• The Journal of the Korea institute of electronic communication sciences
• /
• v.7 no.5
• /
• pp.1213-1219
• /
• 2012

As Korea is expected to enter an aging society in near future, the number of patients who need a long-term prescribtion is expected to increase as well. In particular, Korea shows the highest in both the incident rate and the death rate among OECD member nations. The current situation requires more strict monitoring and management for patients' taking medicine, there are a few practical problems such as personnel expenses. Recently the concept of directly observed treatment (DOT) that is based on the IT technologies has been introduced. This paper, therefore, proposes a digital DOT system with a smart pillbox and drives key requirements for the smart pillbox that plays an important and essential role in the proposed digital DOT system.

• 보건세계
• /
• v.59 no.3
• /
• pp.8-12
• /
• 2012

- DOT하 결핵환자 치료 성공율을 90% 이상 달성 ${\rightarrow}$ 치료 완료후 2년이내 균양성 재발율을 3% 미만으로 달성 - 질병관리본부와 결핵연구원, 보건소 및 민간 병의원에서 치료받고 있는 결핵환자에 대한 WHO의 결핵조기퇴치 기본 전략인 직접복약확인체계(DOTS, Directly observed treatment short course)시범사업 본격 실시

• The Journal of the Korea institute of electronic communication sciences
• /
• v.10 no.5
• /
• pp.571-578
• /
• 2015

Even though DOT (Directly Observed Treatment) is the most definite method for the patients who need a long-term medication, its implementation is almost impossible considering the manpower and economic cost for it. The smart medication management and monitoring system that has appeared as an alternative requires a device for its implementation. In this paper, we propose so-called a smart pillbox for the smart medication management and monitoring system and the multi-user authentication scheme for sharing the smart pillbox among the patients. Through the smart pillbox and the multi-user authentication scheme, it is expected that the recovery rate would be raised by enabling the patients to take medicine in both timely and correct manner.

• 대한예방의학회:학술대회논문집
• /
• 2002.10a
• /
• pp.533-533
• /
• 2002

• Journal of Integrative Natural Science
• /
• v.3 no.2
• /
• pp.96-102
• /
• 2010

It is still controversial where the improved stability of n-octadecyltriethoxysilane self-assembled monolayer (OTE SAM) on plasma-pretreated mica surface exactly originates from. To date, it has been well known that the extensive cross-polymerization between silane headgroups is a crucial factor for the outstanding mechanical strength of the monolayer. However, this study directly observed that the stability comes not only from the cross-links but also, far more importantly, from the direct chemical bonds between silane headgroups and mica surface. To observe this phenomenon, n-octadecyltrichlorosilane monolayers were self-assembled on both untreated and plasma treated mica surfaces, and their adhesion properties at various stress conditions and force profiles in pure water were investigated and compared through the use of the surface forces apparatus technique. It revealed that, in pure water, there is a substantial difference of stability between untreated and plasma treated cases and the plasma treated surface is mechanically much more stable. In particular, the protrusion behavior of the monolayer during contact repetition experiment was always observed in the untreated case, but never in the plasma treated case. It directly demonstrates that the extensive chemical bonds indeed exist between silane head-groups and plasma treated mica surface and dramatically improve the mechanical stability of the OTE monolayer-coated mica substrate.

• Membrane and Water Treatment
• /
• v.8 no.2
• /
• pp.125-136
• /
• 2017

Reverse osmosis technology is being used on large scale for treatment of ground water, brackish water, wastewater and sea water. The most challenging issue in RO process is carbonate scaling which is directly linked with the efficiency and economy. Considering the natural phenomena of carbonate scaling different adaptations have been made to control scaling on the surface of RO membrane including acid dosage and antiscalant addition. As carbonate scaling is directly related with pH level of feed water, present study describes an experimental approach to reduce scaling on RO membrane by lowering the feed water pH by purging $CO_2$. In this comparative study four different conditions including control process (without any scale inhibitor), with dosage of antiscalant, with purging of $CO_2$ and with co addition of antiscalant and $CO_2$ in a feed stream line; it was established that $CO_2$ is a better appliance to reduce carbonate scaling on the membrane surface by reduce pH of feed stream. It was also observed that $CO_2$ and antiscalant mutually function better for scale control.

• Archives of Pharmacal Research
• /
• v.17 no.1
• /
• pp.11-16
• /
• 1994

Cis-dichlorodiammineplatinum(II)(cisplatin) is one of the most effective antitumor agents currently available for cancer therapy. However, its clinical use has been limited by its severe side effects, especially nephrotoxicity. To evaluate the effect or radical scavengers on cisplatin nephrotoxicity in rats, cisplatin and Vitamin C were given intraperitoneally. Remarkable protective effects of Vitamin C against nephrotoxicity of cisplatin were observed when Vitamin C was administered to rats 1hr before cisplatin injection. hepatotoxicity induced by combination treament of cisplatin and Vitamin C was evaluated by measuring serum glutamic pyruvate transmainase(sGPT) and serum glutamic oxalate transminase(sGOT). Combination treatment did not affect the levels of sGPT and sGOT, and any combination treatment did not induce metallothionein biosynthesis in kidny, Vitamin C which has radical scavenging effect induce metallothionein biosynthesis in kidney. Vitamin C which has radical scavenging effect directly reduced nephrotoxicity of cisplatin in vivo. Thus, it seems that free radical is the cause of cisplatin nepthrotoxicity. Also, combination treatment did not reduce anticancer activity of cisplatin. The present results indicate that Vitamin C, when it is given with cisplatin, may provide protection against cisplatin nephrotoxicity without reducing anticancer activity.

• Biomolecules & Therapeutics
• /
• v.2 no.2
• /
• pp.103-107
• /
• 1994

Cisplatin is one of the most effective antitumor agents currently available for cancer therapy. However, its clinical use has been limited by its severe side effects, especially nephrotoxicity. Therefore, brazilin, which has a radical scavenging effect, was given intraperitoneally to evaluate the effect on cisplatin nephrotoxicity in rats. Remarkable protective effects against nephrotoxicity of cisplatin were observed when brazilin was administered to rats simultaneously with cisplatin. Hepatotoxicity induced by combination treatment of cisplatin and brazilin was evaluated by measuring serum glutamic pyruvate transaminase and serum glutamic oxalate transaminase. Combination treatment did not affect the levels of sGPT and SGOT, and any combination treatment did not induce metallothionein in kidney. Brazilin which has radical scavenging effect directly reduced nephrotoxicity of wisplatin in vivo. Thus, it seems that nephrotoxicity of cisplatin was caused by free radicals. The present results Indicate that brazilin, when it is given with cisplatin, may provide protection against cisplatin nephrotoxicity in rats.

• Journal of environmental and Sanitary engineering
• /
• v.19 no.3 s.53
• /
• pp.1-12
• /
• 2004

This study was conducted to evaluate the variation characteristics of influent and effluent quality from sewage treatment facilities using activated sludge processes and to assess the impact caused by discharge of treated sewage on the receiving water Monthly data of five water quality items (BOD, COD, SS, T-N, T-P) were used to understand the water quality at three sewage treatment plants in Seoul for five years from 1999 to 2003. Concentration differences of water quality parameters were observed between upstream and downstream site at the sewage treatment plant outfall to investigate the impact of discharge in Tan stream and Han river basin. 1. Due to the effect of continuous improvement in sewer system, the concentrations of influent went on increasing generally. 2. Effluent concentrations of BOD, COD and SS showed the trend of a little decreasing, but the trend of increasing in T-N and T-P. 3. In Tan stream basin, the impact of sewage treatment plant discharge was not observed directly, because concentration of discharge was lower than stream water's. But discharges from sewage treatment plants affected water quality at downstream site in Han river, concentration of T-P especially.

• Archives of Reconstructive Microsurgery
• /
• v.9 no.1
• /
• pp.49-55
• /
• 2000

Nonunion and avascular necrosis are well-recognized complications of severe ankle injury especially aftrer talar neck fracture. The treatment of avascular necrosis is controversial and methods of treatment are limited. Many modalities have been introduced for the treatment of avascular necrosis of talus. The prolonged non-weight bearing for 2~3 years is not practical but also is occasionally complicated by late segmental collapse. Operative treatment includes tibiotalar arthrodesis and talectomy with tibiocalcaneal arthrodesis, but arthrodesis in patients with talar avascular necrosis is technically demanding and cause stiff, immobile foot and relatively high failure rate was reported. It is desirable to preserve their original joint if possible. Vascularized fibular grafting has been reported as a joint preserving treatment option for osteonecrosis of the hip but has not been described for the ankle. The authors applied free vascularized fibular grafts for 3 cases of avascular necrosis of talus. We observed evidences of revascularization of necrotic talar body and progression of fracture healing and obtained satisfactory results at mean 8 months of follow-up. Vascularized fibular grafting is one of the better alternatives for treating avascular necrosis of talus. It is expected that vascularized fibular grafting can prevent the necrotic talar dome from progressing to collapse and promote directly restored vascularization and new bone formation.