• Interdisciplinary Bio Central
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• v.4 no.1
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• pp.1.1-1.7
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• 2012

Background: The F-box proteins represent one of the largest families of proteins in eukaryotes. Apart from being a component of the ubiquitin (Ub)/26 S proteasome pathways, their regulatory roles in other cellular and developmental pathways have also been reported. One interesting feature of the genes encoding the proteins of this particular family is their variable selection patterns across different lineages. This resulted in the presence of lineage specific F-box proteins across different species. Findings: In this study, 48 non-redundant F-box proteins in E. siliculosus have been identified by a homology based approach and classified into three classes based on their variable C-terminal domains. A greater number of the F-box proteins have domains similar to the ones identified in other species. On the other hand, when the proteins having unknown or no C-terminal domain (as predicted by InterProScan) were analyzed, it was found that some of them have the polyglutamine repeats. To gain evolutionary insights on the genes encoding the F-box proteins, their selection patterns were analyzed and a strong positive selection was observed which indicated the adaptation potential of the members of this family. Moreover, four lineage specific F-box genes were found in E. siliculosus with no identified homolog in any other species. Conclusions: This study describes a genome wide in silico analysis of the F-box proteins in E. siliculosus which sheds light on their evolutionary patterns. The results presented in this study provide a strong foundation to select candidate sequences for future functional analysis.

• Journal of Korean Academy of Nursing
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• v.45 no.3
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• pp.439-448
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• 2015

Purpose: The purpose of this study was to examine validity and reliability of Webel and colleagues'HIV Self-Management Scale when used with a Korean sample. Methods: The original 20-item HIV Self-Management Scale was translated into Korean using translation and back-translation. Nine HIV nurse experts tested content validity. Principal component analysis (PCA) and confirmatory factor analysis (CFA) of data from 203 patients was used to test construct validity. Concurrent validity was evaluated using correlation with patients'self-rating as a "mart patient"measured using a visual analogue scale. Internal consistency was tested by Cronbach' alpha coefficients. Results: All items were rated as having satisfactory content validity. Based on PCA and consideration of conceptual meaning, a three-factor solution was selected, explaining 48.76% of the variance. CFA demonstrated the adequacy of the three-domain structure of the construct HIV self-management: daily self-management health practices, social support and HIV self-management, and chronic nature of HIV self-management. Goodness-of-fit indices showed an acceptable fit overall with the full model (${\chi}^2/df_{(164)}=1.66$, RMSEA=0.06, SRMR=0.05, TLI=0.91, and CFI=0.92). The Korean version of the HIV Self-Management Scale (KHSMS) was significantly correlated with patients'self-rated smart patient (r=.41). The subscale Cronbach' alpha coefficients ranged from .78 to .81; alpha for the total scale was .89. Conclusion: The KHSMS provides a valid and reliable measure of self-management in Korean patients with HIV. Continued psychometric testing is recommended to provide further evidence of validity with this population.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.14 no.4
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• pp.113-120
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• 2014

In this paper, we examine Asymmetric Multi-Processing Environment to provide LDW service. Asymmetric Multi-Processing Environment consists of high-speed MCU to support rapid image processing and low-speed MCU for controlling with other ECU at the control domain. Also we designed rapid image process application and LDW application Software Component(SW-C) according to the development process rule of AUTOSAR. To communicate between two MCUs, timer based polling based IPC was designed. Also to communicate with other ECUs(Electronic Control Units), we designed CAN messages to provide alarm information and receiving CAN message to catch the Turn signal. We confirm the possibility of the various ADAS development using an Asymmetric Multi-Processing Environment and AUTOSAR platform. We also expect providing ISO 26262 functional safety.

• Journal of the Society of Naval Architects of Korea
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• v.54 no.3
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• pp.227-241
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• 2017

In this study, a Volterra system for the variations of metacentric height (GM) in waves is employed to simulate the parametric roll phenomena of ships in head sea condition. Using the present Volterra system, the transfer function of each harmonic component in the GM variation is computed for different ship models, including mathematical models and a real containership, and the results are validated through the comparison with the values obtained using the direct calculations based on a weakly nonlinear time-domain method. Then, a semi-analytic approach employing a 1-degree of freedom equation for roll motion is developed to simulate the parametric roll motions in irregular waves. In the derived approach, the nonlinear and time-varying restoring forces in the waves are approximated using the Volterra system. Through simulations of the parametric roll for different sea states, the effects of the 1st and 2nd-order harmonic components of the variations in the occurrence and amplitude of the parametric roll motions are investigated. Because of the strong nonlinearities in the phenomena, a stochastic analysis is conducted to examine the statistical properties of the roll motions in consideration of the sensitivities and uncertainties in the computations.

• Atmosphere
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• v.25 no.1
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• pp.67-83
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• 2015

Predicting the location and intensity of precipitation still remains a main issue in numerical weather prediction (NWP). Resolution is a very important component of precipitation forecasts in NWP. Compared with a lower resolution model, a higher resolution model can predict small scale (i.e., storm scale) precipitation and depict convection structures more precisely. In addition, an ensemble technique can be used to improve the precipitation forecast because it can estimate uncertainties associated with forecasts. Therefore, NWP using both a higher resolution model and ensemble technique is expected to represent inherent uncertainties of convective scale motion better and lead to improved forecasts. In this study, the limited area ensemble prediction system for the convective-scale (i.e., high resolution) operational Unified Model (UM) in Korea Meteorological Administration (KMA) was developed and evaluated for the ensemble forecasts during August 2012. The model domain covers the limited area over the Korean Peninsula. The high resolution limited area ensemble prediction system developed showed good skill in predicting precipitation, wind, and temperature at the surface as well as meteorological variables at 500 and 850 hPa. To investigate which combination of horizontal resolution and ensemble member is most skillful, the system was run with three different horizontal resolutions (1.5, 2, and 3 km) and ensemble members (8, 12, and 16), and the forecasts from the experiments were evaluated. To assess the quantitative precipitation forecast (QPF) skill of the system, the precipitation forecasts for two heavy rainfall cases during the study period were analyzed using the Fractions Skill Score (FSS) and Probability Matching (PM) method. The PM method was effective in representing the intensity of precipitation and the FSS was effective in verifying the precipitation forecast for the high resolution limited area ensemble prediction system in KMA.

• Advances in aircraft and spacecraft science
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• v.3 no.4
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• pp.427-445
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• 2016

Star sensors are the attitude estimation sensors of the satellite orbiting in its path. It gives information to the control station on the earth about where the satellite is heading towards. It captures the images of a predetermined reference star. By comparing this image with that of the one captured from the earth, exact position of the satellite is determined. In the process of imaging, stray lights are eliminated from reaching the optic lens by the mechanical enclosures of the star sensors called Baffles. Research in space domain in the last few years is mainly focused on increased payload capacity and reduction in launch cost. In this paper, a star sensor baffle made of Aluminium is considered for the study. In order to minimize the component weight, material wastage and to improve the structural performance, an alternate material to Aluminium is investigated. Carbon Fiber Reinforced Polymer is found to be a better substitute in this regard. Design optimisation studies are carried out by adopting suitable design modifications like implementing an additional L-shaped flange, Upward flange projections, downward flange projections etc. A better configuration of the baffle, satisfying the design requirements and achieving manufacturing feasibility is attained. Geometrical modeling of the baffle is done by using UNIGRAPHICS-Nx7.5(R). Structural behavior of the baffle is analysed by FE analysis such as normal mode analysis, linear static analysis, and linear buckling analysis using MSC/PATRAN(R), MSC-NASTRAN(R) as the solver to validate the stiffness, strength and stability requirements respectively. Effect of the layup sequence and the fiber orientation angle of the composite layup on the stiffness are also studied.

• Journal of Korean Society for Atmospheric Environment
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• v.20 no.5
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• pp.633-645
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• 2004

A critical component of air pollution modeling is the representation of meteorological fields within a model domain, since an accurate air quality simulation requires an accurate portrayal of the three-dimensional wind fields. The present study investigated data assimilation using surface observational data in the complex coastal regions to simulate an accurate meteorological fields. Surface observational data were categorized into three groups(Near coastal region, Far coastal regiln 1, Far costal region 2) by the locations where the data are. Experiments were designed and MM5 was used in each case of regions. Case 1 is an experiment without data assimilation, Case N is executed with data assimilation using observational data by meteorological stations and AWS data located in the near coastal region, within 1 km. Case F1 is also an experiment with data assimilation using observational data by meteorological stations and AWS data located in the far coastal regiln 1, more than 1km and less than 5km from the coastal lines. Case F2 is appled to data assimilation using observational data by meteorological stations and AWS data located in the far coastal region 2, beyond 5km from the coastal lines. The result of this study indicated that data assimilation using data in the far coastal region 1 and 2 provided an attractive method for generating accurate meteorological fields, especially in the complex coastal regions.

• Proceedings of the Korean Society of Developmental Biology Conference
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• 2003.10a
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• pp.24-25
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• 2003

The zebrafish (Danio rerio) is now the pre-eminent vertebrate model system for clarification of the roles of specific genes and signaling pathways in development. I will talk about positional cloning of two developmental mutants in zebrafish. The first mutant is headless: The vertebrate organizer can induce a complete body axis when transplanted to the ventral side of a host embryo by virtue of its distinct head and trunk inducing properties. Wingless/Wntantagonists secreted by the organizer have been identified as head inducers. Their ectopic expression can promote head formation, whereas ectopic activation of Wnt signalling during early gastrulation blocks head formation. These observations suggest that the ability of head inducers to inhibit Wntsignalling during formation of anterior structures is what distinguishes them from trunk inducers that permit the operation of posteriorizing Wnt signals. I describe the zebrafish headless (hdl) mutant and show that its severe head defects are due to a mutation in T-cell factor-3 (Tcf3), a member of the Tcf/Lef family. Loss of Tcf3 function in the hdl mutant reveals that hdl represses Wnt target genes. I provide genetic evidence that a component of the Wntsignalling pathway is essential in vertebrate head formation and patterning. Second mutant is mind bomb: Lateral inhibition, mediated by Notch signaling, leads to the selection of cells that are permitted to become neurons within domains defined by proneuralgene expression. Reduced lateral inhibition in zebrafish mib mutant embryos permits too many neural progenitors to differentiate as neurons. Positional cloning of mib revealed that it is a gene in the Notch pathway that encodes a RING ubiquitin ligase. Mib interacts with the intracellular domain of Delta to promote its ubiquitylation and internalization. Cell transplantation studies suggest that mib function is essential in the signaling cell for efficient activation of Notch in neighboring cells. (중략)

• Journal of the Korea Convergence Society
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• v.4 no.2
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• pp.21-27
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• 2013

Spot welding is automation of assembly process, without increasing the vehicle weight and economy, there is a fuel economy improvement of motor vehicles and to widely used in the automotive industry. But By irregular load from the road surface while at the vehicle is running, stress concentration occurs in the weld point, fatigue failure occurs frequently. Considering change of stiffness is the essential fatigue life of the evaluation spot weld. In this paper, by performing a linear static analysis was to understand the vulnerable part. Acquire to the fatigue properties of the spot weld, take the load history of the three levels in the time domain, was performed by setting as a condition of quasi-static fatigue analysis. and Fatigue life prediction method of the spot weld was by applying the method according to the fatigue damage accumulation and the conventional method was compared analyzed with the results shown.

• Journal of Gastric Cancer
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• v.15 no.3
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• pp.201-208
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• 2015

Purpose: The AT-rich interactive domain 1A (ARID1A ) gene encodes BRG1-associated factor 250a, a component of the SWItch/Sucrose NonFermentable chromatin remodeling complex, which is considered a tumor suppressor in many tumors. We aimed to investigate the prognostic significance of ARID1A expression in gastric cancers and explore its relationship with clinicopathologic parameters such as mismatch repair protein expression. Materials and Methods: Four tissue microarrays were constructed from 191 resected specimens obtained at Soonchunhyang University Cheonan Hospital from 2006 to 2008. Nuclear expression of ARID1A was semiquantitatively assessed and binarized into retained and lost expression. Results: Loss of ARID1A expression was observed in 62 cases (32.5%). This was associated with more frequent vascular invasion (P=0.019) and location in the upper third of the stomach (P=0.001), and trended toward more poorly differentiated subtypes (P=0.054). ARID1A loss was significantly associated with the mismatch repair-deficient phenotype (P=0.003). ARID1A loss showed a statistically significant correlation with loss of MLH1 (P=0.001) but not MSH2 expression (P=1.000). Kaplan-Meier survival analysis showed no statistically significant difference in overall survival; however, patients with retained ARID1A expression tended to have better overall survival than those with loss of ARID1A expression (P=0.053). In both mismatch repair-deficient and mismatch repair-proficient groups, survival analysis showed no differences related to ARID1A expression status. Conclusions: Our results demonstrated that loss of ARID1A expression is closely associated with the mismatch repair-deficient phenotype, especially in sporadic microsatellite instability-high gastric cancers.