• Anxiety and mood
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• v.4 no.2
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• pp.91-98
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• 2008

Depression and anxiety disorders are common psychiatric illnesses whose etiology remains partially understood. The etiology of depression and anxiety disorders is multi-factorial, and abnormalities in neurotransmitter, neuroendocrine system, and brain activation have been implicated in those conditions. However, the pathophysiology of depression and anxiety disorder is certainly not well understood, and some patients with depression or anxiety disorders do not respond to antidepressant therapy. Recently, immunological factors such as cytokines are known to be closely related to central nervous system as well as depression and anxiety disorders. This review highlights recent progress in understanding the function of cytokines in depression and anxiety disorders.

• CELLMED
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• v.2 no.1
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• pp.2.1-2.11
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• 2012

Tea polyphenols especially catechins have long been studied for their antioxidant and radical scavenging properties. Scientists throughout the world have investigated the usefulness of the regular green tea consumption in several disease conditions. In-vitro and in-vivo experiments on catechins especially epigallocatechingallate have revealed a significant role in many ways. Reactive oxygen species have been increasingly implicated in the pathogenesis of many diseases and important biological processes. Toxic effects of these oxidants, commonly referred to as oxidative stress, can cause cellular damage by oxidizing nucleic acids, proteins, and membrane lipids. Oxidative stress has been related to aging and age related disorders. It is found that in a wide variety of pathological processes, including cancer, atherosclerosis, neurological degeneration, Alzheimer's disease, ageing and autoimmune disorders, oxidative stress has its implications. Catechins have been reported to be useful in combating aging and age related disorders like cancer, cardiovascular disorders and neurodegenerative diseases. In this mini review we will discuss such studies done across the globe.

• IMMUNE NETWORK
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• v.12 no.4
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• pp.129-138
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• 2012

Allergic disorders such as atopic dermatitis and asthma are common hyper-immune disorders in industrialized countries. Along with genetic association, environmental factors and gut microbiota have been suggested as major triggering factors for the development of atopic dermatitis. Numerous studies support the association of hygiene hypothesis in allergic immune disorders that a lack of early childhood exposure to diverse microorganism increases susceptibility to allergic diseases. Among the symbiotic microorganisms (e.g. gut flora or probiotics), probiotics confer health benefits through multiple action mechanisms including modification of immune response in gut associated lymphoid tissue (GALT). Although many human clinical trials and mouse studies demonstrated the beneficial effects of probiotics in diverse immune disorders, this effect is strain specific and needs to apply specific probiotics for specific allergic diseases. Herein, we briefly review the diverse functions and regulation mechanisms of probiotics in diverse disorders.

• Proceedings of the Korean Society for Agricultural Machinery Conference
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• 1996.06c
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• pp.632-637
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• 1996

An expert system for cucumber disease and nutritional disorders(ESCD) was developed using HCLIPS in which several interface programs were added to CLIPS developed in NASA. The knowledges for constructing knowledge base was obtained from interviews with farmers, agrochemical vendors and employees of agrochemical company. The ESCD is able to diagnose eleven diseases and twelve nutritional disorders which farmers, agrochemical vendors and employees of agrochemical company. The ESCD is able to diagnose eleven diseases and twelve nutritional disorders which could frequently found in fields and greenhouses. Validation of ESCD by twenty -four experts proved a possibility of its practical use for diagnosing cucumber diseases and nutritional disorders in the future.

• Sleep Medicine and Psychophysiology
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• v.14 no.1
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• pp.5-12
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• 2007

Sleep changes substantially with age. There is a phase advance in the circadian sleep cycle and increased waking after sleep onset. The elderly people wake more frequently during the night and experience fragmented sleep and excessive daytime sleepiness. The prevalence of sleep disorders increases with age, and the composition of sleep disorders in the elderly differs from that in the young. The most frequently encountered sleep disorders are psychophysiologic insomnia, sleep disturbance due to dementia, sleeprelated respiratory disorder, restless legs syndrome and periodic limb movement disorder, and REM sleep behavior disorder. To treat the elderly sleep problem appropriately, it is important to know how sleep pattern changes as we age and to understand the cause of sleep-related symptoms. This article will review the sleep physiology and common sleep disorders in the elderly.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.12 no.11
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• pp.5541-5554
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• 2018

A voice is one of the most significant non-verbal elements for communication. Disorders in vocal organs, or habitual muscular setting for articulatory cause vocal disorders. Therefore, by analyzing the vocal disorders, it is possible to predicate vocal diseases. In this paper, a method of predicting vocal disorders using the jitter, shimmer, and harmonics-to-noise ratio (HNR) extracted from vocal records is proposed. In order to extract jitter, shimmer, and HNR, one-second's voice signals are recorded in 44.1khz. In an experiment, 151 voice records are collected. The collected data set is clustered using cobweb clustering method. 21 classes with 12 leaves are resulted from the data set. According to the semantics of jitter, shimmer, and HNR, the class whose centroid has lowest jitter and shimmer, and highest HNR becomes the normal vocal group. The risk of vocal disorders can be predicted by measuring the distance and direction between the centroids.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.48 no.3
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• pp.155-158
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• 2022

Objectives: The aim of this study was to observe the relationship between impacted mandibular third molars and development of temporomandibular joint (TMJ) disorders. Knowledge of the factors that have an adverse effect on the TMJ is necessary for proper diagnosis, treatment, and prognosis of TMJ disorders. Materials and Methods: The study was performed on 80 patients aged between 20 and 60 years with impacted mandibular third molars, over a period of two months. The patients were examined clinically and radiologically to determine the type of impaction and detect the associated TMJ symptoms or disorders. Results: In the 80 patients, 63.8% (51/80) of TMJ disorders were found in the horizontal group, 46.3% (37/80) in the mesioangular group, 42.5% (34/80) in the distoangular group, and 30.0% (24/80) in the vertical group of impacted mandibular third molars. Conclusion: The study concluded that type of impacted mandibular third molar is factor in the development of temporomandibular disorders.

• Anxiety and mood
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• v.19 no.2
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• pp.27-36
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• 2023

Interest in anxiety has a long history, and this topic has played a significant role in the field of mental health. The concept of anxiety has evolved diversely over time and across cultures, influencing our understanding, diagnosis, and treatment approaches for anxiety disorders. In this paper, we have reviewed and summarized various concepts and theories related to anxiety that have evolved over several centuries. Furthermore, we have examined how the diagnostic criteria in the DSM (Diagnostic and Statistical Manual of Mental Disorders) have changed within this historical context. A precise understanding of the history of the concept of anxiety and anxiety disorders is believed to have a positive impact on shaping the future path of anxiety disorders in psychiatry.

• Biomolecules & Therapeutics
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• v.32 no.2
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• pp.183-191
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• 2024

The Unfolded Protein Response (UPR) serves as a critical cellular mechanism dedicated to maintaining protein homeostasis, primarily within the endoplasmic reticulum (ER). This pathway diligently responds to a variety of intracellular indicators of ER stress with the objective of reinstating balance by diminishing the accumulation of unfolded proteins, amplifying the ER's folding capacity, and eliminating slow-folding proteins. Prolonged ER stress and UPR irregularities have been linked to a range of neuropsychiatric disorders, including major depressive disorder, bipolar disorder, and schizophrenia. This review offers a comprehensive overview of the UPR pathway, delineating its activation mechanisms and its role in the pathophysiology of neuropsychiatric disorders. It highlights the intricate interplay within the UPR and its profound influence on brain function, synaptic perturbations, and neural developmental processes. Additionally, it explores evolving therapeutic strategies targeting the UPR within the context of these disorders, underscoring the necessity for precision and further research to effective treatments. The research findings presented in this work underscore the promising potential of UPR-focused therapeutic approaches to address the complex landscape of neuropsychiatric disorders, giving rise to optimism for improving outcomes for individuals facing these complex conditions.

• Korean Journal of Radiology
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• v.24 no.2
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• pp.109-132
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• 2023

Lymphatic disorders encompass a broad spectrum of diseases involving the lymphatic system, ranging from traumatic lymphatic leaks to lymphatic malformations. Lymphatic disorders can be categorized into traumatic and non-traumatic disorders according to their etiology. These two categories may be further divided into subgroups depending on the anatomical location of the lymphatic pathology and their association with clinical syndromes. Thoracic duct embolization was a milestone in the field of lymphatic intervention that encouraged the application of percutaneous embolization techniques to treat leaks and reflux disorders in the lymphatic system. Additional access routes for embolization, including retrograde thoracic duct and transhepatic lymphatic access, have also been developed. This article comprehensively reviews a variety of options for the treatment of lymphatic disorders, from conservative management to the most recent embolization techniques.