• Radiation Oncology Journal
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• v.36 no.3
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• pp.172-181
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• 2018

Successful anticancer strategies require a differential response between tumor and normal tissue (i.e., a therapeutic ratio). In fact, improving the effectiveness of a cancer therapeutic is of no clinical value in the absence of a significant increase in the differential response between tumor and normal tissue. Although radiation dose escalation with the use of intensity modulated radiation therapy has permitted the maximum tolerable dose for most locally advanced cancers, improvements in tumor control without damaging normal adjacent tissues are needed. As a means of increasing the therapeutic ratio, several new approaches are under development. Drugs targeting signal transduction pathways in cancer progression and more recently, immunotherapeutics targeting specific immune cell subsets have entered the clinic with promising early results. Radiobiological research is underway to address pressing questions as to the dose per fraction, irradiated tumor volume and time sequence of the drug administration. To exploit these exciting novel strategies, a better understanding is needed of the cellular and molecular pathways responsible for both cancer and normal tissue and organ response, including the role of radiation-induced accelerated senescence. This review will highlight the current understanding of promising biologically targeted therapies to enhance the radiation therapeutic ratio.

• Structural Engineering and Mechanics
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• v.35 no.2
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• pp.191-203
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• 2010

To investigate the critical buckling load and post-buckling behavior of an axially loaded pile entirely embedded in soil, the non-linear large deflection differential equation for a pinned pile, based on the Winkler-model and the discretionary distribution function of the foundation coefficient along pile shaft, was established by energy method. Assuming that the deflection function was a power series of some perturbation parameter according to the boundary condition and load in the pile, the non-linear large deflection differential equation was transformed to a series of linear differential equations by using perturbation approach. By taking the perturbation parameter at middle deflection, the higher-order asymptotic solution of load-deflection was then found. Effect of ratios of soil depth to pile length, and ratios of pile stiffness to soil stiffness on the critical buckling load and performance of piles (entirely embedded and partially embedded) after flexural buckling were analyzed. Results show that the buckling load capacity increases as the ratios of pile stiffness to soil stiffness increasing. The pile performance will be more stable when ratios of soil depth to pile length, and soil stiffness to pile stiffness decrease.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.34 no.4
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• pp.1043-1052
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• 2014

This paper deals with in-plane free vibrations of the horseshoe circular arch. Simultaneous ordinary differential equations governing free vibration of the arch are derived with respect to the radial and tangential deformations. Particularly, differential equations are obtained under the arc length coordinate rather than the angular one in order to extend the horseshoe arch whose subtended angle is greater than ${\pi}$ radians. The differential equations are numerically solved for calculating the natural frequencies accompanying with the corresponding mode shapes. In parametric studies, effects of the rotatory inertia, slenderness ratio and circumferential arc length ratio on frequency parameters are extensively discussed.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.28 no.2C
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• pp.100-109
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• 2003

A differential index assignment scheme is proposed for the image encoding system in which a variable-length tree-structured vector quantizer is adopted. Each source vector is quantized into a terminal node of VLTSVQ and each terminal node is represented as a unique binary vector. The proposed index assignment scheme utilizes the correlation between interblocks of the image to increase the compression ratio with the image quality maintained. Simulation results show that the proposed scheme achieves a much higher compression ratio than the conventional one does and that the amount of the bit rate reduction of the proposed scheme becomes large as the correlation of the image becomes large. The proposed encoding scheme can be effectively used to encode R images whose pixel values we, in general, highly correlated with those of the neighbor pixels.

• Steel and Composite Structures
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• v.19 no.5
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• pp.1279-1298
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• 2015

In this paper, free vibration characteristics of a rotating double tapered functionally graded beam is investigated. Material properties of the beam vary continuously through thickness direction according to the power-law distribution of the volume fraction of the constituents. The governing differential equations of motion are derived using the Hamilton's principle and solved utilizing an efficient and semi-analytical technique called the Differential Transform Method (DTM). Several important aspects such as taper ratios, rotational speed, hub radius, as well as the material volume fraction index which have impacts on natural frequencies of such beams are investigated and discussed in detail. Numerical results are tabulated in several tables and figures. In order to demonstrate the validity and accuracy of the current analysis, some of present results are compared with previous results in the literature and an excellent agreement is observed. It is showed that the natural frequencies of an FG rotating double tapered beam can be obtained with high accuracy by using DTM. It is also observed that nondimensional rotational speed, height taper ratio, power-law exponent significantly affect the natural frequencies of the FG double tapered beam while the effects of hub radius and breadth taper ratio are negligible.

• Transactions of Materials Processing
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• v.30 no.4
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• pp.195-200
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• 2021

In this study, we investigated the dominant processing variables that would influence the microstructural development of AA6061 deformed by differential speed rolling (DSR) at ambient temperature. For this purpose, we carried out a series of DSR on the samples to investigate the effects of roll speed ratio, sample rotation, and number of operation under specific rotation. Among these, the condition with a height reduction of 75% at a speed ratio of 1:4 through rotation along rolling direction (RR) displayed the pronounced results of more homogenous matrix-structure and superior mechanical properties than the others tested in this study. This was mainly due to the cross shearing of macro-shear pattern in segment where dynamic recrystallization took place with ease throughout the sample. Thus, an average microhardness value of 101 Hv was obtained in the present sample deformed by 4-pass DSR with RR where macro cross-shearing was effectively applied.

• Steel and Composite Structures
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• v.50 no.1
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• pp.25-43
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• 2024

In this article, a mathematical model is developed to predict the dynamic behavior of bio-inspired composite beam with helicoidal orientation scheme under variable axial load using a unified higher order shear deformation beam theory. The geometrical kinematic relations of displacements are portrayed with higher parabolic shear deformation beam theory. Constitutive equation of composite beam is proposed based on plane stress problem. The variable axial load is distributed through the axial direction by constant, linear, and parabolic functions. The equations of motion and associated boundary conditions are derived in detail by Hamilton's principle. Using the differential quadrature method (DQM), the governing equations, which are integro-differential equations are discretized in spatial direction, then they are transformed into linear eigenvalue problems. The proposed model is verified with previous works available in literatures. Parametric analyses are developed to present the influence of axial load type, orthotropic ratio, slenderness ratio, lamination scheme, and boundary conditions on the natural frequencies of composite beam structures. The present enhanced model can be used especially in designing spacecrafts, naval, automotive, helicopter, the wind turbine, musical instruments, and civil structures subjected to the variable axial loads.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.49 no.5
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• pp.37-43
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• 2012

The closed-loop multiple-input multiple-output (MIMO) system has been adopted by long term evolution (LTE) system. Many techniques are proposed to enhance the transmission of LTE's advanced version to meet the increasing requirement, in which differential codebook gains a lot of interest. Previous researches on designing differential codebooks focused on quasi-diagonal unitary matrix which cannot guarantee the equal gain property. The equal gain property is very important to uplink because the performance of uplink is very sensitive to the peak-to-average power ratio (PAPR). In this paper, we derive the analytical expression of average bit error rate and PAPR for differential precoding MIMO system. Using the analytical results, we investigate the performances of several differential precoding schemes considering non-linear amplifier at the transmitter. Some selected simulation results indicate that the conventional differential precoding schemes have good performances without the consideration of non-linear amplifier. While considering non-linear amplifier, the proposed differential codebook outperforms other differential precoding schemes because it maintains the equal gain per transmit antenna.

• Geophysics and Geophysical Exploration
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• v.20 no.4
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• pp.207-215
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• 2017

To develope shale play which is one of unconventional energy resources, horizontal drilling and hydraulic fracturing are necessary and those are applied to the place where the differential horizontal stress ratio (DHSR) is low. The differential horizontal stress ratio is generally calculated by the minimum and maximum horizontal stress, but it is also calculated from dynamic elastic constants and anisotropic parameters. In this study we analyzed anisotropic properties through the core samples from Danyang limestone and calculated DHSR. The three types of core samples shaped in three directions (vertical, parallel and 45 degree to bedding) were used for laboratory test. We measured P-, S-wave velocities, and density and then calculated dynamic elastic constants, compliance and DHSR. According to the results of the core sample analysis the calculated DHSR is 0.185. Thomsen parameters of the Danyang limestone used in this study are characterized by the P- and S-wave velocities varying along the bedding symmetry axis. It is observed that the DHSR value is more affected by the change in compliance value than the Poisson's ratio. It is necessary to measure SH-wave velocity for more correct petrophysical properties.

• Journal of Industrial Technology
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• v.18
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• pp.439-442
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• 1998

In this paper, we firstly suggested C&D (Common mode and Differential mode) model for the representation of a stereophonic signal. Then a measure of stereophonic channel separability is defined as the ratio of differential mode energy to total energy in frequency domain. After that, a new channel separability enhancement scheme is proposed by the control of common mode rejection. Finally, some experimental results are presented in order to verify our scheme.