• Proceedings of the KSME Conference
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• 2001.11b
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• pp.499-504
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• 2001

A validation of a 3D CFD model for predicting local subcooling of moderator in the vicinity of calandria tubes in a CANDU reactor is performed. The small scale moderator experiments performed at Sheridan Park Experimental Laboratory(SPEL) in Ontario, Canada[1] is used for the validation. Also a comparison is made between previous CFD analyses based on 2DMOTH and PHOENICS, and the current model analysis for the same SPEL experiment. For the current model, a set of grid structures for the same geometry as the experimental test section is generated and the momentum, heat and continuity equations are solved by CFX-4.3, a CFD code developed by AEA technology. The matrix of calandria tubes is simplified by the porous media approach. The standard $k-\varepsilon$ turbulence model associated with logarithmic wall treatment and SIMPLEC algorithm on the body fitted grid are used and buoyancy effects are accounted for by the Boussinesq approximation. For the test conditions simulated in this study, the flow pattern identified is a buoyancy-dominated flow, which is generated by the interaction between the dominant buoyancy force by heating and inertial momentum forces by the inlet jets. As a result, the current CFD moderator analysis model predicts the moderator temperature reasonably, and the maximum error against the experimental data is kept at less than $2.0^{\circ}C$ over the whole domain. The simulated velocity field matches with the visualization of SPEL experiments quite well.

• 한국터널공학회:학술대회논문집
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• 2005.04a
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• pp.233-247
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• 2005

Most tunnel lining material which has been used in the domestic is a concrete. But many problems as the construction period, the cost, and the crack occurrence for the design, construction, and management were happened in the concrete lining. For this reason, many research institutes like the Korea Highway Corporation recognize the necessity of an alternate material development and grow on the interest for that. So in this study, the seismic behaviour characteristics for the application of the Corrugated Steel Plate Lining in cut-and-cover tunnel are evaluated as several conditions for the backfill height, the cutting slope, and the relative density of backfill soil are changed. The compressive stress which is calculated in the Corrugated Steel Plate Lining by the seismic load is decreased as the backfill height increases and the cut slope grows gentle. Also, the moment shows the tendency of decrease according to the increase of the backfill height. But in the case of the relative density of the backfill soil is small, the moment increases according to the increase of the backfill height and affects the dynamic behaviour characteristic. So it is considered that the relative density of the backfill soil is also the important point. As the result in analyzing the seismic response characteristics of the reinforcement spacing of the Corrugated Steel Plate, the variation in the compressive force is hardly happened, but the moment and the shear force increase on the reinforcement spacing being narrow.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.17
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• pp.7467-7471
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• 2014

SCY1-like 1-binding protein 1 (SCYL1BP1) is a newly identified transcriptional activator domain containing protein with many unknown biological functions. Recently emerging evidence has revealed that it is a novel regulator of the p53 pathway, which is very important for the development of human cancer. However, the effects of SCYL1BP1 on human lung squamous carcinoma cell biological behavior remain poorly understood. In this study, we present evidence that SCYL1BP1 can promote the degradation of MDM2 protein and further inhibit the G1/S transition of lung squamous carcinoma cell lines. Functional assays found that reintroduction of SCYL1BP1 into lung squamous carcinoma cell lines significantly inhibited cell proliferation, migration, invasion and tumor formation in nude mice, suggesting strong tumor suppressive function of SCYL1BP1 in lung squamous carcinoma. Taken together, our data suggest that the interaction of SCYL1BP1/MDM2 could accelerate MDM2 degradation, and may function as an important tumor suppressor in lung squamous carcinomas.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.22 no.4
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• pp.248-257
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• 2010

Applicability of the MIKE21 model as a real time coupled tide-surge model is examined prior to the application as an inundation model. Though the model domain contains the whole southern coasts of Korean Peninsula, the results of tide simulations show good agreement with the observed values. Moreover, the coupled tide-surge model simulates water levels well, especially near the sites which typhoon MAEMI(0314) struck, such as at Tongyung, Masan and Pusan. In addition, it is confirmed that the interaction between storm surge and tide is notable where the water depth is small and the tidal range is large, which indicates the necessity of coupled model especially at the southwestern coast.

• Journal of Educational Research in Mathematics
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• v.15 no.4
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• pp.461-488
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• 2005

This article presents new perspectives for classification of students' mathematical errors on the basis of experiential structuralism. Experiential structuralism's mechanism gives us new insights on mathematical errors. The hard core of mechanism is consist of 6 autonomous capacity spheres that are responsible for the representation and processing of different reality domains. There are specific forces that are responsible for this organization of mind. There are expressed in terms of a set of five organizational principles. Classification of mathematical errors is ascribed by the theory to the interaction between the 6 autonomous capacity spheres. Different types of classification require different autonomous capacity spheres. We can classify mathematical errors in the domain of linear function problem solving comparing cognitive psychological mechanism of experiential structuralism.

• Asian-Australasian Journal of Animal Sciences
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• v.25 no.8
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• pp.1184-1189
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• 2012

White spot syndrome virus (WSSV) is one of the major viral pathogens affecting shrimp aquaculture. Four proteins, WSSV199, WSSV 222, WSSV 249 and WSSV 403, from WSSV are predicted to encode a RING-H2 domain, which in presence of ubiquitin conjugating enzyme (E2) in shrimp can function as viral E3 ligase and modulate the host ubiquitin proteasome pathway. Modulation of host ubiquitin proteasome pathway by viral proteins is implicated in viral pathogenesis. In the present study, a time course expression profile analysis of WSSV Open Reading Frame (ORF) 199 and Penaeus monodon ubiquitin conjugating enzyme (PmUbc) was carried out at 0, 3, 6, 12, 24, 48 and 72 h post WSSV challenge by semi-quantitative RT-PCR as well as Real Time PCR. EF1${\alpha}$ was used as reference control to normalize the expression levels. A significant increase in PmUbc expression at 24 h post infection (h.p.i) was observed followed by a decline till 72 h.p.i. Expression of WSSV199 was observed at 24 h.p.i in WSSV infected P. monodon. Since the up-regulation of PmUbc was observed at 24 h.p.i where WSSV199 expression was detected, it can be speculated that these proteins might interact with host ubiquitination pathway for viral pathogenesis. However, further studies need to be carried out to unfold the molecular mechanism of interaction between host and virus to devise efficient control strategies for this chaos in the shrimp culture industry.

• BMB Reports
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• v.34 no.4
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• pp.355-364
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• 2001

Major human Nucleoside diphosphate kinases (NDPKs) exist as hetero-oligomers, consisting of NDPK-A and NDPK-B, rather than homo-oligomer. To investigate their biological function depending on the oligomeric structure in vivo, we characterized the biochemical properties of cellular NDPK. Cellular NDPKs, which are made up of a unique combination of isoforms, were purified from human erythrocyte and placenta. We found that cellular NDPK and recombinant isoforms NDPKs have their own distinct biochemical properties in autophosphorylation, stability toward heat or urea, and DNA binding. Cellular NDPK was found to have unique characteristics rather than the expected additive properties of recombinant isoforms. The mutations in the dimeric interface of NDPK-B (R34G, N69H or K135L) caused defective DNA binding and simultaneously reduced the enzymatic stability These results suggest that the oligomeric interaction could play a major role in the stability of catalytic domain and might be related to the regulation of various cellular functions of NDPK.

• Biomedical Science Letters
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• v.9 no.3
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• pp.159-165
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• 2003

Ankyrins are a ubiquitously expressed family of intracellular adaptor proteins involved in targeting diverse proteins to specialized membrane domains in both the plasma membrane and the endoplasmic reticulum. Recently, the studies with C-terminus of ankyrins have identified that ankyrin-B is capable of interacting with Hsp40 and sAnkl is capable of interacting with obscurin and titin, but the function of C-terminal domain of ankyrin-G remains unknown. To identify proteins interacting C-terminus of ankyrin-G, we used the C-terminus of ankyrin-G as a bait for a yeast two-hybrid screen of brain cDNA library. Approximately 1.33$\times$l0$^6$ transformants were screened, of which 13 positive clones were obtained as determined by activation of HIS3, ADE2 and MELl reporter genes. Sequence analyses of these 13 plasmids revealed that cDNA inserts of 13 colonies showed highly homologous to 11 genes, including 5 known (i.e., Na$^+$/K$^+$ ATPase $\beta$1, SERBPl, UTF2, cytochrome C oxidase and collagen IV $\alpha$2) and 6 unknown genes. The evaluation of the proteins that emerge from these experiments provides a rational approach to investigate the those proteins significant in interaction with ankyrin-G.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.27 no.9
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• pp.1209-1219
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• 2003

The dynamic behaviors of the single vortex interacting with $CH_4-Air$ jet diffusion flame are investigated numerically. The numerical method is based on a predict-corrector scheme for a low Mach number flow. A two-step global reaction mechanism is adopted as a combustion model. Studies are conducted in fixed initial velocities for the three cases according as where $CO_2$ is added; (1) without dilution, (2) dilution in fuel stream and (3) dilution in oxidizer stream. A single vortex is generated by an axisymmetric jet, which is made by an impulse of a cold fuel when a flame is developed entirely in a computational domain. The simulation shows that $CO_2$ dilution in fuel stream results in somewhat larger vortex radius, and greater amount of entrainment of surrounding fluid than in other cases. Thus, the dilution of $CO_2$ in fuel stream enhances the mixing in single vortex and increases the stretching of the flame surface. The budgets of the vorticity transport equation are examined to reveal the mechanism of vortex formation when $CO_2$ is added. It is found that, in the case of $CO_2$ dilution in fuel stream, the vortex destruction due to volumetric expansion and the vortex production due to baroclinic torque are more dominant than in other cases.

• Proceedings of the Korean Vacuum Society Conference
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• 2014.02a
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• pp.114.1-114.1
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• 2014

Copper is considered to be the most promising substrate for the growth of high-quality and large area graphene by chemical vapor deposition (CVD), in particular, on the (111) facet. Because the interactions between graphene and Cu substrates influence the orientation, quality, and properties of the synthesized graphene, we studied the interactions using angle-resolved photoemission spectroscopy. The evolution of both the Shockley surface state of the Cu(111) and the p band of the graphene was measured from the initial stage of CVD growth to the formation of a monolayer. Graphene growth was initiated along the Cu(111) lattice, where the Dirac band crossed the Fermi energy ($E_F$) at the K point without hybridization with the d-band of Cu. Then two rotated domains were additionally grown as the area covered with graphene became wider. The Dirac energy was about 0.4 eV and the energy of the Shockley surface state of Cu(111) shifted toward the $E_F$) by 0.15 eV upon graphene formation. These results indicate weak interactions between graphene and Cu, and that the electron transfer is limited to that between the Shockley surface state of Cu(111) and the p band of graphene. This weak interaction and slight lattice mismatch between graphene and Cu resulted in the growth of rotated graphene domains ($9.6^{\circ}$ and $8.4^{\circ}$), which showed no significant differences in the Dirac band with respect to different orientations. These rotated graphene domains resulted in grain boundaries which would hinder a large-sized single monolayer growth on Cu substrates.