• Journal of Pharmaceutical Investigation
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• v.39 no.6
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• pp.411-416
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• 2009

The aim of this study was to investigate the frequency of the SNPs on PEPT1 exon 5 and 16 and to analyze haplotype frequency on PEPT1 exon 5 and 16 in Korean population. A total of 519 healthy subjects was genotyped for PEPT1, using pyrosequencing analysis and polymerase chain reaction-based diagnostic tests. Haplotype was statistically inferred using an algorithm based on the expectation-maximization (EM). PEPT1 exon 5 G381A genotyping revealed that the frequency for homozygous wild-type (G/G), heterozygous (G/A) and homozygous mutant-type (A/A) was 30.4, 53.4 and 16.2%, respectively. PEPT1 exon 16 G1287C genotyping revealed that the frequency for homozygous G/G, heterozygous G/C and homozygous C/C type was 88.8, 10.0 and 1.2%, respectively. Based on these genotype data, haplotype analysis between PEPT1 exon 5 G381A and exon 16 G1287C using HapAnalyzer and PL-EM has proceeded. The result has revealed that linkage disequilibrium between alleles is not obvious (|D'|=0.3667).

• Journal of the Korean Institute of Intelligent Systems
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• v.15 no.6
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• pp.673-681
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• 2005

As it is the most important to make sure security and reliability for nuclear Power Plant, it's considered the most crucial issues to develop a fault detective and diagnostic system in spite of multiple hardware redundancy in itself. To develop an algorithm for a fault diagnosis in the nuclear PWR steam generator, this paper proposes a method based on ART2(adaptive resonance theory 2) neural network that senses and classifies troubles occurred in the system. The fault diagnosis system consists of fault detective part to sense occurred troubles, parameter estimation part to identify changed system parameters and fault classification part to understand types of troubles occurred. The fault classification part Is composed of a fault classifier that uses ART2 neural network. The Performance of the proposed fault diagnosis a18orithm was corroborated by applying in the steam generator.

• The Journal of the Society of Korean Medicine Diagnostics
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• v.17 no.2
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• pp.77-89
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• 2013

Objectives Tongue diagnosis is an important diagnostic method in traditional Eastern medicine, and it has a high potential to be used in the future healthcare because of easy, quick, and non-contact measuring features. Recently, research and development efforts on computerized tongue diagnosis systems (CTDS) have been active that led to the technical advancements in the field of photographing techniques, image extraction and classification algorithms. In this study, we analyzed the trends in the CTDS patents. Using the WIPS search engine (www.wipsglobal.com), quantitative and qualitative patent analyses were performed through Korea, China, Japan, U.S.A and Europe. Methods For a systematic search and data analysis, we defined patent categories based on the application area and technical details. By applying thus-obtained categorical key words, we obtained 360 relevant patents on photographing techniques, image extraction and classification algorithms for the purpose of diagnosis or security. Results As a result, companies related to image acquisition, medical imaging and mobile devices and research groups of universities in East Asia were major patent applicants. In all the five countries, the number of patents have been increasing since 1980. In particular, technology related to color correction and image segmentation were most actively patented categories, and expected to continue a high application rate.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.12 no.6
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• pp.65-73
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• 2012

Wrist wearable device for the measurement of pulse rate, ECG, and activity during normal daily life, which could be used for the continuous monitoring and remote transmission of acquired data, was developed. Pressure sensor, device attached electrodes, and 3-degree accelerometer were used. Analysis algorithm and firmware program were established for providing diagnostic information for the users. Results of this study, possible for the management of health report and transmission of the results through bluetooth by wearing simple personal wrist device, could be used for the development of portable device in the u-healthcare environment.

• Journal of the Institute of Electronics Engineers of Korea SP
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• v.48 no.4
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• pp.142-152
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• 2011

In general, existing emergency evacuation guiding systems depend on visual techniques like emergency lights or LEDs. Actually people in the case of fire emergency condition may not obtain a range of view because of smoke from the fire. This paper introduces a technique to design an emergency guiding system using directivity sound to cope with this problem. In this case all speakers are serially connected for audio signal transmission in a serial fashion to achieve convenient speaker installation. Floyd algorithm is used to find shortest evacuation paths. Because serially connected multi-channel speakers are weak in case of disconnection, this paper uses a technique to solve the diagnostic problem. In the proposed system, a PC based on the USB protocol is used for control and observation. The system has achievements, such as increasing evacuation rate under emergency conditions, and serial transmission of audio signal for easy maintenance and low installation cost.

• Journal of the Korea Society of Computer and Information
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• v.16 no.2
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• pp.17-23
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• 2011

In this paper, daily life stress monitoring system is proposed. The proposed wireless ECG module, reducing the noise and increasing the size of signal, amplification circuit was designed for. Using HRV(Heart Rate Variability), extracted by measuring R-wave, stress diagnostic algorithms to assess the stress of human emotion were developed. For monitoring the activities, the proposed system is consist of small rectangular size for portable and by simple measurement it is possible to measure at any time. Through experiments, the proposed approach to represent user's stress level can be confirmed. Through that, it can see appropriate structure to obtain R-wave for stress assess as well as high resemblance to the clinical electrocardiogram. In this paper, performed experiments was developed nonrestraint measuring and wearable wireless biometric scanner that is able to monitor the heart's electrical activity of everyday life.Using this, the algorithm system, that is able to assess stress index through time-domain and frequency-domain analysis of the front and the rear of performing stress load protocol, was developed,

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.23 no.5
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• pp.18-28
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• 2009

To analyze influences under faults caused by a stator winding short and to evaluate an effectiveness of a diagnostic algorithm a faulty model for an inverter-driven permanent magnet synchronous motor is presented. Even though the conventional dq motor model obtained through the transformation of phase voltage model is widely used to analyze and control the motor, it can not be used in the analysis of a faulty motor since the 3-phase balanced condition is no longer hold under the fault caused by a stator winding short, and thus, it is very difficult to obtain motor input voltages from the pole voltage of an inverter. To overcome this problem, a faulty model for an inverter-driven permanent magnet synchronous motor is proposed by considering the line voltage of 3-phase variables. The effectiveness of the proposed faulty model is verified through comparative simulations and experiments using DSP TMS320F28335 and motor built to allow a partial short of inter-turn.

• Genomics & Informatics
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• v.4 no.4
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• pp.161-166
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• 2006

The establishment of DNA microarray technology has enabled high-throughput analysis and molecular profiling of various types of cancers. By using the gene expression data from microarray analysis we are able to investigate diagnostic applications at the molecular level. The most important step in the application of microarray technology to cancer diagnostics is the selection of specific markers from gene expression profiles. In order to select markers of Immortalization and transformation we used c-myc and $H-ras^{V12}$ oncogene-transfected NIH3T3 cells as our model system. We have identified 8751 differentially expressed genes in the immortalization/transformation model by multivariate permutation F-test (95% confidence, FDR<0.01). Using the support vector machine algorithm, we selected 13 discriminative genes which could be used to predict immortalization and transformation with perfect accuracy. We assayed $H-ras^{V12}$-transfected 'transformed' cells to validate our immortalization/transformation dassification system. The selected molecular markers generated valuable additional information for tumor diagnosis, prognosis and therapy development.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.1
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• pp.95-100
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• 2016

Background: Survival time of lymphoma patients can be estimated with the help of microarray technology. In this study, with the use of iterative Bayesian Model Averaging (BMA) method, survival time of Mantle Cell Lymphoma patients (MCL) was estimated and in reference to the findings, patients were divided into two high-risk and low-risk groups. Materials and Methods: In this study, gene expression data of MCL patients were used in order to select a subset of genes for survival analysis with microarray data, using the iterative BMA method. To evaluate the performance of the method, patients were divided into high-risk and low-risk based on their scores. Performance prediction was investigated using the log-rank test. The bioconductor package "iterativeBMAsurv" was applied with R statistical software for classification and survival analysis. Results: In this study, 25 genes associated with survival for MCL patients were identified across 132 selected models. The maximum likelihood estimate coefficients of the selected genes and the posterior probabilities of the selected models were obtained from training data. Using this method, patients could be separated into high-risk and low-risk groups with high significance (p<0.001). Conclusions: The iterative BMA algorithm has high precision and ability for survival analysis. This method is capable of identifying a few predictive variables associated with survival, among many variables in a set of microarray data. Therefore, it can be used as a low-cost diagnostic tool in clinical research.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.10
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• pp.6069-6075
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• 2013

Background: At present, the diagnosis of colorectal cancer (CRC) requires a colorectal biopsy which is an invasive procedure. We undertook this pilot study to develop an alternative method and potential new biomarkers for diagnosis, and validated a set of well-integrated tools called ClinProt to investigate the serum peptidome in CRC patients. Methods: Fasting blood samples from 67 patients diagnosed with CRC by histological diagnosis, 55 patients diagnosed with colorectal adenoma by biopsy, and 65 healthy volunteers were collected. Division was into a model construction group and an external validation group randomly. The present work focused on serum proteomic analysis of model construction group by ClinProt Kit combined with mass spectrometry. This approach allowed construction of a peptide pattern able to differentiate the studied populations. An external validation group was used to verify the diagnostic capability of the peptidome pattern blindly. An immunoassay method was used to determine serum CEA of CRC and controls. Results: The results showed 59 differential peptide peaks in CRC, colorectal adenoma and health volunteers. A genetic algorithm was used to set up the classification models. Four of the identified peaks at m/z 797, 810, 4078 and 5343 were used to construct peptidome patterns, achieving an accuracy of 100% (> CEA, P<0.05). Furthermore, the peptidome patterns could differentiate the validation group with high accuracy close to 100%. Conclusions: Our results showed that proteomic analysis of serum with MALDI-TOF MS is a fast and reproducible approach, which may provide a novel approach to screening for CRC.