• 대한임베디드공학회논문지
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• 제15권2호
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• pp.71-78
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• 2020

This paper proposes vision sensors and deep learning-based around view monitoring system for ship berthing. Ship berthing to the port requires precise relative position and relative speed information between the mooring facility and the ship. For ships of Handysize or higher, the vesselships must be docked with the help of pilots and tugboats. In the case of ships handling dangerous cargo, tug boats push the ship and dock it in the port, using the distance and velocity information receiving from the berthing aid system (BAS). However, the existing BAS is very expensive and there is a limit on the size of the vessel that can be measured. Also, there is a limitation that it is difficult to measure distance and speed when there are obstacles near the port. This paper proposes a relative distance and speed estimation system that can be used as a ship berthing assist system. The proposed system is verified by comparing the performance with the existing laser-based distance and speed measurement system through the field tests at the actual port.

• 한국전자통신학회논문지
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• 제18권1호
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• pp.143-148
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• 2023

현재 도선과 예선은 선박의 접·이안과 입출항을 지원함으로써 선박, 항만, 인명에 대한 사고 발생을 방지하여 재산상 피해를 최소화하거나 제거하는 기능을 수행한다. 도·예선 시스템은 항만의 기능이 원활하게 이루어지게 하는 필수적인 기능으로 항만의 물동량에 가장 큰 영향을 미치는 시스템이다. 본 연구에서는 도·예선의 운영정보를 활용하여 항만의 운영 효율화, 선박 대기시간 단축, 선박 운영의 최적화, 최적의 도·예선 배정이 가능한 도·예선 정보체계 분석 운영시스템을 개발하였다.

• 기계저널
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• 제25권4호
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• pp.282-288
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• 1985

에너지 절약 장치로서 Heat pump 기술은 선진 각국에서 70년대 이후 관심 깊게 연구개발을 계속하고 있으며 지금도 보일러-열펌프 닥킹시스템(boiler-heat pump docking system), 과 성능 열펌프시스템(super efficient heat pump system)등 더욱 성능이 우수한 장치 연구를 위하여 박 차를 가하고 있다. 외국의 경우 현재 공조용으로 사용되고 있는 열펌프는 원래 냉동기 기술을 기초로 하여 개발하였기 때문에 낮은 온도의 열원에서부터 60.deg. C 정도까지의 온수를 제조 하는 것은 기술적으로 충분하다. 이를 일반 산업용으로 하기 위하여 보다 더 높은 온도의 열을 공급하기 위해서는 새로운 연구가 활발하게 전개되어 왔다. 그 결과 저온배열을 100.deg. C 내 외로 올리는 기술이 개발되고 이의 응용 예가 많으며 구미 각국에서는 정부의 지원을 얻어 실 습플렌트(demonstration plant)가 다수 설립되고 있다. 이하 각장에서는 열펌프 기술의 국제적인 동향과 우리나라의 현실, 보급장애요인 그리고 장래전망을 기술하고 또 열펌프의 보급확대 방 안을 논술하고자 한다.

• 한국항공우주학회지
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• 제43권12호
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• pp.1124-1131
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• 2015

이 논문은 지상에서 초소형 위성의 랑데부/도킹 알고리즘 개발을 위하여 미세중력환경을 모사해주는 5자유도 지상 테스트베드에 관하여 기술한다. 테스트베드는 지면과의 마찰력을 없애주는 하부와 이 하부에 연결되어 3자유도의 회전운동을 하는 상부로 구성된다. 영상기반의 항법알고리즘 개발을 위하여 카메라와 LIDAR, AHRS 센서를 사용하였고 액추에이터로는 8개의 냉가스 추력기와 3축 방향의 반작용 휠을 사용하였다. 모든 시스템 소프트웨어는 온보드와 리눅스를 기반으로 C++을 사용하여 구현되었다.

• 셀메드
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• 제2권3호
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• pp.29.1-29.9
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• 2012

The prevalence of allergic disease has been increasing over the past few decades in the majority of Western industrialized nations. There are some socioeconomic disparities regarding allergic disease status and management. Pyeongwee-San (KMP6) is Korean medicine for the treatment of gastrointestinal tract disease. It is known that KMP6 has an improving effect on the spleen and stomach functions in traditional Korean medical theory. Here, we hypothesized that KMP6 could be used to regulate the inflammatory reaction. We show the molecular mechanisms of Pyeongwee-San (KMP6) on inflammatory reactions. A molecular docking simulation showed that hesperidin, component of KMP6, regulate the enzymatic activity by interaction in the active site of caspase-1. KMP6 control the activity of caspase-1 in activated human mast cell line (HMC-1 cells). KMP6 reduced the expression of receptor interacting protein (RIP)-2 in HMC-1 cells. Thymic stromal lymphopoietin protein production and mRNA expression were inhibited by KMP6. In the activated HMC-1 cells, KMP6 suppressed the activation of mitogen-ativated protein kinase and nuclear factor-kappaB. In addition, KMP6 significantly inhibited the expression of inflammatory cytokines. Our findings indicate that KMP6 may attenuate allergic reactions via the regulation of caspase-1/RIP-2 signaling pathway. These studies will help advance the social welfare system.

• 동의생리병리학회지
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• 제31권6호
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• pp.313-327
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• 2017

The purpose of this study is to predict the effects of macroscopic and integrative therapies by finding active ingredients, potential targets of Astragalus membranaceus (Am) and Cornus officinalis (Co) for diabetic nephropathy. We have constructed network pharmacology-based systematic and network methodology by system biology, chemical structure, chemogenomics. We found several active ingredients of Astragalus membranaceus (Am) and Cornus officinalis (Co) that were speculated to bind to specific receptors which had been known to have a role in the progression of diabetic nephropathy. Four components of Am and eleven components of Co could bind to iNOS; two ingredients of Am and six ingredients of Co could docking to cGB-PDE; one component of Am and nine components of Co could bind to ACE; three ingredients of Co with neprilysin; three components of Co with ET-1 receptor; four ingredients of Am and fourteen ingredients of Co with mineralocorticoid receptor; one component of Am and seven components of Co with interstitial collagenase; one ingredient of Am and ten ingredients of Co with membrane primary amine oxidase; one component of Am and four components of Co with JAK2; two ingredients of Am and one ingredient of Co with MAPK 12; one component of Am and five components of Co could docking to TGF-beta receptor type-1. From this work we could speculate that the possible mechanisms of Am and Co for diabetic nephropathy are anti-inflammatory, antioxidant and antihypertensive effects.

• Bulletin of the Korean Chemical Society
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• 제34권11호
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• pp.3199-3205
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• 2013

The inclusion behavior of sulfobutylether-${\beta}$-cyclodextrin (SBE-${\beta}$-CD) with perphenazine (PPH) was first studied by flow injection (FI)-chemiluminescence (CL) analysis with proposed $lg[(I_0-I_s)/I_s]=lgK_{P-CD}+nlg[C_{PPH}]$ model and molecular docking. Results showed that a 1:1 complex of SBE-${\beta}$-CD/PPH could online form, with the formation constant $K_{P-CD}$ of $2.57{\times}10^7Lmol^{-1}$ at 298 K. The thermodynamic parameters showed that the inclusion behavior of SBE-${\beta}$-CD/PPH was a spontaneous process by hydrophobic interaction. The molecular docking results revealed PPH entered into the larger cavity of SBE-${\beta}$-CD with two hydrogen bonds. Based on the linear relationship of the decrement of luminol/SBE-${\beta}$-CD/PPH CL intensity against the logarithm of PPH concentration ranging from 0.03 to 30.0 ng $mL^{-1}$, the present FI-CL analysis using luminol/SBE-${\beta}$-CD/PPH system was successfully applied to PPH determination in biological fluids and tablets with recoveries from 94.5 to 105.6% and RSDs less than 2.6% (n = 5).

• 정보과학회 논문지
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• 제42권1호
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• pp.15-22
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• 2015

본 논문에서는 대규모의 계산 작업을 고성능으로 처리해야 하는 신약재창출 시뮬레이션 분야에 분산 슈퍼컴퓨팅 기술을 적용한 사례에 대해 논의하고자 한다. 신약재창출이란 기존에 알려진 약물의 새로운 적응증을 규명하는 것을 의미하며, 이러한 신약재창출은 비교적 짧은 수행시간을 갖는 대규모의 도킹(docking) 연산들을 고성능으로 처리해야한다는 점에서 Many-Task Computing (MTC) 성격을 지니고 있다. 이러한 MTC 응용들의 대표 사례로서 신약재창출 시뮬레이션을 분산 슈퍼컴퓨팅 환경 기반의 HTCaaS 시스템에 적용하였으며, 이를 통해 효율적인 작업 배포, 동적인 자원 할당 및 로드 밸런싱, 안정성 및 다양한 자원들의 효율적인 통합 등이 이러한 과학 응용들을 지원하는 데 있어 필수적인 기능임을 확인할 수 있었다.

• Molecules and Cells
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• 제28권5호
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• pp.447-453
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• 2009

The quorum sensing (QS) inhibitors that antagonize TraR, a receptor protein for N-3-oxo-octanoyl-L-homoserine lactones (3-oxo-C8-HSL), a QS signal of Agrobacterium tumefaciens were developed. The structural analogues of 3-oxo-C8-HSL were designed by in silico molecular modeling using SYBYL packages, and synthesized by the solid phase organic synthesis (SPOS) method, where the carboxamide bond of 3-oxo-C8-HSL was replaced with a nicotinamide or a sulfonamide bond to make derivatives of N-nicotinyl-L-homoserine lactones or N-sulfonyl-L-homoserine lactones. The in vivo inhibitory activities of these compounds against QS signaling were assayed using reporter systems and compared with the estimated binding energies from the modeling study. This comparison showed fairly good correlation, suggesting that the in silico interpretation of ligand-receptor structures can be a valuable tool for the pre-design of better competitive inhibitors. In addition, these inhibitors also showed anti-biofilm activities against Pseudomonas aeruginosa.

• Clinical and Experimental Vaccine Research
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• 제13권2호
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• pp.132-145
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• 2024

Purpose: Enterovirus 71, a pathogen that causes hand-foot and mouth disease (HFMD) is currently regarded as an increasing neurotropic virus in Asia and can cause severe complications in pediatric patients with blister-like sores or rashes on the hand, feet, and mouth. Notwithstanding the significant burden of the disease, no authorized vaccine is available. Previously identified attenuated and inactivated vaccines are worthless over time owing to changes in the viral genome. Materials and Methods: A novel vaccine construct using B-cell derived T-cell epitopes from the virulent polyprotein found the induction of possible immune response. In order to boost the immune system, a beta-defensin 1 preproprotein adjuvant with EAAAK linker was added at the N-terminal end of the vaccine sequence. Results: The immunogenicity of the designed, refined, and verified prospective three-dimensional-structure of the multi-epitope vaccine was found to be quite high, exhibiting non-allergenic and antigenic properties. The vaccine candidates bound to toll-like receptor 3 in a molecular docking analysis, and the efficacy of the potential vaccine to generate a strong immune response was assessed through in silico immunological simulation. Conclusion: Computational analysis has shown that the proposed multi-epitope vaccine is possibly safe for use in humans and can elicit an immune response.