• Animal Bioscience
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• 제36권4호
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• pp.642-653
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• 2023

Objective: This study was conducted to evaluate effects of β-glucan with vitamin E supplementation on the growth performance, blood profiles, immune response, fecal microbiota, fecal score, and nutrient digestibility in weaning pigs. Methods: A total of 200 weaning pigs with an average body weight (BW) of 7.64±0.741 kg were allotted to five treatment groups and were divided based on sex and initial BW in four replicates with ten pigs per pen in a randomized complete block design. The experimental diets included a corn-soybean meal-based basal diet with or without 0.1% or 0.2% β-glucan and 0.02% vitamin E. The pigs were fed the diets for 6 weeks. A total of 15 barrows were used to evaluate the nutrient digestibility by the total collection method. The BW and feed intake were measured at the end of each phase. Blood samples were collected at the end of each phase, and fecal samples were collected at the end of the experiment. Results: The addition of β-glucan with vitamin E to weaning pig feed increased BW, average daily gain, and average daily feed intake. A significant decrease in yeast and mold and Proteobacteria and a tendency for Lactobacillus to increase compared to the control was shown when 0.1% β-glucan and 0.02% vitamin E were added. The fecal score in weaning pigs was lower in the treatments supplemented with 0.1% or 0.2% β-glucan and 0.02% vitamin E compared to the control. In addition, vitamin E was better supplied to weaning pigs by increasing the concentration of α-tocopherol in the blood of weaning pigs when 0.02% vitamin E was supplemented. However, there was no significant difference in either the immune response or nutrient digestibility. Conclusion: Inclusion of 0.1% β-Glucan with 0.02% vitamin E in a weaning pig's diet were beneficial to the growth performance of weaning pigs by improving intestinal microbiota and reducing the incidence of diarrhea.

• 한국자원식물학회지
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• 제21권1호
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• pp.103-109
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• 2008

Nelumbo nucifera root(NNR) is used to clear summerheat(暑熱), bear Yang(陽) upwards and stop bleeding as mentioned in traditional Korean medicine. Also, it has been known that NNR is effective for lowering blood pressure and hyperlipidemia. The rhizome is considered to be nutritive, demulcent, diuretic and cholagogue and is used to treat piles, dyspepsia and diarrhea. An increasingly growing market for nutraceuticals and functional foods has triggered the study on natural sources for nutraceuticals, health foods and functional foods. But rhizome was inconvenient to formulate liquid dosage form(extract) by way of hot water because of its limited storage. Also the majority of the consumers have a complaint against the dosage. The purpose of this study was to develop the functional materials from NNR without side effects. We formulated the solid dosage form viz tablet and granule from the lotus root. Sensory evaluation was performed in terms of smell, taste, color and overall of lotus root and all colored forms(brown, dark brown, light green and yellow) of tablet and granule to evaluate the acceptability of the formulated tablets and granules. In sensory evaluation, among the formulated tablets and granules, light green granules obtained best score overall and yellow tablets showed the overall improved acceptability. In conclusion, lotus rhizome could be recommended as functional food. Further studies to clarify bioactive functions of Nelumbo nucifera in experimental animal model on atopic dermatitis are in progress.

• Journal of Nutrition and Health
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• 제21권2호
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• pp.81-87
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• 1988

This study attempted to investigate the relationships between vegetable preference and physical status. The subjects were 127 kindergarten children living Kwang-ju. In this study, vegetable preference and health status of the children were investigated by response of thier mothers through questionnaires. Also, rate of dental caries and anthropometric measures were obtained by examination. The results are summarized as follows; 1) Anthropometric mesures of the subjects were higher than those of Korean standards for children. 2) The mean hedonic score for vegetable preference in subjects was 2.6. The difference in vegetable preference between male and femal was not significant except for a squash item. 3) Vegetable prefernce has a significant correlation with the def. tooth rate. Especially preference of spinach, wild sesame leaf, and cucumber were negatively related to the def. tooth rate. 4) Vegetable preference and anthropometric measures did not show any significant correlation. 5) Children who ate sweets for snacks frequently disliked vegetable and showed high rate of dental caries significantly(p<0.001). Children who had anorexia and constipation disliked vegetables significantly (p<0.01). Children who complained diarrhea symptom showed significant high rte of dental caries(p<0.01). From the results above, as the negative relationship between vegetable preference and def. tooth rate was found, many cooking methods of vegetables should be studied and nutrition education should be oriented to recommend an increased intake of vegetables by children.

• Journal of Gastric Cancer
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• 제14권1호
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• pp.15-22
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• 2014

Purpose: To evaluate the prevalence of esophageal reflux-induced symptoms after gastrectomy owing to gastric cancer and assess the relationship between esophageal reflux-induced symptoms and quality of life. Materials and Methods: From January 2012 to May 2012, 332 patients were enrolled in this cross-sectional study. The patients had a history of curative resection for gastric cancer at least 6 months previously without recurrence, other malignancy, or ongoing chemotherapy. Esophageal reflux-induced symptoms were evaluated with the GerdQ questionnaire. The quality of life was evaluated with the European Organization for Research and Treatment QLQ-C30 and STO22 questionnaires. Results: Of the 332 patients, 275 had undergone subtotal gastrectomy and 57 had undergone total gastrectomy. The number of GerdQ(+) patients was 58 (21.1%) after subtotal gastrectomy, and 7 (12.3%) after total gastrectomy (P=0.127). GerdQ(+) patients showed significantly worse scores compared to those for GerdQ(-) patients in nearly all functional and symptom QLQ-C30 scales, with the difference in the mean score of global health status/quality of life and diarrhea symptoms being higher than in the minimal important difference. Additionally, in the QLQ STO22, GerdQ(+) patients had significantly worse scores in every symptom scale. The GerdQ score was negatively correlated with the global quality of life score (r=-0.170, P=0.002). Conclusions: Esophageal reflux-induced symptoms may develop at a similar rate or more frequently after subtotal gastrectomy compared to that after total gastrectomy, and decrease quality of life in gastric cancer patients. To improve quality of life after gastrectomy, new strategies are required to prevent or reduce esophageal reflux.

• Clinical and Experimental Pediatrics
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• 제49권5호
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• pp.489-493
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• 2006

목 적 : 본 연구의 목적은 만삭아에서 신생아 괴사성 장염의 위험인자를 알고자 함이다. 방 법 : 1998년 1월 1일부터 2005년 8월 1일까지 본원 소아과 신생아실에 입원한 환아 중 신생아 괴사성 장염으로 진단된 20례와 각각의 경우에 대해 짝짓기 방식으로 선정된 건강한 만삭아 40례를 대상으로 병력지 검토를 통하여 후향적으로 조사되어 졌다. 결 과 : 괴사성 장염군의 평균 재태연령과 출생 체중은 38.42주와 2,915 g이었고 대조군은 38.61주와 3,148 g이었다. 대조군과 비교 하였을 때 신생아 괴사성 장염군 환아들에서 모체의 융모 양막염, 지연된 설사, 1분 아프가 점수 <7, 호흡기 문제, 선천성 심질환의 빈도가 유의하게 높았다(유의수준 <0.05). 반면 전자간증, 모체의 당뇨, 모체의 약물 남용, 태변 착색된 양수, 다혈구증, 교환 수혈의 빈도에는 유의한 차이가 없었다. 결 론 : 만삭아들의 대부분은 괴사성 장염이 발생하기 전에 선행하는 인자가 있다. 본 연구에서는 여러 가지 유발인자들 중에 지연된 설사가 가장 큰 관련성이 있는 것으로 나타났다.

• 한국초지조사료학회지
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• 제28권1호
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• pp.41-48
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• 2008

본 실험은 농산부산물인 감껍질, 맥강, 발효미강 및 활성탄을 혼합하여 만든 첨가 사료가 거세 한우의 질병, 성장 및 도체특성에 미치는 영향을 규명하고자 시험한 결과, 송아지 설사는 무처리구(Control)가 가장 발병율이 높았던 반면 첨가량이 가장 높은 T3구(5% 첨가구)가 가장 낮은 발병율을 보였다. 호흡기 질병 발병율은 3% 첨가구(T2)에 가장 낮게 나타났으며, 호흡기와 설사 동시 발생율은 Control구가 가장 높게 나타났다. 일당 증체량은 T2(0.76kg)>T1(0.7kg), T3(0.70)>Control구(0.67kg) 순으로 높게 나타났다. 등지방 두께는 T2>T3>Control>T1구 순으로 등심단면적은 T3>T1>Control>T2 순으로 나타났다. 그리고 육량등급은 1% 첨가구(T1)가 2.3은 가장 높게 나타났다. 지방색, 조직감, 성숙도에서는 상호 처리간 차이가 나타나지 않았지만 근내지방 및 육질 등급은 T2구에서 각각 5.0 및 3.5로서 가장 높게 나타났다. 특히 육색은 농산부산물 사료 첨가량이 증가할수록 높게 나타났다. 위의 결과로 볼 때 농산부산물 혼합 사료는 질병발생 억제, 육량증가 및 육질개선에 다양한 용도로 사용 가능한 것으로 사료된다.

• 사상체질의학회지
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• 제25권4호
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• pp.432-441
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• 2013

Objectives Despite the treatment with antibiotics, patients with sepsis has a high mortality (80%) in the underlying disease group. The aim of this study was to report the improvement of septic condition of the cholangiocarcinoma patient after the treatment with Handayeolso-tang, Fel Tauri, and antibiotics. Methods We retrospectively reviewed the medical records. The patient's subjective symptoms such as chilling and abdominal pain were evaluated by NRS and the performance status was evaluated by ECOG. This case was literally compared with relevant published studies on prognosis of sepsis. Results Despite poor prognostic factor(MEDS score 18), the patient's symptoms such as fever, chilling, abdominal pain, and diarrhea and ECOG(Eastern Cooperative Oncology Group) improved. The patient was hemodynamically stabilized on 3rd day from the treatment, and her laboratory test results were normalized on 7th day. Conclusions A female patient of metastatic cholangiocarcinoma came to the hospital for cholangitis, later causing septic shock. Both her symptoms and laboratory tests showed significant improvement after the treatment of antibiotics, Handayeolso-tang and Fel Tauri. To our knowledge, this is the first case reporting the synergistic combination of Korean oriental medicine and Western medicine approaching to sepsis.

• Asian-Australasian Journal of Animal Sciences
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• 제24권6호
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• pp.851-856
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• 2011

This study was conducted to evaluate the effects of flavor supplementation on pre- and post-weaning performance and behavior of piglets and sows. A total of 30 sows (Landrace${\times}$Yorkshire) and their litters were employed in this study. Sows were randomly assigned to 3 dietary treatments (10 replications per treatment). Dietary treatments included: i) CON, basal diet; ii) TRT1, CON+0.1% vanilla supplement; iii) TRT2, CON+0.1% cheese supplement. The behavior of sows (nursery, eating and standing) and piglets (eating, sleeping and fighting) in each treatment was monitored throughout experiment. Each piglet was weighted at 5, 10, 15 and 21 d after birth to evaluate the average daily gain. Sows and piglets were bled on the weaning d to evaluate the blood characteristics. Back fat and estrus interval were investigated. In this study, there were no differences (p>0.05) in diarrhea score and blood characteristics among treatments. Likewise, the behavior was not influenced (p>0.05) by the dietary flavor supplementation. However, administration of flavor increased (p<0.05) the pre-weaning feed intake, post-weaning average daily gain (ADG) and gain/feed (G/F) ratio. No significant difference was observed (p>0.05) on the blood characteristics, behavior, backfat loss and estrus interval among treatments. In conclusion, administration of flavor could increase creep feed intake pre-weaning and piglet ADG post-weaning, whereas inclusion of flavor had no influence on blood characteristics and performance in sow and piglets.

• 대한수의학회지
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• 제54권2호
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• pp.67-73
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• 2014

Preventive and therapeutic effects of egg yolk antibody, immunoglobulin Y (IgY), against canine parvovirus (CPV) was evaluated in 25 pups orally challenged with CPV-2a. Oral administration of IgY using powder, paste and coated paste delivery systems was compared. Each type of IgY was administered orally for 17 days from 3 days before challenge. The group of pups administered coated IgY showed mild symptoms such as a moderate decrease in total white blood cell count, no depression, vomiting and diarrhea when compared with other groups. The overall clinical score of the group of pups administered coated IgY was significantly lower than that of the challenge control group. However, mortality did not differ among groups because not all pups received symptomatic treatment. These results implied that oral treatment of coated IgY could improve therapeutic effects against CPV challenge if pups received symptomatic treatment.

• Clinical and Experimental Pediatrics
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• 제58권1호
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• pp.28-32
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• 2015

Purpose: Diencephalic syndrome is an uncommon cause of failure to thrive in early childhood that is associated with central nervous system neoplasms in the hypothalamic-optic chiasmatic region. It is characterized by complex signs and symptoms related to hypothalamic dysfunction; such nonspecific clinical features may delay diagnosis of the brain tumor. In this study, we analyzed a series of cases in order to define characteristic features of diencephalic syndrome. Methods: We performed a retrospective study of 8 patients with diencephalic syndrome (age, 5-38 months). All cases had presented to Seoul National University Children's Hospital between 1995 and 2013, with the chief complaint of poor weight gain. Results: Diencephalic syndrome with central nervous system (CNS) neoplasm was identified in 8 patients. The mean age at which symptoms were noted was $18{\pm}10.5$ months, and diagnosis after symptom onset was made at the mean age of $11{\pm}9.7$ months. The mean z score was $-3.15{\pm}1.14$ for weight, $-0.12{\pm}1.05$ for height, $1.01{\pm}1.58$ for head circumference, and $-1.76{\pm}1.97$ for weight-for-height. Clinical features included failure to thrive (n=8), hydrocephalus (n=5), recurrent vomiting (n=5), strabismus (n=2), developmental delay (n=2), hyperactivity (n=1), nystagmus (n=1), and diarrhea (n=1). On follow-up evaluation, 3 patients showed improvement and remained in stable remission, 2 patients were still receiving chemotherapy, and 3 patients were discharged for palliative care. Conclusion: Diencephalic syndrome is a rare cause of failure to thrive, and diagnosis is frequently delayed. Thus, it is important to consider the possibility of a CNS neoplasm as a cause of failure to thrive and to ensure early diagnosis.