• Journal of Lipid and Atherosclerosis
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• v.5 no.1
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• pp.61-77
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• 2016

Objective: This study aims to analyze cost-effectiveness of two most-commonly used statins from the perspective of the Korean national health system. Methods: The scope of the analysis included rosuvastatin (5 mg, 10 mg, and 20 mg) and atorvastatin (10 mg, 20 mg, 40 mg, and 80 mg). Effectiveness was defined as percentage (%) and absolute (mg/dL) reductions of low-density lipoprotein cholesterol (LDL-C) from the baseline. They were derived from published randomized controlled studies for rosuvastatin and atorvastatin. Effectiveness was defined as reductions in LDL-C levels per mg dose of the drugs. The annual direct medical costs including drug acquisition costs and monitoring costs over the one-year time horizon were calculated for each alternative. The average cost-effectiveness ratios (ACERs) and incremental cost-effectiveness ratios (ICERs) for each statin dose were calculated. Results: The ACERs for all doses of rosuvastatin (5 mg, 10 mg, and 20 mg) were lower than those for all doses of atorvastatin (10 mg, 20 mg, 40 mg, and 80 mg). Rosuvastatin 10 mg was the most cost-effective statin for LDL-C reduction. In cost-effectiveness analyses for corresponding doses of rosuvastatin and atorvastatin, rosuvastatin was the superior strategy which suggests both higher effectiveness and lower costs than atorvastatin. However, we have to consider this analysis is highly influenced by current price of statins in each market. Conclusion: For reduction of LDL-C levels in Korean patients with dyslipidemia, rosuvastatin 10mg is the most cost-effective statin in the current Korean market.

• Food Science and Preservation
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• v.16 no.4
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• pp.490-498
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• 2009

This study attempted to examine the profitability and marketing costs of seed potato under contract farming system of BADC (Bangladesh Agricultural Development Corporation) with the help of primary and secondary data. Total 45 contract farmers were randomly selected. Attempts were made to calculate costs, returns and profitability of seed potato production under contract farming system, and to identify marketing channels of seed potato. The field level data were collected by a farm survey during the months of April 2005 through direct interviews with contract farmers and registered dealers using a structure survey questionnaire. The results showed that the gross return per hectare was Tk. 252,464 for all categories of farms. Cost of seeds, fertilizers, pesticides, irrigation and human labor were critical inputs for profitability of seed potato. Cobb-Douglas production function analysis was used to determine the effects of the key variables to seed potato production under contract farming system. The elasticity of seed potato production was at 0.727 for all categories of farms. The findings exhibited that the summation of elasticity of different inputs for seed potato production was less than one, implying that the production function exhibited decreasing returns to scale. Registered dealers and Upazila Sales Centers were involved in seed potato marketing formed a straightforward marketing channel. The total marketing costs of registered dealers were Tk. 759.49 per ton of seed potato. The net marketing margin of registered dealers was estimated at Tk. 465.51 per ton of seed potato. The selected contract farmers and registered dealers faced a number of problems and some of recommendations were suggested.

• Industrial Engineering and Management Systems
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• v.11 no.2
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• pp.183-187
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• 2012

In this paper, we study the fixed charge transportation problem with uncertain variables. The fixed charge transportation problem has two kinds of costs: direct cost and fixed charge. The direct cost is the cost associated with each source-destination pair, and the fixed charge occurs when the transportation activity takes place in the corresponding source-destination pair. The uncertain fixed charge transportation problem is modeled on the basis of uncertainty theory. According to inverse uncertainty distribution, the model can be transformed into a deterministic form. Finally, in order to solve the uncertain fixed charge transportation problem, a numerical example is given to show the application of the model and algorithm.

• Journal of the Korean Society of Safety
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• v.30 no.1
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• pp.1-7
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• 2015

This study first addresses the ineffectiveness of indirect regulation on industrial machines. Analysis of causes of industrial accidents associated with industrial machines further reveals the fact that technical causes need to be resolved at the manufacturing stage to reduce the frequency and strength of industrial accidents. Balanced safety certification on manufacturers and safety inspection on users of industrial machines are then suggested to effectively resolve such technical causes. The effectiveness of such safety certification and safety inspection can be justified by cost-benefit analysis. Particularly, balance in expected benefits of safety certification and safety inspection is a key issue for validity of such analysis. The accumulated benefit-costs for press brake and portable sawing machine confirm the effectiveness of such safety system.

• Proceedings of the KSME Conference
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• 2001.06c
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• pp.398-401
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• 2001

There are two methods to calculate design sensitivity such as direct differentiation method and adjoint method. A sort of direct differentiation method for design sensitivity analysis costs too much when number of design variables is much larger than the number of response functions whose design sensitivity analyses are required. Therefore, an adjoint method is suggested for the case that the dimension of design variables is lager than the number of response function. An adjoint method is required to compute adjoint variables from the simultaneous linear system equation, the so-called adjoint equation, requiring only the eigenvalue and its associated eigenvectors for mode being differentiated. This method has been extended to the repeated eigenvalue problem. In this paper, we propose an adjoint method for deign sensitivity analysis of damped vibratory systems with distinct eigenvalues.

• Proceedings of the KIEE Conference
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• 2005.07a
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• pp.347-349
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• 2005

This paper presents the results of an investigation and assessment of the direct short term impacts of electric service interruption incurred by livestock customers. The study used a direct visit survey to determine the customer assessment of electric service interruption and characteristic. The variation in interruption cost with the characteristics of interruptions such as duration, time of day, frequency, and day of interruption was also investigated.

• Proceedings of the KIEE Conference
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• 2005.07a
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• pp.350-352
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• 2005

This paper presents the results of an investigation and assessment of the direct short term impacts of electric service interruption incurred by public customers. The study used a direct visit survey to determine the customer assessment of electric service interruption and characteristic. The variation in interruption cost with the characteristics of interruptions such as duration, time of day, frequency, and day of interruption was also investigated.

• Proceedings of the IEEK Conference
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• 1999.11a
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• pp.784-787
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• 1999

This paper describes a direct digital frequency synthesizer using the CORDIC algorithm, which can be implemented efficiently for a digital sinusoid synthesis. To optimize the hardware design parameters, we perform numerical analysis of the quantization effects for the CORDIC-based architecture. A pipelined architecture is employed to obtain a high data throughput,. We estimate and summarize its hardware costs for a variable accuracy, and a CORDIC-based architecture for 9 bit accuracy is emulated in FPGA.

• Korean Journal of Agricultural Science
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• v.23 no.2
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• pp.330-341
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• 1996

As the agricultural marketing environments, which are consumers' tastes and preferences, producers' involvements in marketing business, government policy and liberalization of domestic market, have rapidly changed, current marketing systems are facing transitional periods. To cope with changing marketing environments, it is desirable to develop new marketing system that efficiently direct the flow of agricutlural products from producers to consumers. Cyber-marketing system, in which producers and consumers could conduct direct transaction with each other using computer internet system, would be suggested so that marketing stages and costs can be reduced. However, for cyber-marketing to be managed successfully, it is a need to establish data base and information network system for producers' group and consumers' group and to improve the marketing functional performances such as grading, packaging, and storage system.

• Proceedings of the KIEE Conference
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• summer
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• pp.141-143
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• 2004

This paper presents the results of an investigation of the direct short term impacts of electric service interruption incurred by agriculture customers. The study used a direct visit survey to determine the customer assessment of electric service interruption and characteristic. The variation in interruption cost with the characteristics of interruptions such as duration, time of day, frequency, and day of interruption was also investigated.