• Environmental Mutagens and Carcinogens
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• v.25 no.1
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• pp.40-46
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• 2005

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) displays high toxicity in animals and has been implicated in human carcinogenesis. Although the mechanism of carcinogenesis by TCDD is unclear, it is considered to be a non-genotoxic compound and tumor promoter. In our experiment, we investigated the effects of TCDD on gene expression in mouse skin carcinogenesis. We used cDNA microarray to detect the differential gene expression in tumors induced in hairless mouse skin by MNNG plus TCDD protocol. We found that erb-2, c-ets2 and p27$^{kip1}$ were significantly up-regulated, but TNFR2, AKT-l, integrin $\beta$l, maspin, IGF-l, c-raf-l, Rb were significantly down-regulated, in tumor region, respectively. We also found that the expression of 53 genes involved in cen cycle, signal transduction, apoptosis, adhesion molecule, angiogenesis, and invasion, were changed two fold more, in tumor surrounding region. These data suggest that TCDD alters the expression of a large array of genes involved in apoptosis, cytokine production and angiogenesis in mouse skin carcinogenesis.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.5
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• pp.1047-1054
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• 2012

Atrial fibrillation (AF) is the most common arrhythmia encountered in clinical practice, and its risk increases with age. Conventionally, the way of detecting AF was the time·frequency domain analysis of RR variability. However, the detection of ECG signal is difficult because of the low amplitude of the P wave and the corruption by the noise. Also, the time·frequency domain analysis of RR variability has disadvantage to get the details of irregular RR interval rhythm. In this study, we describe an atrial fibrillation pattern analysis based on symbolization and information entropy. We transformed RR interval data into symbolic sequence through differential partition, analyzed RR interval pattern, quantified the complexity through Shannon entropy and detected atrial fibrillation. The detection algorithm was tested using the threshold between 10ms and 100ms on two databases, namely the MIT-BIH Atrial Fibrillation Database.

• KIPS Transactions on Computer and Communication Systems
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• v.2 no.2
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• pp.83-92
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• 2013

RSA-CRT is a widely used algorithm that provides high performance implementation of the RSA-signature algorithm. Many previous studies on each operation step have been published to verify the physical leakages of RSA-CRT when used in smart devices. This paper proposes SAED (subtraction algorithm analysis on equidistant data), which extracts sensitive information using the event information of the subtraction operation in a reduction algorithm. SAED is an attack method that uses algorithm-dependent power signal changes. An adversary can extract a key using differential power analysis (DPA) of the subtraction operation. This paper indicates the theoretical rationality of SAED, and shows that its results are better than those of other methods. According to our experiments, only 256 power traces are sufficient to acquire one block of data. We verify that this method is more efficient than those proposed in previously published studies.

• Journal of Biosystems Engineering
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• v.41 no.4
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• pp.319-327
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• 2016

Purpose: Automated guidance systems (AGSs) for mobile farm machinery have several advantages over manual operation in the crop production industry. Many researchers and companies have tried to develop such a system. However, it is not easy to evaluate the performance of an AGS because there is no established device used to evaluate it that complies with the ISO 12188 standard. The objective of this study was to develop a tracking sensor system using five laser distance measurement sensors. Methods: One sensor-for long-range distance measurement-was used to measure travel distance and velocity. The other four sensors-for mid-range distance measurement-were used to measure lateral deviation. Stationary, manual driving, and A-B line tests were conducted, and the results were compared with the real-time kinematic differential global positioning system (RTK-DGPS) signal used by the AGS. Results: For the stationary test, the average error of the tracking sensor system was 1.99 mm, and the average error of the RTK-DGPS was 15.19 mm. For the two types of driving tests, the data trends were similar. A comparison of the changes in lateral deviation showed that the data stability of the developed tracking system was better. Conclusions: Although the tracking system was not capable of measuring long travel distances under strong sunlight illumination because of the long-range sensor's limitations, this dilemma could be overcome using a higher-performance sensor.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.21 no.8
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• pp.1619-1625
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• 2017

Civil global navigation satellite system (GNSS) does not meet user performance requirements for specific PNT (Positioning, Navigation, and Time) applications. Therefore, various differential systems are used to augment GNSS for improving positioning accuracy and integrity. The MTSAT satellite augmentation system (MSAS) is the Japanese satellite based augmentation system. This paper is for analyzing the characteristics of Japanese MSAS in Korean peninsula. First of all, it was done for analyzing not only DGNSS navigation signal but also the navigation parameter through simulation and experimental tests. As a result of data analyses, the sufficient navigation satellites to determine 3-D position based on DGNSS are simultaneously available at MSAS monitering station and the southern region of Korean peninsula. It was verified that the carrier to noise signals are stable to maintain the reliable 3-D position and that the level of 2m (2drms) accuracy is very similar to the ordinary worldwide DGNSS as well.

• Proceedings of the KIEE Conference
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• 2007.07a
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• pp.1988-1989
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• 2007

Polyethylene is widely used as the insulator for power cable. To investigate the conduction mechanism for power cable insulation under ac high field, it is very important to acquire the dissipation current under actual running field. Recently, we have developed the unique system, which make possible to observe the nonlinear dissipation current waveform. In this system, to observe the nonlinear properties with high accuracy, capacitive current component is canceled by using inverse capacitive current signal instead of using the bridge circuit for canceling it. We have already reported that the dissipation currents of $40\;{\mu}m$ thick LDPE film at 10 kV/mm and over 140 Hz, it starts to show nonlinearity and odd number's harmonics were getting large. To investigate the conduction mechanis ms in this region, especially space charge effect, various kinds of estimation, such as time variations of instantaneous resistivity for one cycle, FFT spectra of dissipation current waveforms and so on, has been examined. As the results of these estimations, it was found that the dissipation current will depend on not only the instantaneous value of electric field but also the time differential of applied electric field due to taking a balance between applied field and internal field. Furthermore, two large peaks of dissipation current for each half cycle were observed under certain condition. In this paper, to clarify the reason why it shows two peaks for each half cycle, the film thickness dependences of dissipation current waveforms were observed by using the three different thickness LDPE films.

• Journal of the Korean Arthroscopy Society
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• v.13 no.3
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• pp.276-279
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• 2009

Fibroma of tendon sheath is an uncommon benign soft tissue tumor with a predilection for the hand or upper extremities with extremely rare intra-articular involvement. It is mostly comprised of slow-growing fibrous lobules made up of scattered fibroblasts in a dense stroma with slit-like vascular channels. An unique case in a 54-year-old male patient involving the glenohumeral joint arising from postersuperior joint capsule is reported. Magnetic Resonance Imaging (MRI) reveals a focal nodular mass with decreased signal intensity on all pulse sequences and pathology confirmation was made with arthroscopic excision. Intra-articular fibroma of tendon sheath should be considered in the differential diagnosis of intra-articular soft tissue masses during shoulder arthroscopy.

• Archives of Pharmacal Research
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• v.22 no.3
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• pp.243-248
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• 1999

Sialic acids are key determinants for biological processes, such as cell-cell interaction and differentiation. Sialyltransferases contribute to the diversity in carbohydrate structure through their attachment of sialic acid in various terminal positions on glycolipid and glycoprotein (N-linked and O-linked) carbohydrate groups. Gal$\beta$ 1,3(4)GlcNAc $\alpha$2,3-sialyltransferase (ST3Gal III) is involved in the biosynthesis of $sLe^{X}$ and sLe^{a}$ known as selection ligands and tumor-associated carbohydrate structures. The appearance and differential distribution of ST3Gal III mRNA during mice embryogenesis [embryonic (E) days; E9, E11, E13, E15] were investigated by in situ hybridization with digoxigenin-labeled RNA probes coupled with alkaline phosphatase detection. On E9, all tissues were positive for ST3Gal III mRNA expression whereas ST3Gal III mRNA on E11 was not detected throughout all tissues. On E13, ST3GAl III mRNA was expressed in different manner in various tissues. In this stage, ST3Gal III mRNA was positive only in the liver, pancreas and bladder. On E15, specific signal for ST3GAl III was detected in the liver, lung and forebrain. These results indicate that ST3Gal III is differently expressed at developmental stages of mice embryo, and this may be importantly related with regulation of organogenesis in mice.

• Clinical and Experimental Pediatrics
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• v.64 no.7
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• pp.355-363
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• 2021

Background: Nephrotic syndrome (NS) is a common renal disorder in children attributed to podocyte injury. However, children with the same diagnosis have markedly variable treatment responses, clinical courses, and outcomes, suggesting molecular heterogeneity. Purpose: This study aimed to explore the molecular responses of podocytes to nephrotic plasma to identify specific genes and signaling pathways differentiating various clinical NS groups as well as biological processes that drive injury in normal podocytes. Methods: Transcriptome profiles from immortalized human podocyte cell line exposed to the plasma of 8 subjects (steroid-sensitive nephrotic syndrome [SSNS], n=4; steroid-resistant nephrotic syndrome [SRNS], n=2; and healthy adult individuals [control], n=2) were generated using microarray analysis. Results: Unsupervised hierarchical clustering of global gene expression data was broadly correlated with the clinical classification of NS. Differential gene expression (DGE) analysis of diseased groups (SSNS or SRNS) versus healthy controls identified 105 genes (58 up-regulated, 47 down-regulated) in SSNS and 139 genes (78 up-regulated, 61 down-regulated) in SRNS with 55 common to SSNS and SRNS, while the rest were unique (50 in SSNS, 84 genes in SRNS). Pathway analysis of the significant (P≤0.05, -1≤ log2 FC ≥1) differentially expressed genes identified the transforming growth factor-β and Janus kinase-signal transducer and activator of transcription pathways to be involved in both SSNS and SRNS. DGE analysis of SSNS versus SRNS identified 2,350 genes with values of P≤0.05, and a heatmap of corresponding expression values of these genes in each subject showed clear differences in SSNS and SRNS. Conclusion: Our study observations indicate that, although podocyte injury follows similar pathways in different clinical subgroups, the pathways are modulated differently as evidenced by the heatmap. Such transcriptome profiling with a larger cohort can stratify patients into intrinsic subtypes and provide insight into the molecular mechanisms of podocyte injury.

• Journal of the Korean Society of Marine Environment & Safety
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• v.27 no.2
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• pp.402-408
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• 2021

GNSS-Reflectometry (GNSS-R) is a technique for measuring and analyzing signals transmitted from satellites, reflecting on the surface of land or sea. GNSS-R is mainly used for measuring the water level variation, typhoon and meteorological anomaly, soil moisture, and snow depth. This paper describes the concept and measurement principle of GNSS-R technology, especially focusing on the field of marine utilization and its feasibility. In particular, it presents the applications of this technique for monitoring the safety of marine environment as well as the marine vessel and their utilization areas based on currently available infrastructure on the ground and maritime reference stations, such as the existing differential GNSS reference stations and integrity monitors (DGNSS RSIM), and GNSS reference station infrastructure, using the ground-based and the satellite-based GNSS-R approaches.