• Mass Spectrometry Letters
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• v.12 no.3
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• pp.93-105
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• 2021

Exosomes have gained the attention of the scientific community because of their role in facilitating intercellular communication, which is critical in disease monitoring and drug delivery research. Exosome research has grown significantly in recent decades, with a focus on the development of various technologies for isolating and characterizing exosomes. Among these efforts is the use of matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS), which offers high-throughput direct analysis while also being cost and time effective. MALDI is used less frequently in exosome research than electrospray ionization due to the diverse population of extracellular vesicles and the impurity of isolated products, both of which necessitate chromatographic separation prior to MS analysis. However, MALDI-MS is a more appropriate instrument for the analytical approach to patient therapy, given it allows for fast and label-free analysis. There is a huge drive to explore MALDI-MS in exosome research because the technology holds great potential, most notably in biomarker discovery. With methods such as fingerprint analysis, OMICs profiling, and statistical analysis, the search for biomarkers could be much more efficient. In this review, we highlight the potential of MALDI-MS as a tool for investigating exosomes and some of the possible strategies that can be implemented based on prior research.

• Archives of Plastic Surgery
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• v.40 no.2
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• pp.91-96
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• 2013

Background A thinned anterolateral thigh (ALT) flap is often harvested to achieve optimal skin resurfacing. Several techniques have been described to thin an ALT flap including an adipocutaneous flap, an adipofascial flap and delayed debulking. Methods By systematically reviewing all of the available literature in English and French, the present manuscript attempts to identify the common surgical indications, complications and donor site morbidity of the adipofascial variant of the ALT flap. The studies were identified by performing a systematic search on Medline, Ovid, EMBASE, the Cochrane Database of Systematic Reviews, Current Contents, PubMed, Google, and Google Scholar. Results The study selection process was adapted from the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement, and 15 articles were identified using the study inclusion criteria. These articles were then reviewed for author name(s), year of publication, flap dimensions and thickness following defatting, perforator type, type of transfer, complications, thinning technique, number of cases with a particular area of application and donor site morbidity. Conclusions The adipofascial variant of the ALT flap provides tissue to fill large defects and improve pliability. Its strong and safe blood supply permits adequate immediate or delayed debulking without vascular complications. The presence of the deep fascia makes it possible to prevent sagging by suspending and fixing the flap for functional reconstructive purposes (e.g., the intraoral cavity). Donor site morbidity is minimal, and thigh deformities can be reduced through immediate direct closure or liposuction and direct closure. A safe blood supply was confirmed by the rate of secondary flap debulking.

• Journal of the Korea Computer Graphics Society
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• v.21 no.2
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• pp.11-20
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• 2015

We present a new interactive technique for directing the motion sequences of an animated character by dragging its specific body part to a desired location in the three-dimensional virtual environment via a hand motion tracking device. The motion sequences of our character is synthesized by reordering subsequences of captured motion data based on a well-known graph representation. For each new input location, our system samples the space of possible future states by unrolling the graph into a spatial search tree, and retrieves one of the states at which the dragged body part of the character gets closer to the input location. We minimize the difference between each pair of successively retrieved states, so that the user is able to anticipate which states will be found by varying the input location, and resultantly, to quickly reach the desired states. The usefulness of our method is demonstrated through experiments with breakdance, boxing, and basketball motion data.

• The Korean Journal of Cytopathology
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• v.18 no.1
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• pp.29-35
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• 2007

This study purposed to evaluate a $CellPrep^{(R)}$ (CP) of liquid-based cytology (LBC) to search for a less expensive and automated alternative cytologic preparation technique applicable to usually encountered cytologic specimens. Cervicovaginal direct-to-vial split samples from 457 gynecologic patients, 40 body fluid samples, and 34 urine samples were processed with the CP technique and the results were compared with those of currently used $ThinPrep^{(R)}$ (TP) method. Both CP and TP methods provide evenly distributed thin layers of cells with little cellular overlaps or significant obscuring elements in most of cases. Staining quality of both preparations showed a little difference due to the difference of fixative solutions without significant distractions in cytologic interpretation. On the supposition that TP was a gold standard, sensitivity, specificity, positive predictive value, and negative predictive value of CP cytology were 89%, 98%, 86%, and 99% in the cervicovaginal smear, 89%, 82%, 80%, and 90% in body fluid, and all of these values were 100% in urine samples. To testify the availability of immunohistochemistry on CP preparations, cytokeratin, vimentin, and Ki-67 were applied on body fluid specimens, and all of these antibodies were specifically stained on targeted cells. Conclusively, the CP method gave comparable results to those of TP in terms of smear quality and cytologic diagnostic evaluation, and was available on immunohistochemistry. The CP method could offer a cost-effective and automated alternative to the current expensive techniques of liquid-based cytology on popular cytologic materials including cervicovaginal, body fluid, and urine specimens.

• Journal of KIISE:Information Networking
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• v.29 no.1
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• pp.97-107
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• 2002

In general, under interactive broadcasting environment, user finds additional service using top-down menu. However, user can't know that additional service provides information until retrieval has finished and top-down menu requires multi-level retrieval. This paper proposes the new method for additional service providing not using top-down menu but using object selection. For the purpose of this method, the movie of a MPEG should be synchronized with the object information(position, size, shape) and object tracking technique is required. Synchronization technique uses the Directshow provided by the Microsoft. Object tracking techniques use a motion-based tracking and a model-based tracking together. We divide object into two parts. One is face and the other is substance. Face tracking uses model-based tracking and Substance uses motion-based tracking base on the block matching algorithm. To improve precise tracking, motion-based tracking apply the temporal prediction search algorithm and model-based tracking apply the face model which merge ellipse model and color model.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.24 no.7B
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• pp.1351-1360
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• 1999

In frequency selective channels, conventional PN code acquisition schemes are not ideal candidates. This is because they are primarily designed for the AWGN channel. In this paper, a direct-sequence spread-spectrum(DSSS) PN code acquisition system based on digital matched filtering (DMF) with automatic threshold control(ATC) algorithm is presented and analyzed with regards to probability of detection and probability of false alarm. These two important probabilities, the probability of detection ($P_D$) and the probability of false alarm ($P_{FA}$) are derived and analyzed in considering Doppler shift, sampling rate, mean acquisition time, and PN chip rate in frequency selective Rayleigh fading channel when using serial-search method as detection technique. From computer simulation results of a DMF acquisition system model, it is shown that the performance of the acquisition system using ATC algorithm is better than that of constant threshold system.

• Journal of Korean Society of Archives and Records Management
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• v.24 no.2
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• pp.65-88
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• 2024

This pilot study explores a method of extracting metadata values and descriptions from records using named entity recognition (NER), a technique in natural language processing (NLP), a subfield of artificial intelligence. The study focuses on handwritten records from the Guro Industrial Complex, produced during the 1960s and 1970s, comprising approximately 1,200 pages and 80,000 words. After the preprocessing process of the records, which included digitization, the study employed a publicly available language API based on Google's Bidirectional Encoder Representations from Transformers (BERT) language model to recognize entity names within the text. As a result, 173 names of people and 314 of organizations and institutions were extracted from the Guro Industrial Complex's past records. These extracted entities are expected to serve as direct search terms for accessing the contents of the records. Furthermore, the study identified challenges that arose when applying the theoretical methodology of NLP to real-world records consisting of semistructured text. It also presents potential solutions and implications to consider when addressing these issues.

• The KIPS Transactions:PartD
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• v.12D no.4 s.100
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• pp.543-552
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• 2005

As random access memory chip gets cheaper, it becomes affordable to realize main memory-based database systems. The disk-based spatial indexing techniques, however, cannot direct apply to main memory databases, because the main purpose of disk-based techniques is to reduce the number of disk accesses. In main memory-based indexing techniques, the node access time is much faster than that in disk-based indexing techniques, because all index nodes reside in a main memory. Unlike disk-based index techniques, main memory-based spatial indexing techniques must reduce key comparing time as well as node access time. In this paper, we propose an efficient spatial index structure for main memory-based databases, called Tmr-tree. Tmr-tree integrates the characteristics of R-tree and T-tree. Therefore, Nodes of Tmr-tree consist of several entries for data objects, main memory pointers to left and right child, and three additional fields. First is a MBR of a self node, which tightly encloses all data MBRs (Minimum Bounding Rectangles) in a current node, and second and third are MBRs of left and right sub-tree, respectively. Because Tmr-tree needs not to visit all leaf nodes, in terms of search time, proposed Tmr-tree outperforms R-tree in our experiments. As node size is increased, search time is drastically decreased followed by a gradual increase. However, in terms of insertion time, the performance of Tmr-tree was slightly lower than R-tree.

• The Journal of the Convergence on Culture Technology
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• v.6 no.3
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• pp.431-436
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• 2020

Information service organizations that provide science and technology information with a relatively short information life cycle for free or paid are in need of reflecting rapidly changing user needs and behaviors and grafting the latest technologies. The purpose of this study is to derive improvements for each system by comparing and analyzing general recognition of science and technology information users' domestic and foreign science and technology information sites and importance by science and technology information attributes. A total of 816 users of science and technology information participated in the online survey, and the collected data were analyzed by quantitative methods including IPA (Importance Performance Analysis) technique. The importance was evaluated by the impact value calculated through regression analysis. As a result of data analysis, the general recognition of users on science and technology information sites was relatively high in national science and technology information services, and Google Scholar and Science Direct were also high. Google Scholar was found to have more strength than improvement. A better understanding of the user's preferred system is a good driving force for improving the lack of existing systems. It is necessary to improve the information retrieval of the science and technology information service system, that is, to improve the search speed and functions, and also to improve the user interface with improved convenience and usability.

• Journal of Distribution Science
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• v.8 no.3
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• pp.49-56
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• 2010

At the initial stage of Internet advertising, banner advertising came into fashion. As the Internet developed into a central part of daily lives and the competition in the on-line advertising market was getting fierce, there was not enough space for banner advertising, which rushed to portal sites only. All these factors was responsible for an upsurge in advertising prices. Consequently, the high-cost and low-efficiency problems with banner advertising were raised, which led to an emergence of keyword advertising as a new type of Internet advertising to replace its predecessor. In the beginning of 2000s, when Internet advertising came to be activated, display advertisement including banner advertising dominated the Net. However, display advertising showed signs of gradual decline, and registered minus growth in the year 2009, whereas keyword advertising showed rapid growth and started to outdo display advertising as of the year 2005. Keyword advertising refers to the advertising technique that exposes relevant advertisements on the top of research sites when one searches for a keyword. Instead of exposing advertisements to unspecified individuals like banner advertising, keyword advertising, or targeted advertising technique, shows advertisements only when customers search for a desired keyword so that only highly prospective customers are given a chance to see them. In this context, it is also referred to as search advertising. It is regarded as more aggressive advertising with a high hit rate than previous advertising in that, instead of the seller discovering customers and running an advertisement for them like TV, radios or banner advertising, it exposes advertisements to visiting customers. Keyword advertising makes it possible for a company to seek publicity on line simply by making use of a single word and to achieve a maximum of efficiency at a minimum cost. The strong point of keyword advertising is that customers are allowed to directly contact the products in question through its more efficient advertising when compared to the advertisements of mass media such as TV and radio, etc. The weak point of keyword advertising is that a company should have its advertisement registered on each and every portal site and finds it hard to exercise substantial supervision over its advertisement, there being a possibility of its advertising expenses exceeding its profits. Keyword advertising severs as the most appropriate methods of advertising for the sales and publicity of small and medium enterprises which are in need of a maximum of advertising effect at a low advertising cost. At present, keyword advertising is divided into CPC advertising and CPM advertising. The former is known as the most efficient technique, which is also referred to as advertising based on the meter rate system; A company is supposed to pay for the number of clicks on a searched keyword which users have searched. This is representatively adopted by Overture, Google's Adwords, Naver's Clickchoice, and Daum's Clicks, etc. CPM advertising is dependent upon the flat rate payment system, making a company pay for its advertisement on the basis of the number of exposure, not on the basis of the number of clicks. This method fixes a price for advertisement on the basis of 1,000-time exposure, and is mainly adopted by Naver's Timechoice, Daum's Speciallink, and Nate's Speedup, etc, At present, the CPC method is most frequently adopted. The weak point of the CPC method is that advertising cost can rise through constant clicks from the same IP. If a company makes good use of strategies for maximizing the strong points of keyword advertising and complementing its weak points, it is highly likely to turn its visitors into prospective customers. Accordingly, an advertiser should make an analysis of customers' behavior and approach them in a variety of ways, trying hard to find out what they want. With this in mind, her or she has to put multiple keywords into use when running for ads. When he or she first runs an ad, he or she should first give priority to which keyword to select. The advertiser should consider how many individuals using a search engine will click the keyword in question and how much money he or she has to pay for the advertisement. As the popular keywords that the users of search engines are frequently using are expensive in terms of a unit cost per click, the advertisers without much money for advertising at the initial phrase should pay attention to detailed keywords suitable to their budget. Detailed keywords are also referred to as peripheral keywords or extension keywords, which can be called a combination of major keywords. Most keywords are in the form of texts. The biggest strong point of text-based advertising is that it looks like search results, causing little antipathy to it. But it fails to attract much attention because of the fact that most keyword advertising is in the form of texts. Image-embedded advertising is easy to notice due to images, but it is exposed on the lower part of a web page and regarded as an advertisement, which leads to a low click through rate. However, its strong point is that its prices are lower than those of text-based advertising. If a company owns a logo or a product that is easy enough for people to recognize, the company is well advised to make good use of image-embedded advertising so as to attract Internet users' attention. Advertisers should make an analysis of their logos and examine customers' responses based on the events of sites in question and the composition of products as a vehicle for monitoring their behavior in detail. Besides, keyword advertising allows them to analyze the advertising effects of exposed keywords through the analysis of logos. The logo analysis refers to a close analysis of the current situation of a site by making an analysis of information about visitors on the basis of the analysis of the number of visitors and page view, and that of cookie values. It is in the log files generated through each Web server that a user's IP, used pages, the time when he or she uses it, and cookie values are stored. The log files contain a huge amount of data. As it is almost impossible to make a direct analysis of these log files, one is supposed to make an analysis of them by using solutions for a log analysis. The generic information that can be extracted from tools for each logo analysis includes the number of viewing the total pages, the number of average page view per day, the number of basic page view, the number of page view per visit, the total number of hits, the number of average hits per day, the number of hits per visit, the number of visits, the number of average visits per day, the net number of visitors, average visitors per day, one-time visitors, visitors who have come more than twice, and average using hours, etc. These sites are deemed to be useful for utilizing data for the analysis of the situation and current status of rival companies as well as benchmarking. As keyword advertising exposes advertisements exclusively on search-result pages, competition among advertisers attempting to preoccupy popular keywords is very fierce. Some portal sites keep on giving priority to the existing advertisers, whereas others provide chances to purchase keywords in question to all the advertisers after the advertising contract is over. If an advertiser tries to rely on keywords sensitive to seasons and timeliness in case of sites providing priority to the established advertisers, he or she may as well make a purchase of a vacant place for advertising lest he or she should miss appropriate timing for advertising. However, Naver doesn't provide priority to the existing advertisers as far as all the keyword advertisements are concerned. In this case, one can preoccupy keywords if he or she enters into a contract after confirming the contract period for advertising. This study is designed to take a look at marketing for keyword advertising and to present effective strategies for keyword advertising marketing. At present, the Korean CPC advertising market is virtually monopolized by Overture. Its strong points are that Overture is based on the CPC charging model and that advertisements are registered on the top of the most representative portal sites in Korea. These advantages serve as the most appropriate medium for small and medium enterprises to use. However, the CPC method of Overture has its weak points, too. That is, the CPC method is not the only perfect advertising model among the search advertisements in the on-line market. So it is absolutely necessary that small and medium enterprises including independent shopping malls should complement the weaknesses of the CPC method and make good use of strategies for maximizing its strengths so as to increase their sales and to create a point of contact with customers.