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Risk assessment for norovirus foodborne illness by raw oyster (Ostreidae) consumption and economic burden in Korea

  • Yoo, Yoonjeong;Oh, Hyemin;Lee, Yewon;Sung, Miseon;Hwang, Jeongeun;Zhao, Ziwei;Park, Sunho;Choi, Changsun;Yoon, Yohan
    • Fisheries and Aquatic Sciences
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    • v.25 no.5
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    • pp.287-297
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    • 2022
  • The objective of this study was to evaluate the probability of norovirus foodborne illness by raw oyster consumption. One hundred fifty-six oyster samples were collected to examine the norovirus prevalence. The oyster samples were inoculated with murine norovirus and stored at 4℃-25℃. A plaque assay determined norovirus titers. The norovirus titers were fitted with the Baranyi model to calculate shoulder period (h) and death rate (Log PFU/g/h). These kinetic parameters were fitted to a polynomial model as a function of temperature. Distribution temperature and time were surveyed, and consumption data were surveyed. A dose-response model was also searched through literature. The simulation model was prepared with these data in @RISK to estimate the probability of norovirus foodborne. One sample of 156 samples was norovirus positive. Thus, the initial contamination level was estimated by the Beta distribution (2, 156), and the level was -5.3 Log PFU/g. The developed predictive models showed that the norovirus titers decreased in oysters under the storage conditions simulated with the Uniform distribution (0.325, 1.643) for time and the Pert distribution (10, 18, 25) for temperature. Consumption ratio of raw oyster was 0.98%, and average consumption amount was 1.82 g, calculated by the Pert distribution [Pert {1.8200, 1.8200, 335.30, Truncate (0, 236.8)}]. 1F1 hypergeometric dose-response model [1 - (1 + 2.55 × 10-3 × dose)-0.086] was appropriate to evaluate dose-response. The simulation showed that the probability of norovirus foodborne illness by raw oyster consumption was 5.90 × 10-10 per person per day. The annual socioeconomic cost of consuming raw oysters contaminated with norovirus was not very high.

Regional Distribution of Interstitial Cells of Cajal, (ICC) in Human Stomach

  • Yun, Hyo-Yung;Sung, Ro-Hyun;Kim, Young-Chul;Choi, Woong;Kim, Hun-Sik;Kim, Heon;Lee, Gwang-Ju;You, Ra-Young;Park, Seon-Mee;Yun, Sei-Jin;Kim, Mi-Jung;Kim, Won-Seop;Song, Young-Jin;Xu, Wen-Xie;Lee, Sang-Jin
    • The Korean Journal of Physiology and Pharmacology
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    • v.14 no.5
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    • pp.317-324
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    • 2010
  • We elucidated the distribution of interstitial cells of Cajal (ICC) in human stomach, using cryosection and $c-Kit$ immunohistochemistry to identify $c-Kit$ positive ICC. Before $c-Kit$ staining, we routinely used hematoxylin and eosin (HE) staining to identify every structure of human stomach, from mucosa to longitudinal muscle. HE staining revealed that the fundus greater curvature (GC) had prominent oblique muscle layer, and $c-Kit$ immunostaining $c-Kit$ positive ICC cells were found to have typical morphology of dense fusiform cell body with multiple processes protruding from the central cell body. In particular, we could observe dense processes and ramifications of ICC in myenteric area and longitudinal muscle layer of corpus GC. Interestingly, $c-Kit$ positive ICC-like cells which had morphology very similar to ICC were found in gastric mucosa. We could not find any significant difference in the distribution of ICC between fundus and corpus, except for submucosa where the density of ICC was much higher in gastric fundus than corpus. Furthermore, there was no significant difference in the density of ICC between each area of fundus and corpus, except for muscularis mucosa. Finally, we also found similar distribution of ICC in normal and cancerous tissue obtained from a patient who underwent pancreotomy and gastrectomy. In conclusion, ICC was found ubiquitously in human stomach and the density of ICC was significantly lower in the muscularis mucosa of both fundus/corpus and higher in the submucosa of gastric fundus than corpus.

Analysis on Current Distribution of Four-Layer HTSC Power Transmission Cable with a Shield Layer

  • Lim Sung-Hun
    • Journal of Electrical Engineering and Technology
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    • v.1 no.3
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    • pp.308-312
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    • 2006
  • The inductance difference between conducting layers of high-Tc superconducting (HTSC) power transmission cable causes the current sharing of each conducting layer to be unequal, which decreases the current transmission capacity of HTSC power cable. Therefore, the design for even current sharing in HTSC power transmission cable is required. In this paper, we investigated the current distribution of HTSC power cable with a shield layer dependent on the pitch length and the winding direction of each layer. To analyze the effect of the shield layer on the current sharing of the conducting layers of HTSC power cable, the current distribution of HTSC power cable without a shield layer was compared with the case of HTSC power cable with a shield layer. It could be found through the analysis from the computer simulations that the shield layer of HTSC power cable could be contributed to the improvement of current distribution of conducting layers at the specific pitch length and the winding direction of conducting layer. The result and discussion for the current distribution calculated for HTSC power transmission cable with a shield layer were presented and compared with the cable without a shield layer.

Drivers Driving Habits Data and Risk Group Cluster Analysis (운전자 행동자료 및 고위험군 군집 분석)

  • Kim, Yong-Chul
    • The Journal of Korea Institute of Information, Electronics, and Communication Technology
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    • v.9 no.2
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    • pp.243-247
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    • 2016
  • Driving Event Data such as the rapid acceleration, the rapid deceleration, the sudden braking, and the sudden departure, and over speeding provide important information to predict or analyze the driving habits and accident risk of a driver. Most of the data that represent the driver's driving habits generally fit to the parametric distribution, whereas extreme parts of the data to estimate the accident risk of a driver may not. This paper presents an empirical distribution that is divided into two regions, one is from the normal distribution, and the other is from the general pareto distribution for the driving habits of a driver.

Prediction of steel corrosion in magnesium cement concrete based on two dimensional Copula function

  • Feng, Qiong;Qiao, Hongxia;Wang, Penghui;Gong, Wei
    • Computers and Concrete
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    • v.21 no.2
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    • pp.181-187
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    • 2018
  • In order to solve the life prediction problem of damaged coating steel bar in magnesium cement concrete, this study tries to establish the marginal distribution function by using the corrosion current density as a single degradation factor. Representing the degree of steel corrosion, the corrosion current density were tested in electrochemical workstation. Then based on the Copula function, the joint distribution function of the damaged coating was established. Therefore, it is indicated that the corrosion current density of the bare steel and coated steel bar can be used as the boundary element to establish the marginal distribution function. By using the Frank-Copula function of Copula Archimedean function family, the joint distribution function of the damaged coating steel bar was successfully established. Finally, the life of the damaged coating steel bar has been lost in 7320d. As a new method for the corrosion of steel bar under the multi-dimensional factors, the two-dimensional Copula function has certain practical significance by putting forward some new ideas.

VELOCITY DISTRIBUTION OF DARK MATTER GALACTIC HALO

  • OH K. S.
    • Journal of The Korean Astronomical Society
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    • v.30 no.1
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    • pp.95-106
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    • 1997
  • We investigate the velocity distribution of dark matter in the disk of a galaxy like the Milky Way at the solar radius. Using N-body simulations with the total mass and z-component of angular momentum conserved, we calculate the response of a dissipationless dark matter galactic halo during the dissipational collapse of the baryonic matter in spiral galaxy formation. The initial distribution of dark matter and baryonic particles is assumed to be a homogeneous mixture based on a King model. The baryonic matter is assumed to contract, forming the final luminous components of the galaxy, namely the disk and, in some cases, a bulge and central point. Both slow and fast growth of the luminous components are considered. We find that the velocity distribution of dark matter particles in a reference frame rotating slowly about the galaxy center in the plane of the disk is similar to a Maxwellian, but it is somewhat boxier, being flatter at the peak and truncated in the tails of the distribution. We tabulate parameters for the best-fitting Maxwellian and modified-Maxwellian distributions. There is no significant difference between slow collapse and fast collapse for all these results. We were unable to detect any effect of disk formation on the z-dependence of the dark matter density distribution.

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Goodness-of-fit tests for randomly censored Weibull distributions with estimated parameters

  • Kim, Namhyun
    • Communications for Statistical Applications and Methods
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    • v.24 no.5
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    • pp.519-531
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    • 2017
  • We consider goodness-of-fit test statistics for Weibull distributions when data are randomly censored and the parameters are unknown. Koziol and Green (Biometrika, 63, 465-474, 1976) proposed the $Cram\acute{e}r$-von Mises statistic's randomly censored version for a simple hypothesis based on the Kaplan-Meier product limit of the distribution function. We apply their idea to the other statistics based on the empirical distribution function such as the Kolmogorov-Smirnov and Liao and Shimokawa (Journal of Statistical Computation and Simulation, 64, 23-48, 1999) statistics. The latter is a hybrid of the Kolmogorov-Smirnov, $Cram\acute{e}r$-von Mises, and Anderson-Darling statistics. These statistics as well as the Koziol-Green statistic are considered as test statistics for randomly censored Weibull distributions with estimated parameters. The null distributions depend on the estimation method since the test statistics are not distribution free when the parameters are estimated. Maximum likelihood estimation and the graphical plotting method with the least squares are considered for parameter estimation. A simulation study enables the Liao-Shimokawa statistic to show a relatively high power in many alternatives; however, the null distribution heavily depends on the parameter estimation. Meanwhile, the Koziol-Green statistic provides moderate power and the null distribution does not significantly change upon the parameter estimation.

Evaluation of hydraulic behavior within parallel arranged upflow sedimentation basin using CFD simulation(II) -A CFD methodology for the design of distribution channel for improving inlet equity (CFD를 이용한 병열 배열형 상향류식 침전지 수리해석에 관한 연구(II) - 침전지 내 유입유량 균등성 향상을 위한 유입 분배수로 개선 -)

  • Park, No-Suk;Kim, Seong-Su;Choi, Jong-Woong;Wang, Chang-Keun
    • Journal of Korean Society of Water and Wastewater
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    • v.28 no.2
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    • pp.217-223
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    • 2014
  • In order to suggest the methodology for improving the equity of flow distribution in open channel with multiple outlet, CFD simulations were carried out for actual scale distribution channel being operated in domestic G_WTP(Water Treatment Plant). Also, before and after installing the longitudinal multi hole(diameter=250 mm, 116 holes) baffle suggested by this research, turbidity measurements data were collected for evaluating the effects of hydraulic modification for inlet flow equity. From the both results, total turbidity of settled water was lowered by 30 % and equity of flow distribution was improved about 60 % compared with before hydraulic structure modification.

Effects of Storage Temperature on Quality of Fresh Ginseng during Distribution (수삼의 저장온도가 유통 중 품질에 미치는 영향)

  • Lee, Ji Hyun;Chio, Ji Weon;Hong, Yoon Pyo;Kim, Geum Soog
    • Korean Journal of Medicinal Crop Science
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    • v.23 no.6
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    • pp.431-438
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    • 2015
  • Background : This study was conducted to determine out the effect of storage temperature on the quality of fresh ginseng (Panax ginseng C. A. Meyer) during distribution. Methods and Results : Fresh ginseng was washed, packed in $30{\mu}m$ low density polyethylene (LDPE) film, then stored at 0, -2 and $-4^{\circ}C$. After 4 weeks of storage, ginseng was then stored at $5^{\circ}C$, as a simulation of the distribution process. Ginseng stored at $-4^{\circ}C$ showed higher respiration rate, ethylene production and electrolyte conductivity during the distribution phase than those stored at 0 and $-2^{\circ}C$. Decay and browning rate rapidly increased following 3 weeks of distribution in samples stored $-4^{\circ}C$. However ginseng stored $-2^{\circ}C$, which is below freezing point, for 4 weeks did not show the physiological change or quality deterioration. Ginsenoside contents decreased during storage for all plant, but did not differ significantly between storage temperatures. Conclusions : Storage at temperatures below $-2^{\circ}C$ can negatively affect respiratory characteristics and electrolyte leakage and increase quality deterioration and decay rates during distribution.

Measurements of Velocity Distribution Function in Circular Open Channel Flows by Stereoscopic PIV (3차원 PIV에 의한 원형 개수로 유동의 속도분포 함수 측정)

  • Yoon, Ji-In;Sung, Jae-Yong
    • Korean Journal of Air-Conditioning and Refrigeration Engineering
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    • v.23 no.5
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    • pp.365-374
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    • 2011
  • For the first time, the present study has measured the velocity distribution function in circular open channel flow in a three-dimensional shape using a stereoscopic PIV system. For a given channel slope, water depth was varied from 30% to 80% of the channel diameter. Then, the characteristics of the velocity distribution function was compared according to the change of the water depth. Unlike a rectangular channel, the present experiment exhibited quite different shapes in the velocity distribution function whether the water depth is higher than 50% or not. Especially, the position of maximum velocity in the central and side wall changes in a different manner for the water depth above 50%. By differentiating the velocity distribution function, local wall friction coefficient was evaluated as a function of wall position. If the water depth goes down, the difference between the maximum and minimum values in the local wall friction coefficient increases, and the averaged value a1so increases.