• 한국초등수학교육학회지
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• 제16권2호
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• pp.227-252
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• 2012

본 논문은 그동안 별반 연구되지 않았던 측정 영역과 관련하여, 길이와 넓이를 대상으로 안내 정도와 측정의 주요 학습 요소를 분석 기준으로 하여 제7차와 현행 교육과정 자료를 비교분석하였다. 분석 결과 교과서와 익힘책에 제시된 안내 정도와 측정의 학습요소가 비슷한 점이 많았으나, 현행 교육과정 자료에서 안내형의 비율이 줄어들고 복합형과 개방형의 비율이 늘어난 점, 그리고 측정값 계산의 비율이 줄어들고 측정추론 양감 어림, 측정단위, 측정의 구성요소에 대한 비율이 늘어난 점이 차이점으로 드러났다. 이와 같은 연구결과를 토대로 본 논문은 측정 영역의 교과서 개정과 교과서 분석에 대한 시사점을 제시한다.

• BMB Reports
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• 제40권4호
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• pp.571-576
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• 2007

Three anti-apoptosis genes, Ls-iap2, iap3 and p49 were found in Leucania separata multiple nuclear polyhedrovirus. Amino acid sequence homology of Ls-IAP2 and Ls-IAP3 with Op-IAP2 and Op-IAP3 from Orgyia pseddotsugata MNPV were 20% and 42%, while that of Ls-P49 is 28% with Sl-P49 from Spodoptera littorolis MNPV. Ls-IAP2 contains one baculoviral IAP repeat (BIR) domain followed by a RING domain, while Ls-IAP3 contains two BIRs and a RING. Ls-P49 contains a reactive site loop, predicted cleavage site (KKLD$^{74}{\downarrow}$G) that is different from Sl-P49 (TVID$^{94}{\downarrow}$G). Expressed Ls-iap3 or Ls-p49 under presence of actinomycin D in SF9 cells, DNA ladder assayrevealed that Ls- IAP3 or Ls-P49 could block the apoptosis of SF9 cells induced by actinomycin D. Replication of p35 deficient-mutant Autographa californica MNPV in SF9 cells was also rescued when Ls-iap3 or Ls-p49 was expressed transiently. No anti-apoptotic activity was observed for Ls-IAP2. The results showed that both of Ls-IAP3 and Ls-P49 were functional apoptotic suppressors in SF9 cells.

• 한국통신학회논문지
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• 제31권12C호
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• pp.1288-1296
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• 2006

이 논문에서는 모바일 네트워크에서 이동 노드의 로밍을 위한 해시 기반의 인증 방법을 제안한다. IEEE 802.11과 802.16 기반의 인증 방법은 많은 지연 시간과 계산 과부하로 인하여 핸드오버와 로밍의 인증방법으로 적용하기 부적절하다. 따라서 다양한 방법들이 제안되었지만, 기존의 방법들은 인증의 보안을 약화시키거나 이동시마다 홈 인증 서버에 과도한 인증 부담?을 부여한다. 이 논문에서는 계층적 인증키 관리 구조를 통해 홈 인증 서버의 관리 부담 감소와 핸드오버를 위한 인증 방법의 보안 강화에 초점을 맞추고 있다. 제안하는 방법은 인증키에 해시 키 체인을 적용하여 계층적으로 관리함으로써 흠 인증 서버의 관리 부담을 로컬 인증 서버와 엑세스 포인트로 분산시키고 각 인증 서버와 엑세tm 포인트간에 인증키를 독립화하여 보안을 강화한다.

• Molecules and Cells
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• 제43권3호
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• pp.286-297
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• 2020

Mammalian patatin-like phospholipase domain containing proteins (PNPLAs) play critical roles in triglyceride hydrolysis, phospholipids metabolism, and lipid droplet (LD) homeostasis. PNPLA7 is a lysophosphatidylcholine hydrolase anchored on the endoplasmic reticulum which associates with LDs through its catalytic region (PNPLA7-C) in response to increased cyclic nucleotide levels. However, the interaction of PNPLA7 with LDs through its catalytic region is unknown. Herein, we demonstrate that PNPLA7-C localizes to the mature LDs ex vivo and also colocalizes with pre-existing LDs. Localization of PNPLA7-C with LDs induces LDs clustering via non-enzymatic intermolecular associations, while PNPLA7 alone does not induce LD clustering. Residues 742-1016 contains four putative transmembrane domains which act as a LD targeting motif and are required for the localization of PNPLA7-C to LDs. Furthermore, the N-terminal flanking region of the LD targeting motif, residues 681-741, contributes to the LD targeting, whereas the C-terminal flanking region (1169-1326) has an anti-LD targeting effect. Interestingly, the LD targeting motif does not exhibit lysophosphatidylcholine hydrolase activity even though it associates with LDs phospholipid membranes. These findings characterize the specific functional domains of PNPLA7 mediating subcellular positioning and interactions with LDs, as wells as providing critical insights into the structure of this evolutionarily conserved phospholipid-metabolizing enzyme family.

• 한국항해항만학회:학술대회논문집
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• 한국항해항만학회 2006년도 International Symposium on GPS/GNSS Vol.1
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• pp.235-240
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• 2006

The paper will give an overview of the mission of GalTeC and then concentrate on two main aspects. The first more detailed aspect, is the analysis of the key performance parameters for the Galileo system services and presenting a technical overview of methods and algorithms used. The second more detailed aspect, is the service volume prediction including service dimensioning using the Prediction tool. In order to monitor and validate the Galileo SIS performance for Open Service (OS) and Safety Of Life services (SOL) regarding the key performance parameters, different analyses in the SIS domain and User domain are considered. In the SIS domain, the validation of Signal-in-Space Accuracy SISA and Signal-in-Space Monitoring Accuracy SISMA is performed. For this purpose first of all an independent OD&TS and Integrity determination and processing software is developed to generate the key reference performance parameters named as SISRE (Signal In Space Reference Errors) and related over-bounding statistical information SISRA (Signal In Space Reference Accuracy) based on raw measurements from independent sites (e.g. IGS), Galileo Ground Sensor Stations (GSS) or an own regional monitoring network. Secondly, the differences of orbits and satellite clock corrections between Galileo broadcast ephemeris and the precise reference ephemeris generated by GalTeC will also be compared to check the SIS accuracy. Thirdly, in the user domain, SIS based navigation solution PVT on reference sites using Galileo broadcast ephemeris and the precise ephemeris generated by GalTeC are also used to check key performance parameters. In order to demonstrate the GalTeC performance and the methods mentioned above, the paper presents an initial test result using GPS raw data and GPS broadcast ephemeris. In the tests, some Galileo typical performance parameters are used for GPS system. For example, the maximum URA for one day for one GPS satellite from GPS broadcast ephemeris is used as substitution of SISA to check GPS ephemeris accuracy. Using GalTeC OD&TS and GPS raw data from IGS reference sites, a 10 cm-level of precise orbit determination can be reached. Based on these precise GPS orbits from GalTeC, monitoring and validation of GPS performance can be achieved with a high confidence level. It can be concluded that one of the GalTeC missions is to provide the capability to assess Galileo and general GNSS performance and prediction methods based on a regional and global monitoring networks. Some capability, of which first results are shown in the paper, will be demonstrated further during the planned Galileo IOV phase, the Full Galileo constellation phase and for the different services particularly the Open Services and the Safety Of Life services based on the Galileo Integrity concept.

• 한국자기학회:학술대회 개요집
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• 한국자기학회 2007년도 The 1st International Symposium on Advanced Magnetic Materials
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• pp.170.2-170.2
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• 2007

• 한국IT서비스학회:학술대회논문집
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• 한국IT서비스학회 2003년도 춘계학술대회
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• pp.647-664
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• 2003

[ $\circ$ ] Enterprise architecture is essential for ROI of e-Enterprise. $\circ$ An architecture is described from business, application, data and technical views and these must be complete and consistent. $\circ$ UML-based CBD is currently the best approach to obtaining architecture-centric, flexible and interoperable systems. $\circt$ Reuse of architecture, components, shared services and app frameworks is key to achieving both quality and productivity. $\circ$ Web service, the NBT, cannot be tapped without the architecting capability. $\circ$ Architects with world-class domain as well as software engineering knowledge are key to success of Korean software industry.

• Molecules and Cells
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• 제37권7호
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• pp.526-531
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• 2014

Human PARP family consists of 17 members of which PARP-1 is a prominent member and plays a key role in DNA repair pathways. It has an N-terminal DNA-binding domain (DBD) encompassing the nuclear localisation signal (NLS), central automodification domain and C-terminal catalytic domain. PARP-1 accounts for majority of poly-(ADP-ribose) polymer synthesis that upon binding to numerous proteins including PARP itself modulates their activity. Reduced PARP-1 activity in ageing human samples and its deficiency leading to telomere shortening has been reported. Hence for cell survival, maintenance of genomic integrity and longevity presence of intact PARP-1 in the nucleus is paramount. Although localisation of full-length and truncated PARP-1 in PARP-1 proficient cells is well documented, subcellular distribution of PARP-1 fragments in the absence of endogenous PARP-1 is not known. Here we report the differential localisation of PARP-1 Nterminal fragment encompassing NLS in PARP-$1^{+/+}$ and PARP-$1^{-/-}$ mouse embryo fibroblasts by live imaging of cells transiently expressing EGFP tagged fragment. In PARP-$1^{+/+}$ cells the fragment localises to the nuclei presenting a granular pattern. Furthermore, it is densely packaged in the midsections of the nucleus. In contrast, the fragment localises exclusively to the cytoplasm in PARP-$1^{-/-}$ cells. Flourescence intensity analysis further confirmed this observation indicating that the N-terminal fragment requires endogenous PARP-1 for its nuclear transport. Our study illustrates the trafficking role of PARP-1 independently of its enzymatic activity and highlights the possibility that full-length PARP-1 may play a key role in the nuclear transport of its siblings and other molecules.

• ETRI Journal
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• 제37권4호
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• pp.696-706
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• 2015

This paper presents an achievable secure videoconferencing system based on quantum key encryption in which key management can be directly applied and embedded in a server/client videoconferencing model using, for example, OpenMeeting. A secure key management methodology is proposed to ensure both a trusted quantum network and a secure videoconferencing system. The proposed methodology presents architecture on how to share secret keys between key management servers and distant parties in a secure domain without transmitting any secrets over insecure channels. The advantages of the proposed secure key management methodology overcome the limitations of quantum point-to-point key sharing by simultaneously distributing keys to multiple users; thus, it makes quantum cryptography a more practical and secure solution. The time required for the encryption and decryption may cause a few seconds delay in video transmission, but this proposed method protects against adversary attacks.

• BMB Reports
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• 제49권3호
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• pp.159-166
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• 2016

Several members of tumor necrosis factor receptor (TNFR) superfamily that these members activate caspase-8 from death-inducing signaling complex (DISC) in TNF ligand-receptor signal transduction have been identified. In the extrinsic pathway, apoptotic signal transduction is induced in death domain (DD) superfamily; it consists of a hexahelical bundle that contains 80 amino acids. The DD superfamily includes about 100 members that belong to four subfamilies: death domain (DD), caspase recruitment domain (CARD), pyrin domain (PYD), and death effector domain (DED). This superfamily contains key building blocks: with these blocks, multimeric complexes are formed through homotypic interactions. Furthermore, each DD-binding event occurs exclusively. The DD superfamily regulates the balance between death and survival of cells. In this study, the structures, functions, and unique features of DD superfamily members are compared with their complexes. By elucidating structural insights of DD superfamily members, we investigate the interaction mechanisms of DD domains; these domains are involved in TNF ligand-receptor signaling. These DD superfamily members play a pivotal role in the development of more specific treatments of cancer.