• 한국동물위생학회지
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• 제44권1호
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• pp.35-43
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• 2021

Rabbit infectious hemorrhagic fever has been reported in rabbits worldwide. The disease is also frequently reported on Korean rabbit farms, and the pathological study of 9 rabbits on such disease-occurring farms was attempted to identify the pathogen. Clinical signs were torticollis and ear ulceration. Most rabbit died with bloody nasal discharges. At necropsy, multiple hemorrhages and inflammation were observed in heart, lung, liver and uterus. The main histopathologic features were hemorrhagic suppurative meningoencephalitis, fibrinous bronchointerstitial pneumonia, bacteremia, liver cell necrosis, multifocal hemorrhages in kidney and disseminated intravascular coagulopathy. The viral VP60 gene of RHDV was identified by Reverse Transcriptase PCR. Pasteurella multocida organisms were cultured, identified by biochemical test and serotyped as A by multiplex capsular typing PCR. In conclusion, the fatal hemorrhagic disease was due to combined infection with both RHDV and P. multocida in rabbits. To our knowledge, this is the first case report about co-infection with both RHDV and P. multocida in rabbits in Korea.

• Journal of Chest Surgery
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• 제23권2호
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• pp.275-284
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• 1990

A serious problem after cardiovascular surgery known as Multiple Organ Failure[MOF] whereby several vital organs successively demonstrate dysfunction in spite of intensive postoperative treatment has recently arisen. We have made a retrospective study of the clinical records of 137 patients who underwent cardiovascular surgery during past two years [1987-1988]. Fourteen patients [10%] developed multi-organ failure postoperatively with the results of seven death [50%]. In fatal group, preoperative poor cardiac function [Cardiac Index<2.0L/min/m2] was considered important prognostic factor and infection 5 disseminated intravascular coagulation complicating gastrointestinal bleeding were the leading cause of death. In conclusion, evaluation of multiple factors concerning multi-organ failure demonstrates preoperative poor functional preservation of vital organs is the main factor. So early diagnosis k management for each of the failing organs & prevention of infection are mandatory of the treatment of these critically ill patients.

• Pediatric Infection and Vaccine
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• 제24권3호
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• pp.188-192
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• 2017

호흡기세포융합바이러스는 소아 하기도 감염의 주된 원인으로 대부분의 양호한 경과를 보이지만, 일부에서는 호흡부전과 같은 심한 경과를 보이기도 한다. 이러한 심한 호흡기세포융합바이러스 감염에는 드물지 않게 폐외증상이 동반될 수 있다. 저자들은 기계 환기를 필요로 하는 하기도 감염과 함께 급성 심근염, 전격성 간 기능부전을 보인 심한 호흡기세포융합바이러스 감염을 경험하였기에 문헌고찰과 함께 보고하는 바이다.

• Investigative Magnetic Resonance Imaging
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• 제19권3호
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• pp.186-190
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• 2015

Acute disseminated encephalomyelitis (ADEM) is a demyelinating and inflammatory condition of the central nervous system, occurring predominantly in white matter. ADEM involving the rhombencephalon without affecting the white matter is very rare. Here, we present an unusual case of ADEM involving only the rhombencephalon in a 4-year-old Asian girl. The patient complained of pain in the right lower extremities, general weakness, ataxia, and dysarthria. The initial brain CT showed subtle ill-defined low-density lesions in the pons and medulla. On brain MRI, T2 high signal intensity (T2-HSI) lesions with mild swelling were present in the pons, both middle cerebellar peduncles, and the anterior medulla. The initial diagnosis was viral encephalitis involving the rhombencephalon. Curiously, a cerebrospinal fluid (CSF) study revealed no cellularity, and negative viral marker findings. Three weeks later, follow up brain MRI showed that the extent of the T2-HSI lesions in the brain stem had decreased. After reinvestigation, it was found that she had a prior history of upper respiratory infection. In this case, we report the very rare case of a patient showing isolated involvement of the rhombencephalon in ADEM, mimicking viral rhombencephalitis on CT and MR imaging. ADEM can involve unusual sites such as the rhombencephalon in isolation, without involvement of the white matter or deep gray matter and, therefore, should be considered even when it appears in unusual anatomical areas. Thorough history taking is important for making a correct diagnosis.

• Tuberculosis and Respiratory Diseases
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• 제60권1호
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• pp.97-101
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• 2006

Coccidioidomycosis is a rare systemic fungal infection in Korea. However, the incidence of coccidioidomycosis has recently begun to increase due to the increasing incidence of people traveling overseas to endemic areas. In previously reported cases of coccidioidomycosis in Korea, the radiographic findings usually showed a solitary pulmonary nodule, pleural effusion, cavitation, and hilar lymphadenopathy, but no miliary nodules. We report a case of disseminated coccidioidomycosis with miliary nodules in an immunocompetent patient. A 32 year old male, who had traveled in Corona, New Mexico, USA, was admitted for an evaluation of persistent cough with fever. Chest radiography revealed initially diffuse multiple small nodules that appeared to be miliary tuberculosis. However, a subsequent evaluation revealed that he had disseminated coccidioidomycosis.

• Journal of Preventive Medicine and Public Health
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• 제46권2호
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• pp.62-73
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• 2013

Objectives: An outbreak of hepatitis A occurred at a residential facility for the disabled in July 10, 2011. This investigation was carried out to develop a response plan, and to find the infection source of the disease. Methods: A field epidemiologist investigated the symptoms, vaccination histories, living environments, and probable infection sources with 51 residents and 31 teachers and staff members. In July 25, 81 subjects were tested for the hepatitis A virus antibody, and specimens of the initial 3 cases and the last case were genetically tested. Results: Three cases occurred July 10 to 14, twelve cases August 3 to 9, and the last case on August 29. Among the teachers and staff, no one was IgM positive (on July 25). The base sequences of the initial 3 and of the last case were identical. The vehicle of the outbreak was believed to be a single person. The initial 3 patients were exposed at the same time and they might have disseminated the infection among the patients who developed symptoms in early August, and the last patient might have, in turn, been infected by the early August cases. Conclusions: The initial source of infection is not clear, but volunteers could freely come into contact with residents, and an infected volunteer might have been the common infection source of the initial patients. Volunteers' washing their hands only after their activity might be the cause of this outbreak. Although there may be other possible causes, it would be reasonable to ask volunteers to wash their hands both before and after their activities.

• Tuberculosis and Respiratory Diseases
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• 제39권4호
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• pp.355-360
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• 1992

저자들은 57세 남자환자에서 전형적인 Nocardiosis의 임상상을 보이고 객담 및 피부 농양에서 Nocardia asteroides가 분리 동정된 1예를 경험하였기에 이를 문헌고찰과 함께 보고하는 바이다.

• Tuberculosis and Respiratory Diseases
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• 제58권4호
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• pp.399-403
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• 2005

우리나라는 콕시디오이데스 진균증의 유행지역이 아니기 때문에 유행지역에 대한 해외여행자나 이민거주자가 아니면 임상적으로 의심하기가 쉽지 않다. 저자들은 해외여행력과 이민거주자가 아닌 내국인으로 당뇨와 의인성 쿠싱 증후군을 오랫동안 간과해 왔던 상태에서 일광화상 후 생긴 피부상처 치료도중 우연히 파종성 콕시디오이데스 진균증을 진단하게 되었기에 문헌고찰과 함께 보고하는 바이다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제33권5호
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• pp.445-448
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• 2011

Mortality associated with maxillofacial infection is relatively low due to the development of antibiotics, and improved oral care. However, inappropriate treatment, delayed treatment, old age, underlying systemic disease, and drug-resistant microorganisms can potentially result in life threatening situations such as cavernous sinus thrombosis, mediastinitis, and sepsis. Sepsis is the most dangerous state with high mortality, ranging from 20~60%. The treatment of sepsis involves properly monitoring vital functions, fluid resuscitation, surgical drainage, and empirical use of high doses of antibiotics until culture results are available. Ventilatory support maybe be required as well. We encountered a 64-year-old patient who died from sepsis that developed as the result of an odontogenic infection. The initial diagnosis was right temporal, infraorbital, buccal, pterygomandibular space abscess. Despite surgical and medical supportive care, the condition progressed to sepsis and after four days the patient died due to multiple organ failure.

• 대한소아치과학회지
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• 제34권3호
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• pp.526-531
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• 2007

톡소플라즈마증은 원충인 toxoplasma gondii의 감염에 의해 일어난다. Toxoplasma gondii는 동물에 기생하고 있는 것으로 알려져 있다. 사람에 대한 감염원으로는 개나 고양이 등 애완동물과 돼지, 소, 말 등의 가축 등이 제시되고 있다. 병든 동물의 분비물이나 배출물로부터 경구 감염이 된다고 생각되며, 돼지, 소, 양 등의 식육으로부터 감염되는 것으로도 알려져 있다. 톡소플라즈마증은 선천형과 후천형으로 나뉘며, 그 임상 증상도 다르게 나타난다. 선천형인 경우 뇌수종, 맥락 망막염, 경련, 지능장애, 소두증이 나타나며 후천형은 산재성 형태와 임파종 형태로 다시 나뉘며, 임파종 형태가 남자에서 좀 더 흔하게 나타난다. 본 증례는 선천성 톡소플라즈마증을 보이는 8세 2개월의 여아의 임상적 양상, 의과적 병력, 방사선학적 평가, 치과적 문제점에 대한 보고이다.