• Strategy21
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• s.44
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• pp.79-102
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• 2018

2015년 미 해군에서 발간한 미 수상함대전략(Surface Force Strategy)에 따르면, 미 해군은 반접근-지역거부(Anti-Acess and Anti-Denial, A2/AD) 전략에 대한 대응책으로 '분산된 치명성(Distributed Lethality, DL)'이라는 신 작전개념을 개발 중에 있다. 이 개념은 각 유닛(unit)의 공격력(offensive power)을 향상시키고 지리적으로 분산 시킴으로써(geographical dispersion) 생존성을 향상시키는데 목적을 두고 있다. 하지만 동맹국(한국/일본 등)이 '분산된 치명성(DL)' 개념에 기여할 수 있는 영역이 다양함에도 불구하고, 지금까지 미 해군 내에서는 동맹국과 어떻게 공조해야 할 것인가에 대한 논의가 부족한 것이 사실이다. 따라서, 미 해군은 향후 '분산된 치명성(DL)' 이라는 작전개념에 동맹국이 줄 수 있는 이점을 추가적으로 적용하는 '동맹국을 활용한 분산된 치명성(Distributed Lethality with Allies, DL+A)' 개념을 발전시켜야 할 것이다. '동맹국을 활용한 분산된 치명성(DL+A)' 개념이란 동맹국이 가지고 있는 전력, 시설, 플랫폼 등 가용자산을 최대한 활용하여 기존의 '분산된 치명성(DL)' 개념을 강화시키는 신 작전개념이다. 미 해군은 본 논문에서 제시하는 신 작전개념(DL+A)을 적용함으로써 다양한 영역(정찰, 군수, 지리적 요충지, 플랫폼)에서 동맹국으로부터 지원을 받을 수 있을 것이다. 또한, 동맹국은 미 해군의 신 작전개념을 적용함으로써 A2/AD 전략에 대비한 안보능력을 향상시킬 수 있을 것이다.

• Strategy21
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• s.44
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• pp.28-53
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• 2018

The U.S. has recently developed Free and Open Indo-Pacific strategy and Distributed Lethality strategy based on a common perception that they are responding to China's threats. In the future, it is anticipated the following. Strengthen cooperation of the U.S.-India-Vietnam navy, Maximizing the combined combat power between the U.S. and regional navies, Improving its ability to restore damage control, Economic cooperation between the Pacific and Indian countries. The meanings given to the Korean navy are as follows. First, South Korea should pursue cooperation with the Indian Navy, which will grow into a regional balance on China's growth. The growth of the Indian navy is expected to increase cooperation with other Pacific countries. The government should seek ways to promote cooperation with india navy in various fields. Secondly, it is a joint drill between the U.S. Navy and the Korean Navy. Recently, the Korea-U.S. joint drill has not been conducted and many changes are expected to be made regarding the implementation of the joint drill in the future. Therefore, it is necessary to respond to possible changes in the naval relationship between Korea navy and the U.S. navy Also, due to distributed lethality strategy, preparations for operations and training with U.S.navy will be necessary. Lastly, it should contribute to cooperation among regional countries in preparation for maritime territorial disputes. The growth of the Chinese navy and the territorial disputes in the East and South China sea has raised the possibility of accidental military clashes at sea. Therefore, the government should make efforts to create multilateral security cooperation systems that can continue to promote the prevention of armed conflict.

• Strategy21
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• s.41
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• pp.52-84
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• 2017

After finishing Cold War, the U.S. Navy's ability to Sea control has been gradually eroded last 15-20 years. The global security environment demands that the surface Navy rededicate itself to sea control, as a new group of potential adversaries is working to deny U.S. navy command of the sea. China has been increasing their sea denial capability, such as extended anti-surface cruise missile and anti-surface ballistic missile. To cope with this situation, the U.S. Naval Surface Forces Command has announced Surface Forces Strategy: Return to Sea Control. It is a new operating and organizing concept for the U.S. surface fleet called 'distributed lethality'. Under distributed lethality, offensive weapons such as new ASCMs are to be distributed more widely across all types of Navy surface ships, and new operational concept for Navy surface fleet's capability for attacking enemy ships and make it less possible for an enemy to cripple the U.S. fleet by concentrating its attack on a few very high-value Navy surface ships. By increasing the lethality of the surface ships and distributing them across wide areas, the Navy forces potential adversaries to not only consider the threat from our carrier-based aircraft and submarines, but they now consider the threat form all of those surface ships. This idea of using the distributed lethality template to generate surface action groups and adaptive force package and to start thinking about to increase the lethal efficacy of these ships. The U.S. Navy believes distributed lethality increases the Navy's sea control capability and expands U.S. conventional deterrence. Funding new weapons and renovated operating concept to field a more lethal and distributed force will enable us to establish sea control, even in contested area. The U.S. Navy's Surface Forces Strategy provides some useful implications for The ROK Navy. First the ROK Navy need to reconsider sea control mission. securing sea control and exploiting sea control are in a close connection. However, recently the ROK Navy only focuses on exploiting sea control, for instance land attack mission. the ROK Navy is required to reinvigorate sea control mission, such as anti-surface warfare and anti-air warfare. Second, the ROK Navy must seek the way to improve its warfighting capability. It can be achieved by developing high-edge weapons and designing renewed operating concept and embraced new weapon's extended capabilities.

• Journal of Plant Biology
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• v.12 no.3
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• pp.1-7
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• 1969

The lethal actions in Arabidopsis thaliana and Lemna polyrhiza brought about by certain inorganic form of Mn, Ba, Hg, Cu salts, and organic form of Na salts, were studied with aseptic artificial media. These metal ions at certain concentrations caused lethality of either Arabidopsis or Lemna when the media were without Ca ion. On the contrary, addition of Ca to the media protected the organisms from such lethality. It was postulated for the present from the proceeding evidence that Ca adsorbed and distributed along the sites between the plasma and cell membrane acts for suppressing permeation of toxic level of metal ions causing the lethality of these plants.

• Advances in Traditional Medicine
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• v.7 no.4
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• pp.336-340
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• 2007

Plants from the genus Centaurea (C.) (Family: Asteraceae alt. Compositae), widely distributed in Asia, Europe and North America, have traditionally been used in the treatment of various ailments. As a part of our on-going studies on the plants from the genus C. for their phytochemistry and biological activities, extracts of the seeds of Turkish endemic C. species, C. bornmuelleri and C. huber-morathii, were tested for their cytotoxicity towards the CaCo2 colon cancer cell line as well as for the toxicity towards the brine shrimps, using the MTT and the brine shrimp lethality assays, respectively. Among the extracts, the MeOH extract of these plants showed significant toxicity towards the brine shrimps ($LD_{50}=55.2{\times}10^{-2}\;and\;42.4{\times}10^{-2}mg/ml$, respectively). The MeOH extract of both C. species also inhibited the growth of CaCo2 colon cancer cells in the MTT assay ($IC_{50}$=29.9 and 33.0 g/ml, respectively). As the most prominent activities in both assays were observed with the MeOH extracts, it can be assumed that the compound(s) responsible for these activities are polar in nature.

• Journal of the Korean Institute of Gas
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• v.21 no.5
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• pp.77-82
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• 2017

Thus, chemicals are managed under 9 related central government department and 16 relevant laws with program such as Process Safety Management and Offsite Consequence Analysis in korea. Guidelines for set the endpoint concentration for chemcals based on the ERPG-2 (Emergency Response Planning Guidelines-2) and AEGL-2 (Acute Exposure Guidelines Level-2). but ERPG and AEGL do not describe exposure for less than 10 minutes. because of this, each guidelines define criteria differently for short time less than 10 minutes exposure. This indefinite exposure criteria would give rise to a confusion in the chemical plants, and potentially lead to a critical decision making error when accidents happen. In an effort to apply guidelines with evenly-distributed initial time frame, AEGL concentrations within 10 minute exposure time were evaluated by examining statistical regression curves. The results were in good agreement with those from the Probit Function based on each AEGL grade to explain 3 different threshold levels of exposure effects. Resultant re-enforced guidelines for endpoint chemical concentrations are, therefore, to provide powerful tool to assess and manage the risk associated with any potential chemical accidents at an early stage.

• Reproductive and Developmental Biology
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• v.33 no.2
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• pp.93-98
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• 2009

In this study, bovine Dnmt1 cDNA was sequenced and detected Dnmt1 mRNA level in bovine tissues by northern blot, methylation pattern of genome by southern blot, specific localization of Dnmt1 in mouse and bovine preimplantation embryos by immunocytostaining and Dnmt1 protein level in ovary and testis by western blot. Bovine Dnmt1 cDNA sequence showed more homology with that of human than mouse and rat. The RNA level of Dnmt1 was 10 times higher expression in placenta than other tissues. This indicates that placenta was hypermethylated compared to others organs. The genomic DNA could not be cut by a specific restriction enzyme (HpaII) in placenta, lung and liver of bovine. It suggests that Dnmt1 in some somatic cells was already methylated. Dnmt1, which has the antibody epitope 1316~1616, was distributed in nucleus and cytoplasm including the stage of pronuclear stage and maturation of oocyte and gradually weaken to blastocyst stage compare to negative. In addition, Dnmt1 was strongly expressed in tetraploid embryo and cloned 8-cell than IVF 8-cell. An aberrant pattern of DNA methylation in cloned embryo may be abnormal development of fetus, embryonic lethality and placenta dysfunction. The somatic specific band (190kDa) was appeared in ovary and testis, but oocyte specific band (175kDa) was not. Further investigations are necessary to understand the complex links between the methyltransferases and the transcriptional activity of genes in the cloned bovine tissues.

• Journal of Intelligence and Information Systems
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• v.24 no.4
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• pp.137-154
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• 2018

Animal infectious diseases, such as avian influenza and foot and mouth disease, occur almost every year and cause huge economic and social damage to the country. In order to prevent this, the anti-quarantine authorities have tried various human and material endeavors, but the infectious diseases have continued to occur. Avian influenza is known to be developed in 1878 and it rose as a national issue due to its high lethality. Food and mouth disease is considered as most critical animal infectious disease internationally. In a nation where this disease has not been spread, food and mouth disease is recognized as economic disease or political disease because it restricts international trade by making it complex to import processed and non-processed live stock, and also quarantine is costly. In a society where whole nation is connected by zone of life, there is no way to prevent the spread of infectious disease fully. Hence, there is a need to be aware of occurrence of the disease and to take action before it is distributed. Epidemiological investigation on definite diagnosis target is implemented and measures are taken to prevent the spread of disease according to the investigation results, simultaneously with the confirmation of both human infectious disease and animal infectious disease. The foundation of epidemiological investigation is figuring out to where one has been, and whom he or she has met. In a data perspective, this can be defined as an action taken to predict the cause of disease outbreak, outbreak location, and future infection, by collecting and analyzing geographic data and relation data. Recently, an attempt has been made to develop a prediction model of infectious disease by using Big Data and deep learning technology, but there is no active research on model building studies and case reports. KT and the Ministry of Science and ICT have been carrying out big data projects since 2014 as part of national R &D projects to analyze and predict the route of livestock related vehicles. To prevent animal infectious diseases, the researchers first developed a prediction model based on a regression analysis using vehicle movement data. After that, more accurate prediction model was constructed using machine learning algorithms such as Logistic Regression, Lasso, Support Vector Machine and Random Forest. In particular, the prediction model for 2017 added the risk of diffusion to the facilities, and the performance of the model was improved by considering the hyper-parameters of the modeling in various ways. Confusion Matrix and ROC Curve show that the model constructed in 2017 is superior to the machine learning model. The difference between the2016 model and the 2017 model is that visiting information on facilities such as feed factory and slaughter house, and information on bird livestock, which was limited to chicken and duck but now expanded to goose and quail, has been used for analysis in the later model. In addition, an explanation of the results was added to help the authorities in making decisions and to establish a basis for persuading stakeholders in 2017. This study reports an animal infectious disease prevention system which is constructed on the basis of hazardous vehicle movement, farm and environment Big Data. The significance of this study is that it describes the evolution process of the prediction model using Big Data which is used in the field and the model is expected to be more complete if the form of viruses is put into consideration. This will contribute to data utilization and analysis model development in related field. In addition, we expect that the system constructed in this study will provide more preventive and effective prevention.