• 한국간호교육학회지
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• 제18권2호
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• pp.206-219
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• 2012

Purpose: Incorporating simulation modalities into nursing education is known to be effective in enhancing education outcomes. Standardizing the nomenclature of simulation modalities and developing a comprehensive conceptual framework for guiding the development of simulation modules are mandated given the prevalence and disorganization of simulation education. This article, thus, was aimed to summarize literature and propose a conceptual framework for structuralizing simulation education in Korea. Methods: A comprehensive literature review on CINAHL, PubMed, RISS, KISS, DBpia and renowned Korean nursing journals was conducted including articles from 2002 to 2011. Results: The nomenclature of simulation modalities was clarified and summarized. Twenty-eight studies on the effects of simulation education were summarized in a table demonstrating the state of the science in simulation research. In addition, 'a conceptual framework for three-dimensional nursing simulation education' was proposed, described in detail, and diagramed. According to 'the 3D simulation framework', each three axes, i.e., the scope of practice, complexity, and student competency, has three phases in accomplishing a high level of competency. Conclusion: The proposed '3D simulation framework' is hoped to be a theoretical guide in designing a clinical curriculum utilizing simulation and developing detailed simulation modules in clinical practicum courses.

• 한국사회복지학
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• 제67권3호
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• pp.57-82
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• 2015

본 연구의 목적은 동네환경과 정신장애인의 지역사회통합과의 관계에서 지역사회응집력의 조절효과를 검증하는 데 있다. 스트레스과정 모델, 사회해체이론, 그리고 동네무질서모델을 이론적 근거로 연구모형을 설정하였다. 서울과 경기도에 거주하는 정신장애인 총 692명에게 설문조사를 실시하여 자료를 수집한 뒤, 조절회귀분석을 수행하였다. 주요한 연구결과는 첫째, 동네무질서가 사회적 통합에 직접적 영향을 미치는 것으로 나타났다. 둘째, 지역사회응집력의 조절 효과는 물리적, 사회적, 심리적 통합 모두에서 유의미하게 나타났다. 연구결과를 바탕으로 정신장애인의 지역사회통합을 달성하기 위해서는 개인차원이나 서비스 차원의 개입전략에서 더 나아가 지역사회차원의 개입이 필요함을 제안하였다.

• Asian Pacific Journal of Cancer Prevention
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• 제15권2호
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• pp.561-568
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• 2014

Background: The skin is the largest body organ that regulates excretion of metabolic waste products, temperature, and plays an important role in body protection against environmental physical and chemical, as well as biological factors. These include agents that may act as oxidants or catalysts of reactions producing reactive oxygen species (ROS), reactive nitrogen species (RNS), and other oxidants in skin cells. An increased amount of the oxidants, exceeding the antioxidant defense system capacity is called oxidative stress, leading to chronic inflammation, which, in turn, can cause collagen fragmentation and disorganization of collagen fibers and skin cell functions, and thus contribute to skin diseases including cancer. Moreover, research suggests that oxidative stress participates in all stages of carcinogenesis. We report here a summary of the present state of knowledge on the role of oxidative stress in pathogenesis of dermatologic diseases, defensive systems against ROS/RNS, and discuss how physical activity may modulate skin diseases through effects on oxidative stress. The data show duality of physical activity actions: regular moderate activity protects against ROS/RNS damage, and endurance exercise with a lack of training mediates oxidative stress. These findings indicate that the redox balance should be considered in the development of new antioxidant strategies linked to the prevention and therapy of skin diseases.

• 유통과학연구
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• 제16권7호
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• pp.47-56
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• 2018

Purpose - This study aims to not only investigate spatial pattern of immigrants' residence and crime occurrences in South Korea, but shed light on how geographic distribution of immigrants and immigrant segregation affect crime rates. Research design, data, and methodology - Th unit of analysis is Si-Gun-Gu municipal level entities of South Korea. The crime data was obtained by Korea National Police Agency and two major types(violence and property) of crime were measured. Most demographic, social, and economic variables were derived from Korean Census Data in 2015. In order to examine spatial patterns of immigrants' distribution and crime rates in South Korea, the present study utilized GIS mapping technique and Exploratory Spatial Data Analysis(ESDA) tools. The causal linkage was investigated by a series of regression models using STATA. Results - Spatial inequality between urban metropolitan vs rural areas was visualized by mapping. Assuming large Moran's I value, spatial autocorrelation appeared to be quite strong. Several neighborhood characteristics such as residential stability and economic prosperity were found to be important factors leading to crime rate change. Residential distribution and segregation for immigrants were negatively significant in the regression models. Conclusions - Unlike the traditional arguments of social disorganization theory, immigrant segregation appeared to reduce violent crime rate and the high proportion of immigrants also turned out to be a crime prevention factor.

• Asian-Australasian Journal of Animal Sciences
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• 제19권12호
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• pp.1799-1808
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• 2006

This study was designed to explore the effects of marbling on meat quality characteristics and intramuscular connective tissue of beef longissimus muscle. Chemical determinations, histological and mechanical measurements were performed on the raw and cooked meat at d 4 postmortem. The results showed that crude fat, collagen, fiber diameter and maximum transition temperature of intramuscular connective tissue increased (p<0.05) with the increase of marbling score. The cooking losses, collagen solubility, WBSF and perimysial thickness decreased (p<0.05) with the increasing marbling. WBSF correlated (p<0.05) with moisture, crude fat, collagen, cooking losses, sarcomere length and perimysial thickness. The development of marbling results in the decline in cooking losses, the avoidance of sarcomere shortening, and the disorganization of the perimysia, which accounts for the improvement of beef tenderness.

• The Korean Journal of Physiology and Pharmacology
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• 제10권1호
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• pp.13-17
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• 2006

Experimentally induced cortical disorganization exhibits many anatomical features which are characteristic of cortical malformations in children with early-onset epilepsy. We used an immunocytochemical technique and extracellular field potential recordings from the dorsal hippocampus to determine whether the excitability of the CA1 pyramidal cells was enhanced in rats with exnerimentallv induced hippocampal dysplasia. Compared with control rats, the MAM-treated rats displayed a decrease of paired pulse inhibition. When $GABA_A$ receptor antagonists were blocked with $10{\mu}M$ bicuculline the amplitude of the second population spike of the MAM-treated of rats was similar to that of the first population spike, as was in the control rats. The MAM-treated rats had fewer somatostatin and parvalbumin-immunoreactive neurons than the control rats. These results suggest that the enhanced neuronal responsiveness of the in vivo recording of the CA1 in this animal model may involve a reduction of CA1 inhibition.

• 동의생리병리학회지
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• 제22권2호
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• pp.390-396
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• 2008

Osteoarthritis(OA) diseases are characterized by joint pain, tenderness, limitation of movement, crepitus, occasional effusion, and variable degrees of inflammation without systemic effects. We investigated the effects of Achyrantis radixs cream treatment and low intensity ultrasound in monosodium iodoacetate(MIA) induced experimental osteoarthritis rat. Sprague-Dawley 40 rats of 7-8 weeks, weight $250\;{\pm}\;50$ g were divided into four groups including the control group and ostoarthritis group(30 rats). Histopathological examination, Mankin's score, and immunohistochemical were performed. Histological findings in control group that are similar to those observed in human osteoarthritis, such as disorganization of chondrocytes, erosion and fibrillation of cartilage surface, and subchondral bone exposure. Safranin O-fast green staining revealed that marked diffuse reduction of proteoglycans and chondrocyte treated with MIA. The Mankin's score were closely correlated to the grade of histological findings. The level of Bax and caspase-3 expression decreased experimental groups. This study shows that a Acyranthes Radix cream treatment and low intensity ultrasound exerts a beneficial influence on the severity of chondral lesion in osteoarthritis rats. This treatments could related to a reduced level of chondrocyte apoptosis through anti-apoptotoc capacities of MIA-induced apoptotic protein overexpression.

• Clinical and Experimental Pediatrics
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• 제55권10호
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• pp.371-376
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• 2012

Purpose: Puromycin aminonucleoside (PAN) specifically injures podocytes, leading to foot process effacement, actin cytoskeleton disorganization, and abnormal distribution of slit diaphragm proteins. p130Cas is a docking protein connecting F-actin fibers to the glomerular basement membrane (GBM) and adapter proteins in glomerular epithelial cells (GEpCs; podocytes). We investigated the changes in the p130Cas expression level in the PAN-induced pathological changes of podocytes in vitro. Methods: We observed changes in the p130Cas expression in cultured rat GEpCs and mouse podocytes treated with various concentrations of PAN and antioxidants, including probucol, epigallocatechin gallate (EGCG), and vitamin C. The changes in the p130Cas expression level were analyzed using confocal immunofluorescence imaging, Western blotting, and polymerase chain reaction. Results: In the immunofluorescence study, p130Cas showed a diffuse cytoplasmic distribution with accumulation at distinct sites visible as short stripes and colocalized with P-cadherin. The fluorescences of the p130Cas protein were internalized and became granular by PAN administration in a dose-dependent manner, which had been restored by antioxidants, EGCG and vitamin C. PAN also decreased the protein and mRNA expression levels of p130Cas at high doses and in a longer exposed duration, which had been also reversed by antioxidants. Conclusion: These findings suggest that PAN modulates the quantitative and distributional changes of podocyte p130Cas through oxidative stress resulting in podocyte dysfunction.

• Applied Microscopy
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• 제28권4호
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• pp.539-549
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• 1998

The silk glands of the spiders are of several types. Among the several types of spider's silk glands, the principal fibers used in constructing the eggcase are products of the tubuliform glands (TBG), which are present only in females. Development of these glands parallels maturations of the ovaries and fat bodies. In order to understand the mechanism of eggcase-silk production, this paper has examined the fine structural changes of the TBG during the period of egg maturation in the garden spider, Argiope aurentia. Between the two kinds of secretory granules observed in the glandular epithelium of the mature TBG, the electron-dense granules which have paracrystalline structure are revealed to be the precursors of the eggcase silk fibers. During the production of eggcase, rapid release of the secretory product occurs at apical surface by the mechanism of apocrine secretion. Moreover, secondary lysosomes appear due to the rapid disorganization of cellular components during the eggcase formation. Examinations of formed fibers indicate a multicomponent internal structure, and electron micrographs reveal each fiber contains numerous electron lucent fibrils embedded in an amorphous electron dense matrix. The secretory precursors are produced as separated vesicles via well-oriented rER, and no Golgi complex has been found in the glandular epithelial cells.

• 한국항공운항학회지
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• 제20권3호
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• pp.63-67
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• 2012

Spaceflight induces a number of cardiovascular physiological alterations. To study adaptations to microgravity on Earth, the tail-suspended, hindlimb-unloaded rat model has been used to simulate the effects of microgravity. Despite the extensive use of this model to infer physiological adaptations of many organs to microgravity, little information has been obtained on the effect of tail suspension(TS) on cardiac adaptations in the rat. This study was aimed to investigate the effects of simulated microgravity on the rat myocardium using the TS model. Twenty-four male Sprague-Dawley rats were randomly assigned to 3 experimental groups(1, 7 and 14 days of TS) and a control group. A microscopic examination was performed to assess histopathological changes in the myocardial morphology. The hearts from the control group, the 1 day-TS rats and the 7 day-TS rats revealed no evident abnormalities in cardiomyocyte size and morphology. At day 14 of TS, in contrast, the ventricular cardiomyocytes appeared more separated from each other and were slightly smaller in size compared with those of the control group. Also seen were scattered areas exhibiting focal disorganization of muscle fibers and some degenerating cardiomyocytes, of which the nuclei had become pyknotic or disappeared. In this study, we demonstrated that the ventricular cardiomyocytes underwent degeneration and atrophy at the microscopic level during exposure to simulated microgravity in TS rats.