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Influence of Melatonin on Reproductive Function in Male Golden Hamsters (수컷 골든 햄스터의 생식기능에 미치는 멜라토닌의 영향)

  • Choi, Don-Chan
    • Development and Reproduction
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    • v.5 no.1
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    • pp.1-8
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    • 2001
  • Golden hamsters show the reproductive activity that is determined by the photoperiod (length of light per day). Photoperiod is an environmental factor that is predictable through an entire year. The hamsters are sexually active in summer during which day length exceeds night time. The critical length is at least 12.5 hours of light in a day where reproductive function is maintained. The information of photoperiod is mediated by the pineal gland because removal of pineal gland blocks the influence of photoperiod on reproductive activity. The hamsters without pineal gland maintain sexual activity and promote it in a situation that suppresses gonadal activity. The pineal gland secretes melatonin that reflects the photoperiod. The appropriate administrations of melatonin into both pineal intact and pinealectomized hamsters lead to a gonadal reression. The results suggest that melatonin constitutes a part of control mechanism whereby environmental information is transduced to neuroendocrine signal respensible for the functional integrity of the reproductive system. Despite of the intense studies, the action site of melatonin is on the whole unknown. It is mainly due to the lack of acute efffct of melatonin on the secretion of reproductive hormones. However, sexually regressed animals display the low levelsof gonadotropins and the augmentation of the hypothalamic gonadotropin-releasing hormone (GnRH) content, implying that the antigonadotropic effects either by photoperiod and/or by the treatment of melatonin are mediated by the GnRH neuronal system. The action mechanism by which melatonin exerts its effect on GnRH neuron needs to be investigated. Recent cloning of melatonin receptor will contribute to examine various and putative potencies of melatonin via its anatomical identification and the action mechanism of melatonin on target tissues at the molecular level.

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Effects of Sex Education Program related to the Unit of Reproduction and Development on Middle School Boys' Sex-related Knowledge and Attitude towards Sex (생식과 발생 단원과 연계한 성교육 프로그램이 중학교 남학생들의 성지식 및 성태도에 미치는 영향)

  • Kim, Sun Young;Park, Su Bin
    • Journal of Science Education
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    • v.42 no.2
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    • pp.148-164
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    • 2018
  • This study developed the sex education program based on the 'reproduction and development' unit of the middle school science, and examined its effectiveness on middle school boys' sex-related knowledge and attitude towards sex. The sex education program consisted of six topics of the structures and functions of generative organs, the importance of life, abortion, the human generation process, venereal diseases and AIDS, and responsibility of self-determination on sexual behavior. The results indicated that the experimental group demonstrated the statistically higher scores of the knowledge on sex than the control groups' scores, especially in the subcategories of 'pregnancy and delivery' and 'sex-related health'. However, both groups did not display any statistical difference on the attitude toward sex. In the subcategory of the attitude towards sex, the experimental group showed the statistically higher scores on 'self-determination and selection' and 'a health relationship'. In addition, the Pearson correlation results indicated the strongest relationship between the attitude toward sex and 'the self-determination and selection'. These results implicated that the sex education program related to the unit of reproduction and development in the middle school science helps the middle school boys develop the better knowledge and attitude towards sex.

In vitro response of rat microglia and human polymorphonuclear cells (PMN) to immunoactive compounds

  • Lombardi, Valter RM;Eetcheverria, Ignacio;Fernandez-Novoa, Lucia;Diaz, Joaquin;Seoane, Silvia;Cacabelos, Ramon
    • Advances in Traditional Medicine
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    • v.5 no.3
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    • pp.216-230
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    • 2005
  • Although the field of study in immune enhancing compounds is relatively new, natural products from plants represent a rich and promising source of novel molecules with immunomodulating properties, Microglial cells, the main immune effector cells of the brain, usually display a ramified morphology and low expression levels of immunologically relevant antigens such as MHC class I and class II. Since any compound which participates in activation of phagocytic cells contributes to the production of potentially toxic factors, the search for convenient in vitro test-systems and study of mechanisms of action of these agents are of great interest. Human blood polymorphonuclear (PMN) cells and primary microglial cells isolated from Sprague-Dawley rats were used as cellular screening tests for study of phagocytosis-stimulating action of immunomodulating agents. Numbers of phagocytic activity were evaluated by the phagocyte ingestion of yeast cells and NO-synthase activity, nitrite production, and nitroblue tetrazolium test were determined after phagocyte stimulation. It was possible to demonstrate that indexes of phagocytic activity can be used as quantitative indicators for measurement immunomodulating activity. As a positive control, Zymosan A-induced phagocytosis in both PMN cells and primary microglial cells was used. $IFN-{\gamma}$ (0.1 -1 U/ml) stimulated phagocytosis in PMN cells 1.2 times after 2 - 3 h incubation, although at higher concentrations (10 - 100 U/ml) it strongly inhibited phagocytosis. In a similar way, at higher concentrations, $IFN-{\gamma}$ (100 - 500 U/ml) suppressed phagocytosis in zymosan-A stimulated microglial cells. When Polypodium leucotomus, cambricum and vulgare extracts were tested alone, increased levels of phagocytosis were observed in PMN. In addition, microglial cells showed both increased phagocytosis and MHC class-II antigen expressions. Surprisingly, when PMN and microglia were treated with a combination of Polypodium and $IFN-{\gamma}$, phagocytosis was not inhibited. We did not find changes in NO-synthase activity and nitrite production in both microglia and PMN cells activated by different immunomodulating agents. These results indicate that primary microglial cell cultures as well as human PMN cells can provide reproducible quantitative results in screening phagocytic activity of different immunoactive compounds. Furthermore, both inhibitory or activation mechanisms might be studied using these in vitro experimental approaches.

Effect of Virtual Reality Training for the Enclosed Space Entry (밀폐공간진입을 위한 가상현실(VR) 훈련의 효과)

  • Chae, Chong-Ju;Lee, Jin-Woo;Jung, Jin-Ki;Ahn, Young-Joong
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.24 no.2
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    • pp.232-237
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    • 2018
  • According to the MAIIF report, from 1998 to 2009, 101 incidents involving entering enclosed spaces aboard ships resulted in 93 deaths and 96 casualties. IMO has therefore amended the Recommendations for entering Enclosed Spaces Entry and SOLAS 1974 Convention Chapter 3 Regulation 19, which mandates enclosed spaces entry and rescue drill on a regular basis. The training of entering such enclosed spaces should be practical, recognizing all possible risks of entering enclosed spaces aboard ships, while also considering the safety of trainees during the training. Recently, educational contents utilizing virtual reality (VR) have been applied in various fields to improve education and training effects, and these methods have proven to have advantages in actual and repetitive learning without being limited to physical space. In this study, the effectiveness, characteristics and differentiation of training of entering enclosed spaces aboard ships using VR were compared with traditional class room lectures through quantitative evaluation and questionnaires of training participants. Through the evaluation and questionnaire, it was found that participants using VR understood and learned the required training elements better than the control group, all of whom were trained through the normal class room lecture. Moreover, participants reported to display preference for training with the help of VR. As a result of the study, it was confirmed that the learning effects of VR onboard training can be used as an effective training method, especially by using video and other types of simulators.

An Effect of Visual Acuity Protection by Natural Pigment (Anthocyanine) Extracted from Fermented Purple Sweet Potato (발효 자색고구마 추출 천연색소(anthocyanine)에 의한 시력보호 효과)

  • Seo, Eun-Sun;Ryu, Geun-Chang
    • Journal of Korean Ophthalmic Optics Society
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    • v.17 no.4
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    • pp.395-401
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    • 2012
  • Purpose: The purpose of this study was to research any effect on vision protecting or decreasing VDT syndrome of extracted anthocyanine from fermented purple sweet potato and blueberry. Methods: Subjects were aged 19-20 years old who do not have ophthalmic and systemic diseases and over -N4.00 D of refraction error. 40 mg of extracted anthocyanine from fermented purple sweet potato, from blueberry, and control group, placebo were dosed at separate try. After 2 hours later, subjects were directed perform visual display terminal (VDT) work for 2 hours. Objective refractive error was measured before dosing anthocyanine and after VDT work for 2 hours. Degree of head ache, eye pain and strain and subjective symptoms of neck, shoulder and waist was also examined through interviews by dividing its degree into severe, moderate, slight or none. Results: After 2 hours VDT work, vision protection effect in terms of refractive error for dominant eye was decreased by $0.031{\pm}0.21$ D in the group of extracted anthocyanine from fermented purple sweet potato, $0.006{\pm}0.32$ D in the group of extracted anthocyanine from blueberry. However, there was significantly myopic progression in the placebo group by $0.144{\pm}0.28$ D (t=2.27, p=0.03). Conclusions: It is considered that extracted anthocyanine from fermented purple sweet potato inhibits increase of refraction anomalies of dominant eye rather than non-dominant eye after VDT work.

Development of ArcGIS-based Model to Estimate Monthly Potential Soil Loss (월단위 토양유실가능성 추정을 위한 ArcGIS 기반의 모형 개발)

  • Yu, Na Young;Lee, Dong June;Han, Jeong Ho;Lim, Kyoung Jae;Kim, Jonggun;Kim, Ki Hyoung;Kim, Soyeon;Kim, Eun Seok;Park, Youn Shik
    • Journal of The Korean Society of Agricultural Engineers
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    • v.59 no.1
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    • pp.21-30
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    • 2017
  • Soil erosion has been issued in many countries since it causes negative impacts on ecosystem at the receiving water bodies. Therefore best management practices to resolve the problem in a watershed have been developed and implemented. As a prior process, there is a need to define soil erosion level and to identify the area of concern regarding soil erosion so that the practices are effective as they are designed. Universal Soil Loss Equation (USLE) were developed to estimate potential soil erosion and many Geographic Information System (GIS) models employ USLE to estimate soil erosion. Sediment Assessment Tool for Effective Erosion Control (SATEEC) is one of the models, the model provided several opportunities to consider various watershed peculiarities such as breaking of slope length, monthly variation of rainfall, crop growth at agricultural fields, etc. SATEEC is useful to estimate soil erosion, however the model can be implemented with ArcView software that is no longer used or hard to use currently. Therefore SATEEC based on ArcView was rebuild for the ArcGIS software with all modules provided at the previous version. The rebuilt SATEEC, ArcSATEEC, was programmed in ArcPy and works as ArcGIS Toolset and allows considering monthly variations of rainfall and crop growth at any watershed in South-Korea. ArcSATEEC was applied in Daecheong-dam watershed in this study, monthly soil erosion was estimated with monthly rainfall and crop growth variation. Annual soil erosion was computed by summing monthly soil erosion and was compared to the conventional approach to estimate annual soil erosion. The annual soil erosion estimated by the conventional approach and by summing monthly approach did not display much differences, however, ArcSATEEC was capable to provide monthly variation of soil erosion.

Research on Communication and The Operating of Server System for Vehicle Diagnosis and Monitoring (차량진단 및 모니터링을 위한 통신과 서버시스템 운용에 관한 연구)

  • Ryoo, Hee-Soo;Won, Yong-Gwan;Park, Kwon-Chul
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.48 no.6
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    • pp.41-50
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    • 2011
  • This article is concerned with the technology to provide car driver the car's status which are composed of car trouble code in car engine and many sensors. In addition, it installs vehicle diagnostic programs on wireless communication's portable device, for example, Smart phone, PDA, PMP, UMPC. As a result, this is to provide car manager with many information of car sensors when we go to car maintenance. it can monitor relevant information on vehicle by portable device in real time, alert drivers with specific messages and also enable them to address abnormalities immediately. Moreover, the technology could help the drivers who perhaps don't know very well about their vehicles to drive safely and economically as well; the reason is because the whole system is composed of just Vehicle-information collecting device and personal wireless communication's portables and transfers the relating data to server computers through wireless network in order to handle information on vehicles. This technology make us monitor vehicle's running, failure and disorder by using wireless communication's portable device. Finally, this study system is composed of a lot of application to display us the car's status which get car's inner sensor information while driving a car.

A Study on the Phobia Treatment Using 3D Virtual Reality System (3D 가상환경시스템 이용한 공포증 치료에 대한 연구)

  • Paek Seung-Eun
    • The Journal of Information Technology
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    • v.5 no.4
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    • pp.45-55
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    • 2002
  • Virtual Reality(VR) is a new technology which makes humans communicate with computer. It allows the user to see, hear, feel and interact in a three-dimensional virtual world created graphically. In this paper, we introduced VR into psychotherapy area and developed VR system for the exposure therapy of acrophobia. Acrophobia is an abnormal fear of heights. Medications or cognitive-behavior methods have been mainly used as a treatment. Lately the virtual reality technology has been applied to that kind of anxiety disorders. A virtual environment provides patient with stimuli which arouses phobia, and exposing to that environment makes him having ability to over come the fear. In this study, the elevator stimulator that composed with a position sensor, head mount display, and audio system, is suggested. To illustrate the physiological difference between a person who has a feel of phobia and without phobia, heart rate was measured during experiment. And also measured a person's HR after the virtual reality training. In this study, we demonstrated the subjective effectiveness of virtual reality psychotherapy through the clinical experiment.

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Research on Light Application System for the Dynamic Moving Effect of The Design on Porcelain (도자기 표면의 문양을 역동적으로 움직이는 효과를 갖는 광응용 시스템연구)

  • Ryoo, Hee Soo
    • Journal of the Institute of Electronics and Information Engineers
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    • v.51 no.11
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    • pp.205-210
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    • 2014
  • This is concerned with the technology to display the design on Porcelain and adjust malfunction for moving effect and light intensity by curator. More precisely, the technology makes it possible that the porcelain is connected to Light module which is the device for controlling light emission and rotating rolling plate, etc that are connected to LED light module, optical fiber and controller that is for scenario from the given storytelling. In addition, with a WiFi portable device (Smart-phone, other mobile device). equipped with a scenario programs, information for operation, failure and malfunction can be obtained and analyzed in real-time, and menu color and alarm is alerted when the displaying design is in abnormal status, which makes the early reactions to the status. Furthermore, the collected data can be sent through WiFi network to the device and PC managed by the curator specialized in managing the design on the Porcelain, thus the technology could help the curator who have less knowledge about moving pattern on the Porcelain. There is always a possibility of malfunction due to various condition that are caused by wring-harness when modules are wired-connected. In this research, in order to overcome this problem, we propose a system configuration that can do monitoring and diagnosis with a device for collecting data from LED control module, Light emission sensor and a personal WiFi device. Also, we performed connection between optical Fiber and LED and interlock for the system defined by the definition for information and storytelling scenario.

Georadar System Using Network-Analyzer (네트웍 분석기를 이용한 레이다탐사 시스템의 구현)

  • Cho Seong-Jun;Kim Jung-Ho;Lee Seoung Kon;Son Jeong-Sul;Chung Seung-Hwan
    • Geophysics and Geophysical Exploration
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    • v.5 no.4
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    • pp.272-279
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    • 2002
  • During field survey of ground penetrating radar or borehole radar, we often encounter some problems which could be solved easily by modifying structure of the system such as antenna length, shape or array. In addition, it is necessary that the user could easily modify configuration of the radar system na test various array of antennas in order to verify and confirm numerical modeling results concerning radar antennas. We have developed network-analyzer-based, stepped-frequency georadar system. This system had been comprised with coaxial cable to confirm possibility of the system, then we have upgraded the system to use optical cable that is composed of optical/electric transducers, electric/optical transducers, amp, pre-amp and antennas. The software for the aquisition of data has been developed to control the system automatically using PC with GPIB communication and to display the obtained data graphically. We have tested the system in field survey na the results have been compared with those of RAMAC/GPR system.