• Korean Journal of Clinical Laboratory Science
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• v.54 no.2
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• pp.110-118
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• 2022

Candidemia is a major cause of nosocomial infections resulting in increased morbidity and mortality. It remains a serious risk in inpatients and increases medical treatment costs. From 2009 to 2018, Candida strains (3,533) isolated from blood culture tests at the S Hospital were analyzed according to the period, year, sex, age, ward, etc. During the entire period, 54,739 of 717,996 blood culture tests showed a positive rate (7.6%) and the Candida isolation rate was 3,533 (6.4%) out of 1,036 patients. Among the Candida isolates, C. albicans was most common (33.8%), followed by C. tropicalis (28.6%), C. glabrata (19.8%), C. parapsilosis (7.8%), and C. krusei (4.0%). In early (2009~2013)/late (2014~2018) isolation, C. tropicalis decreased by 3.8% and C. glabrata increased by 3.4%. After 50 years of age, the higher the separation frequency. C. parapsilosis (31.3%) in 1~10s, C. tropicalis (30.3%) and C. glabrata (27.6%) in 41~50s, and C. tropicalis (28.6%) in 80s are relatively frequent. has been separated C. krusei was isolated in a relatively high proportion from females (60.9%). Therefore, a systematic and continuous nosocomial infection control system should be established for appropriate treatment as per antifungal treatment guidelines. The system should continuously monitor the distribution of Candida species and provide rapid identification results.

• Tuberculosis and Respiratory Diseases
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• v.44 no.2
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• pp.232-240
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• 1997

Background : Postprimary pulmonary tuberculosis is located mainly in upper lobes. The tuberculous lesion involving the lower lobes usually arises from the upper lobe cavity through endobronchial spread. When tuberculosis is confined to the lower lung field, it often masquerades as pneumonia, lung cancer, bronchiectasis, or lung abscess. Thus the correct diagnosis may be sometimes delayed for a long time. Methods : We carried out, retrospectively, a clinical study on 50 patients confirmed with lower lung field tuberculosis who visited the Department of Pulmonary Medicine at Hanyang University Hospital from January 1992 to December 1994. The following results were obtained. Results : Lower lung field tuberculosis without concomitant upper lobe disease occurred in fifty patients representing 6.9% of the total admission with active pulmonary tuberculosis over a period of 3 years. It occurred most frequently in the third decade but age distribution was relatively even. The mean age was 43 years old. Female was more frequently affected than male (male to female ratio 1 : 1.9). The most common symptom was cough(68%), followed by sputum(52%), fever(38%), and chest discomfort(30%). On chest X-ray of the 50patients, consolidation was the most common finding in 52%, followed by solitary nodule(22%) collapse(16%), cavitary lesion(10%), in decreasing order. The disease confined to the right side in 25 cases, left side 20 cases, and both sides 5 cases. Endobronchial tuberculosis (1) Endobronchial involvement was proved by bronchoscopic examination in 20 of 50patients. (2) Mean age was 44years old and female was more affected than man (male to female ratio 1 : 3). Sputum AFB stain and Mycobacterium tuberculosis culture were positive only in 50% of cases unlikely upper lobe tuberculosis, additional diagnostic methods were needed. In our study, bronchoscopic examination and percutaneous fine needle aspiration biopsy increased diagnostic yield by 18% and 32%, respectively. The most common associated condition was diabetes mellitus(18%) and others were anemia, anorexia nervosa, stomach cancer, and systemic steroid usage. Conclusion : When we find a lower lung field lesion, we should suspect tuberculosis if the patient has diabetes mellitus, anemia, systemic steroid usage, malignancy or other immune suppressed states. Because diagnostic yield of sputum AFB smear & Mycobacterium tuberculosis culture was low, additional diagnostic methods such as bronchoscopy and fine needle aspiration biopsy were needed.

• Environmental Sciences Bulletin of The Korean Environmental Sciences Society
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• v.2 no.2
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• pp.169-179
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• 1998

This paper was performed to estimate interrelations between humus level of sediments and nutrient release from sediments in Dae-cheong reservoir. For investigations, sediments were sampled in June and October, in 1997 at fish farms, embayment, and the main stream of Dae-cheong reservoir. Items for investigation are as follows; water content, weight loss on ignition(IG), porosities of sediments, contents of element such as hydrogen, nitrogen, carbon, and nutrient release rates. Water contents and porosities were measured to conjecture the physical trait and grain size trait. Weight loss on ignition was measured to determine the contents of organic substance. For determination of the humus level of sediments, carbon and nitrogen contents were measured by elemental analyzer. As a result of elemental analysis, C/N ratio was determined in the range of $3.0\~13.1$. From the elemental analysis, humus level of Dae-cheong reservoir sediment was estimated from mesohumic state to oligotrophic state. For the determination of nutrient release rate, $PO_4-P$ and $NH_4-N$ concentrations of interstitial water and overlying water were measured. By using the concentration difference between interstitial water and overlying water and using the Fick's diffusion law, the release rates of phosphorus and nitrogen from the sediment samples were calculated. Release rates of nutrients which directly influence to the water quality were $0.05\~8.63mgP/m^2day$ and $4.99\~36.56mgP/m^2day$. It was found that release rate was measured higher in the 1st sampling period than in the 2nd sampling period. For the determination of phosphorus content in sediment, TPs were measured in 807\~1542{\mu}g/g$ in the 1st samling period and $677\~5238{\mu}g/g$ in the End samling period. Phosphorus release rate and phosphorus content were not interrelated each other.

• Korean Chemical Engineering Research
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• v.52 no.5
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• pp.632-637
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• 2014

A microfluidic method for the in situ production of monodispersed alginate hydrogels using biocompatible polymer gelation by crosslinker mass transfer is described. Gelation of the hydrogel was achieved in situ by the dispersed calcium ion in the microfluidic device. The capillary number (Ca) and the flow rate of the disperse phase which are important operating parameters mainly influenced the formation of three distinctive flow regions, such as dripping, jetting, and unstable dripping. Under the formation of dripping region, monodispersed alginate hydrogels having a narrow size distribution (C.V=2.71%) were produced in the microfluidic device and the size of the hydrogels, ranging from 30 to $60{\mu}m$, could be easily controlled by varying the flow rate, viscosity, and interfacial tension. This simple microfluidic method for the production of monodisperse alginate hydrogels shows strong potential for use in delivery systems of foods, cosmetics, inks, and drugs, and spherical alginate hydrogels which have biocompatibility will be applied to cell transplantation.

• Journal of the Korean earth science society
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• v.35 no.6
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• pp.401-411
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• 2014

In order to enhance the Au Ag leach rate, a mechanochemical activation process and a mixed thiourea-thiocyanate solution has been applied to Au concentrate. To achieve mechanochemical activation, the Au concentrate was mechanically ground using a dry and a wet process. The results of a particle size distribution analysis and an XRD analysis, average particle size and crystallite size were much smaller in the dry-sample than in the concentrate sample. As well the size was smaller in the wet-sample than in the dry-sample. In SEM and XRD analysis, the amorphization effect was observed in the wet-sample due to mechanochemical activation. Au Ag leaching experiments were carried out with a thiourea solution, a thiocyanate solution and a mixed thiourea-thiocyanate solution. The Au Ag leach rate was much greater in the dry-ground-sample than in the concentrate sample, and the leach rate was greater in the wet-ground-sample than in the dry-sample. The Au Ag leach rate was much greater in the thiocyanate solution than in the thiourea solution, and the leaching rate was much greater in the mixed thiourea-thiocyanate solution than in the thiocyanate solution. Up to a 99% leach rate for Au Ag were only achieved in the wet-sample using the mixed thiourea-thiocyanate leaching solution.

• Journal of Acupuncture Research
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• v.17 no.4
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• pp.149-159
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• 2000

Bee-venom Acupucture has good effect on pain control but We may be anxious about the problem of side-effect. Bee-venom components are composed of phospholipase $A_2$, hyaluronidase, melitin, apamin, MCD peptide, citrate and so on. Especially Apamin, MCD peptide and histamine cause severe reacting that is named Anaphylaxis. Anaphylaxis is a clinical syndrome characterized by the acute system reaction of multiple organ systems to an IgE-mediated immunologic mediator release in previously sensitized individuals. Respiratory and dermatologic manifestations are the most commonly expressed clinical features of anaphylaxis, and a majority of anaphylactic reactions initially appear to be localized to these two systems. Anaphylatic reaction of bee-venom are expressed clinically ulticaria, itching sensation, erythema, dizziness, nausea, hypotension and so on. Especially ulticaria and erythema are end points of increased vascular permeability and vasodilatation at the other extreme of the clinical spectrum, Gastrointestinal mucosal edema and smooth muscle contraction can result in cramping abdominal pain, nausea, and vomiting. Therefore, we have observed anaphylatic reaction of bee-venom in 11 patients, who visited WonKwang University Kunpo Oriental Medical Center, treated bee venom. The results were summarized as follows : 1. The patient distribution ratio, in regard to sex, was shown to be 1 : 2.67 for male to females. In regard to age, it was shown that people in their 30's was the most predominant case, followed by people in their 20's, 30's, 50's and 60's, respectively. 2. When Anaphylaxis was occured, it was observed to abnormality of CBC, LFT, IgE, IgG. 3. In regard to patient condition, it was observed that fatigue was most frequent. 4. In regard to the number of times and quantity of bee venom inj., it was observed that anaphylaxis is most frequent at 7-10 times(1.6-2.0cc) 5. In regard to duration of reaction, it was observed that people in their l0min' was most frequent. In disappearing duration of anaphylaxic reaction, The results showed under 60min lcases(9%), 60-120min 7cases(64%) and 180-240min 3cases(27%). 6. In symptoms of anaphylaxis, The results showed hypotension 8cases(19%), itching sensation 7cases(16%), nausea 4cases(9%), erythema 4cases(9%) and dizziness 4cases(9%). In mentality, The results showed drowsy 8case(73%) and alert 3cases(27%). 7. Generally, patients were treated with Avil, Dexa IM and PDS, peniramine, cimetidine, Q-zyme per os after H/S, N/S inj. $O_2$ was supplied according to patient's symptom. In 1 severe case, Dopamine was iv injected.

• Geophysics and Geophysical Exploration
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• v.11 no.4
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• pp.368-372
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• 2008

This study evaluates the usefulness and capability of surface electrical resistivity technique for identifying the weak zones or subsurface cavities in karst area with limestone formation. Weak zones or cavities near surface can be potentially dangerous and several problems are associated with collapse of roads or buildings accompanied by subsidence phenomena. In this paper, both two and three dimensional resistivity investigation were conducted to investigate subsidence along a road in Yongweol-ri, Muan-gun, South Korea. The results of the resistivity survey using dipole-dipole array provide a clear view of the weathered regolith, the distribution of weak zones or cavities and bedrock. Several low resistivity areas were identified and subsequent drilling led to the discovery of several weak zone or clay-filled underground cavities. The drilling results show excellent correlation with the resistivity images. It is illustrated, the ability of electrical technique to produce high resolution images of subsurface, which are useful for subsidence assessment. Also the results of this study have demonstrated that two and three dimensional electrical resistivity surveys are useful for delineating the subsidence area. Based on resistivity imaging, the map of hazardous zone has been developed.

• Journal of Korean Academy of Oral and Maxillofacial Radiology
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• v.22 no.2
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• pp.185-193
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• 1992

The purpose of this study was to evaluate the prevalence and distribution of tooth number anomaly by means of the analysis of panoramic radiographs in 6,531 patients visited the Dental Infirmary of Kyungpook National University Hospital from January 1983 to May 1992. The results were as follows: 1. The prevalence of congenitally missing teeth except third molar was revealed to be 10.8%, and there was a hihger prevalence in females(44.6%) than in males(55.4%). Mandibular 2nd premolars(23.2 %) were absent most frequently, followed by maxillary lateral incisors(18.4 %), mandibular lateral incisors(18.3%), and maxillary second premolars(15.4 %) in descending order of frequency. As to the number of congenitally missing teeth, the percentage of missing one tooth was 48%, missing two teeth was 35.4 %, missing three teeth was 6.6%. 2. he prevalence of congenitally missing third molars was revealed to be 39.7%. There was a higher prevalence n the maxilla(60.3%) than in the mandible(39.7%). Maxillary right 3rd molars(30.6%) were absent most frequently, followed by maxillary left 3rd molar(29.7%), mandibular right 3rd molar(202%), mandibular left 3rd molar(19.5%) in descending order of frequency. 3. The prevalence of supernumerary teeth was revealed to be 4.2%, and there was a higher prevalence in males(65.7%) than in females(34.3 ). They were ound most frequently in maxillary central incisor area(64.8%), followed by maxillary lateral incisor area(132%), posterior area of maxillary third molar(8.7%) in descending order of frequency. As to the number of supernumerary teeth; The percentage of one supernumerary tooth was 79.9%, two supernumerary teeth was 8.9%, three supernumerary teeth was 1.2 %.

• Publications of The Korean Astronomical Society
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• v.12 no.1
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• pp.111-143
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• 1997

We have developed a spherical FCT code in order to simulate the interaction of supernova remnants with stellar wind bubbles. We assume that the density profile of the supernova ejecta follows the Chevalier mode1(1982) where the outer portion has a power-law density distribution($\rho{\propto}\gamma^{-n}$) and the SN ejecta has a kinetic energy of $10^{51}$ ergs. The structure of wind bubble has been calculated with the stellar mass loss rate $\dot{M}=5\times10^{-6}M_{\odot}/yr$ and the wind velocity $\upsilon=2\times10^3$ km/s We have simulated seven models with different initial conditions In the first two models we computed the evolution of SNRs with n=7 and n=14 in the uniform medium The numerical results agree with the Chevalier's similarity solution at early times. When all of the power-law portion of the ejecta is swept up by the reverse shock, the evolution slowly converges to the Sedov-Taylor stage. There is not much difference between the two cases with different n's The other five models simulate SNRs produced inside wind bubbles. In model III, we consider the SN ejecta of 1.4 $M_{\odot}$ and the radius of bubble ~2.76 pc so that ratio of the mass $\alpha(=M_{W.S}/M_{ej}$ is 2. We follow the complex hydrodynamic flows produced by the interaction of SN shocks with stellar shocks and with the contact discontinuities, In the model III, the time scale for the SN shock to cross the wind shell $\tau_{cross}$ is similar to the time scale for the reverse shock to sweep the power-law density profile $\tau_{bend}$. Hence the SN shock crosses the wind shell. At late times SN shock produces another shell in the ambient medium so that we have a SNR with double shell structure. From the numerical results of the remaining models, we have found that when $\tau_{cross}/\tau_{bend}\leq2$, or equivalently when $\alpha\leq50$, the SNRs produced inside wind bubbles have double shell structure. Otherwise, either the SN shock does not cross the wind shell or even if it crosses at one time, the reverse shock reflected at the center accelerates the wind shell to merge into the SN shock Our results confirm the conclusion of Tenorio-Tagle et a1(1990).

• Publications of The Korean Astronomical Society
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• v.12 no.1
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• pp.63-84
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• 1997

We carried out high-resolution(FWHM=3' .3) HI 21 cm observations of the supernova remnant(SNR) PKS0607+17 and HII region S261 using Arecibo 305-m telescope. The observation was to investigate whether the high-velocity(HV) gas detected in the southern area of PKS0607+17 by Koo & Heiles(1991) is physically associated with the SNR or not. The velocity of the HV gas ranges from +64 km/s to +87 km/s, which is difficult to result from the Galactic rotation. The HV gas could be the gas accelerated by supernova blast wave. However, because the observation of Koo and Heiles(1991) was carried out using Hat Creek radio telescope(FWHM $\simeq$ 36'), the association of the HV gas with the SNR could not be investigated. Using the Arecibo HI 21cm data, we have found that the HV gas appears m the southern part of the SNR and its velocity ranges from +61 km/s to +77 km/s. But the HV gas is scattered m the whole field, not only toward PKS0607+17 but also outside the SNR Accordingly the HV gas is probably not associated with the SNR, but is accidentally aligned along the same line of sight toward the SNR. Instead we have found that HI clouds at low velocities could be possibly associated with the SNR. In Arecibo HI 21cm channel maps the HI gas seems to surround the southern boundary of the SNR at $V_{LSR}$ = +19.6 ~ +40.2 km/s. But because the region of the Arecibo HI 21cm observation is not wide enough to examine the HI gas distribution, we investigated this area using the Berkely low-latitude HI survey data(Weaver & Williams 1974) too. There we found HI gas surrounding the radio continuum boundary of PKS0607+17 at $V_{LSR}$ = +21.6 ~ +258 km/s. It is possible that this HI gas is associated with the SNR, in which case, the velocity of the SNR $V_o$ $\simeq$ +26 km/s, its distance d $\simeq$ 12.5 kpc and its radius R $\simeq$ 145 pc. If we assume that the expansion velocity is ~10 km/s, then the age of the SNR is $\sim4.4\times10^6$ years. PKS0607+17 could be one of the oldest SNRs in the Galaxy. We also studied HI propertities of the HII region S261, which is $\sim1^{\circ}$ away from PKS0607+17. There has been no high-resolution m 21 cm observational study on S261. We discovered HI cloud located at the north-eastern part of S261 at $V_{LSR}$ = +5 km/s ~ +10 km/s, which is possibly associated with the HII region. The central velocity of the HI cloud $V_{LSR}$ = +7.2 km/s and the corresponding distance d = 1.5 kpc. This velocity is comparable to the radio recombination line velocities.