• 제목/요약/키워드: Disease research

검색결과 12,775건 처리시간 0.042초

Building and Analyzing Panic Disorder Social Media Corpus for Automatic Deep Learning Classification Model (딥러닝 자동 분류 모델을 위한 공황장애 소셜미디어 코퍼스 구축 및 분석)

  • Lee, Soobin;Kim, Seongdeok;Lee, Juhee;Ko, Youngsoo;Song, Min
    • Journal of the Korean Society for information Management
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    • 제38권2호
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    • pp.153-172
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    • 2021
  • This study is to create a deep learning based classification model to examine the characteristics of panic disorder and to classify the panic disorder tendency literature by the panic disorder corpus constructed for the present study. For this purpose, 5,884 documents of the panic disorder corpus collected from social media were directly annotated based on the mental disease diagnosis manual and were classified into panic disorder-prone and non-panic-disorder documents. Then, TF-IDF scores were calculated and word co-occurrence analysis was performed to analyze the lexical characteristics of the corpus. In addition, the co-occurrence between the symptom frequency measurement and the annotated symptom was calculated to analyze the characteristics of panic disorder symptoms and the relationship between symptoms. We also conducted the performance evaluation for a deep learning based classification model. Three pre-trained models, BERT multi-lingual, KoBERT, and KcBERT, were adopted for classification model, and KcBERT showed the best performance among them. This study demonstrated that it can help early diagnosis and treatment of people suffering from related symptoms by examining the characteristics of panic disorder and expand the field of mental illness research to social media.

Health Literacy in the Korean Elderly and Influencing Factors (한국 노인의 건강 문해(Health Literacy)실태와 영향 요인 -인구사회학적 특성을 중심으로-)

  • Lee, Tae Wha;Kang, Soo Jin
    • 한국노년학
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    • 제28권4호
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    • pp.847-863
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    • 2008
  • This study aimed to measure the health literacy among Korean elderly living in the community, and to explore the factors influencing health literacy of the elderly. A descriptive correlational research design was used. The sample consisted of 411 elders who were conveniently selected from the community welfare center users in Seoul and Gyeong-gi province. Data were collected from face-to-face interviews by trained interviewers between January, 7 and February, 4, in 2008. Health literacy was measured by Korean Health Literacy Scale developed by Lee(2008). Descriptive statistics, ANOVA, t-test, and multiple regression were used to analyse the data. In result, the mean score of health literacy was 17.46(${\pm}5.73$) with a range of 0 to 25, 42.8% of elderly had limited health literacy problems. Multiple regression showed that 26.5% of variance in health literacy was accounted for by the combination of education, age, living arrangement, and income. In conclusion, various strategies to improve health literacy in elderly population in the areas of health education and disease management should be needed to reduce health disparities among elderly.

Improvement of Permanent Disability Benefit System in Korean Worker's Compensation Insurance from the Perspective of Life Cycle (생애주기를 고려한 산재보험 장해연금 개선 방안 연구)

  • Oh, Jongeun
    • 한국사회정책
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    • 제23권1호
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    • pp.203-225
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    • 2016
  • The permanent disability benefit(PDB) system whose purpose lies in helping affected workers with their self-realization through compensating them for their work-related injury or disease and facilitating their timely return to work is very important in terms of social welfare. Actually, the portions of PDB's in all WCI expenditures have been on the sharp increase. In spite of its positive aspects like this, however, an excessive amount of PDB's may have negative impacts on the affected workers' will to work or return to work, and increasing trends in the amount of PDB's payable in annuity will remain in an aging or aged society a potentially risky factor posing a threat to the soundness of WCI budgets. In this respect, the author attempted herein to identify the long-term reality of trends in the number of claimants entitled to PDB's and the amount of PDB's payable to them through making the long-term budget projections of PDB's; address problems with PDB's payable in annuity, which are or will potentially be one of the gravest burdens in securing the soundness of WCI budgets; and discuss how to optimize the amount of PDB's through studying & analyzing overseas cases and income replacement rates and what kinds of improvements are thinkable. It's recommended to reduce the absolute amount of benefits payable in annuity in a phased way considering claimants' life-cycle instead of sticking to the current system, which takes the form of lifelong pension plan.

First Report of Tomato Spotted Wilt Virus in Angelica acutiloba (당귀에서 발생한 토마토반점위조바이러스의 감염 첫 보고)

  • Kwak, Hae-Ryun;Hong, Su-Bin;Choi, Hyeon-Yong;Park, Gosoo;Hur, On-Sook;Byun, Hee-Seong;Choi, Hong-Soo;Kim, Mikyeong
    • Research in Plant Disease
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    • 제27권2호
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    • pp.84-90
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    • 2021
  • In June 2019, Angelica acutiloba plants showing virus-like symptoms such as chlorotic local lesion and mosaic on the leaves were found in a greenhouse in Nonsan, South Korea. To identify the causal virus, we collected 6 symptomatic A. acutiloba leaf samples and performed reverse transcription polymerase chain reaction (RT-PCR) analysis using specific detection primers for three reported viruses including tomato spotted wilt virus (TSWV). RT-PCR results showed that five symptomatic samples were positive for TSWV. Mechanical sap inoculation of one of the collected TSWV isolate (TSWV-NS-AG28) induced yellowing, chlorosis and mosaic symptoms in A. acutiloba and necrotic local lesions and mosaic in Solanaceae species. Phylogenetic analysis based on the complete genome sequences showed that TSWV-NS-AG28 had a maximum nucleotide identity with TSWVNS-BB20 isolated from butterbur in Nonsan, South Korea. To our knowledge, this is the first report of TSWV infection in A. acutiloba.

Current research status and analysis methods on the effects of food surface properties on particulate matter adsorption (식품 표면 특성에 따른 미세먼지 흡착 연구 현황 및 분석 방법)

  • Lim, Dayoung;Park, Sun-Young;Lee, Dong-Un;Chung, Donghwa
    • Food Science and Industry
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    • 제54권1호
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    • pp.11-28
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    • 2021
  • Air pollution caused by particulate matters (PM) has become a global issue. PM is known to threaten human health by causing respiratory and cardiovascular disease. PM can be introduced to human gastrointestinal track through food intake, causing inflammation and changes in gut microbiota. Even at low PM concentrations, prolonged exposure to PM can cause significant accumulation of PM in food products. The adsorption of PM onto food surfaces is expected to be strongly influenced by the properties of food surfaces, but few studies have been reported. This paper examines several important food surface properties that may affect the interactions between PM and food surfaces, including surface wettability, surface charge, and surface microstructure. Understanding the adsorption of PM onto food surfaces can provide useful guidance for classifying PM-sensitive foods and controlling food chains, including cultivation, processing, preservation, and cooking, to ensure food safety against PM.

First Report of Tomato Spotted Wilt Virus on Iris domestica in South Korea (약용작물 범부채에 발생한 Tomato Spotted Wilt Virus 국내 첫 보고)

  • Chung, Bong Nam;Yoon, Ju-Yeon;Cho, In-Sook
    • Research in Plant Disease
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    • 제27권1호
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    • pp.32-37
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    • 2021
  • In May 2020, necrosis and necrotic ring patterns were observed on leaves of three of 140 Iris domestica plants in a demonstration garden in Wanju, Jeollabuk-do. Three symptomatic plants were found to be infected by tomato spotted wilt virus (TSWV). To analyze the whole genomic sequence of one TSWV isolate, 'Blackberry lily-kr1', L, M, and S genome segments were sequenced and analyzed by comparison of nucleotide sequences of the three segments with corresponding sequences of other TSWV isolates. 'Blackberry lily-kr1' isolate was most closely related to 'JJ' isolate (MF159046) or 'HJ' isolate (LC273305) in the L segment, and to 'JJ' isolate (MF159058 and KY021439) in the M and S segments, respectively. Phylogenetic analysis by Maximum likelihood method using MEGA X program with 'Blackberry lily-kr1' isolate showed high relationship with 'JJ' pepper isolate or 'HJ' Humulus japonicas isolate in the all three segment. Necrosis and double ring patterns on leaves were formed in the glasshouse after inoculation of healthy I. domestica plants with sap of 'Blackberry lily-kr1'-infected Nicotiana rustica plants. This result suggests that I. domestica plants showing necrotic ring patterns in the open field are caused by TSWV infection. This is the first report of TSWV infection of I. domestica in Korea.

Oral Health Status and Behavior Factors Associated with Self-Rated Health Status among the Elderly in South Korea: The 7th Korea National Health and Nutrition Examination Survey (2016-2018) (우리나라 노인의 구강건강상태 및 관리행태와 주관적 건강상태와의 관련성: 제7기 국민건강영양조사(2016-2018)를 이용하여)

  • Hong, Joo Hee;Lee, Yongjae;Kim, Taehyun;Kim, Roeul;Chung, Woojin
    • Health Policy and Management
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    • 제31권1호
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    • pp.74-90
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    • 2021
  • Background: It is getting important to improve the oral health status of the elderly because oral health status may affect their health status of the whole body. In this respect, we aimed to explore the association of oral health status and behavior factors with self-rated health status by sex. Methods: Using the data from the 7th Korea National Health and Nutrition Examination Survey for health surveys and oral examinations (2016-2018), we analyzed a total of 3,070 people aged 65 or older (men: 1,329; women: 1,741). Our dependent variable, self-rated health status, was divided into two groups: not good (bad and very bad) and good (very good, good, and fair), whereas our independent variables of interest were oral health status and behavior factors. In addition to descriptive analysis and the Rao-Scott chi-square test, reflecting survey characteristics, we conducted hierarchical multivariable logistic regression analyses adjusted for socio-demographics and health status and behavior factors. All analyses were stratified by sex. Results: The proportion of people having 'not good' self-rated health was 36.5% in women but 24.5% in men. In a model adjusted for all covariates, the self-rated health status showed significant association with the self-rated oral health status. For example, in men, the risk of having 'not good' self-rated health was high in people having 'poor' (odds ratio [OR], 5.31; 95% confidence interval [CI], 2.34-12.03) self-rated oral health status and in those having 'fair' (OR, 4.03; 95% CI, 1.68-9.70) in comparison with those having 'good' self-rated oral health status. Dental status regarding speaking difficulty seemed to be very important in influencing self-rated health status. For instance, in women, compared to people having 'no discomfort' speaking difficulty, the risk of having 'not good' self-rated health was high in people having 'not bad' (OR, 1.60; 95% CI, 1.14-2.24) and 'discomfort' (OR, 1.79; 95% CI, 1.30-2.47) speaking difficulty. The covariates significantly associated with the risk of having 'not good' self-rated health were: physical activity, chronic disease, stress, and body mass index in both sexes; health insurance type and drinking only in men; and economic activity only in women. Conclusion: Oral health status and behavioral factors were associated with self-rated health status among the elderly, differently by sex. This suggests that public health policies toward better health in the elderly should take their oral health status and oral health behaviors into account in a sex-specific way.

Effect of Sophora flavescens Extract on Reinforcing Skin Barrier and Alleviating Inflammation (고삼 추출물의 피부장벽 강화와 염증완화 효과)

  • Roh, Kyung-Baeg;Shin, Seoungwoo;Yoon, Sohyun;Weon, Jin Bae;Oh, Se-young;Kim, Junoh;Park, Deokhoon;Jung, Eunsun
    • Journal of the Society of Cosmetic Scientists of Korea
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    • 제46권4호
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    • pp.361-369
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    • 2020
  • Atopic dermatitis (AD) is a common and multifactorial inflammatory skin disease that is characterized by skin barrier dysfunction, inflammation, and chronic pruritus. AD has a complex etiology that includes genetic, immunological, and environmental factors that cause skin barrier abnormalities and immune dysfunctions. Sophora flavescens (SF) has been used in traditional Chinese medicine, but little research has been conducted on its anti-AD efficacy. In this study, we evaluated the effect of SF extract (SFE) on improving skin barrier function and immune abnormalities, which are the main symptoms of AD. SFE has the capacity to enhance the formation of cornified envelope (CE) that plays an important role in the skin barrier function. In addition, it was confirmed that SFE increased the expression of hyaluronic acid related to skin moisture. The effect of SFE against Staphylococcus aureus (S. aureus), which increases specifically in AD lesions, confirmed that SFE inhibited the production of pro-inflammatory cytokines induced by S. aureus. Furthermore, SFE was shown to inhibit the expression of pro-inflammatory cytokines induced by substance P (SP), the cause of skin neurogenic inflammation. These results demonstrate that SFE could be one of potential candidate agent for the treatment of AD by improving the skin barrier function and immune responses.

Exploring the Thalamus of the Human Brain using Tractography Analysis at 3Tesla MRI (3 Tesla MRI에서 트랙토그래피 분석을 이용한 시상 탐색)

  • Im, Sang-Jin;Kim, Joo-Yeon;Baek, Hyeon-Man
    • Journal of the Korean Society of Radiology
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    • 제15권4호
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    • pp.555-564
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    • 2021
  • Thalamus is known to play an important role in the regulation of nerve function. Thalamus, located in the center of the brain, is involved in sleep, arousal, and emotional regulation, and has been reported to be associated with multiple sclerosis, essential tremors, and neurodegenerative diseases such as Parkinson's disease. In addition, it has been reported that iron deposits in the thalamus can cause depressive symptoms with age. Although there are discrepancies between studies, it can be deduced that the thalamus region has a clear effect on neurological disorders due to a strong relationship between the thalamus and neurological functions such as emotional control and processing. Through tractography analysis, the connectivity between the detailed areas of each subcortical region was investigated in the form of a matrix, showing strong connectivity and weak interhemispheric connectivity. In the 59> group, the WM connectivity of thalamus was found to be weaker than those of the two groups. Comparisons between the two groups showed that the young groups (10-39 and 40-59) had higher connection intensity than the 59> group and that statistically significant differences in 3 connection pathways were found in each hemisphere. A decrease in thalamus-related connection strength in aging has shown that it can affect emotional and neurological disorders such as anxiety and depression, and network measurements can help assess cognitive impairment across clinical conditions.

Dysphagia Rehabilitation Treatment for Children With Feeding Disorder : A Systemic Review (섭식장애가 있는 아동의 연하재활치료 : 체계적 고찰)

  • Jeon, Joo Young;Park, Hae Yean
    • The Journal of Korean Academy of Sensory Integration
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    • 제19권1호
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    • pp.39-53
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    • 2021
  • Objective : The purpose of this study was to systematically review dysphagia rehabilitation treatment for children with feeding disorders. Methods : The articles evaluated in this study were collected from the PubMed, Medline Complete, and CINAHL databases and subsequently reviewed using the PRISMA flow chart and PICOS approach. A total of 13 papers were analyzed for study quality, disease groups, evaluation tools, interventions, and post-intervention effects. Results : Of the reviewed papers, six (46.15%) related to autism spectrum disorder (ASD) and seven (53.85%) to cerebral palsy (CP) with age ranges of between 2 and 8 years for the ASD studies and between 12 months and 18 years for CP. In evaluating the types of feeding disorder involved, the ASD group exhibited predominantly behavioral conditions while the CP subjects had a larger number of functional oral and swallowing issues. In terms of interventions, behavior modifications were used most frequently with ASD while oral-sensory motor, texture modifications, and electrical stimulation were applied at the same frequency with children with CP. All interventions were found to be effective. Conclusion : In this study, research into children with feeding disorders was reviewed according to condition, evaluation tool, and method of intervention. It is expected that this review can be used as basic data for developing a protocol that will allow clinicians to efficiently apply condition-specific interventions for eating disorders without resorting to trial and error.