthermore, the closer the distance between the PTV and kidneys, the less the left kidney V15 with VMAT (p = 0.037). Delineation of kidney(s) by integrating all respiratory phases had no additional benefit. Conclusions: VMAT significantly increased monitor units, reduced treatment time and radiation dose to the liver and kidneys. The benefit of VMAT was definite in reducing the left kidney V15, especially in geometrically challenging conditions of overlap or close separation between PTV and kidney(s).

Dosimetric and Clinical Predictors of Acute Esophagitis in Lung Cancer Patients in Turkey Treated with Radiotherapy

  • Etiz, Durmus;Bayman, Evrim;Akcay, Melek;Sahin, Bilgehan;Bal, Cengiz
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.7
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    • pp.4223-4228
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    • 2013
  • Background: The purpose of this study was to determine the clinical and dosimetric factors associated with acute esophagitis (AE) in lung cancer patients treated with conformal radiotherapy (RT) in Turkey. Materials and Methods: In this retrospective review 104 lung cancer patients were examined. Esophagitis grades were verified weekly during treatment, and at 1 week, and 1 and 2 months afterwards. The clinical parameters included patient age, gender, tumor pathology, number of chemotherapy treatments before RT, concurrent chemotherapy, radiation dose, tumor response to RT, tumor localization, interruption of RT, weight loss, tumor and nodal stage and tumor volume. The following dosimetric parameters were analyzed for correlation of AE: The maximum ($D_{max}$) and mean ($D_{mean}$) doses delivered to the esophagus, the percentage of esophagus volume receiving ${\geq}10$ Gy ($V_{10}$), ${\geq}20$ Gy ($V_{20}$), ${\geq}30$ Gy ($V_{30}$), ${\geq}35$ Gy ($V_{35}$), ${\geq}40$ Gy ($V_{40}$), ${\geq}45$ Gy ($V_{45}$), ${\geq}50$ Gy ($V_{50}$) and ${\geq}60$ Gy ($V_{60}$). Results: Fifty-five patients (52.9%) developed AE. Maximum grades of AE were recorded: Grade 1 in 51 patients (49%), and Grade 2 in 4 patients (3.8%). Clinical factors had no statistically significant influence on the incidence of AE. In terms of dosimetric findings, correlation analyses demonstrated a significant association between AE and $D_{max}$ (>5117 cGy), $D_{mean}$ (>1487 cGy) and $V_{10-60}$ (percentage of volume receiving >10 to 60 Gy). The most significant relationship between RT and esophagitis were in $D_{max}$ (>5117 cGy) (p=0.002) and percentage of esophageal volume receiving >30 Gy ($V_{30}$ >31%) (p=0.008) in the logistic regression analysis. Conclusions: The maximum dose esophagus greater than 5117 cGy and approximately one third (31%) of the esophageal volume receiving >30 Gy was the most statistically significant predictive factor associated with esophagitis due to RT.

Evaluation of the heart and lung dosimetric parameters in deep inspiration breath hold using 3D Slicer

  • Eskandari, Azam;Nasseri, Shahrokh;Gholamhosseinian, Hamid;Hosseini, Sare;Farzaneh, Mohammad Javad Keikhai;Keramati, Alireza;Naji, Maryam;Rostami, Atefeh;Momennezhad, Mehdi
    • Radiation Oncology Journal
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    • v.38 no.1
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    • pp.68-76
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    • 2020
  • Purpose: The present study was conducted to compare dosimetric parameters for the heart and left lung between free breathing (FB) and deep inspiration breath hold (DIBH) and determine the most important potential factors associated with increasing the lung dose for left-sided breast radiotherapy using image analysis with 3D Slicer software. Materials and Methods: Computed tomography-simulation scans in FB and DIBH were obtained from 17 patients with left-sided breast cancer. After contouring, three-dimensional conformal plans were generated for them. The prescribed dose was 50 Gy to the clinical target volume. In addition to the dosimetric parameters, the irradiated volumes and both displacement magnitudes and vectors for the heart and left lung were assessed using 3D Slicer software. Results: The average of the heart mean dose (Dmean) decreased from 5.97 to 3.83 Gy and V25 from 7.60% to 3.29% using DIBH (p < 0.001). Furthermore, the average of Dmean for the left lung was changed from 8.67 to 8.95 Gy (p = 0.389) and V20 from 14.84% to 15.44% (p = 0.387). Both of the absolute and relative irradiated heart volumes decreased from 42.12 to 15.82 mL and 8.16% to 3.17%, respectively (p < 0.001); however, these parameters for the left lung increased from 124.32 to 223.27 mL (p < 0.001) and 13.33% to 13.99% (p = 0.350). In addition, the average of heart and left lung displacement magnitudes were calculated at 7.32 and 20.91 mm, respectively. Conclusion: The DIBH is an effective technique in the reduction of the heart dose for tangentially treated left sided-breast cancer patients, without a detrimental effect on the left lung.

Assessment of Dosimetric Leaf Gap According to Measuring Active Volume of Detector (검출기 측정 용적에 따른 Dosimetric Leaf Gap 변화와 정확성 검증에 대한 연구)

  • Dae-Hyun, Kim
    • Journal of the Korean Society of Radiology
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    • v.16 no.7
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    • pp.863-870
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    • 2022
  • DLG (Dosimetric Leaf Gap) and transmission factor are important parameters of MLC modeling in treatment planning system. In this study, DLG and transmission factor of HD-MLC were measured using detector with different measuring volumes, and the accuracy of the treatment plans was evaluated according to the DLG values. DLG was measured using the dynamic sweeping gap method with Semiflux3D and MicroDiamond detectors. Then, 10 radiation treatment plans were generated to optimize the DLG value and compared with the measurement results. Photon energies 6, 8, 10 MV, the DLG measured by Semiflux3D were 0.76, 0.83, and 0.85 mm, and DLG measured by MicroDiamond were 0.78, 0.86, and 0.9 mm. All plans were measured by portal dosimetry and analyzed using Gamma Evaluation. In the 6 MV photon beams, the average gamma passing rate were 94.3% and 98.4% for DLG 0.78 mm and 1.15 mm. In the 10 MV photon beam, the average gamma passing rate were 91.2% and 97.6% for DLG 0.9 mm and 1.25 mm. HD-MLC needs accurate modeling in the treatment planning system. DLG could be used measured data using small volume detector. However, for better radiation therapy, DLG should be optimized at the commissioning stage of LINAC.