• 대한한방내과학회지
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• 제40권5호
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• pp.948-956
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• 2019

Objectives: The purpose of this study was to describe the effectiveness of Jeoreongchajeonja-tang as a treatment for patients with diarrhea-predominant irritable bowel syndrome (IBS-D). Methods: Two irritable bowel syndrome patients who had visited Semyung University Korean Medical Hospital were enrolled. The patients were diagnosed according to the Rome III criteria, and the treatment effect was assessed using the Gastrointestinal Symptom Rating Scale (GSRS) and the colon transit time. Results: After treatment with Jeoreongchajeonja-tang for 4 weeks, the GSRS score was improved and colon transit time was delayed. Conclusions: This study suggests that Jeoreongchajeonja-tang is effective for improving diarrhea-predominant irritable bowel syndrome. More extensive study is needed in the future.

• 사상체질의학회지
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• 제24권2호
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• pp.61-70
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• 2012

1. Objectives : The aim of this study was to report significant improvement of chronic diarrhea and hematochezia after treatment with Dojeokgangki-tang in a Soyangin Patient with Crohn's Disease. 2. Methods : The patient's subjective and objective symptoms were observed daily throughout the hospitalization period, and the Crohn's disease activity index(CDAI) was calculated to gauge the progress or lack of progress. 3. Results : The symptoms of diarrhea and hematochezia disappeared by the end of the hospitalization period without recurrence, and the CDAI score dropped from 92.5 to 47. 4. Conclusions : A patient with Crohn's disease, who was in the state of repetitive relapse and remission after long term clinical courses was treated with Dojeokgangki-tang in a short period and the the symptoms of diarrhea and hematochezia disappeared without recurrence. Then the patient could stop taking corticosteriods and taper off immune-suppressing drugs.

• Clinical and Experimental Pediatrics
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• 제53권12호
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• pp.1006-1011
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• 2010

Purpose: This study aimed to identify 'objective' differential factors for normal frequent loose stool (NFLS) and diarrheal illness with dehydration and nutritional deficiency (DIDN) among infants with chronic frequent loose stool (CFLS). Methods: Data were analyzed from infants under 2 years of age with CFLS who had been transferred from general pediatricians. These 46 patients were divided into 2 groups (NFLS versus DIDN). Nocturnal stool was defined as evacuation between 10 pm and 6 am. Maximal stool amount/day (measured using the mother's hand) was specified as the highest score during the period of CFLS obtained by adding up each evacuation's score (range, 0-2 points). Results: There were 36 cases of NFLS and 10 of DIDN. A failure to gain weight ($P$=0.0001), fever ($P$=0.0079), colic/abdominal pain ($P$=0.0014), gross blood in stool (except allergic proctocolitis) ($P$=0.0113), nocturnal stool ($P$=0.0001), and the score of stool amount ($P$=0.0001) were found to significantly differentiate the groups. A failure to gain weight was observed in 39% of even NFLS. The frequency, mucus content, and microbiological findings of stools, as well as diaper dermatitis were not found to significantly differentiate the groups. Conclusion: NFLS was more common than DIDN in infants with CFLS. The most 'objective' differential factors were nocturnal stool and the score of stool amount (${\geq}7$ points/day).

• Journal of Animal Science and Technology
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• 제63권1호
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• pp.104-113
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• 2021

This study was conducted to investigate the efficiency of a microencapsulated mixture of organic acids (MOA) with low protein in piglet feed on growth performance, diarrhea score, nutrient digestibility, fecal microbial counts, and blood profiles in weaning pigs. A total of 80 pigs [(Landrace × Yorkshire) × Duroc; 6.8 ± 0.48 kg] were randomly assigned to four dietary treatment groups: high protein (HP); low protein (LP); MOA1, LP + 0.2% MOA; and MOA2, LP + 0.3% MOA. The MOA2 group had higher average daily weight gains (during days 0-14 and days 0-28), diarrhea score (during days 0-14, during days 14-28 and days 0-28) and greater digestibility of dry matter (days 14 and 28) compared to the LP group (p < 0.05). However, there were no significant differences (p > 0.05) between the pigs fed diets with the MOA1 and MOA2 in blood profiles and fecal microflora. In conclusion, this study indicates that piglets fed 0.3% MOA in low protein diets maintained similar growth performance and nutrient digestibility, but alleviated the incidence of diarrhea compared to piglets fed high protein diets.

• Pediatric Infection and Vaccine
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• 제16권1호
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• pp.61-72
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• 2009

목 적: 저자들은 입원 중인 환아들을 대상으로 노로바이러스 장염의 임상 특징을 로타바이러스 장염과 비교하여 조사하였다. 방 법: 2005년부터 2006년까지 한 소아과에 입원 중인, 위장관염 증세를 보여 대변 검사를 시행했던 3,261 검체의 원인체를 검출하였다. 노로바이러스 양성인 266개와 로타바이러스 양성인 303개의 검체 중, 비교적 순수하게 장염 증세만 보였던 노로바이러스 감염 73명과 로타바이러스 감염 182명의 검체를 선별하여 환아들의 임상 기록을 후향적으로 분석했다. 결 과: 노로바이러스 양성군의 남녀비는 1.43:1, 로타바이러스 양성군은 1.56:1로 두 군 모두 남아에서 검출률이 높았다. 평균(중간)연령은 각각 36.7 (22)개월과 24.4 (19)개월로 노로바이러스 양성군의 호발 연령이 더 많았다. 계절적으로 노로바이러스 양성군이 겨울에 국한되어 발생했다. 노로바이러스 양성군의 임상 증상은 구토, 설사, 발열 순이었고, 평균 구토기간은 2.1일, 설사기간은 1.2일, 발열기간은 1.2일, 하루 최대 구토 횟수는 3.5회, 설사 횟수는 4.5회로 전체적인 Severity score는 10.16점이었으며, 로타바이러스 양성군은 설사, 구토, 발열 순이었고, 평균 설사기간은 4.3일, 구토기간은 2.2일, 발열기간은 2.2일, 하루 최대 설사 횟수는 6.5회, 하루 최대 구토 횟수는 3.3회로 전체적인 Severity score는 11.9으로 나타나 노로바이러스 양성군이 증상의 중증도가 다소 낮았다. 노로바이러스 양성군은 어릴수록 증상의 중증도가 심하게 나타났으나, 로타바이러스 양성군은 연령에 따른 중증도의 차이를 보이지 않았다. 단독감염과 혼합감염의 중증도는 차이를 보이지 않았다. 혈액 검사 상 두 군 간에 유의한 차이는 없었다. 결 론: 소아 노로바이러스 장염의 역학, 임상 증상 뿐만아니라 예방에 대한 더 많은 연구가 필요하다.

• 사상체질의학회지
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• 제32권1호
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• pp.50-57
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• 2020

Objectives Allergic reaction to antibiotics is associated with increased use. And rate of Irritable Bowel Syndrome(IBS) is on the increase associated with stress, depression, anxiety, or previous intestinal problem. This case study reports significant improvement of patients with diarrhea accompanied by IBS who had suffered from allergic reaction to antibiotics after treatment with Sasang constitutional medicine. Methods This patient was diagnosed as Taeeumin type. Sasang constitutional medicine was taken by the patient, almost three times per day during treatment periods. We measured the degree of the main symptoms such as diarrhea, abdominal discomfort, insomnia, itching etc, using Visual Analogue Scale(VAS). Results The symptoms of diarrhea, abdominal discomfort, and insomnia were improved. VAS score was decreased from 4~5 to 0~1 for about two weeks. Conclusions This case shows that Sasang constitutional medicine treatment can contribute to improve main symptoms accompanied by IBS.

• 농업과학연구
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• 제43권5호
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• pp.794-801
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• 2016

This study was conducted to evaluate the effect of supplementation Oreganum aetheroleum essential oil on reproductive performance in sows and growth performance of their offspring of weaning pig. 12 sows ($Landrace{\times}Yorkshire$) were randomly assigned within parities to 1 of 3 dietary treatments to give 4 replicates per treatment. Dietary treatments were as follows: 1) CON (basal diet) 2) ANT (basal diet + Efrotomycin 0.08%) and 3) ORE (basal diet + Oreganum aetheroleum essential oil 0.05%), EXP. 1, diets were fed from d 107 of gestation to weanling. EXP. 2, diets were fed from after weaning to 3 weeks. In the Exp.1, no significant difference (p > 0.05) was observed in sow's average parity, sow backfat thickness, the number of piglets, feed intake of sows, the average of piglet weight, and piglet survival ratio between CON, ANT, and ORE treatments. Besides, in the Exp. 2, the inclusion of efrotomycin and Oreganum aetheroleum essential oil in the diets significantly (p < 0.05) increased final body weight, ADG, ADFI, and G/F in weanling pigs. In addition, weanling pigs fed ANT and ORE diets led to decrease the number of weanling pigs with diarrhea as well as fecal score. In conclusion, supplementation of efrotomycin and Oreganum aetheroleum essential oil enhanced growth performance, and decreased the number of weanling pigs with diarrhea and fecal score. However, no significant effect on grow performance was observed in sow and piglet.

• 척추신경추나의학회지
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• 제5권1호
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• pp.57-66
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• 2010

항통을 주소로 내원한 환자의 크론병에 대한 침구(鍼灸)치료로 복통 및 설사의 관해 상태가 되는 양호한 효과를 얻었기에 보고하는 바이다. 다만, 치료 기간이 짧아 증상의 변화의 추적이 필요한 상태이며, 다양한 임상적 연구를 위한 임상사례 데이터가 축적되어야 할 것으로 사료된다.

• Journal of Animal Science and Technology
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• 제55권2호
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• pp.109-113
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• 2013

The aim of the present study was to investigate the effects of partial substitution of an extruded or extruded-pelleted corn product for unprocessed corn of the starter diet on growth performance and incidence of diarrhea in weanling pigs. Seventy-two 21-day-old weanling pigs were allotted to 24 pens and provided ad libitum with one of the four experimental diets for 3 wk in two serial feeding trials during summer beginning from late June. The treatments were a milk product-soy-corn-based control diet containing 25% unprocessed corn and the other three diets only substituted with 12.5% extruded corn Suprex$^{(R)}$, Optigrain$^{(R)}$, an extruded mixture of wheat, rye and durum, or extruded-pelleted corn for an equal percentage of unprocessed corn of the control diet. All diets were supplemented with 100 ppm sulfathiazone, 50 ppm penicillin, and 100 ppm chlortetracycline for preventive medication. The initial and final weights as well as gain : feed were less in the second trial than in the first one (P<0.05). However, effects of the dietary treatments were not detected in any of the performance variables including final weight, ADG, ADFI, and gain : feed, nor were there any interactions between the trial and dietary treatment. In addition, almost all pigs exhibited normal firm feces in both trials and therefore there was no main effect in the fecal consistency score. Results suggest that partial substitution of the thermally processed corn for unprocessed corn of the milk product-corn-soy-based and medicated starter diet has no effect on growth performance or incidence of diarrhea in weanling pigs.

• Journal of Animal Science and Technology
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• 제57권10호
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• pp.33.1-33.7
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• 2015

The objective of this study was to evaluate effects of a combined use of extracts of medicinal herbs Taraxaumi mongolicum, Viola yedoensis Makino, Rhizoma coptidis, and Radix isatidis (MYCI) on porcine epidemic diarrhea (PED). Twenty-two 3-day-old piglets received an oral challenge with $3{\times}10^{3.5}$ $TCID_{50}$ of the virulent PED virus (PEDV) in PBS or PBS only and daily oral administration of 60 mg of the MYCI mixture suspended in milk replacer or the vehicle for 7 days in a $2{\times}2$ factorial arrangement of treatments. Average daily gain (ADG) increased (p < 0.05) in response to the MYCI treatment in the PEDV-challenged piglets (-18 vs. 7 g for the vehicle- vs. MYCI-administered group), but not in unchallenged animals (27 vs. 28 g). Diarrhea score and fecal PEDV shedding, however, were not influenced by the MYCI treatment. The PEDV challenge caused severe intestinal villus atrophy and crypt hyperplasia, both of which were alleviated by administration of the MYCI mixture as indicated by an increase in the villus height and a decrease in the crypt depth due to the treatment. Overall, medicinal herb extracts used in this study ameliorated impaired growth performance and intestinal lesion of newborn piglets challenged with the virulent PEDV. Therefore, our results suggest that the MYCI mixture could be used as a prophylactic or therapeutic agent against PED.