• 한국항행학회논문지
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• 제11권2호
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• pp.187-195
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• 2007

본 논문에서는 광섬유에서의 색 분산과 비선형효과에 의해 발생되는 신호왜곡을 보상하기 위해 광 위상 공액기를 채택한 1,000km의 전송거리를 갖는 WDM 시스템에서 모든 WDM 채널을 효과적으로 보상할 수 있는 광 위상 공액기의 최적 위치 값과 광섬유 구간의 최적분산 계수 값들을 WDM 채널 신호의 소광비에 따라 도출하였다. WDM 시스템은 40Gbps의 채널 전송률을 갖는 16개 채널로 구성되고 각 채널은 5dB, 10dB, 20dB의 소광비를 갖는 NRZ 형식으로 가정하였다. 모든 WDM 채널들의 효과적 보상을 위해서는 고려한 두 파라미터들 중 하나만을 가지고도 충분하다는 것을 확인하였다. 그리고 이들 각각의 최적 값들은 WDM 채널 신호의 소광비에 의존하지 않는다는 것을 확인하였다. 즉 소광비에 상관없이 광 위상 공액기를 496km에 위치시키거나 두 광섬유 구간의 분산 계수 차이를 0.055ps/nm/km로 하면 모든 WDM 채널들을 2dB 이내의 전력 패널티로 양호하게 전송할 수 있는 것을 확인하였다.

• Archives of Pharmacal Research
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• 제26권7호
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• pp.564-568
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• 2003

Pharmacokinetic and pharmacodynamic properties of gliclazide were studied after an oral administration of gliclazide tablets in healthy volunteers. After an overnight fasting, gliclazide tablet was orally administered to 11 volunteers; Additional 10 volunteers were used as a control group (i.e., no gliclazide administration). Blood samples were collected, and the concentration determined for gliclazide and glucose up to 24 after the administration. Standard pharmacokinetic analysis was carried out for gliclazide. Pharmacodynamic activity of the drug was expressed by increase of glucose concentration ($\Delta$PG), by area under the increase of glucose concentration-time curve ($AUC_{$\Delta$PG}$) or by the difference in increase of glucose concentration ($D_{$\Delta$PG}$) at each time between groups with and without gliclazide administration. Pharmacokinetic analysis revealed that $C_{max}, T_{max}$, CL/F (apparent clearance), V/F (apparent volume of distribution) and half-life of gliclazide were $4.69\pm1.38 mg/L, 3.45\pm1.11 h, 1.26\pm0.35 L/h, 17.78\pm5.27 L, and 9.99\pm2.15 h$, respectively. When compared with the no drug administration group, gliclazide decreased significantly the $AUC_{$\Delta$PG}$ s at 1, 1.5, 2, 2.5, 3 and 4 h (p＜0.05). The $\Delta$PGs were positively correlated with $AUC_{gliclazide}$ at 1 and 1.5 h (p＜0.05), and the correlation coefficient was maximum at 1 h (r = 0.642) and gradually decreased at 4 h after the administration. The $AUC_{$\Delta$PG}$s were positively correlated with $AUC_{gliclazide}$ at 1, 2, 3 and 4 h (p＜0.05), and the maximum correlation coefficient was obtained at 2 h (r=0.642) after the administration. The $D_{$\Delta$PG}$ reached the maximum at 1 h, remained constant from 1 h to 3 h, and decreased afterwards. Therefore, these observations indicated that maximum hypoglycemic effect of gliclazide was reached at approximately at 1.5 h after the administration and the effect decreased, probably because of the homeostasis mechanism, in health volunteers.

• Mass Spectrometry Letters
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• 제2권1호
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• pp.1-7
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• 2011

China's rapid economic growth has resulted in significant environmental side effects. Therefore, China has been interested in reducing her dependence on foreign oil and gas by developing technologies needed for hydrogen, in addition to her increasing energy mix of nuclear and renewable energy form, such as solar and wind power. There are three isotopes of hydrogen, i.e. protium (P or H), deuterium (D), and tritium (T). Both deuterium and tritium are important materials in nuclear fuel cycle industry. Tritium is one of the critical radioactive nuclides. Planning for and implementing contamination control as a part of normal operation and maintenance activities is an important function in any hydrogen facility, especially tritium facility. The development of hydrogen isotopes analysis is the key issues in this area. Mass spectrometry (MS) with medium (about 600) and high resolution (> 1,400) is commercially available; however, the routine analysis of hydrogen isotopes is done with low-resolution MS (< 200) in China. This paper summarizes the progress of MS measurement technology for hydrogen isotope abundance in China, focusing on our lab's research program and technical status. An analyzing method has been introduced for accurate measurement of tritium abundance in the H.D.T system by low resolution MAT-253 MS. The quotient of compression ratio coefficient is determined by building up equipment for laboratory-scale preparation of secondary standard gases and by considering the difference in sensitivity between hydrogen isotopes. The results show that the measured value is reproducible within the relative error range of 0.8% for gas samples of different tritium abundance.

• Archives of Pharmacal Research
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• 제17권6호
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• pp.443-451
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• 1994

The binding characteristics of pirenzepine and oxomemazine to muscarinic receptor were studied to evaluate the selectivity of oxomemazine for the muscarinic receptor subtypes in rat cerebral microsomes. Equililbrium dissociation constant $(K_D){\;}of{\;}(-)[^3H]$quinuclidinyl benzilate$([^3H)QNB)$ determined from saturation isotherms was 64-pM. Analysis of the pirenzepine inghibition curve of [$^3H$]QNB binding to cerebral microsome indicatd the presence of two receptor subtypes with high $(K_1 = 16 nM, M_1 receptor)$two receptor subypes with about 20-fold difference in the affinity for high $(k_1 = 84nM, {\;} O_H receptor){\;} and {\;}low{\;} (K_1{\;} ={\;} 1.65\muM, {\;} O_L receptor$) affinity sites. The percentage populations of $M_1{\;} and M_3$, /TEX> receptors to the total receptors were 61 : 39, and those of $O_H{\;} and{\;} O_L$ receptors 39 : 61, resepectively. Both pirenzepine and oxomemazine increaed the $K_D$ value for $[^3H]QNB$ without affecting the binding site concentrations and Hii coefficient for the $[^3H]QNB$ without affecting the binding site concentractions and Hill coefficient for the [$^{3}$H]QNB binding. Oxomemazine had a 10-fold higher affinity at $M_1$ receptors than at $M_3$ receptors, and pirenzepine a 8-fold higher affinity at $O_H$ receptors were of $O_H$ receptors and 71% of $M_3$ receptors. However, $M_3$for oxomemazine and $O_H$for pirenzepine were composed of a uniform population. These results suggest that oxomemazine could be classified as a selective drug for $M_1$ receptors and also demonstrate that rat cerebral microsomes contain three different subtypes of $M_1{\;} M_3$ and the other site which is different from $M_1, {\;} M_2$, /TEX> receptors.

• 한국컴퓨터정보학회논문지
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• 제28권1호
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• pp.87-92
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• 2023

음성 인식 시스템의 지속적인 발전으로 음성에 대한 인식율은 급속도로 발전되었지만 사용 환경에서의 잡음과 여러 음성이 혼합되어 발생하는 잡음으로 정확한 음성을 인식할 수 없는 단점을 가진다. 환경 잡음이 있는 음성을 처리할 때 음성 인식률을 높이기 위해서는 잡음을 제거해야 하며, 기존의 HMM, CHMM, GMM, 그리고 AI 모델이 적용된 DNN에서도 예상치 못한 잡음이 발생하거나 기본적으로 디지털 신호에 양자화 잡음이 추가되면 소스 신호가 변경되거나 손상되어 인식률이 저하된다. 이를 해결하기 위해 각 음성 프레임에 대한 음성 신호의 특징을 효율적으로 추출하기 위해 MFCC를 개선하여 처리하였으며, 음성 신호에 대한 잡음을 제거하기 위해 가우시안 모델을 적용한 잡음 편차 추정을 이용한 잡음 제거 방법을 개선하여 적용하였다. 제안된 모델에 대한 성능 평가는 음성에 대한 정확성 평가를 위해 교차 상관 계수를 사용하여 처리하였으며, 제안하는 방법의 인식률을 평가한 결과 이들에 대한 상관 계수에 대한 평균값 차이는 0.53 dB 개선된 것을 확인하였다.

• 한국보건간호학회지
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• 제11권1호
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• pp.26-38
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• 1997

This study has been done for the purpose of identifying performance of health promoting behavior and the variables affecting health promoting behavior in college students. 350 college students at D university in P city were chosen by cluster sampling. The data were collected by questionnaire from December 4 to December 20, 1996. The instruments used for this study included health promoting lifestyle, self-esteem, health locus of control and perceived health status. The data were analyzed by use of mean, ANOVA, Pearson correlation coefficient and stepwise multiple regression. The results are summarized as follows; 1. The average item score for the health promoting behavior was low at 2.49. In the sub-categories, the highest degree of performance was , 2.99, and the lowest degree was , 1.43. 2. There was no statistically significant difference between the mean for health promoting behavior of the female, 2.49 and that of the male, 2.48(t=-0.3664, p=.7143). But there was statistically significant difference among the mean for health promoting behavior classified by grade(F=3.67, p=.0126). 3. Performance of health promoting behavior was positively correlated with and , and negatively correlated with and . 4. The most important factor affecting performance of health promoting behavior was .

• 대한전기학회논문지:전기물성ㆍ응용부문C
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• 제54권7호
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• pp.308-314
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• 2005

The 2 GHz film bulk acoustic wave resonator(FBAR), one of the most necessary device of the next generation mobile communication system, consisted of solidly mounted resonator(SMR) structure using Brags reflector, was researched in this paper The FBAR applied SiO$_{2}$ and W had large difference of the acoustic impedance to reflector Al to electrode and ZnO to piezoelectric layer. Specially, the FBAR applied the two-step deposition method to improve the c-axis orientation and increase reproducibility of the fabrication device had good performance. The electrical properties of plasma such as impedance, resistance, reactance, $V_{pp},\;I{pp}$, VSWR and phase difference of voltage and current, was analyzed and measured by RF sensor with the variable experiment process factors such as gas ratio, RF power and base vacuum level about concerning the thickness, c-axis orientation, adhesion and roughness. The FBAR device about the optimum condition resulted reflection loss(S$_{11}$) of -17 dB, resonance frequency of 1.93 GHz, electric-mechanical coefficient(k$_{eff}$) of 2.38 $\%$ and Qualify factor of 580. It was seen better qualify than the common dielectric filter at present and expected on business to the filter device of 2 GHz bandwidth with the MMIC technology.

• 한국정보처리학회논문지
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• 제6권4호
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• pp.868-876
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• 1999

본 논문에서는 MPEG으로 압축된 비디오(MPEG-compressed video)를 대상으로 내용기반 색인(content-based indexing)에 기초가 될 동영상 자도 d분할에 관한 효과적인 방법을 제안한다. 제안하는 방법은 MPEG 시퀀스의Ⅰ(Intra), P(Predictive), B(bidirectional) 픽쳐 구성에 구애받지 않고 장면 전환점(scene change)을 검출해 낸다. 컷(cut) 검출을 위해서는 Ⅰ픽쳐의 dc 계수와 P, B 픽쳐의 매크로 블록 참조 특성을 이용하여 차이 측도(difference measure)를 설정한다. 그리고 점진적인 (gradual)장면 전환에서는 p, B 픽쳐의 참조 블록 비율을 이용하여 정확하게 장면 전환 지점을 검출한다. 이때 MPEG 시퀀스를 완전히 복원하지 않고 필요한 데이터만을 추출해 내어 전체 데이터 처리 과정을 좀 더 효율적으로 구성한다. 차이 척도의 성능과 검출 결과는 정확도(precision)와 완전추출도(recall)를 기준으로 비교분석하고, 제안한 방법을 다양한 MPEG 시퀀스에 적용시켜 검출 결과와 수행 시간 측면에서 그 효율성을 확인하였다.

• Clinical and Experimental Pediatrics
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• 제62권6호
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• pp.217-223
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• 2019

Purpose: To determine the diagnostic value of eosinopenia and the neutrophil-to-lymphocyte ratio (NLR) in the diagnosis of early onset neonatal sepsis (EONS). Methods: This cross-sectional study was conducted in the Neonatology Ward of R.D. Kandou General Hospital Manado between July and October 2017. Samples were obtained from all neonates meeting the inclusion criteria for EONS. Data were encoded using logistic regression analysis, the point-biserial correlation coefficient, chi-square test, and receiver operating characteristic curve analysis, with a P value <0.05 considered significant. Results: Of 120 neonates who met the inclusion criteria, 73 (60.8%) were males and 47 (39.2%) were females. Ninety (75%) were included in the sepsis group and 30 (25%) in the nonsepsis group. The mean eosinophil count in EONS and non-EONS groups was $169.8{\pm}197.1cells/mm^3$ and $405.7{\pm}288.9cells/mm^3$, respectively, with statistically significant difference (P<0.001). The diagnostic value of eosinopenia in the EONS group (cutoff point: $140cells/mm^3$) showed 60.0% sensitivity and 90.0% specificity. The mean NLR in EONS and non-EONS groups was $2.82{\pm}2.29$ and $0.82{\pm}0.32$, respectively, with statistically significant difference (P<0.001). The diagnostic value of NLR in the EONS group (cutoff point, 1.24) showed 83.3% sensitivity and 93.3% specificity. Conclusion: Eosinopenia has high specificity as a diagnostic marker for EONS and an increased NLR has high sensitivity and specificity as a diagnostic marker for EONS.

• 한국항공우주학회지
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• 제45권3호
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• pp.241-251
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• 2017

EFD-CFD 워크샵 중 Case3인 RAE Wing A 형상에 대해 전산유체역학 해석을 수행하였다. 해석자로 3개의 상용 CFD 해석 코드(Star-CCM+, Fluent, CFX)와 오픈 소스 CFD 코드(SU2)를 사용하였다. 격자는 상용 격자 생성 코드인 Pointwise를 이용하여 격자의 수에 따라 4가지를 생성하였다. 마하수 0.4, 0.8에서 는 받음각 2도, 마하수 0.9에서 받음각 1도에서 해석하였다. coarse격자부터 fine 격자까지는 압력계수 곡선과 수직력 계수는 비슷한 결과를 보였으나 항력 계수에서는 차이가 있었다. Star-CCM+과 Fluent의 해석에서 차분법의 차수가 높을수록 충격파의 위치를 앞으로 예측하였다. 수렴에 다다르는 계산시간은 Fluent, Star-CCM+, CFX의 순으로 나타났고 SU2는 이에 비해 수렴하는데 많은 시간이 들었다.