• Pediatric Infection and Vaccine
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• v.13 no.2
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• pp.115-123
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• 2006

Purpose : We investigated whether there had been any change in the epidemiology of Streptococcus pneumoniae in Korea before and after introduction of heptavalent pneumococcal conjugate vaccine(PCV7). Methods : Between September 2001 and August 2006, clinical isolates were collected from patients with pneumococcal infection in Severance Hospital, Seoul, Korea. We analyzed trends in serotype distribution and antibiotic resistance before and after the introduction of PCV7. Results : There were 363 strains of Streptococcus pneumoniae isolated from clinical specimens; 143 before and 220 after PCV7 introduction. The predominant serotypes, in order of decreasing frequency, were 19F, 19A, 23F, 6B, 6A, 3, 9V, 14, 11A, 4, 29, and 18C; 152 isolates(41.9%) belonged to types included in PCV7. The proportion of clinical isolates that were nonsusceptible to penicillin increased from 58.8% in 2001 to 83.6% in 2006(P=0.046). There was no significant diminution in pneumococcal infection caused by vaccine serotypes after the introduction of PCV7. In children younger than age 2 years, the proportion of clinical isolates that were vaccine serotypes was higher than in persons older than age 15 years (59.3% vs 37.8%, P=0.004). Conclusions : There was no significant diminution in pneumococcal infection caused by vaccine serotypes after the introduction of PCV7, therefore more universal pneumococcal immunization program is recommended especially for children younger than age 2 years.

• Journal of Powder Materials
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• v.9 no.5
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• pp.315-321
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• 2002

Pure tantalum powder has been produced by combining Na as a reducing agent, $K_2TaF_{7}$ as feed material, KCl and KF as a diluent in a stainless steel(SUS) bomb, using the method of metallothermic reduction. The present study investigated the effect of the amount of the diluent and reaction temperature on the characteristics of tantalum powder in the production process. The temperature applied in this study $850^{\circ}C$ and the amount of the additional reductant from +5% of the theoretical amount used for the reduction of the entire $K_2TaF_{7}$. The results showed that as the amount of the diluent increased, the reaction temperature became lower because the diluent prevented a temperature rise. Also, according to the mixture ratio of the feed materials and the diluent changed from 1 : 0.25 to 1 : 2, the particle size decreased from $5\mutextrm{m}$ to $1\mutextrm{m}$ and a particle size distribution which is below 325 mesh in fined powder increases from 71% to 83%. The average size of Tantalum powder, $2-4\mutextrm{m}$, was close to that of the commercial powders($2-5\mutextrm{m}$). Also under this condition, impurities contained in the powder were within the range allowed for the commercial Ta powders.

• Korean Journal of Applied Biomechanics
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• v.14 no.3
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• pp.83-98
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• 2004

The purpose of this study was to investigate the test-retest of plantar pressures using the F-Scan system over speeds and plantar regions. 6 healthy female subjects in 20's were recruited for the study. Plantar pressure measurements during locomotor activities can provide information concerning foot function, particularly if the timing and magnitude of the loading profile can be related to the location of specific foot structures such as the metatarsal heads. The Tekscan F-Scan system consists of a flexible, 0.18mm thick sole-shape having 1260 pressure sensors, the sensor insole was trimmed to fit the subjects' right. left shoes - sneakers shoes & dress shoes. It was calibrated by the known weight of the test subject standing on one foot. The Tekscan measurements show the insole pressure distribution as a function of the time. This finding has important implications for the development of plantar pressure test protocols where the function of the forefoot is important. According to the result of analysis it is as follows 1) Center of force trajectory in women's dress shoes display direct movement, compare with center of force trajectory in Sneaker shoes displays a little bit curved slow pronation movement. Sneaker shoes in forefoot part display very quick supination movement, therefore, this shoes effects negative effectiveness for ankle's stability Considering center of force trajectory analyzing the more center of force close straight line, the more movement can be quick movement for locomotion. For foot pressure distribution, center of force trajectory in locomotion is better to curved trajectory with pronation movement. So sneaker shoes style is good shoes considering center of pressure distribution trajectory compare with women's dress shoes. 2) Women's dress shoes increased peak pressure in medial, this is effected by high hill's height. The more increased women's dress shoes's height, the more women's peak pressure will increase, pronation can increase compare with before. Supination movement increase, this focused pressure in lateral, also, supination increased more. If the supination movement increased, foot pressure focused in lateral, therefore, it is appeared force distribution in gait direction. This is bad movement in foot's stability. 3) Women's dress shoes in landing phase displayed a long time, this is when women's dress shoes wear, gait movement is unbalance, so, landing phase displayed a long time. For compensation in gait, swing phase quick movement. 4) Women's dress shoes displayed peak pressure distribution in lateral of rearfoot part, Sneakers shoes displayed peak pressure distribution in medial of forefoot part. Its results has good impact absorption compare with women's dress shoes. In forefoot part, sneakers shoes has good propulsive force compare with women's dress shoes.

• Journal of Animal Environmental Science
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• v.20 no.4
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• pp.155-160
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• 2014

This study was researched for use by data for the improvement of ventilation system of optimum environmental control systems. The ventilation system for windowless swine housing was installed negative pressure system that circular pipe duct for inlet was installed on the ceiling and axial flow fan for exhaust was installed on the sidewall. The temperatures in the pen was measured using infrared thermography camera and thermocouple with data-logger. The temperature measurement points was selected by infrared thermography camera is alley (G), inlet (A), front-upper (B), front-lower (C), rear-upper (D), rear-lower (E), forward fan (F). The temperature measured at those selected points for temperature distribution was $28^{\circ}C$ that was maintained setting temperature in suitably. The temperature deviations of F point and A~E points in windowless swine housing was less then average $0.5^{\circ}C$. The result of air velocity of measured points was suitable to the breeding of pigs.

• Water for future
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• v.14 no.4
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• pp.53-72
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• 1981

In this study, South Korea is divided into 5 zones and is studied about the analysis of time-regional distribution of previpitation frequency and rainfall intensity in Korea. In the previpitation frequency analysis, the basic data groups of 39 stations were selected. The diagram of previpitation frequency was drawn, and the time-regional distribution of precipitation frequency was analized. In the rainfall intensity analysis, the basic data groups of 36 stations were selected. The probable rainfall, I-D-F curve, and regression equation between 24hr. and 10min.-18hr. areal depth were obtained. The results of this study are following; 1) The precipitation class of max. recurrence probability in every season except summer was commonly (1) 1-5mm, (2) 0.1-1mm, (3) 5-10mm in order. 2) The zone of max. recurrence frequency owing to the precipitation class was zone II in precipitation frequency of below 20mm, zone IV in precipitation frequency of 30-40mm, zone I in precipitation frequency of above 70mm for a year. 3) The recurrence probability of precipitation in Korea can be represented to the equation of exponential function; $$W(x)=e^{\alpha+\beta}$$ 4) The first and third zones were expected heavy rain for the short and long duration. 5) The I.D.F. curves were drawn, and established that the time interval for the least deviation of I.D.F curve is 10~40min., 40min. -4hr., 4~24hr. 6) The regression equations of areal mean depth between 24hr. and 10min.-18hr. for each zone were obtained. 7)The probable rainfall of 36 points were calculated.

• KSBB Journal
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• v.18 no.4
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• pp.255-260
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• 2003

In vivo bioassays for biological medicines have been considered final resort to unequivocally assess the biological activities for them because there are some cases in which the biological activities obtained from in vivo bioassay and in vitro bioassay quite differ each other. The in vivo biological activity of EPO depends on its sialic acid contents which confer microheterogeneity-isoforms to this protein. We have devise a method which consists of a in vitro bioassay using BaF3 cell line and a capillary zone electrophoresis (CZE) for the measurement of the EPO isoform distribution. The biological activity of EPO obtained using in vitro bioassay with BaF3 cell line showed good correlation (C.V.(％) 7.34, 5.85, 8,16, 8.08, 8.8) to EPO content measured either spectrophotometric assay (A280 0.1 ％ ＝0.743) or radio immunoassay. The assay validation results of in vitro bioassay with 3 lot of in house EPO showed good results to EPO content measured either in vivo assay or radio immunoassay. and also showed good results the robustness of our method in terms of precision, accuracy, repeatability. The isoform distribution for EPO-BRP (1 : 1 mixture of epoetin-${\alpha}$ and epoetin-${\beta}$, European Pharmacopoeia) by CZE method resulted in isoform 2 through isoform 8. The major peaks in electrophoregram were composed of isoform 3 through 7. Our recombinant EPO (epoetin-${\alpha}$) having equivalent in vivo biological activity showed the isoform distribution of isoform 3 through 9. The major peaks consisted of isoform 4 through 8. The peak area of isoform 4 was always smaller than that of isoform 5. The preparations of recombinant epoetin-${\alpha}$ with lower in vivo biological activity than EPO-BRP showed the isoform 2 through 8 in their electrophoregrams whose major peaks consisted of the isoform 3 through 7. The peak area of isoform 4 was larger than that of isoform 5.

• Journal of Welding and Joining
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• v.17 no.1
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• pp.88-96
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• 1999

The effects of root gap on welding residual stress and deformation are dealt with the multi-pass weldment with three kinds(0, 6, 30mm) of root gap by F.E.M common code, and then compared with experiment data. In this analysis, an 100% ramp heat input model was used to avoid numerical convergence problem due to an instantaneous increase in temperature near the fusion zone, and the effect of a moving arc in a two dimensional plane was also included. During the analysis, a small time increment was applied in a period with instantaneous temperature fluctuation while a large time increment was used in the rest period. The residual stress is distributed as symmetric types and maximum value is also equivalent when the weldment with 0mm and 6mm root gap is welded. In the case of 30mm root gap welding, the distribution of the residual stress extends over a wide range as asymmetric types due to the built-up weld, and most of the residual stress is biased in the side of a built-up weld part. In case of 0mm gap welding and 6mm gap welding, a little angular distortion occurs, but the level of deformation is small. When the weldment with 30mm root gap is welded, the angular deformation of the asymmetric types, however, occurs larger than the other specimens. The experimental and the analytic results show good coincidence and indicate that the welding residual stress and deformation distribution of 30 mm root gap specimen may be asymmetric and the amplitude is larger than those of root gap specimen under standard.

• Parasites, Hosts and Diseases
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• v.58 no.6
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• pp.709-714
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• 2020

Knockdown resistance (kdr) mutations in the voltage-gated sodium channel (VGSC) of mosquitoes confer resistance to insecticides. Although insecticide resistance has been suspected to be widespread in the natural population of Aedes aegypti in Myanmar, only limited information is currently available. The overall prevalence and distribution of kdr mutations was analyzed in Ae. aegypti from Mandalay areas, Myanmar. Sequence analysis of the VGSC in Ae. aegypti from Myanmar revealed amino acid mutations at 13 and 11 positions in domains II and III of VGSC, respectively. High frequencies of S989P (68.6%), V1016G (73.5%), and F1534C (40.1%) were found in domains II and III. T1520I was also found, but the frequency was low (8.1%). The frequency of S989P/V1016G was high (55.0%), and the frequencies of V1016G/F1534C and S989P/V1016G/F1534C were also high at 30.1% and 23.5%, respectively. Novel mutations in domain II (L963Q, M976I, V977A, M994T, L995F, V996M/A, D998N, V999A, N1013D, and F1020S) and domain III (K1514R, Y1523H, V1529A, F1534L, F1537S, V1546A, F1551S, G1581D, and K1584R) were also identified. These results collectively suggest that high frequencies of kdr mutations were identified in Myanmar Ae. aegypti, indicating a high level of insecticide resistance.

• Journal of Environmental Science International
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• v.32 no.7
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• pp.493-502
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• 2023

This study was conducted to understand the regional distribution characteristics of swans(Cygnus spp.) in downstream of t he Nakdong River , R.O.Korea from October 2008 to September 2013. During this period, a total of two species and 37,518 ind ividuals of Swans(Cygnus spp.) were observed, including 31,596 Whooper Swans(Cygnus cygnus) and 5,922 Tundra Swans (Cygnus columbianus), respectively. The average number of individuals observed in fifteen different areas was 2255.33 in D aemadeung(A), 143.50 in Jangja·Sinjado(B), 304.00 in Sajado·Doyodeung(C), 1928.00 in Lower Ulsukdo(D), 1392.67 in Ulsu kdo(E), 50.17 in Ilwoongdo(F), 91.17 in Yeommak(G), 5.17 in Maekdogang(H), 0.00 in Pyeonggangcheon(I), 0.00 in Lower Noksan sluice(J), 2.83 in Upper Noksan sluice(K), 6.17 in Jomangang·Doonchido(L), 4.50 in Chideung(M), 0.83 in Joongsado (N)and 66.17 in Daejeo sluice(O). The total average of these fifteen areas was 480.81. There was a significant difference am ong the survey areas (Kruskal-Wallis test, 𝒳²=4055.68, P<0.001). In particular, the observed numbers were larger in Dae madeung, Lower Ulsukdo and Ulsukdo than in the other regions.

• Korean Journal of Mathematics
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• v.12 no.1
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• pp.15-22
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• 2004

In this paper we establish some recurrence relations satisfied by quotient moments of upper record values from the power distribution. Let {$X_n$, $n{\geq}1$} be a sequence of independent an identically distributed random variables with a common continuous distribution function(cdf) $F(x)$ and probability density function(pdf) $f(x)$. Let $Y_n=max\{X_1,X_2,{\cdots},X_n\}$ for $n{\geq}1$. We say $X_j$ is an upper record value of {$X_n$, $n{\geq}1$}, if $Y_j$ > $Y_{j-1}$, $j$ > 1. The indices at which the upper record values occur are given by the record times {$u(n)$}, $n{\geq}1$, where $u(n)=min\{j{\mid}j>u(n-1),X_j>X_{u(n-1)},n{\geq}2\}$ and $u(1)=1$. Suppose $X{\in}POW(0,1,{\theta})$ then $$E\left(\frac{X^r_{u(m)}}{X^{s+1}_{u(n)}}\right)=\frac{\theta}{s}E\left(\frac{X^r_{u(m)}}{X^s_{u(n-1)}}\right)+\frac{(s-\theta)}{s}E\left(\frac{X^r_{u(m)}}{X^s_{u(n)}\right)\;and\;E\left(\frac{X^{r+1}_{u(m)}}{X^s_{u(n)}}\right)=\frac{\theta}{n+1}\left[E\left(\frac{X^{r+1}_{u(m-1)}}{X^s_{u(n+1)}}\right)-E\left(\frac{X^{r+1}_{u(m)}}{X^s_{u(n-1)}}\right)+\frac{r+1}{\theta}E\left(\frac{X^r_{u(m)}}{X^s_{u(n)}}\right)\right]$$.