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Synthesis and Characterization of Poly(alkyl $\alpha$, L-glutamate-co-ethylene oxide)

  • Kim, Gunwoo;Kim, Jin-Yeol;Daewon Sohn;Lee, Youngil
    • Macromolecular Research
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    • v.10 no.1
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    • pp.49-52
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    • 2002
  • Rod-coil amphiphilic block copolymers, PALG-PEOs, poly(alkyl $\alpha$, L-glutamate-co-ethylene oxide)s, were successfully synthesized in three steps: 1) esterification of L-glutamic acid, 2) synthesis of ${\gamma}$-alkyl L-gultamate N-carboxyanhydride, and 3) polymerization of NCA monomers. These molecules form polymeric micelles with the hydrophobic core and hydrophilic corona in aqueous solution, which were characterized by light scattering and static fluorescence measurement.

A Study on the Bias Reduction in Split Variable Selection in CART

  • Song, Hyo-Im;Song, Eun-Tae;Song, Moon Sup
    • Communications for Statistical Applications and Methods
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    • v.11 no.3
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    • pp.553-562
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    • 2004
  • In this short communication we discuss the bias problems of CART in split variable selection and suggest a method to reduce the variable selection bias. Penalties proportional to the number of categories or distinct values are applied to the splitting criteria of CART. The results of empirical comparisons show that the proposed modification of CART reduces the bias in variable selection.

왕염손(王念孫) 《대대례고운보(大戴禮古韻譜)》 운례 연구

  • Do, Hye-Suk
    • 중국학논총
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    • no.69
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    • pp.75-90
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    • 2021
  • 《大戴禮》由戴德編纂, 三十九篇流傳。儒家經典之一, 記述了先秦時期儒家學派的學說。戴聖編纂的《禮記》與《大戴禮》相區別, 又名《小戴禮》。《大戴禮·夏小正》以韻文體形式記述了上古時期的農耕意識, 將農業生產相關意識與一年十二個月的典型季節特徵結合起來。這裏需要注意的是《大戴禮·夏小正》爲韻文體的部分, 韻文體具有韻例。清代古音學家對先秦時期的押韻現象進行了歸納分析, 研究了上古音。《大戴禮·夏小正》爲韻文體, 被清代音學家視爲研究資料寶庫。《大戴禮》中除了《夏小正》之外, 還有許多篇名中存在着韻例。王念孫是清代古音學家, 著作《古韻譜》群經中收錄了《大戴禮》的韻例, 共有171個。整體上以押韻爲主流, 合韻混雜其中。本稿對王念孫《大戴禮古韻譜》的韻例進行分析, 將《古韻譜》的二十一部重新組爲《合韻譜》的二十二部。研究方法將《大戴禮古韻譜》的韻例與《大戴禮》原文對照, 分析王念 孫押韻與合韻體系。另外, 在將《大戴禮古韻譜》的二十一部改編爲二十二部的過程中, 參考了《合韻譜》的合韻例。 王念孫在《古韻譜》中主張二十一部, 後來《合韻譜》承認冬部獨立, 主張二十二部。王念孫主張的二十二部也是清代考學派的最終結果。本稿審視此點, 通過《大戴禮古韻譜》的韻例分析, 從東部獨立出來冬部, 以二十二部體制重新構成。

Metabolic Engineering of Rational Screened Saccharopolyspora spinosa for the Enhancement of Spinosyns A and D Production

  • Jha, Amit Kumar;Pokhrel, Anaya Raj;Chaudhary, Amit Kumar;Park, Seong-Whan;Cho, Wan Je;Sohng, Jae Kyung
    • Molecules and Cells
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    • v.37 no.10
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    • pp.727-733
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    • 2014
  • Spinosyns A and D are potent ingredient for insect control with exceptional safety to non-target organisms. It consists of a 21-carbon tetracyclic lactone with forosamine and tri-Omethylated rhamnose which are derived from S-adenosyl-methionine. Although previous studies have revealed the involvement of metK1 (S-adenosylmethionine synthetase), rmbA (glucose-1-phosphate thymidylyltransferase), and rmbB (TDP-D-glucose-4, 6-dehydratase) in the biosynthesis of spinosad, expression of these genes into rational screened Saccharopolyspora spinosa (S. spinosa MUV) has not been elucidated till date. In the present study, S. spinosa MUV was developed to utilize for metabolic engineering. The yield of spinosyns A and D in S. spinosa MUV was $244mgL^{-1}$ and $129mgL^{-1}$, which was 4.88-fold and 4.77-fold higher than that in the wild-type ($50mgL^{-1}$ and $27mgL^{-1}$), respectively. To achieve the better production; positive regulator metK1-sp, rmbA and rmbB genes from Streptomyces peucetius, were expressed and co-expressed in S. spinosa MUV under the control of strong $ermE^*$ promoter, using an integration vector pSET152 and expression vector pIBR25, respectively. Here-with, the genetically engineered strain of S. spinosa MUV, produce spinosyns A and D up to $372/217mgL^{-1}$ that is 7.44/8.03-fold greater than that of wild type. This result demonstrates the use of metabolic engineering on rationally developed high producing natural variants for the production.

Making Process for Magnetite Powder (Magnetite 분말의 제조)

  • Ho-Sang Lee;Kyu-Jin Kim
    • Resources Recycling
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    • v.9 no.5
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    • pp.28-32
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    • 2000
  • In this study, the new processing method to produce magnetite for mono-component black toner was studied using spray roaster. The produced magnetite is compared with TMB 125 made by Magnox, USA. When the weight ratio of the ferrous chloride and the ferric chloride is varied from 3:7~7:3 under $N_2$ atmosphere, the 100% major phase of magnetite is obtained. However, when the content of he ferrous chloride is higher than 70wt%, the content of FeO is increased. The phase of $\Gamma-Fe_2O_3$ is shown in th range of over 70wt% of the ferric chloride. The magnetite produced by spray roasting has a saturation magnetization of 80~85 emu/g and a coercivity of 110~130 Oe. The shape of the particle is irregular sphere and hte size of the magnetite is the range of $0.3~0.5\mu\textrm{m}$. It is shown that the magnetite made by spary roasting is enough to apply to the magnetic material of toner.

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Synthesis and herbicidal activities of 2-[4-(6-chloro-2-benzoxazolyloxy)-phenoxy]propionamide derivatives (2-[4-(6-chloro-2-benzoxazolyloxy)phenoxy]-propionamide 유도체의 합성과 제초 활성)

  • Chang, Hae-Sung;Chung, Kun-Hoe;Ko, Young-Kwan;Ryu, Jae-Wook;Woo, Jae-Chun;Koo, Dong-Wan;Kang, Yong-Hee;Kim, Tae-Joon;Kim, Jin-Seog;Chung, Bong-Jin;Kwon, Oh-Yeon;Kim, Dae-Whang
    • The Korean Journal of Pesticide Science
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    • v.8 no.2
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    • pp.145-149
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    • 2004
  • A series of 2-[4-(6-chloro-2-benzoxazolyloxy)phenoxy]-propionamide were synthesized and evaluated for post herbicidal activity under upland condition. 2-[4-(6-chloro-2-benzoxazolyloxy)phenoxy]-N-(2-fluorophenyl)-N methyl propionamide showed high herbicidal activity against barnyardgrass with good selectivity on rice.

A Synthesis of New Fluorine-containing Phenylformamidines and Their Insecticidal Activities (새로운 불소함유 Phenylformamidine 유도체의 합성과 살충활성)

  • Lee, Dong-Guk;Chung, Kun-Hoe;Ko, Young-Kwan;Ryu, Jae-Wook;Woo, Jae-Chun;Koo, Dong-Wan;Choi, Yong-Ho;Park, No-Joong;Hong, Mi-Sook;Kim, Tae-Joon
    • The Korean Journal of Pesticide Science
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    • v.12 no.3
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    • pp.295-301
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    • 2008
  • Phenylformamidines are well known as insecticides for their specific activity against the insects. It has now been established that they show insecticidal activity as agonists on the octopamine receptor which is located in the synapse membrane. In this study we tried to test the effect of fluorine substituted aromatic formamidines and 1,3,5-triazapenta-1,4-dienes. Among the compounds, 2h, 2k, 21, 3g, 3h, 3k showed good activity against mite and aphid and 4f and 4g showed high activity against mite.