• Title/Summary/Keyword: Dihydrocucurbitain B

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Antitumor activity of Trichosanthes kirilowii

  • Ryu, Shi-Yong;Lee, Seung-Ho;Lee, Sang-Un;Lee, Chong-Ock;No, Zaesung;Ahn, Jong-Woong
    • Archives of Pharmacal Research
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    • v.17 no.5
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    • pp.348-353
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    • 1994
  • The activity fractionation upon the MeOH extract of the root of trichosanthes kirilowii led to the isolation of eight cucurbitane tritepense namely cucurbitacin .betha. (I), isocucurbitacin .betha.(II), cucurbitacin D(III), isocucurbitacin D(IV), 3-epi-isocucurbitacin .betha(V), dihydrocucurbitain .betha. (VI), dihydroisocucurgbitachin .betha. (VII) and dihydrocucurbitacin E (VIII), as active principles. All isolates were shown to exhibit significant cytotoxicity against cultured human tumor cells, including A-549, Sk-OV-3, Sk-MEL-2, XF-498 and HCT 15, with an exceptionally high potency.

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