• Bulletin of the Korean Chemical Society
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• 제34권2호
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• pp.595-599
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• 2013

The coordination of pyridyl-N to pentacyanoferrate for the detection of small organic antigens in solution is presented. The unique contribution of this paper is the direct conjugation of pyridyl-N in small organic antigens to pentacyanoferrate. Pentacyanoferrate is promising as an electrochemical label owing to its good electro-chemical properties, which can be utilized to generate an electrical signal in homogeneous electrochemical immunoassays. The facilely synthesized pyridyl-N to pentacyanoferrate was characterized by the electrochemical and spectroscopic methods. Hippuric acid (HA) has been detected competitively on the interaction of free HA and pentacyanoferrate-(4-aminomethylpyridine-hippuric acid) (Fe-HA) to its antibody, with the detection limit of 0.50 ${\mu}g\;mL^{-1}$. While pentacyanoferrate-based immunoassay is in its simplicity and infancy, the proposed immunoassay offers attractive opportunities for developing pyridyl-N-based the electrochemical detection of small organic antigens in the health care area.

• Journal of Communications and Networks
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• 제7권1호
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• pp.29-35
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• 2005

This paper deals with the problem of multiuser detection over a direct-sequence code-division multiple access (DS-CDMA) channel with incomplete channel state informations (I-CSI). We devise and assess two novel recursive detectors based on the expectation conditional maximization (ECM) algorithm and the generalized likelihood ratio (GLR) principle, respectively. Both receivers entail an affordable computational complexity. Moreover, the performance assessment, conducted via Monte Carlo techniques, shows that they achieve satisfactory performance levels and outperform linear detectors.

• 전기학회논문지
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• 제62권1호
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• pp.120-126
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• 2013

This paper proposes a novel scheme of fault detection and self-recovery for space-borne dual ring counters subject to transient faults. The considered ring counter is equipped with hardware redundancy, but it has a limited output domain where direct access to the current state is unavailable. We employ the theory of corrective control to detect any transient fault occurring to the counter bits and to realize immediate self-recovery of the ring counter back to the normal state. The structure of the fault-tolerant controller is designed to be minimal regardless of the counter size. To validate the applicability, we implement the proposed system on a commercial FGPA board.

• 한국진공학회:학술대회논문집
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• 한국진공학회 2013년도 제45회 하계 정기학술대회 초록집
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• pp.87-87
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• 2013

The interface between nanomaterials and biosystems is emerging as one of the broadest and most dynamic areas of science and technology, bringing together biology, chemistry, physics and many areas of engineering, biomedicine. The combination of these diverse areas of research promised to yield revolutionary advances in healthcare, medicine, and life science. For example, the creation of new and powerful nanosensors that enable direct, sensitive, and rapid analysis of biological and chemical species can advance the diagnosis and treatment of disease, discovery and screening of new drug molecules. Nanowire based sensors are emerging as a powerful and general platform for ultrasensitive and multiplex detection of biological and chemical species. Here, we present the studies about noble metal nanowire sensors that can be used for sensitive detection of a wide-range of biological and chemical species including nucleic acids, proteins, and toxic metal ions. Moreover, the optical and electrochemical applications of noble metal nanowires are introduced. Noble metal nanowires are successfully used as plasmonic antennas and nanoelectrodes, thereby provide a pathway for a single molecule sensor, in vivo neural recording, and molecular injection and detection in a single living cell.

• 한국정보처리학회:학술대회논문집
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• 한국정보처리학회 2019년도 추계학술발표대회
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• pp.760-761
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• 2019

Smart manufacturing is a process of integrating computer-related technologies in production and by doing so, achieving more efficient production management. The recent development of supercomputers has led to the broad utilization of artificial intelligence (AI) and machine learning techniques useful in predicting specific patterns. Despite the usefulness of AI and machine learning techniques in smart manufacturing processes, there are many fundamental issues with the direct deployment of these technologies related to data management. In this paper, we focus on solving the outlier detection issue in smart manufacturing applications. More specifically, we apply a state-of-the-art outlier detection technique, called Elliptic Envelope, to detect anomalies in simulation-based collected data.

• Food Science and Biotechnology
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• 제17권5호
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• pp.1038-1046
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• 2008

This study was carried out to develop a small-sized biosensor based on surface plasmon resonance (SPR) for the rapid identification of insecticide residues for food safety. The SPR biosensor module consists of a single 770 nm-light emitting diodes (LED) light source, several optical lenses for transferring light, a hemisphere sensor chip, photo detector, A/D converter, power source, and software for signal processing using a computer. Except for the computer, the size and weight of the sensor module are 150 (L)$\times$70 (W)$\times$120 (H) mm and 828 g, respectively. Validation and application procedures were designed to assess refractive index analysis, affinity properties, sensitivity, linearity, limits of detection, and robustness which includes an analysis of baseline stability and reproducibility of ligand immobilization using carbamate (carbofuran and carbaryl) and organophosphate (cadusafos, ethoprofos, and chlorpyrifos) insecticide residues. With direct binding analysis, insecticide residues were detected at less than the minimum 0.01 ppm and analyzed in less than 100 sec with a good linear relationship. Based on these results, we find that the binding interaction with active target groups in enzymes using the miniaturized SPR biosensor could detect low concentrations which satisfy the maximum residue limits for pesticide tolerance in Korea, Japan, and the USA.

• 한국컴퓨터산업학회논문지
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• 제2권4호
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• pp.537-546
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• 2001

DSSS(Direct-Sequence Spread-Spectrum) CDMA 시스템에서 MAI(Multiple Access Interference)와 원근 문제를 해결할 수 있는 단일-사용자 검파에 적합한 알고리즘으로 Griffiths’알고리즘과 LCCMA(Linearly Constrained Constant Modulus Algorithm)에 제안되었으며 MMSE 검파기에 적합한 다중-사용자 알고리즘인 MOE 알고리즘 또한 제안되었다. 본 논문은 training sequence의 요구 없이 시스템의 성능을 향상시킬 수 있는 이 세 가지 Blind 적합 알고리즘을 가지고 간섭 사용자의 수나 원하는 사용자의 데이터 업데이트율에 따라 각각의 알고리즘별 성능을 비교 분석하였다. 시뮬레이션 결과 간섭 사용자수와 원하는 사용자의 업데이트율의 변화에 따라 모두 LCCMA 알고리즘이 뛰어난 성능을 보았다. Blind 적용은 하나의 training sequence의 필요성을 없앰으로써 더욱 융통성 있는 네트웍디자인을 가능케 했다.

• Journal of Microbiology and Biotechnology
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• 제14권3호
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• pp.612-619
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• 2004

A competitive direct enzyme-linked immunosorbent assay (cdELISA) was developed for selective and rapid detection of a glycopeptide antibiotic, teicoplanin (TP). TP was conjugated to bovine serum albumin (BSA) for use as an immunogen. Repeated subcutaneous injections of 0.5 mg of the conjugate was effective in generating specific polyclonal antibody (PAb) toward TP in rabbits, as determined by cdELISA. TP-horseradish peroxidase conjugate (TP-HRP) was used as an enzyme marker. The cdELISA was developed based on a competition reaction between TP-BSA PAb and TP-HRP conjugate. The TP-BSA PAb was highly sensitive (detection limit, 0.3 ng/ml and specific toward teicoplanin, showing no cross-reactivity to other glycopeptide antibiotics including vancomycin. There were good correlations ($r^2$=0.84 and 0.76, respectively) between cdELISA and microbiological assay, and high-performance liquid chromatography. The cdELISA system developed in this work is expected to be useful not only for selective and rapid monitoring of TP but also for study of TP pharmacokinetics.

• 한국정보통신설비학회:학술대회논문집
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• 한국정보통신설비학회 2009년도 정보통신설비 학술대회
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• pp.309-313
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• 2009

In this paper, the network performance of a turbo coded optical code division multiple access (CDMA) system with cross-layer, which is between physical and network layers, concept is analyzed and simulated. We consider physical and MAC layers in a cross-layer concept. An intensity-modulated/direct-detection (IM/DD) optical system employing pulse position modulation (PPM) for satellite broadcasting communications is considered. In order to increase the system performance, turbo codes composed of parallel concatenated convolutional codes (PCCCs) is utilized. The network performance is evaluated in terms of bit error probability (BEP). From the simulation results, it is demonstrated that turbo coding offers considerable coding gain with reasonable encoding and decoding complexity. Also, it is confirmed that the performance of such an optical CDMA network can be substantially improved by increasing the interleaver length and the number of iterations in the decoding process. The results of this paper can be applied to implement the satellite broadcasting communications.

• Journal of Microbiology and Biotechnology
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• 제5권4호
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• pp.181-187
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• 1995

The cells of Vibrio vulnificus can be induced to the viable but nonculturable (VBNC) state by natural environmental parameters. The V. vulnificus cells in the VBNC state can not be recovered by ordinary laboratory techniques. This nonculturability could often hamper development of effective processing strategies to minimize the number of V. vulnificus in seafoods. Even with V. vulnificus cells in a culturable state, the length of time required to identify the bacteria in contaminated food by phenotyphic characterization may prevent appropriate in-time responses by public health agencies to infections of the bacteria. In the present study, we used polymerase chain reaction (PCR) to develop a rapid and direct detection method for V. vulnificus in small octopus (Octopus variabilis) which is consumed as a raw food in Korea. The region targeted was a 704-base pair (bp) portion of the hemolysin gene, vvhA, of V. vulnificus. The primers designed for PCR amplification were specific for all V. vulnificus sp. tested. Several methods were examined to extract total DNA directly from V. vulnificus seeded into the octopus homogenate and the guanidine isothiocyanate (CITC) method appeared to be most effective. From the octopus homogenate seeded by V. vulnificus at an initial level of $10^2$ CFU/ml of the homogenate and then incubated for 12 h, the targeted sequence was successfully amplified by PCR and the 704-bp DNA fragment was observed by gel electrophoresis. The total completion of this assay requires less than one day.