• 약학회지
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• 제44권4호
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• pp.347-353
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• 2000

To examine influence of artificial digestive juice on the antitumor activity of Ganoderma lucidum-A(GL-A), protein-bound polysaccharide from Ganoderma lucidum, we compared the digested protein-bound polysaccharide with undigested one both on immunopotentiating activity and influence of digestive juices. Protein-bound polysaccharide GL-B was obtained by digesting the antitumor component GL-A with artificial digestive Juices in vitro. When GL-A was administered orally to sarcoma 180 tumor-bearing ICR mice, the life prolonging effect was exhibited in a dose dependent manner Not only GL-A but GL-B increased the production of colony forming unit (CFU) to 10- and 8-fold of that of the control, respectively. Both of the protein-bound polysaccharides also showed the secretion of nitric oxide in RAW 264.7 cell lines to 3.5-and 3.7-fold of that of the control, respectively: GL-A activated components of the alternative complement pathway, whereas GL-B did not. In humoral immunity GL-A increased the activity of alkaline phosphatase in differentiated B cells to 3 times and GL-B to 4 times of that of the control. These results showed that the artificial digestive juices had no influence on the antitumor activity of the protein-bound polysaccharide from Ganoderma lucidum and that its immunomodulating activity retained after treatment with artificial digestive juice. And this provides a basis of the protein-bound polysaccharide of Ganoderma lucidum as an peroral anticancer drug.

• Journal of Pharmaceutical Investigation
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• 제20권4호
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• pp.209-215
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• 1990

The activities of s-amylase, ${\alpha}-amylase$ and protease of three combination products containing digestive enzymes, antacids and herbal drugs on the Korean market were estimated. The effects of antacids and herbal drugs on the activities of digestive enzymes were investigated. Starch-saccarifying activity of s-amylase, starch-dextrinizing activity of ${\alpha}-amylase$ and protein-peptic activity of protease were estimated by Somogy, Mc'Credy, and Casein-Folin method, respectivley. The optimal pH of s-amylase, ${\alpha}-amylase$ and protease were pH 5.0, 4.8 and 7.0, rcspectively. The digestive activities at optimal pH continued about eight hours. The digestive activities of individual enzymes were reduced to 40-90% by antacids and were affected somewhat positively or negatively by herbal drugs. Enzyme activities of the combination products were also affected by pH and reaction time.

• 척추신경추나의학회지
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• 제13권2호
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• pp.35-46
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• 2018

Objectives : To determine the effectiveness of Chuna manual therapy(CMT) for Adult Visceral Diseases. Methods : To find evidence of CMT for adult digestive system disease, we used 9 electronic databases(Pubmed, CAJ, EMBASE, Cochrane Library, Web of Science, KISS, KISTI, NDSL, RISS) up to April 2018. We reviewed randomized control trials(RCTs) using Chuna for Digestive system disease. To assess the methodological quality of each RCT, we used the Cochrane risk of bias tool. Results : We identified 11 RCTs about irritable bowel syndrome, chronic ulcerative colitis, gastritis, gastroptosis, spleen entropathy, gastrointestinal dysfunction after stroke in 356 studies. All studies used total efficiency rate for main outcome. In all studies, CMT was effective for digestive system disease. Conclusions : CMT was effective for Digestive system disease. Risk of bias was high and the difference between the experimental group and the control group was not great. Considering that there were no reports of side effects, it seems possible to apply CMT to the treatment of adult digestive system disease.

• 한국발생생물학회:학술대회논문집
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• 한국발생생물학회 2005년도 제20차 학술대회 논문집
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• pp.51-51
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• 2005

We inestigated the reproductive cycle with ovarian development of Chlamys farreri by histological observations, and seasonal changes in biochemical components of the adductor muscle, digestive diverticula and ovary were studied by biochemical analysis. The reproductive cycle of this species can be classified into five successive stages: early active stage (January to March), late active stage (March to April), ripe stage (April to August), partially spawned stage (June to August) and spent/inactive stage (August to January). According to ANOVA test, there were significant differences (p<0.05) in total protein, total lipid and glycogen contents among months for all of the adductor muscle, digestive diverticula and ovary. Total protein contents in ovary and digestive diverticula showed significant changes(ANOVA, p<0.05) during the study period, while that in the adductor muscle did not. Total protein content was highest in the adductor muscle, followed by ovary, and lowest in digestive diverticula. There was no correlation in total protein content between the adductor muscle and digestive diverticula (p=0.220). But strong positive correlation was found between adductor muscle and ovary (r=0.450, p=0.013). ANOVA showed that there were significant differences in total lipid and glycogen contents among months for all of the adductor muscle, ovary, and digestive diverticula (p<0.05). The monthly changes in total lipid content were highly variable in ovary and digestive gland. High contents of total lipid were foung during April and May-June in ovary, while March and June-July in digestive diverticula. There was a strong negative correlation in total lipid content between ovary and digestive diverticula (r=- 0.397, p=0.030). Unlike total protein of total lipid, glycogen content in the adductor muscle was most dynamic. It showed more than 36-fold changes in the adductor muscle (at most 3-fold change in ovary) during the study period. Glycogen content was higher during May-July in the adductor muscle, While it was higher in March and august in digestive diverticula. There was a strong negative correlation in glycogen content between the adductor muscle and digestive diverticula (r=-0.584, p=0.001).

• 대한한의정보학회지
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• 제19권1호
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• pp.1-34
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• 2013

Objectives : A common cold is a viral disease. There exists only allopathy for it depending on symptoms because of no cure. Korean medicine has taken a serious view of common cold patients with digestive problems as well as patients of the common cold. Accordingly, this study is aimed at finding out the traits of patients with digestive problems among common cold patients. Methods : A survey was conducted with 62 cold patients who got medical treatment in Korean medicine clinics located in small cities and towns including metropolitan cities. The SPSS for Windows( 19.0 Version) was used for statistical analysis. Results : Depending on which clinic common cold patients decided to go to, there was a significant difference in the number of sick days. The group of patients who decided to go straight to oriental medicine clinics had fewer sick days. Only 9.7% of the group of patients who got treatment in Koean medicine clinics had more than 6 sick days. The group of common cold patients with digestive problems had more sick days than the group with no digestive problems, which showed that there was a significant correlation between digestive problems and sick days. When it came to digestive problems depending which clinic common cold patients decided to go to, there was no significant value because of little data collection. However, while 41.9% of the group who went to hospital at first and then to Koean medicine clinic had digestive problems, 24.2% of the group who directly went to Koean medicine clinic had digestive problems. On the whole, 66.1% of the entire common cold patients were shown to have digestive problems. Conclusion : There are relatively many patients with digestive problems among common cold patients, and there is a significant correlation between digestive problems and sick days on common cold.

• 한국패류학회지
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• 제21권1호
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• pp.71-80
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• 2005

We investigated the reproductive cycle with ovarian development of Chlamys farreri by histological observations, and seasonal changes in biochemical components of the adductor muscle, digestive diverticula and ovary were studied by biochemical analysis. The reproductive cycle of this species can be classified into five successive stages: early active stage (January to March), late active stage (March to April), ripe stage (April to August), partially spawned stage (June to August) and spent/inactive stage (August to January). According to ANOVA test, there were significant differences (p < 0.05) in total protein, total lipid and glycogen contents among months for all of the adductor muscle, digestive diverticula and ovary. Total protein contents in ovary and digestive diverticula showed significant changes (ANOVA, p < 0.05) during the study period, while that in the adductor muscle did not. Total protein content was highest in the adductor muscle, followed by ovary, and lowest in digestive diverticula. There was no correlation in total protein content between the adductor muscle and digestive diverticula (p = 0.220). But strong positive correlation was found between adductor muscle and ovary (r = 0.450, p = 0.013). ANOVA showed that there were significant differences in total lipid and glycogen contents among months for all of the adductor muscle, ovary, and digestive diverticula (p < 0.05). The monthly changes in total lipid content were highly variable in ovary and digestive gland. High contents of total lipid were found during April and May-June in ovary, while March and June-July in digestive diverticula. There was a strong negative correlation in total lipid content between ovary and digestive diverticula (r = -0.397, p = 0.030). Unlike total protein or total lipid, glycogen content in the adductor muscle was most dynamic. It showed more than 36-fold changes in the adductor muscle (at most 3-fold change in ovary) during the study period. Glycogen content was higher during May-July in the adductor muscle, while it was higher in March and August in digestive diverticula. There was a strong negative correlation in glycogen content between the adductor muscle and digestive diverticula (r = -0.584, p = 0.001).

• 한국어업기술학회:학술대회논문집
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• 한국어업기술학회 2000년도 춘계수산관련학회 공동학술대회발표요지집
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• pp.539-539
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• 2000

A cytochemical study by the Benedict's reaction method was conducted to find out the cellulase activity in the digestive organs of Helix aspersa. Out of the all digestive organs, the stomach, the intestine, and the digestive gland showed cellulase activities under the transmission electron microscopy.

• 대한한방소아과학회지
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• 제32권1호
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• pp.54-74
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• 2018

Objectives The purpose of this study is to investigate recent trend of diseases in Korean pediatrics and adolescent patients treated with oriental medicine. Methods Using data from the Korean statistical information service and healthcare bigdata hub, top 500 diseases pediatrics and adolescents that were treated with oriental medicine from 2012 to 2016 in admission and outpatient department was collected. Results From the inpatient study, majority of the subjects were between 15 to 19 years old (62.74%), followed by 10 to 14 years old, 5 to 9 years old and under 5 years old. In the outpatient department study, majority was 15 to 19 years old (36.51%), followed by 10 to 14 years old, under 5 years old, 5 to 9 years old. In systemic division of admission part, the most common disease was musculoskeletal related which was 72.32%, followed by brain, nerve, respiratory, dermatology and digestive related diseases. In systemic division of outpatient department, respiratory disease was the most common (41.81%), followed by digestive, dermatology, brain and nerve diseases. For under 5 years old patient group, respiratory disease was the most common, 29.86%, followed by dermatology, musculoskeletal, digestive related diseases. For 5 to 19 years old group of patients, musculoskeletal disease was most common. For the 5 to 14 years old patient group, respiratory related disease was the most common followed by dermatology and digestive diseases. For 15 to 19 years old patient group, digestive disease was the most common followed by respiratory and dermatology related diseases. For under 5 to 9 years old outpatient group, respiratory disease was the most common, and for under 5-year-old group, digestive, growth development, and dermatology disease were common. For the 5 to 9 years old group of patients, musculoskeletal related disease was the most common followed by digestive and dermatology related diseases. For the 10 to 19 years old patient group, musculoskeletal was the most common. For the 10 to 14 years old patient group, respiratory related disease was the most common followed by digestive, dermatology disease. For the 15 to 19 years old patient group, digestive related disease was the most common followed by respiratory, dermatology diseases. Musculoskeletal disease increased every year, in both inpatient and outpatient. Respiratory, brain, nerve, digestive related diseases were generally decreased. In outpatient, respiratory diseases were increased every year but brain, nerve, digestive related diseases were generally decreased. Conclusions More studies about the oriental medicine in chronic disease, such as allergy, metabolic syndrome, in Korean pediatrics and adolescents are needed.

• 한국패류학회지
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• 제32권3호
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• pp.165-174
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• 2016

바지락의 섭식 특성을 분석하기 위해 서해의 곰소만에서 바지락의 소화관 내용물과 표층 해수의 식물플랑크톤 군집에 대해 정량 및 정성분석을 실시하였다. 바지락의 소화관에는 규조류 (71.5%), 와편모류 (13.1%), 미소플랑크톤 (6.6%) 과 중형동물플랑크톤을 포함한 유기쇄설물 등이 관찰되었다. 소화관내에서 섭식량은 겨울과 봄에 많았고 여름과 가을에 낮게 나타난 반면, 표층 해수의 식물플랑크톤 현존량은 가을에 가장 많았다. 또한 바지락의 크기가 클수록 섭식한 먹이생물의 양은 증가하였다. 소화관에서 관찰된 우점종은 저서성 규조류인 Paralia sulcata 및 Navicula arenaria와 와편모류의 cyst 이었던 반면 표층해수에서 우점종은 부유성 규조류인 Chaetoceros 속, Skeletonema 속, Asterionellopsis 속 등과 cryptomonads 및 P. sulcata이었다. 소화관 내용물 분석을 통해 바지락의 주요 먹이원은 저서성 규조류이며, 식물플랑크톤의 크기와 모양에 따라 선택적으로 섭식함을 확인하였다.

• 한국잠사곤충학회지
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• 제27권1호
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• pp.37-41
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• 1985

이 연구는 polyacrylamide gel 전기영동법을 사용해서 상잠의 5령 3일째 유충 및 가잠의 5령 3일째 유충에 있어서 혈액, 소화액 단백질의 전기 영동상과소화액 amylase 활성을 조사하였다. 1. 상잠의 혈액에 있어서 자유충에서는 6본의 주요 단백질 band가 검출되었으며 웅유충에서는 7본의 주요 단백질 band가 검출되었다. 그러나, 가잠에 있어서 암누에에 있어서는 8본, 숫누에에 있어서는 7본이 검출되었다. 상잠과 가잠과의 혈액단백질의 전기영동상에 있어서 다소의 차이가 있었다. 2. 상잠의 소화액에서 15본의 단백질 band가 검출되었으며 가잠에서는 12본의 단백질 band가 검출되었다. 상잠과 가잠과의 소화액 단백질의 전기영동상에 있어서도 다소의 차이가 있었다. 3. 상잠의 소화액 amylase는 가잠과 같이 양극측 BPB 부근까지 강하게 이동하였으며 상잠의 소화액 amylase의 이동도는 0.019이고 가잠의 이동도는 0.020으로서 양종간의 이동도의 차이가 거의 없었다.