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Interictal rCBF SPECT, MRI and Surgical Outcome of Intractable Temporal Lobe Epilepsy (난치성 측두엽간질의 발작간 뇌혈류 SPECT, MRI와 수술성과 비교)

  • Zeon, Seok-Kil;Joo, Yang-Goo;Lee, Sang-Doe;Son, Eun-Ik;Lee, Young-Hwan
    • The Korean Journal of Nuclear Medicine
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    • v.28 no.3
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    • pp.307-312
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    • 1994
  • Interictal single photon emission computed tomography of regional cerebral blood flow (rCBF SPECT) in 18 intractable temporal lobe epilepsy patients(8 male and 10 female patients: average 23.5 years old) were compared with 2.0 T magnetic resonance imaging (MRI). And surgical outcome was analysed with the findings, symptom duration and lateralization of temporal lobe. Preoperatively rCBF SPECT was done in all 18 patients with intravenous injection of 740 MBq 99mTc-HMPAO. MRI was also done preoperatively in 13 patients. Surgical outcome was classified by Engel's outcome classification(four-part classification recommended at the first Palm Desert conference). rCBF SPECT detected correctly lateralising abnormality of temporal lobe hypoperfusion in 13/18(72.2%), contralateral temporal lobe hypoperfusion in 2/18(11.1%) and showed no def-inite abnormality in 3/18(16.7%). The positive predictive value of unilateral temporal lobe hypoperfusion was 87%. MRI detected correct localising abnormality in 8/13(61.5%), such as hippocampal atrophy(7/13), asymmetric temporal horn(6/13), anterior temporal lobe atrophy(1/13), increased signal intensity from hippocampus(1/13) and calcific density(1/13), and no abnormal finding was noted in 5/13(38.5%). There was no false positive findings and the positive predictive value of MRI was 100%. Only 2 cases showed same lateralization findings in rCBF SPECT and MRI. There was no significant correlation between symptom duration and no abnormal findings on SPECT or MRI. Surgical outcome showed class I in 15/18(83.3%), and class II in 2/18(11.1%). One case of no abnormal finding in both SPECT and MRI showed class III surgical outcome. No class IV surgical outcome was noted. Surgical outcome, lateralization of epileptic focus in temporal lobe and abnormal findings in rCBR SPECT or MRI were not significantly correlated.

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Comparison of Magnesium Hydroxide Particles by Precipitation and Hydrothermal Treatment for Flame Retardant Application to Low Density Polyethylene and Ethylene-Co-Vinyl Acetate Resin (침전법과 수열처리로 제조된 수산화마그네슘 비교와 이의 저밀도 폴리에틸렌-에틸렌 비닐 아세테이트 수지 난연제 적용)

  • Hyun, Mi Kyung;Lim, Hyung Mi;Yoon, Joonho;Lee, Dong Jin;Lee, Seung-Ho;Whang, Chin Myung;Jeong, Sang Ok
    • Applied Chemistry for Engineering
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    • v.20 no.2
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    • pp.234-240
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    • 2009
  • $Mg(OH)_2$ particles were prepared by precipitation and a hydrothermal treatment to examine the effect of $MgCl_2$ concentration, alkali type and concentration, temperature, hydrothermal treatment on the formation of $Mg(OH)_2$ particles using full factorial design, as one of DOE (Design of experiment) methods. The primary particle size is similar to the secondary particle size for the samples after the hydrothermal treatment, where the average particle size of $Mg(OH)_2$ increased with increasing the concentration of $MgCl_2$ and hydrothermal temperature and decreasing alkali/Mg molar ratio. On the other hand, for the samples prepared from precipitation, the secondary particle size is larger than the primary particles due to aggregation. The difference in alkaline source is that the particles prepared from $NH_4OH$ exhibit the larger size with better dispersion than those from NaOH. Low density polyethylene and ethylene-co-vinyl acetate (LDPE-EVA) resin composed of the smaller secondary particle size of $Mg(OH)_2$ shows a higher limited oxygen index (LOI) at 50 and 55% loading, but the smaller primary particle size may result in a better grade in UL-94 tests. At the high loading of 60%, all samples with any preparation methods exhibit V-0 grade but the LOI value depends on not only primary particle size but also dispersion state.

Process Optimization of PECVD SiO2 Thin Film Using SiH4/O2 Gas Mixture

  • Ha, Tae-Min;Son, Seung-Nam;Lee, Jun-Yong;Hong, Sang-Jeen
    • Proceedings of the Korean Vacuum Society Conference
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    • 2012.02a
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    • pp.434-435
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    • 2012
  • Plasma enhanced chemical vapor deposition (PECVD) silicon dioxide thin films have many applications in semiconductor manufacturing such as inter-level dielectric and gate dielectric metal oxide semiconductor field effect transistors (MOSFETs). Fundamental chemical reaction for the formation of SiO2 includes SiH4 and O2, but mixture of SiH4 and N2O is preferable because of lower hydrogen concentration in the deposited film [1]. It is also known that binding energy of N-N is higher than that of N-O, so the particle generation by molecular reaction can be reduced by reducing reactive nitrogen during the deposition process. However, nitrous oxide (N2O) gives rise to nitric oxide (NO) on reaction with oxygen atoms, which in turn reacts with ozone. NO became a greenhouse gas which is naturally occurred regulating of stratospheric ozone. In fact, it takes global warming effect about 300 times higher than carbon dioxide (CO2). Industries regard that N2O is inevitable for their device fabrication; however, it is worthwhile to develop a marginable nitrous oxide free process for university lab classes considering educational and environmental purpose. In this paper, we developed environmental friendly and material cost efficient SiO2 deposition process by substituting N2O with O2 targeting university hands-on laboratory course. Experiment was performed by two level statistical design of experiment (DOE) with three process parameters including RF power, susceptor temperature, and oxygen gas flow. Responses of interests to optimize the process were deposition rate, film uniformity, surface roughness, and electrical dielectric property. We observed some power like particle formation on wafer in some experiment, and we postulate that the thermal and electrical energy to dissociate gas molecule was relatively lower than other runs. However, we were able to find a marginable process region with less than 3% uniformity requirement in our process optimization goal. Surface roughness measured by atomic force microscopy (AFM) presented some evidence of the agglomeration of silane related particles, and the result was still satisfactory for the purpose of this research. This newly developed SiO2 deposition process is currently under verification with repeated experimental run on 4 inches wafer, and it will be adopted to Semiconductor Material and Process course offered in the Department of Electronic Engineering at Myongji University from spring semester in 2012.

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Electrochemical Generation of Chlorine Dioxide Using Polymer Ion Exchange Resin (고분자 이온교환수지를 이용한 의료.식품용 멸균제 이산화염소의 전기화학분해 발생)

  • Rho, Seung Baik;Kim, Sang Seob
    • Applied Chemistry for Engineering
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    • v.23 no.1
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    • pp.86-92
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    • 2012
  • A characteristic study of chlorine dioxide generation by the electrolysis system was performed after chlorite ($ClO_2^-$) is adsorbed from sodium chlorite by a polymer ion exchange resin. A strongly basic anion exchange resin was used and a Ti plate coated with Ru and Ir was used as an electrode. Various parameters such as reaction stirring velocity, reaction temperature, chlorine dioxide product concentration, ion exchange resin content and product maker type for the adsorption quantity in the chlorite adsorption of ion exchange resin were investigated and found the ion exchange resin with the maximum adsorption quantity. A generation trend of chlorine dioxide was observed by the electrolysis system and optimum conditions on the desired value were found using response surface design of DOE (Design of Experiments). The strongly basic anion exchange resin with the maximum adsorption quantity was SAR-20 (TRILITE Gel type II) and the adsorption quantity was around 110 mg/IER (g). Observed generation optimum conditions of chlorine dioxide were constant-current (electrode area base; $A/dm^2$) and flow rate of $N_2$ gas (4.7 L/min) at the desired value of sterilization (900~1000 ppm, 1 h).

THE EFFECTS OF TOPICAL CITRIC ACID AND FIBRIN APPLICATIONS ON THE PERIODONTAL REGENERATION OF EXPERIMENTAL DEFECTS IN DOGS (구연산과 섬유소의 치근면 도포가 성견 치주조직 재생에 미치는 영향)

  • Kim, Doe-Gyeun;Park, Jae-Wan;Lee, Jae-Mok;Suh, Jo-Young
    • Journal of Periodontal and Implant Science
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    • v.24 no.1
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    • pp.26-38
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    • 1994
  • The purpose of this study was to evaluate the effects of citric acid and fibrin on the regeneration of periodontal tissues using 4 normal canines of five dogs. Mucoperiosteal flap was raised and experimental defects were made at the buccal root surfaces about $4{\times}6mm$ in length. The denuded root surfaces were covered using coronally repositioning technique after root planing alone at left lower canine, root planing plus fibrin at rigth lower canine, root planing plus citric acid at left upper canine or root planning plus citric acid and fibrin at right upper canine. All of the specimens were tangentially cut(about $3-5{\mu}m$)and available for histologic analysis 1, 3, 7, 14 and 21 days after operations. The results were as follows : At one' day after operations, the amounts of fibrin were similarly higher in the group I, II and III than control group and at 3 days after operations, the apical migrations of the long junctional epithelium were prominent in the control group and group I. At 7 days after operations, the fibrin meshworks of each group were partly changed to the collagen fibers and characteristics of the fibers were almost collagenous rather than fibrinous at 14 days after operations and at 21 days after operations, the orientation of collagen fibers were partly normal in group II and group III, but not in control group and group I. Root resorptions were visible in group II and group III at 14 days after operations and more significant in group II than group III at 21 days.

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The analysis of Change on Property and CO2 Emission Factor of Domestic Transportation Fuel from 2012 to 2015 (2012 ~ 2015년 국내 수송용 연료의 물성 및 CO2 배출계수의 변화추이 분석연구)

  • Kang, Hyungkyu;Doe, Jinwoo;Lim, Wanguy;Hwang, Inha;Ha, Jonghan;Na, Byungki
    • Journal of the Korean Applied Science and Technology
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    • v.33 no.4
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    • pp.855-863
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    • 2016
  • Most greenhouse gases were arisen from the generation and use of energy, more than about 95 % of greenhouse gas from the traffic section was resulted by the transportation fuels. Also, when using the $CO_2$ emission factor suggested at IPCC G/L, there was the weakness which did not reflect the own property of fuel by country. And most industrialized countries have applied with the $CO_2$ emission factor of Tier 2 or Tier 3 to make the national greenhouse report to submit to UN according to the Kyoto Protocol. In this study, the transportation fuels using in domestic like unleaded gasoline, diesel, etc were analysed to identify the physical/chemical properties and these data were used to calculate the $CO_2$ emission factor of each fuels. And the study analysed the time series analysis to compare the property of fuels according to the change of time.

Interrelationship of Matrix Metalloproteinase and $TNF-{\alpha}$ in Human Gingiva with Chronic Periodontitis associated to Type 2 Diabetes Mellitus (단순 만성 치주염 환자 및 2형 당뇨병을 가진 만성 치주염 환자의 치은조직에서 Matrix Metalloproteinase와 $TNF-{\alpha}$ 의 발현 양상 비교)

  • Kim, Doe-Heun;Park, Eei-Kyun;Shin, Hong-In;Cho, Je-Yeol;Suh, Jo-Young;Lee, Jae-Mok
    • Journal of Periodontal and Implant Science
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    • v.36 no.2
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    • pp.409-425
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    • 2006
  • 치주질환의 병원균은 세포벽의 항원에 의하여 조직내 존재하는 mononuclear phagocytes가 활성화되어 cytokine들이 생성됨 으로써 치주 결체조직의 파괴를 진행시킨다. 이런 관련된 cytokine들은 순차적으로 상주하는 치은세포 및 대식세포가 Matrix metalloproteinase 합성을 하도록 유도하여 조직파괴를 시작한다. 이들 Matrix metalloproteinase중 MMP-2, MMP-9 (Gelatinase A,B)는 type IV collagen 및 변성된 interstitial collagen을 파괴하며 치주환자의 치은 열구액, 치은조직, 타액 네에서 높게 보고 되어왔다. 당뇨병은 치주질환의 위험요소중 하나로 달뇨 환자에서는 치주질환의 유병율이 일반인에 비해 높고 치주질환의 중증도도 더 심하여 진행도 빠르다고 알려져 있다. 그 병리 기전 중 하나로는 당뇨 환자에서는 치은 열구액 내 중성구 유래의 Matrix metalloproteinase의 활성 증가 및$TNF-{\alpha}$ 의 활성 증가가 추정되고 있다. 본 실험에서는 제2형 당뇨병 환자와 비당뇨 환자들에서 만성 치주염 부위의 치은 및 건강한 치은에서 염증매개체 중 하나인 MMP-2, MMP-9 및 $TNF-{\alpha}$ 의 발현에 대해 상호 비교 분석함으로서 염증, 혈당이 미치는 영향을 밝히고 제 2형 당뇨병 환자에서 심한 치주조직 파괴의 기전을 연구하고자 하였다. 경북대학교병원 치주과 내원환자 중 제2형 당뇨병 환자와 비당뇨 환자들 및 치주질환이 없는 건강인 대조군을 대상으로 여러 가지 환자요소, 임상 치주상태를 기록하고, 전신적으로 건강한 환자의 건강한 부위(n=8,Group 1), 전신적으로 건강한 환자으 만성 치주염 부위(n=8, Group 2), 제2형 당뇨병 환자의 만성 치주염 부위 (n=8,Group 3)에서 각각 변연치은을 채득하고 액화질소에 급속 동결하였다. Western blotting을 이용하여 각 조직 내 MMP-2, MMP-9 및 $TNF-{\alpha}$ 의 발현을 관찰, densitometer를 이용하여 상대적 발현을 정량, 각 조직의${\beta}-actin$을 이용하여 표준화하여 실험군과 대조군들의 평균치를 비교하였다. 비당뇨 환자들의 만성 치주염 부위 및 제2형 당뇨병 환자의 만성 치주염 부위에서 모두 건강 대조군에 비해 MMP-2와 MMP-9 의 발현이 증가되었다. 또한 MMP-2와 MMP-9는 2형 당뇨 환자의 만성 치주염 부위가 비당뇨 환자의 만성 치주염 부위보다 증가된 발현양상을 보였으며, $TNF-{\alpha}$ 발현 비교시 각 군간 유의성 있는 변화는 없었으나 2형 당뇨환자군에서 MMP-2 및 MMP-9의 증가와 함께 다소 증가 양상을 보였다. 결론적으로 본 실험에서 MMP-2 및 MMP-9의 증가가 만성 치주염 및 2형 당뇨 환자에서의 만성치주염에서 비당뇨환자 보다 MMP-2, MMP-9의 증가양상을 보여 주었으며 $TNF-{\alpha}$ 가 2형 당뇨환자의 만성치주염 진행과정에 기여인자로써 역할을 하는 것으로 생각된다.

The Crosshole Resistivity Method Using the Mixed Array (혼합배열을 사용하는 시추공간 전기비저항 탐사)

  • Cho In-Ky;Han Sung-Hoon;Kim Ki-Ju
    • Geophysics and Geophysical Exploration
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    • v.5 no.4
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    • pp.250-256
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    • 2002
  • Resistivity tomography has become an important tool to image underground resistivity distribution. This method has been widely applied to site investigation for engineering and environmental purpose. In resistivity tomography, various electrode arrays can be used and each array has both merits and demerits. For example, the pole-pole array has high signal to noise ratio (S/N ratio), but its resolution is too low. The dipole-dipole array has low S/N ratio, but its resolution is very high. The Pole-dipole may has intermediate Snf ratio and resolution. The modified Pole-dipole array, recently proposed, shows reasonable S/N ratio and resolution, which are comparable to the pole-dipole array. These electrode arrays except the pole-pole array, however, have the problem that the apparent resistivity can diverge at some special electrode Positions. Also, the Pole-Pole array may not reflect the doe resistivity of an anomalous body. In this study, we propose a new electrode array, mixed array, where pole-dipole and modified pole-dipole ways are selectively used with the relative positions of current and potential electrodes. The mixed array has the same level of S/N ratio and resolution as the pole-dipole array and the apparent resistivity does not diverge in the receiver hole. Furthermore, the apparent resistivity using the array can reflect the true resistivity of the anomalous body.

Effects of University-Based Science Gifted Education Program on the Science Problem-Finding Ability and Cognitive-Affective Factors of Science Gifted Students (대학부설 과학영재교육 프로그램 참여 경험이 과학영재의 과학문제발견력과 정의적.인지적 특성에 미치는 중.장기적 효과)

  • Ahn, Doe-Hee;Han, Ki-Soon;Kim, Myung-Sook
    • Journal of Gifted/Talented Education
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    • v.19 no.2
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    • pp.279-302
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    • 2009
  • This paper was to examine the effects of university-based science gifted education program on scientifically gifted students' science problem finding ability and cognitive-affective factors. For this study, 69 scientifically gifted students with previous Silted education experiences at the university-based science gifted education centers and 91 scientifically gifted students without any previous gifted education experiences were compared. Both groups of students were currently enrolled at a specialized science high school. To compare both groups, scientific problem finding ability, science anxiety, science related attitude, self-efficacy, intrinsic motivation, test anxiety, cognitive strategies, and self-regulation were measured. The results indicate that there was no significant difference on scientific problem finding ability between these two groups. The comparison between the past and now in the aspects of variables observed in the study showed that both groups of students were decreased in the science anxiety and self-efficacy. But the test anxiety was significantly increased compared to the past in both groups. Implications of the study were discussed in depth.

A Comparative Study on Attitudes of Experts, Citizen and Visitors towards Busan Portscape (부산항 항만경관에 대한 전문가, 시민, 방문객 의식 비교연구)

  • Lee, Han-Seok;Doe, Geun-Young
    • Journal of Navigation and Port Research
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    • v.33 no.3
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    • pp.247-254
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    • 2009
  • This is a first and basic study for making Busan port more attractive. The study is intended to clear up the situation and problems of landscape of Busan port area from the viewpoint of landscape experts, citizen and visitors. To reach the goal an attitude comparative study has been conducted using a same questionnaire between landscape experts working in Busan city, Busan citizen and visitors to Busan port area. In questionnaire, firstly the situation of the whole landscape of Busan port area has been asked. The contents of questions on the situation of port landscape are satisfaction about port landscape, harmony between cityscape and portscape, images of portscape, effects of 25 portscape elements on portscape, problems of portscape, and ways of improving portscape. Secondly, each respondent has given answers freely on how to make Busan port area more attractive. As a result of this study there are several important differences of attitudes towards Busan portscape between experts, citizen and visitors. Especially there are some distinctive differences between attitudes of experts and citizen but the attitudes of citizen are similar to those of visitors. At the end of the study some proposals for making an improvement of Busan port landscape have been suggested on the basis of the results of this attitude comparative study.