• Journal of Korean Academy of Oral Health
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• v.42 no.4
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• pp.210-215
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• 2018

Objectives: The main objectives of this study were to verify the antibacterial activity of two essential oils, lavender and peppermint, against dental caries and to review their synergistic effect when used in combination. Our results provide basic data for the evaluation of the use of these two substances towards the prevention and cure of dental caries. Methods: The sample solutions of lavender and peppermint oils were prepared in three different concentrations (30%, 50%, and 70% (v/v)) by diluting them with third-distilled water and Tween 20. Streptococcus mutans was selected as the bacterial species for testing. The disk diffusion method was used to measure the antibacterial activity of the sample solutions. For generating growth curves and measuring the number of clusters of the bacterial, the liquid medium-dilution method was used; the absorbance of the medium was measured at 600 nm after 3, 6, 12 and 24 hours. Results: When the antibacterial activity of the oils was tested via the disk diffusion method, the activity improved with increasing concentrations of all the sample solutions of peppermint, lavender, and the blend, but there was no significant difference between them with respect to the type of oil. In the growth curves of S. mutans, growth inhibition was observed after 12 hours. The inhibitory effect of 30% lavender oil on growth was 64.9% and 80.1% after 12 and 24 hours of treatment, respectively whereas that of peppermint oil was 71.3% and 80.1% after 12 and 24 hours of treatment, respectively. The inhibitory effect of the blended oil was 71.9% and 81.0% after 12 and 24 hours of treatment, respectively. Conclusions: Further research is still required in order to determine the efficacy of lavender and peppermint oils, as well as other essential oils, for wider use in preventing dental caries.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.16
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• pp.7291-7294
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• 2015

Purpsoe: To investigate the diagnostic value of quantitative analysis of a tissue diffusion and virtual touch tissue imaging quantification (VTIQ) technique with acoustic radiation force impulse (ARFI) elastography for assessing enlarged cervical lymph nodes. Materials and Methods: Fifty-six enlarged cervical lymph nodes confirmed by pathologic diagnoses were covered in the study. According to the results of pathologic diagnosis, patients were classified into benign and malignant groups. All the patients were examined by both conventional ultrasonography and elastography. AREA% and shear wave velocity (SWV) in ROI of different groups were calculated and compared using ROC curves. Cut-off points of AREA% and SWV were determined with receiver operating characteristic curves. Results: Final histopathological results revealed 21 cases of benign and 35 cases of malignant lymph nodes. The mean values of AREA% and SWV in benign and malignant groups were $45.0{\pm}17.9%$ and $2.32{\pm}0.57m/s$, and $61.3{\pm}21.29%$ and $4.36{\pm}1.25$)m/s, respectively. For the parameters of elastography, "AREA%" and SWV demonstrated significant differences between groups (p=0.002). AREA% was positively correlated with SWV with a correlation coefficient of 0.809 (P<0.001). Conclusions: Stiffness of different lymph node diseases in patients may differ. Elastography can evaluate changes sensitively and provide valuable information to doctors. The study proved that the VTIQ elastography technique can play an important role in differential diagnosis of lymph nodes.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.3
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• pp.1299-1306
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• 2014

Background: Nano-biotechnology is recognized as offering revolutionary changes in various fields of medicine. Biologically synthesized silver nanoparticles have a wide range of applications. Materials and Methods: Silver nanoparticles (AgNPs) were biosynthesized with an aqueous extract of Pterocladiella (Pterocladia) capillacea, used as a reducing and stabilizing agent, and characterized using UV-VIS spectroscopy, Fourier Transform Infra red (FT-IR) spectroscopy, transmission electron microscopy (TEM) and energy dispersive analysis (EDX). The biosynthesized AgNPs were tested for cytotoxic activity in a human hepatocellular carcinoma ($HepG_2$) cell line cultured in Dulbecco's modified Eagle medium supplemented with 10% fetal bovine serum, 1% antibiotic and antimycotic solution and 2 mM glutamine. Bacterial susceptibility to AgNPs was assessed with Staphylococcus aureus, Bacillus subtilis [Gram+ve] and Pseudomonas aeruginosa and Escherichia coli [Gram-ve]. The agar well diffusion technique was adopted to evaluate the bactericidal activity of the biosynthesized AgNPs using Ampicillin and Gentamicin as gram+ve and gram-ve antibacterial standard drugs, respectively. Results: The biosynthesized AgNPs were $11.4{\pm}3.52$ nm in diameter. FT-IR analysis showed that carbonyl groups from the amino acid residues and proteins could assist in formation and stabilization of AgNPs. The AgNPs showed potent cytotoxic activity against the human hepatocellular carcinoma ($HepG_2$) cell line at higher concentrations. The results also showed that the biosynthesized AgNPs inhibited the entire panel of tested bacteria with a marked specificity towards Bacillus subtillus. Conclusions: Cytotoxic activity of the biosynthesized AgNPs may be due to the presence of alkaloids present in the algal extract. Our AgNPs appear more bactericidal against gram-positive bacteria (B. subtillus).

• 한국해양학회지
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• v.28 no.4
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• pp.339-346
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• 1993

Due to the natural increase of human population and the concentration of industrial complexes to coastal area, the uses of nearshore area were increased drastically, and the tendency will not stop for a while. Therefore, the loss of human life and property damages of the present days for a disaster of the same magnitude should be heavy as compared to those of the past. For the better utilization of the sea and the prevention of the frequent marine natural and man-made disaster, and for the preparedness for the ocean pollutions, through ocean researches are required. the circulation, tidal currents, storm surges, sea surface wind, waves and sea fogs of the Yellow Sea should be investigated first from the oceanographic point of view, and then the dispersion and diffusion of spilled oil and pollutants, beach erosion, red tide, and longterm sea level oscillations can be studied. International cooperation is crucial for the investigation of the sea because of the temporal and geographic scales of the oceanic phenomina.

• Journal of the Korean Society of Safety
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• v.33 no.1
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• pp.128-134
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• 2018

With the increase in frequency of typhoons and heavy rains following the climate change, the scale of damage from the calamities in the mountainous areas has been growing larger and larger, which is different from the past. For the case of Korea where 64% of land is consisted of the mountainous areas, establishment of the check dams has been drastically increased after 2000 in order to reduce the damages from the debris flow. However, due to the lack of data on scale, location and kind of check dams established for reducing the damages in debris flow, the measures to prevent damages based on experience and subjective basis have to be relied on. Under this study, the high-precision DEM data was structured by using the terrestrial LiDAR in the Jecheon area where the debris flow damage occurred in July 2009. And, from the numerical models of the debris flow, Kanako-2D that is available to reflect the erosion and deposition action was applied to install the erosion control facilities (water channel, check dam) and analyzed the effect of reducing the debris flow shown in the downstream.After installing the erosion control facilities, most of debris flow moves along the water channel to reduce the area to expand the debris flow, and after installing the check dam, the flow depth and flux of the debris flow were reduced along with the erosion. However, as a result of analyzing the diffusion area, flow depth, erosion and deposition volume of the debris flow generated from the deposition part after modifying the location of the check dams with the damages occurring on private residences and agricultural land located on the upstream area, the highest reduction effect was shown when the check dam is installed in the maximal discharge points.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2253-2255
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• 2012

Objective: The objective of our present study was to assess the role of serum amyloid A (SAA) in stages and prognosis of renal cell carcinoma. Material and Methods: It was a hospital based retrospective study carried out in the Department of Medicine and Biochemistry of Manipal Teaching Hospital, Pokhara, Nepal between $1^{st}$ January 2008 and $31^{st}$ December 2011. The variables collected were SAA, CRP. Approval for the study was obtained from the institutional research ethical committee. Quantitative analysis of human SAA and C-reactive protein (CRP) was performed by radial immune diffusion (RID) assay for all cases. Results: Of the 422 total cases of renal cell carcinoma, 218 patients had normal and 204 abnormal SAA. SAA levels were grossly elevated in T3 stage ($122.3{\pm}SD35.7$) when compared to the mean for the T2 stage ($84.2{\pm}SD24.4$) (p value: 0.0001). Similarly, SAA levels were grossly elevated in M1 stage ($190.0{\pm}SD12.7$) when compared to the M0 stage ($160.9{\pm}SD24.8$) (p: 0.0001). There was no significant association with elevated CRP levels ($209.1{\pm}SD22.7$, normal $199.0{\pm}SD19.5$). Conclusion: The validity of SAA in serum as being of independent prognostic significance in RCC was demonstrated with higher levels in advanced stage disease.

• Journal of Korea Game Society
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• v.18 no.6
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• pp.95-110
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• 2018

The game industry has grown to represent the domestic cultural industry, but the socio-cultural status of the game is not as high as industrial growth. In the early 2000s, the problem of dysfunctional use of youth games became a social issue and the game culture policy was established for 15 years. The purpose of this study is to examine the effect of policy on the prevention of dysfunction, The prevention of dysfunction of the game is somewhat effective, but the diffusion of positive function is insufficient and the improvement of recognition becomes more negative tendency. The effect is insufficient compared to the policy results. It is necessary to adjust the direction of game culture policy through consideration of securing basic data, post-management of policy, enhancement of cultural meaning, and universality of game culture.

• Journal of the Korea Safety Management & Science
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• v.26 no.1
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• pp.99-106
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• 2024

In the event of an emergency such as facility shutdown during process operation, the by-product gas must be urgently discharged to the vent stack to prevent leakage, fire, and explosion. At this time, the explosion drop value of the released by-product gas is calculated using ISO 10156 formula, which is 27.7 vol%. Therefore, it does not correspond to flammable gas because it is less than 13% of the explosion drop value, which is the standard for flammable gas defined by the Occupational Safety and Health Act, and since the explosion drop value is high, it can be seen that the risk of fire explosion is low even if it is discharged urgently with the vent stock. As a result of calculating the range of explosion hazard sites for hydrogen gas discharged to the Bent Stack according to KS C IEC 60079-10-1, 23 meters were calculated. Since hydrogen is lighter than air, electromechanical devices should not be installed within 23 meters of the upper portion of the Bent Stack, and if it is not possible, an explosion-proof electromechanical device suitable for type 1 of dangerous place should be installed. In addition, the height of the stack should be at least 5 meters so that the diffusion of by-product gas is facilitated in case of emergency discharge, and it should be installed so that there are no obstacles around it.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.7
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• pp.474-484
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• 2019

In this age, where the social environment is changing rapidly and unpredictably, interest in safety from crime is increasing in Korean society. As the desire to live a life free from the fear of crime increases, interest in the construction of safe cities is also rising nationwide. To meet the national demand, the Korean government is promoting a project to link public disaster safety systems by involving municipalities, 112, 119, and other emergency services and institutions through the Smart City Integrated Platform in order to construct a smart safety net. This study investigates the linking of theSmart City Integrated Platform and theIntelligent Security Project. The results are as follows. 1. The linkage's objective is clear. 2. The system sector can provide information to accident-related organizations. 3. The scenario area can be expanded to a crime-prevention sector, and a long-term urban information integration infrastructure can be created. 4. Product testing is enabled by a smart city road map and through continuous consultation with relevant organizations. 5. Project diffusion to other local governments can be promoted with the continued addition of commercial products.

• Journal of Animal Science and Technology
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• v.62 no.4
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• pp.543-552
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• 2020

For efficient prevention and treatment of enteric colibacillosis, understanding about latest virulence factors and antimicrobial resistance of Escherichia coli is essentially needed. The aim of this study was to survey antimicrobial resistance and determine the prevalence of fimbriae and enterotoxin genes among 118 pathogenic E. coli isolates obtained from Korean pigs with diarrhea between 2016 and 2017. The genes for the toxins and adhesins were amplified by polymerase chain reaction (PCR). The susceptibility of the E. coli isolates to antimicrobials were tested using the standard Kirby-Bauer disk diffusion method. The most prevalent fimbrial antigen was F18 (40.7%), followed by F4 (16.9%), and the most prevalent combinations of toxin genes were Stx2e (21.2%), STb:EAST-1 (19.5%), and STa:STb (16.9%), respectively. Among the pathotypes, enterotoxigenic E. coli (ETEC) was the most predominant (67.8%), followed by Shiga-toxin producing E. coli (STEC, 23.7%). We confirmed high resistance rates to chloramphenicol (88.1%), tetracycline (86.4%), streptomycin (86.4%), and ampicillin (86.4%). And the majorities of isolates (90.7%) showed multi-drug resistance which means having resistance to 3 or more subclasses of antimicrobials. Results of this study can be a source of valuable data for investigating the epidemiology of and control measures for enteric colibacillosis in Korean piggeries.