• Bulletin of the Korean Chemical Society
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• 제35권9호
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• pp.2855-2858
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• 2014

• Bulletin of the Korean Chemical Society
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• 제25권2호
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• pp.304-306
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• 2004

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.413.3-414
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• 2002

Paclitaxel is a diterpenoid isolated from Taxus brevifolia and is an active anticancer drug for the treatment of ovarian cancer, breast cancer and Kaposi's sarcoma. Due to its low solubility in water, it is dissolved in Cremophor EL(polyethoxylated castor oil) and ethanol, which cause serious side effects including hypersensitivity. BLK460 was developed as a novel polymeric micellar paclitaxel formulation containing Aceporol460 as solubilizer (omitted)

• 생약학회지
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• 제17권1호
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• pp.62-66
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• 1986

Acanthopanax koreanum Nakai (Araliaceae) is a indigenous medicinal plant growing throughout Jeju-Do in Korea. The plant extract is used in rheumatism, tonic, paralysis and sedative agent. From the roots of A. koreanum, lignan compounds, a diterpenoid, and a polyacetylene compound were isolated and their structures were elucidated by using IR, PMR, CMR and MS spectral data.

• Bulletin of the Korean Chemical Society
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• 제35권2호
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• pp.672-674
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• 2014

• 약학회지
• /
• 제33권4호
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• pp.226-228
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• 1989

In connection with the synthesis of the biologically active pimarane diterpenoids, some synthetic routes to the quaternary carbon unit were examined. Especially, Claisen rearrangement of allyl acetates prepared from acetol provided ${\gamma}-hydroxy$ acid containing vinyl substituent as the desired unit.

• Bulletin of the Korean Chemical Society
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• 제31권4호
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• pp.1035-1037
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• 2010

• Archives of Pharmacal Research
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• 제22권1호
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• pp.75-77
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• 1999

Two diterpenoid compounds, agastanol (1) and agastaquinone (2), were isolated from the roots of Agastache rugosa (Labiatae). Compound 1 and 2 showed significant inhibitory effects against human immunodeficiency virus type 1 (HIV-1) protease activity with $IC_{50}$ values of 360 and $87{\mu}M$, respectively.

• Bulletin of the Korean Chemical Society
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• 제34권5호
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• pp.1589-1591
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• 2013

• 생약학회지
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• 제1권1호
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• pp.3-17
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• 1970

Diterpenoids contain only 20 carbon atoms, and the plants that have been examined for diterpenoids are less numerous. However, a greater variety of the possible cyclization and oxidation patterns has been observed in the diterpenoids. Thus the list of known structures is large. The diterpenoids have often been found in two antipodal forms. Our present state of knowledge does not allow us to draw any conclusions from the distributions of these configurations.